HCV NS5A and IRF9 compete for CypA binding

Journal of Hepatology

Volumn 58, Issue 1, 2013, Pages 16-23

  Bobardt, Michael ^a   Hopkins, Sam ^b   Baugh, James ^a   Chatterji, Udayan ^a   Hernandez, Felicia ^a   Hiscott, John ^c   Sluder, Ann ^b   Lin, Kai ^d   Gallay, Philippe A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Scynexis Inc   (United States)

^c Vaccine and Gene Therapy Institute of Florida   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

cyclophilin A; cyclophilin inhibitors; HCV; IFN; NS5A

Indexed keywords

ALISPORIVIR; CYCLOPHILIN A; CYCLOSPORIN A; DNA BINDING PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; HISTONE H2A; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; NONSTRUCTURAL PROTEIN 5A; PEPTIDYLPROLYL ISOMERASE; RECOMBINANT CYCLOPHILIN A; RECOMBINANT PROTEIN; SCY 635; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; GENETIC TRANSCRIPTION; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VIRUS REPLICATION;

BINDING SITES; BINDING, COMPETITIVE; CYCLOPHILIN A; HEP G2 CELLS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; INTERFERONS; JANUS KINASES; LIGANDS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; VIRAL LOAD; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84871214907     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.08.007     Document Type: Article

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