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Volumn 32, Issue 5, 2014, Pages 525-537

The HCV life cycle: In vitro tissue culture systems and therapeutic targets

Author keywords

Cyclophilin A; Hepatitis C; Host targeting antivirals; MicroRNA 122; Phosphatidylinositol 4 kinase III

Indexed keywords

ALISPORIVIR; ANTIVIRUS AGENT; CYCLOPHILIN A; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; GLYCOPROTEIN E2; INTERFERON; LOCKED NUCLEIC ACID; MICRORNA 122; MIRAVIRSEN; PHOSPHATIDYLINOSITOL 4 KINASE IIIALPHA; PHOSPHATIDYLINOSITOL KINASE; RIBAVIRIN; SCY 635; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; HOST FACTOR;

EID: 84904677342     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000360830     Document Type: Article
Times cited : (28)

References (119)
  • 1
    • 78751621217 scopus 로고    scopus 로고
    • Evolving epidemiology of hepatitis C virus
    • Lavanchy D: Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect 2011; 17: 107.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 107
    • Lavanchy, D.1
  • 2
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB: Natural history of chronic hepatitis C. Hepatology 2002; 36:S35.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 3
    • 23944480609 scopus 로고    scopus 로고
    • Hepatitis C and liver transplantation
    • Brown RS: Hepatitis C and liver transplantation. Nature 2005; 436: 973.
    • (2005) Nature , vol.436 , pp. 973
    • Brown, R.S.1
  • 4
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, et al: Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359.
    • (1989) Science , vol.244 , pp. 359
    • Choo, Q.L.1
  • 5
  • 6
    • 61949320778 scopus 로고    scopus 로고
    • Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type i and effect of antiviral drugs
    • Gottwein JM, et al: Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 2009; 49: 364.
    • (2009) Hepatology , vol.49 , pp. 364
    • Gottwein, J.M.1
  • 8
    • 84873083416 scopus 로고    scopus 로고
    • A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    • Prokunina-Olsson L, et al: A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet 2013; 45: 164.
    • (2013) Nat Genet , vol.45 , pp. 164
    • Prokunina-Olsson, L.1
  • 9
    • 78650971350 scopus 로고    scopus 로고
    • Screening for IL28B gene variants identifies predictors of hepatitis C therapy success
    • Doehring A, et al: Screening for IL28B gene variants identifies predictors of hepatitis C therapy success. Antivir Ther 2010; 15: 1099.
    • (2010) Antivir Ther , vol.15 , pp. 1099
    • Doehring, A.1
  • 10
    • 79960452181 scopus 로고    scopus 로고
    • Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
    • Lange CM, et al: Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection. J Hepatol 2010; 55: 322-327.
    • (2010) J Hepatol , vol.55 , pp. 322-327
    • Lange, C.M.1
  • 11
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, et al: Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461: 798.
    • (2009) Nature , vol.461 , pp. 798
    • Thomas, D.L.1
  • 12
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, et al: Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399.
    • (2009) Nature , vol.461 , pp. 399
    • Ge, D.1
  • 13
    • 84861206498 scopus 로고    scopus 로고
    • Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    • Wu X, et al: Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog 2012; 8:e1002617.
    • (2012) PLoS Pathog , vol.8
    • Wu, X.1
  • 14
    • 84857125662 scopus 로고    scopus 로고
    • Modeling hepatitis C virus infection using human-induced pluripotent stem cells
    • Schwartz RE, et al: Modeling hepatitis C virus infection using human-induced pluripotent stem cells. Proc Natl Acad Sci USA 2012; 109: 2544.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2544
    • Schwartz, R.E.1
  • 15
    • 84863982020 scopus 로고    scopus 로고
    • Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
    • Roelandt P, et al: Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus. J Hepatol 2012; 57: 246.
    • (2012) J Hepatol , vol.57 , pp. 246
    • Roelandt, P.1
  • 16
    • 84855212109 scopus 로고    scopus 로고
    • New targets for antiviral therapy of chronic hepatitis C
    • Buhler S, Bartenschlager R: New targets for antiviral therapy of chronic hepatitis C. Liver Int 2012; 32(suppl 1):9.
    • (2012) Liver Int , vol.32 , Issue.SUPPL. 1 , pp. 9
    • Buhler, S.1    Bartenschlager, R.2
  • 17
    • 84880309916 scopus 로고    scopus 로고
    • Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
    • Scheel TK, Rice CM: Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nat Med 2013; 19: 837.
    • (2013) Nat Med , vol.19 , pp. 837
    • Scheel, T.K.1    Rice, C.M.2
  • 18
    • 84881314351 scopus 로고    scopus 로고
    • Novel therapies for hepatitis C - One pill fits all?
