메뉴 건너뛰기




Volumn 21, Issue 7, 2014, Pages 819-830

Folate pathway disruption leads to critical disruption of methionine derivatives in mycobacterium tuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; BACTERIAL PROTEIN; DAPSONE; FOLIC ACID; FOLIC ACID ANTAGONIST; JSF 1187; MESSENGER RNA; META PROTEIN; METC PROTEIN; METH PROTEIN; METHIONINE; METHIONINE DERIVATIVE; S ADENOSYLMETHIONINE; SPEE PROTEIN; SULFAMETHOXAZOLE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

EID: 84904643358     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.04.009     Document Type: Article
Times cited : (62)

References (59)
  • 1
    • 0031725620 scopus 로고    scopus 로고
    • Thymine metabolism and thymineless death in prokaryotes and eukaryotes
    • S.I. Ahmad, S.H. Kirk, and A. Eisenstark Thymine metabolism and thymineless death in prokaryotes and eukaryotes Annu. Rev. Microbiol. 52 1998 591 625
    • (1998) Annu. Rev. Microbiol. , vol.52 , pp. 591-625
    • Ahmad, S.I.1    Kirk, S.H.2    Eisenstark, A.3
  • 2
    • 0016030365 scopus 로고
    • Trimethoprim action and its analogy with thymine starvation
    • S.G. Amyes, and J.T. Smith Trimethoprim action and its analogy with thymine starvation Antimicrob. Agents Chemother. 5 1974 169 178
    • (1974) Antimicrob. Agents Chemother. , vol.5 , pp. 169-178
    • Amyes, S.G.1    Smith, J.T.2
  • 3
    • 84862016373 scopus 로고    scopus 로고
    • The unsurprising story of MDR-TB resistance in India
    • G.R. Babu, and R. Laxminarayan The unsurprising story of MDR-TB resistance in India Tuberculosis (Edinb.) 92 2012 301 306
    • (2012) Tuberculosis (Edinb.) , vol.92 , pp. 301-306
    • Babu, G.R.1    Laxminarayan, R.2
  • 4
    • 84897573640 scopus 로고    scopus 로고
    • A short history of dapsone, or an alternative model of drug development
    • J. Barr A short history of dapsone, or an alternative model of drug development Pharm. Hist. 53 2011 123 147
    • (2011) Pharm. Hist. , vol.53 , pp. 123-147
    • Barr, J.1
  • 5
    • 0026686943 scopus 로고
    • Tuberculosis: Commentary on a reemergent killer
    • B.R. Bloom, and C.J. Murray Tuberculosis: Commentary on a reemergent killer Science 257 1992 1055 1064
    • (1992) Science , vol.257 , pp. 1055-1064
    • Bloom, B.R.1    Murray, C.J.2
  • 6
    • 33645212866 scopus 로고    scopus 로고
    • Further insight into S-adenosylmethionine-dependent methyltransferases: Structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis
    • F. Boissier, F. Bardou, V. Guillet, S. Uttenweiler-Joseph, M. Daffé, A. Quémard, and L. Mourey Further insight into S-adenosylmethionine-dependent methyltransferases: Structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis J. Biol. Chem. 281 2006 4434 4445
    • (2006) J. Biol. Chem. , vol.281 , pp. 4434-4445
    • Boissier, F.1    Bardou, F.2    Guillet, V.3    Uttenweiler-Joseph, S.4    Daffé, M.5    Quémard, A.6    Mourey, L.7
  • 7
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • B.M. Bolstad, R.A. Irizarry, M. Astrand, and T.P. Speed A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 2003 185 193
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 8
    • 0016740503 scopus 로고
    • Synergy of trimethoprim-sulfamethoxazole
    • S.R. Bushby Synergy of trimethoprim-sulfamethoxazole Can. Med. Assoc. J. 112 1975 63 66
    • (1975) Can. Med. Assoc. J. , vol.112 , pp. 63-66
    • Bushby, S.R.1
  • 9
    • 84871927537 scopus 로고    scopus 로고
    • Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