    • Manns MP, von Hahn T: Novel therapies for hepatitis C - one pill fits all? Nat Rev Drug Discov 2013; 12: 595.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 595
    • Manns, M.P.1    Von Hahn, T.2
  • 19
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann V, et al: Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999; 285: 110.
    • (1999) Science , vol.285 , pp. 110
    • Lohmann, V.1
  • 20
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • Bartosch B, Dubuisson J, Cosset FL: Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med 2003; 197: 633.
    • (2003) J Exp Med , vol.197 , pp. 633
    • Bartosch, B.1    Dubuisson, J.2    Cosset, F.L.3
  • 21
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    • Hsu M, et al: Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA 2003; 100: 7271.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7271
    • Hsu, M.1
  • 22
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, et al: Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005; 11: 791.
    • (2005) Nat Med , vol.11 , pp. 791
    • Wakita, T.1
  • 23
    • 23044437222 scopus 로고    scopus 로고
    • Complete replication of hepatitis C virus in cell culture
    • Lindenbach BD, et al: Complete replication of hepatitis C virus in cell culture. Science 2005; 309: 623.
    • (2005) Science , vol.309 , pp. 623
    • Lindenbach, B.D.1
  • 24
    • 21544440397 scopus 로고    scopus 로고
    • Robust hepatitis C virus infection in vitro
    • Zhong J, et al: Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA 2005; 102: 9294.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9294
    • Zhong, J.1
  • 25
    • 61549094070 scopus 로고    scopus 로고
    • Genotype 1a HCV (H77S) infection system
    • Yi M, Lemon SM: Genotype 1a HCV (H77S) infection system. Methods Mol Biol 2009; 510: 337.
    • (2009) Methods Mol Biol , vol.510 , pp. 337
    • Yi, M.1    Lemon, S.M.2
  • 26
    • 84870372937 scopus 로고    scopus 로고
    • Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
    • Li YP, et al: Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system. Proc Natl Acad Sci USA 2012; 109: 19757.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 19757
    • Li, Y.P.1
  • 27
    • 84893053264 scopus 로고    scopus 로고
    • Highly efficient infectious cell culture of three HCV genotype 2b strains and sensitivity to lead protease, NS5A, and polymerase inhibitors
    • Ramirez S, et al: Highly efficient infectious cell culture of three HCV genotype 2b strains and sensitivity to lead protease, NS5A, and polymerase inhibitors. Hepatology 2014; 59: 395-407.
    • (2014) Hepatology , vol.59 , pp. 395-407
    • Ramirez, S.1
  • 28
    • 47049115607 scopus 로고    scopus 로고
    • Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles
    • Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T: Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol 2008; 82: 7034.
    • (2008) J Virol , vol.82 , pp. 7034
    • Steinmann, E.1    Brohm, C.2    Kallis, S.3    Bartenschlager, R.4    Pietschmann, T.5
  • 29
    • 10644226734 scopus 로고    scopus 로고
    • Kissing-loop interaction in the 3 - end of the hepatitis C virus genome essential for RNA replication
    • Friebe P, Boudet J, Simorre JP, Bartenschlager R: Kissing-loop interaction in the 3 ? end of the hepatitis C virus genome essential for RNA replication. J Virol 2005; 79: 380.
    • (2005) J Virol , vol.79 , pp. 380
    • Friebe, P.1    Boudet, J.2    Simorre, J.P.3    Bartenschlager, R.4
  • 30
    • 0037370622 scopus 로고    scopus 로고
    • Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture
    • Blight KJ, McKeating JA, Marcotrigiano J, Rice CM: Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J Virol 2003; 77: 3181.
    • (2003) J Virol , vol.77 , pp. 3181
    • Blight, K.J.1    McKeating, J.A.2    Marcotrigiano, J.3    Rice, C.M.4
  • 31
    • 84875238839 scopus 로고    scopus 로고
    • Entry and replication of recombinant hepatitis C viruses in cell culture
    • Vieyres G, Pietschmann T: Entry and replication of recombinant hepatitis C viruses in cell culture. Methods 2013; 59: 233.
    • (2013) Methods , vol.59 , pp. 233
    • Vieyres, G.1    Pietschmann, T.2
  • 32
    • 33644862356 scopus 로고    scopus 로고
    • Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
    • Lindenbach BD, et al: Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proc Natl Acad Sci USA 2006; 103: 3805.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3805
    • Lindenbach, B.D.1
  • 33
    • 84880633341 scopus 로고    scopus 로고
    • Different requirements for scavenger receptor class B type i in hepatitis C virus cell-free versus cell-to-cell transmission
    • Catanese MT, et al: Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission. J Virol 2013; 87: 8282.
    • (2013) J Virol , vol.87 , pp. 8282
    • Catanese, M.T.1
  • 34
    • 77649262300 scopus 로고    scopus 로고
    • Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
    • Ploss A, et al: Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci USA 2010; 107: 3141-3145.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3141-3145
    • Ploss, A.1
  • 35
    • 82455188188 scopus 로고    scopus 로고
    • Hepatitis C virus induces interferon-? and interferon-stimulated genes in primary liver cultures
    • Marukian S, et al: Hepatitis C virus induces interferon-? and interferon-stimulated genes in primary liver cultures. Hepatology 2011; 54: 1913-1923.
    • (2011) Hepatology , vol.54 , pp. 1913-1923
    • Marukian, S.1
  • 36
    • 18644378971 scopus 로고    scopus 로고
    • The human scavenger receptor class B type i is a novel candidate receptor for the hepatitis C virus
    • Scarselli E, et al: The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J 2002; 21: 5017.
    • (2002) EMBO J , vol.21 , pp. 5017
    • Scarselli, E.1
  • 37
    • 0032582538 scopus 로고    scopus 로고
    • Binding of hepatitis C virus to CD81
    • Pileri P, et al: Binding of hepatitis C virus to CD81. Science 1998; 282: 938.
    • (1998) Science , vol.282 , pp. 938
    • Pileri, P.1
  • 38
    • 34147219730 scopus 로고    scopus 로고
    • Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
    • Evans MJ, et al: Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 2007; 446: 801.
    • (2007) Nature , vol.446 , pp. 801
    • Evans, M.J.1
  • 39
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    • Ploss A, et al: Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 2009; 457: 882.
    • (2009) Nature , vol.457 , pp. 882
    • Ploss, A.1
  • 40
    • 59649117842 scopus 로고    scopus 로고
    • Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection
    • Liu S, et al: Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol 2009; 83: 2011.
    • (2009) J Virol , vol.83 , pp. 2011
    • Liu, S.1
  • 41
    • 34848847014 scopus 로고    scopus 로고
    • Scavenger receptor class B type i is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
    • Zeisel MB, et al: Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology 2007; 46: 1722.
    • (2007) Hepatology , vol.46 , pp. 1722
    • Zeisel, M.B.1
  • 42
    • 33646743366 scopus 로고    scopus 로고
    • Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses
    • Koutsoudakis G, et al: Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol 2006; 80: 5308.
    • (2006) J Virol , vol.80 , pp. 5308
    • Koutsoudakis, G.1
  • 43
    • 84875978697 scopus 로고    scopus 로고
    • Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies
    • Sourisseau M, et al: Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies. PLoS Pathog 2013; 9:e1003244.
    • (2013) PLoS Pathog , vol.9
    • Sourisseau, M.1
  • 44
    • 50149109390 scopus 로고    scopus 로고
    • CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes
    • Brazzoli M, et al: CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes. J Virol 2008; 82: 8316.
    • (2008) J Virol , vol.82 , pp. 8316
    • Brazzoli, M.1
  • 45
    • 84860193841 scopus 로고    scopus 로고
    • Hepatitis C virus induces CD81 and claudin-1 endocytosis
    • Farquhar MJ, et al: Hepatitis C virus induces CD81 and claudin-1 endocytosis. J Virol 2012; 86: 4305.
    • (2012) J Virol , vol.86 , pp. 4305
    • Farquhar, M.J.1
  • 46
    • 79958291149 scopus 로고    scopus 로고
    • A genetically humanized mouse model for hepatitis C virus infection
    • Dorner M, et al: A genetically humanized mouse model for hepatitis C virus infection. Nature 2011; 474: 208.
    • (2011) Nature , vol.474 , pp. 208
    • Dorner, M.1
  • 47
    • 58149384511 scopus 로고    scopus 로고
    • Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo
    • Meuleman P, et al: Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo. Hepatology 2008; 48: 1761.
    • (2008) Hepatology , vol.48 , pp. 1761
    • Meuleman, P.1
  • 48
    • 80054713474 scopus 로고    scopus 로고
    • A human monoclonal antibody targeting scavenger receptor class B type i precludes hepatitis C virus infection and viral spread in vitro and in vivo
    • Meuleman P, et al: A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo. Hepatology 2012; 55: 364.
    • (2012) Hepatology , vol.55 , pp. 364
    • Meuleman, P.1
  • 49
    • 84862652238 scopus 로고    scopus 로고
    • Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice
    • Lacek K, et al: Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice. J Hepatol 2012; 57: 17.
    • (2012) J Hepatol , vol.57 , pp. 17
    • Lacek, K.1
  • 50
    • 33750356630 scopus 로고    scopus 로고
    • Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction
    • Barth H, et al: Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. J Virol 2006; 80: 10579.
    • (2006) J Virol , vol.80 , pp. 10579
    • Barth, H.1
  • 51
    • 0033607281 scopus 로고    scopus 로고
    • Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor
    • Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX: Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci USA 1999; 96: 12766.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12766
    • Agnello, V.1    Abel, G.2    Elfahal, M.3    Knight, G.B.4    Zhang, Q.X.5
  • 52
    • 70350124913 scopus 로고    scopus 로고
    • Apolipoprotein e on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor
    • Owen DM, Huang H, Ye J, Gale M Jr: Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor. Virology 2009; 394: 99.
    • (2009) Virology , vol.394 , pp. 99
    • Owen, D.M.1    Huang, H.2    Ye, J.3    Gale Jr., M.4
  • 53
    • 79955692689 scopus 로고    scopus 로고
    • EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
    • Lupberger J, et al: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 2011; 17: 589.
    • (2011) Nat Med , vol.17 , pp. 589
    • Lupberger, J.1
  • 54
    • 84856732297 scopus 로고    scopus 로고
    • Identification of the Niemann- Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
    • Sainz B Jr, et al: Identification of the Niemann- Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 2012; 18: 281.
    • (2012) Nat Med , vol.18 , pp. 281
    • Sainz Jr., B.1
  • 55
    • 84879549180 scopus 로고    scopus 로고
    • Identification of transferrin receptor 1 as a hepatitis C virus entry factor
    • Martin DN, Uprichard SL: Identification of transferrin receptor 1 as a hepatitis C virus entry factor. Proc Natl Acad Sci USA 2013; 110: 10777.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 10777
    • Martin, D.N.1    Uprichard, S.L.2
  • 56
    • 0345144016 scopus 로고    scopus 로고
    • Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons
    • Gosert R, et al: Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol 2003; 77: 5487.
    • (2003) J Virol , vol.77 , pp. 5487
    • Gosert, R.1
  • 57
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger D, et al: Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol 2002; 76: 5974.
    • (2002) J Virol , vol.76 , pp. 5974
    • Egger, D.1
  • 58
    • 84885995316 scopus 로고    scopus 로고
    • Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment
    • Paul D, Hoppe S, Saher G, Krijnse-Locker J, Bartenschlager R: Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. J Virol 2013; 87: 10612-10627.
    • (2013) J Virol , vol.87 , pp. 10612-10627
    • Paul, D.1    Hoppe, S.2    Saher, G.3    Krijnse-Locker, J.4    Bartenschlager, R.5
  • 59
    • 84872010602 scopus 로고    scopus 로고
    • Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication
    • Romero-Brey I, et al: Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog 2012; 8:e1003056.
    • (2012) PLoS Pathog , vol.8
    • Romero-Brey, I.1
  • 60
    • 27144513392 scopus 로고    scopus 로고
    • Quantitative analysis of the hepatitis C virus replication complex
    • Quinkert D, Bartenschlager R, Lohmann V: Quantitative analysis of the hepatitis C virus replication complex. J Virol 2005; 79: 13594.
    • (2005) J Virol , vol.79 , pp. 13594
    • Quinkert, D.1    Bartenschlager, R.2    Lohmann, V.3
  • 61
    • 78149359508 scopus 로고    scopus 로고
    • Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase- 1
    • Herker E, et al: Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase- 1. Nat Med 2010; 16: 1295.
    • (2010) Nat Med , vol.16 , pp. 1295
    • Herker, E.1
  • 62
    • 84864581005 scopus 로고    scopus 로고
    • MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles
    • Menzel N, et al: MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. PLoS Pathog 2012; 8:e1002829.
    • (2012) PLoS Pathog , vol.8
    • Menzel, N.1
  • 63
    • 78649633787 scopus 로고    scopus 로고
    • Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors
    • Syder AJ, et al: Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. J Hepatol 2011; 54: 48.
    • (2011) J Hepatol , vol.54 , pp. 48
    • Syder, A.J.1
  • 64
    • 84863012788 scopus 로고    scopus 로고
    • Evaluation of ITX 5061, a scavenger receptor B1 antagonist: Resistance selection and activity in combination with other hepatitis C virus antivirals
    • Zhu H, et al: Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals. J Infect Dis 2012; 205: 656.
    • (2012) J Infect Dis , vol.205 , pp. 656
    • Zhu, H.1
  • 65
    • 84894235263 scopus 로고    scopus 로고
    • Safety and antiviral activity of the HCV entry inhibitor ITX 5061 in treatment-naive HCV-infected adults: A randomized, double-blind, phase 1B study
    • Sulkowski MS, et al: Safety and antiviral activity of the HCV entry inhibitor ITX 5061 in treatment-naive HCV-infected adults: a randomized, double-blind, phase 1B study. J Infect Dis 2014; 209: 658-667.
    • (2014) J Infect Dis , vol.209 , pp. 658-667
    • Sulkowski, M.S.1
  • 66
    • 34047144973 scopus 로고    scopus 로고
    • Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors
    • Chapel C, et al: Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors. J Gen Virol 2007; 88: 1133.
    • (2007) J Gen Virol , vol.88 , pp. 1133
    • Chapel, C.1
  • 67
    • 33645550893 scopus 로고    scopus 로고
    • Antiviral effect of ?-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles
    • Chapel C, et al: Antiviral effect of ?-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles. J Gen Virol 2006; 87: 861.
    • (2006) J Gen Virol , vol.87 , pp. 861
    • Chapel, C.1
  • 68
    • 34548297405 scopus 로고    scopus 로고
    • Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus
    • Steinmann E, et al: Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology 2007; 46: 330.
    • (2007) Hepatology , vol.46 , pp. 330
    • Steinmann, E.1
  • 69
    • 68649083959 scopus 로고    scopus 로고
    • Celgosivir, an ?-glucosidase i inhibitor for the potential treatment of HCV infection
    • Durantel D: Celgosivir, an ?-glucosidase I inhibitor for the potential treatment of HCV infection. Curr Opin Investig Drugs 2009; 10: 860.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 860
    • Durantel, D.1
  • 70
    • 39149122218 scopus 로고    scopus 로고
    • Validation of diacylglycerol acyltransferase 1 as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor
    • Zhao G, et al: Validation of diacylglycerol acyltransferase 1 as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 2008; 51: 380.
    • (2008) J Med Chem , vol.51 , pp. 380
    • Zhao, G.1
  • 71
    • 67650550814 scopus 로고    scopus 로고
    • The isomerase active site of cyclophilin A is critical for hepatitis C virus replication
    • Chatterji U, et al: The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. J Biol Chem 2009; 284: 16998.
    • (2009) J Biol Chem , vol.284 , pp. 16998
    • Chatterji, U.1
  • 72
    • 67449093865 scopus 로고    scopus 로고
    • Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex
    • Liu Z, Yang F, Robotham JM, Tang H: Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex. J Virol 2009; 83: 6554.
    • (2009) J Virol , vol.83 , pp. 6554
    • Liu, Z.1    Yang, F.2    Robotham, J.M.3    Tang, H.4
  • 73
    • 70049096419 scopus 로고    scopus 로고
    • Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics
    • Kaul A, et al: Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog 2009; 5: e1000546.
    • (2009) PLoS Pathog , vol.5
    • Kaul, A.1
  • 74
    • 43949123575 scopus 로고    scopus 로고
    • Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    • Yang F, et al: Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J Virol 2008; 82: 5269.
    • (2008) J Virol , vol.82 , pp. 5269
    • Yang, F.1
  • 75
    • 21244433445 scopus 로고    scopus 로고
    • Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase
    • Watashi K, et al: Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell 2005; 19: 111.
    • (2005) Mol Cell , vol.19 , pp. 111
    • Watashi, K.1
  • 76
    • 79960422127 scopus 로고    scopus 로고
    • Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner
    • Foster TL, Gallay P, Stonehouse NJ, Harris M: Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. J Virol 2011; 85: 7460.
    • (2011) J Virol , vol.85 , pp. 7460
    • Foster, T.L.1    Gallay, P.2    Stonehouse, N.J.3    Harris, M.4
  • 77
    • 79958018094 scopus 로고    scopus 로고
    • Domain 3 of NS5A protein from the hepatitis C virus has intrinsic ?-helical propensity and is a substrate of cyclophilin A
    • Verdegem D, et al: Domain 3 of NS5A protein from the hepatitis C virus has intrinsic ?-helical propensity and is a substrate of cyclophilin A. J Biol Chem 2011; 286: 20441.
    • (2011) J Biol Chem , vol.286 , pp. 20441
    • Verdegem, D.1
  • 78
    • 77951046665 scopus 로고    scopus 로고
    • HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors
    • Chatterji U, et al: HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol 2010; 53: 50.
    • (2010) J Hepatol , vol.53 , pp. 50
    • Chatterji, U.1
  • 79
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K: Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282.
    • (2003) Hepatology , vol.38 , pp. 1282
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 80
    • 84881553622 scopus 로고    scopus 로고
    • Curing a viral infection by targeting the host: The example of cyclophilin inhibitors
    • Lin K, Gallay P: Curing a viral infection by targeting the host: the example of cyclophilin inhibitors. Antiviral Res 2013; 99: 68.
    • (2013) Antiviral Res , vol.99 , pp. 68
    • Lin, K.1    Gallay, P.2
  • 81
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor Debio 025 combined with PEG IFN?2a significantly reduces viral load in treatment-naive hepatitis C patients
    • Flisiak R, et al: The cyclophilin inhibitor Debio 025 combined with PEG IFN?2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 2009; 49: 1460.
    • (2009) Hepatology , vol.49 , pp. 1460
    • Flisiak, R.1
  • 82
    • 84869232160 scopus 로고    scopus 로고
    • Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors
    • Nag A, Robotham JM, Tang H: Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors. J Virol 2012; 86: 12616.
    • (2012) J Virol , vol.86 , pp. 12616
    • Nag, A.1    Robotham, J.M.2    Tang, H.3
  • 83
    • 84863704212 scopus 로고    scopus 로고
    • Alisporivir plus ribavirin is highly effective as interferon-free or interferon- add-on regimen in previously untreated HCV-G2 or G3 patients: SVR12 results from VITAL-1 Phase 2b Study
    • Pawlotsky J-M, et al: Alisporivir plus ribavirin is highly effective as interferon-free or interferon- add-on regimen in previously untreated HCV-G2 or G3 patients: SVR12 results from VITAL-1 Phase 2b Study. J Hepatol 2012; 56:S553.
    • (2012) J Hepatol , vol.56
    • Pawlotsky, J.-M.1
  • 84
    • 84864207679 scopus 로고    scopus 로고
    • Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication
    • Von Hahn T, et al: Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication. Gastroenterology 2012; 143: 439.
    • (2012) Gastroenterology , vol.143 , pp. 439
    • Von Hahn, T.1
  • 85
    • 84862697734 scopus 로고    scopus 로고
    • The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection
    • Hopkins S, et al: The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection. J Hepatol 2012; 57: 47.
    • (2012) J Hepatol , vol.57 , pp. 47
    • Hopkins, S.1
  • 86
    • 84871214907 scopus 로고    scopus 로고
    • HCV NS5A and IRF9 compete for CypA binding
    • Bobardt M, et al: HCV NS5A and IRF9 compete for CypA binding. J Hepatol 2013; 58: 16.
    • (2013) J Hepatol , vol.58 , pp. 16
    • Bobardt, M.1
  • 87
    • 84904625894 scopus 로고    scopus 로고
    • Cyclophilin inhibitors potentiate interferon signaling through diminished PKR phosphorylation in HCV-infected cells
    • Watashi K, Daito T, Sluder A, Borroto-Esoda K, Wakita T: Cyclophilin inhibitors potentiate interferon signaling through diminished PKR phosphorylation in HCV-infected cells. J Hepatol 2013; 58:S5.
    • (2013) J Hepatol , vol.58
    • Watashi, K.1    Daito, T.2    Sluder, A.3    Borroto-Esoda, K.4    Wakita, T.5
  • 88
    • 38049141270 scopus 로고    scopus 로고
    • Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening
    • Supekova L, et al: Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem 2008; 283: 29.
    • (2008) J Biol Chem , vol.283 , pp. 29
    • Supekova, L.1
  • 89
    • 61849160363 scopus 로고    scopus 로고
    • A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
    • Tai AW, et al: A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 2009; 5: 298.
    • (2009) Cell Host Microbe , vol.5 , pp. 298
    • Tai, A.W.1
  • 90
    • 63549101398 scopus 로고    scopus 로고
    • Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication
    • Vaillancourt FH, et al: Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication. Virology 2009; 387: 5.
    • (2009) Virology , vol.387 , pp. 5
    • Vaillancourt, F.H.1
  • 91
    • 66149128094 scopus 로고    scopus 로고
    • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III? in hepatitis C virus replication
    • Berger KL, et al: Roles for endocytic trafficking and phosphatidylinositol 4-kinase III? in hepatitis C virus replication. Proc Natl Acad Sci USA 2009; 106: 7577.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7577
    • Berger, K.L.1
  • 92
    • 70349296821 scopus 로고    scopus 로고
    • Class III phosphatidylinositol 4-kinase and ? Are novel host factor regulators of hepatitis C virus replication
    • Borawski J, et al: Class III phosphatidylinositol 4-kinase ? and ? are novel host factor regulators of hepatitis C virus replication. J Virol 2009; 83: 10058.
    • (2009) J Virol , vol.83 , pp. 10058
    • Borawski, J.1
  • 93
    • 70350541050 scopus 로고    scopus 로고
    • Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening
    • Trotard M, et al: Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. FASEB J 2009; 23: 3780.
    • (2009) FASEB J , vol.23 , pp. 3780
    • Trotard, M.1
  • 94
    • 78751512667 scopus 로고    scopus 로고
    • Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment
    • Reiss S, et al: Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 2011; 9: 32.
    • (2011) Cell Host Microbe , vol.9 , pp. 32
    • Reiss, S.1
  • 95
    • 70349513508 scopus 로고    scopus 로고
    • A genome-wide genetic screen for host factors required for hepatitis C virus propagation
    • Li Q, et al: A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci USA 2009; 106: 16410.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16410
    • Li, Q.1
  • 96
    • 34250354423 scopus 로고    scopus 로고
    • Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology
    • Ng TI, et al: Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology. Hepatology 2007; 45: 1413.
    • (2007) Hepatology , vol.45 , pp. 1413
    • Ng, T.I.1
  • 97
    • 84878499077 scopus 로고    scopus 로고
    • The lipid kinase phosphatidylinositol-4 kinase III? Regulates the phosphorylation status of hepatitis C virus NS5A
    • Reiss S, et al: The lipid kinase phosphatidylinositol-4 kinase III? regulates the phosphorylation status of hepatitis C virus NS5A. PLoS pathogens 2013; 9:e1003359.
    • (2013) PLoS Pathogens , vol.9
    • Reiss, S.1
  • 98
    • 84868143510 scopus 로고    scopus 로고
    • Evaluation of phosphatidylinositol- 4-kinase III? As a hepatitis C virus drug target
    • Vaillancourt FH, et al: Evaluation of phosphatidylinositol- 4-kinase III? as a hepatitis C virus drug target. J Virol 2012; 86: 11595.
    • (2012) J Virol , vol.86 , pp. 11595
    • Vaillancourt, F.H.1
  • 99
    • 84861217162 scopus 로고    scopus 로고
    • Metabolism of phosphatidylinositol 4-kinase III?-dependent PI4P is subverted by HCV and is targeted by a 4-anilino- quinazoline with antiviral activity
    • Bianco A, et al: Metabolism of phosphatidylinositol 4-kinase III?-dependent PI4P is subverted by HCV and is targeted by a 4-anilino- quinazoline with antiviral activity. PLoS Pathog 2012; 8:e1002576.
    • (2012) PLoS Pathog , vol.8
    • Bianco, A.1
  • 100
    • 84877766936 scopus 로고    scopus 로고
    • Molecular mechanisms of RNA interference
    • Wilson RC, Doudna JA: Molecular mechanisms of RNA interference. Annu Rev Biophys 2013; 42: 217.
    • (2013) Annu Rev Biophys , vol.42 , pp. 217
    • Wilson, R.C.1    Doudna, J.A.2
  • 101
  • 102
    • 46749124698 scopus 로고    scopus 로고
    • Positiondependent function for a tandem micro- RNA miR-122-binding site located in the hepatitis C virus RNA genome
    • Jopling CL, Schutz S, Sarnow P: Positiondependent function for a tandem micro- RNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe 2008; 4: 77.
    • (2008) Cell Host Microbe , vol.4 , pp. 77
    • Jopling, C.L.1    Schutz, S.2    Sarnow, P.3
  • 103
    • 58049217312 scopus 로고    scopus 로고
    • MicroRNA-122 stimulates translation of hepatitis C virus RNA
    • Henke JI, et al: microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J 2008; 27: 3300.
    • (2008) EMBO J , vol.27 , pp. 3300
    • Henke, J.I.1
  • 104
    • 84873149944 scopus 로고    scopus 로고
    • Competing and noncompeting activities of miR-122 and the 5 ? -exonuclease Xrn1 in regulation of hepatitis C virus replication
    • Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM: Competing and noncompeting activities of miR-122 and the 5 ? -exonuclease Xrn1 in regulation of hepatitis C virus replication. Proc Natl Acad Sci USA 2013; 110: 1881.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1881
    • Li, Y.1    Masaki, T.2    Yamane, D.3    McGivern, D.R.4    Lemon, S.M.5
  • 105
    • 79952768199 scopus 로고    scopus 로고
    • Masking the 5 ? -terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA- target RNA complex
    • Machlin ES, Sarnow P, Sagan SM: Masking the 5 ? -terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA- target RNA complex. Proc Natl Acad Sci USA 2011; 108: 3193.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3193
    • Machlin, E.S.1    Sarnow, P.2    Sagan, S.M.3
  • 106
    • 84856367312 scopus 로고    scopus 로고
    • Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
    • Shimakami T, et al: Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci USA 2012; 109: 941.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 941
    • Shimakami, T.1
  • 107
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific micro- RNA
    • Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarno P: Modulation of hepatitis C virus RNA abundance by a liver-specific micro- RNA. Science 2005; 309: 1577.
    • (2005) Science , vol.309 , pp. 1577
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarno, P.5
  • 108
    • 84867220979 scopus 로고    scopus 로고
    • Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance
    • Zhang C, et al: Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance. Virology 2012; 433: 479.
    • (2012) Virology , vol.433 , pp. 479
    • Zhang, C.1
  • 109
    • 84869025358 scopus 로고    scopus 로고
    • Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells
    • Da Costa D, et al: Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J Virol 2012; 86: 11919.
    • (2012) J Virol , vol.86 , pp. 11919
    • Da Costa, D.1
  • 110
    • 84882843221 scopus 로고    scopus 로고
    • Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines
    • Vogt A, et al: Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. Virology 2013; 444: 1-11.
    • (2013) Virology , vol.444 , pp. 1-11
    • Vogt, A.1
  • 111
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford RE, et al: Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010; 327: 198.
    • (2010) Science , vol.327 , pp. 198
    • Lanford, R.E.1
  • 112
    • 79953201904 scopus 로고    scopus 로고
    • MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5 ? -UTR
    • Li YP, Gottwein JM, Scheel TK, Jensen TB, Bukh J: MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5 ? -UTR. Proc Natl Acad Sci USA 2011; 108: 4991.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4991
    • Li, Y.P.1    Gottwein, J.M.2    Scheel, T.K.3    Jensen, T.B.4    Bukh, J.5
  • 113
    • 84872177274 scopus 로고    scopus 로고
    • Sequence analysis of HCV variants from a phase IIA trial of miravirsen (MIR), an oligonucleotide targeting miR- 122, in treatment-naive patients with chronic HCV infection
    • Patick AK, et al: Sequence analysis of HCV variants from a phase IIA trial of miravirsen (MIR), an oligonucleotide targeting miR- 122, in treatment-naive patients with chronic HCV infection. J Hepatol 2012; 56:S476.
    • (2012) J Hepatol , vol.56
    • Patick, A.K.1
  • 114
    • 84870437088 scopus 로고    scopus 로고
    • Final results - Randomized, double-blind, placebo-controlled safety, anti-viral proof-of-concept study of miravirsen, an oligonucleotide targeting miR- 122, in treatment-naive patients with genotype 1 chronic HCV infection
    • Reesink HW, et al: Final results - randomized, double-blind, placebo-controlled safety, anti-viral proof-of-concept study of miravirsen, an oligonucleotide targeting miR- 122, in treatment-naive patients with genotype 1 chronic HCV infection. J Hepatol 2012; 56:S26.
    • (2012) J Hepatol , vol.56
    • Reesink, H.W.1
  • 115
    • 84867705216 scopus 로고    scopus 로고
    • Pharmacokinetics of miravirsen, a miR-122 inhibitor, predict the prolonged viral load reduction in treatment-naive genotype 1 HCV-infected patients
    • Persson R, et al: Pharmacokinetics of miravirsen, a miR-122 inhibitor, predict the prolonged viral load reduction in treatment-naive genotype 1 HCV-infected patients. J Hepatol 2012; 56:S477.
    • (2012) J Hepatol , vol.56
    • Persson, R.1
  • 116
    • 84864761391 scopus 로고    scopus 로고
    • Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
    • Hsu SH, et al: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest 2012; 122: 2871.
    • (2012) J Clin Invest , vol.122 , pp. 2871
    • Hsu, S.H.1
  • 118
    • 84888778890 scopus 로고    scopus 로고
    • Hepatitis C virus E2 envelope glycoprotein core structure
    • Kong L, et al: Hepatitis C virus E2 envelope glycoprotein core structure. Science 2013; 342:1090-1094.
    • (2013) Science , vol.342 , pp. 1090-1094
    • Kong, L.1
  • 119
    • 84900798422 scopus 로고    scopus 로고
    • Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2
    • DOI: 10.1038/nature13117. Epub ahead of print
    • Khan AG, et al: Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. Nature 2014. DOI: 10.1038/nature13117. Epub ahead of print.
    • (2014) Nature
    • Khan, A.G.1


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