    • S. Chakraborty, T. Gruber, C.E. Barry 3rd, H.I. Boshoff, and K.Y. Rhee Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis Science 339 2013 88 91
    • (2013) Science , vol.339 , pp. 88-91
    • Chakraborty, S.1    Gruber, T.2    Barry III, C.E.3    Boshoff, H.I.4    Rhee, K.Y.5
  • 11
    • 62149131679 scopus 로고
    • Growth inhibition of bacteria by synthetic pterins: Studies with Streptococcus faecalis, Lactobacillus casei, and Lactobacillus arabinosus
    • L.J. Daniel, L.C. Norris, M.L. Scott, and G.F. Heuser Growth inhibition of bacteria by synthetic pterins: Studies with Streptococcus faecalis, Lactobacillus casei, and Lactobacillus arabinosus J. Biol. Chem. 169 1947 689 697
    • (1947) J. Biol. Chem. , vol.169 , pp. 689-697
    • Daniel, L.J.1    Norris, L.C.2    Scott, M.L.3    Heuser, G.F.4
  • 12
    • 0023574384 scopus 로고
    • Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin
    • M.I. Dawson, D. O'Krongly, P.D. Hobbs, J.R. Barrueco, and F.M. Sirotnak Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10- deazaaminopterin J. Pharm. Sci. 76 1987 635 638
    • (1987) J. Pharm. Sci. , vol.76 , pp. 635-638
    • Dawson, M.I.1    O'Krongly, D.2    Hobbs, P.D.3    Barrueco, J.R.4    Sirotnak, F.M.5
  • 13
    • 78049411009 scopus 로고    scopus 로고
    • Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates
    • L.P. de Carvalho, S.M. Fischer, J. Marrero, C. Nathan, S. Ehrt, and K.Y. Rhee Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates Chem. Biol. 17 2010 1122 1131
    • (2010) Chem. Biol. , vol.17 , pp. 1122-1131
    • De Carvalho, L.P.1    Fischer, S.M.2    Marrero, J.3    Nathan, C.4    Ehrt, S.5    Rhee, K.Y.6
  • 14
  • 15
    • 84891875929 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs
    • M.V. Dias, P. Tyrakis, R.R. Domingues, A.F. Paes Leme, and T.L. Blundell Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs Structure 22 2014 94 103
    • (2014) Structure , vol.22 , pp. 94-103
    • Dias, M.V.1    Tyrakis, P.2    Domingues, R.R.3    Paes Leme, A.F.4    Blundell, T.L.5
  • 16
    • 84940143909 scopus 로고
    • Antagonists of nucleic acid derivatives: VIII. Synergism in combinations of biochemically related antimetabolites
    • G.B. Elion, S. Singer, and G.H. Hitchings Antagonists of nucleic acid derivatives: VIII. Synergism in combinations of biochemically related antimetabolites J. Biol. Chem. 208 1954 477 488
    • (1954) J. Biol. Chem. , vol.208 , pp. 477-488
    • Elion, G.B.1    Singer, S.2    Hitchings, G.H.3
  • 17
    • 84856754603 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid
    • A.S. Fivian-Hughes, J. Houghton, and E.O. Davis Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid Microbiology 158 2012 308 318
    • (2012) Microbiology , vol.158 , pp. 308-318
    • Fivian-Hughes, A.S.1    Houghton, J.2    Davis, E.O.3
  • 18
    • 33750629139 scopus 로고    scopus 로고
    • Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
    • N.R. Gandhi, A. Moll, A.W. Sturm, R. Pawinski, T. Govender, U. Lalloo, K. Zeller, J. Andrews, and G. Friedland Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa Lancet 368 2006 1575 1580
    • (2006) Lancet , vol.368 , pp. 1575-1580
    • Gandhi, N.R.1    Moll, A.2    Sturm, A.W.3    Pawinski, R.4    Govender, T.5    Lalloo, U.6    Zeller, K.7    Andrews, J.8    Friedland, G.9
  • 19
    • 0028972283 scopus 로고
    • The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2
    • K.M. George, Y. Yuan, D.R. Sherman, and C.E. Barry 3rd The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2 J. Biol. Chem. 270 1995 27292 27298
    • (1995) J. Biol. Chem. , vol.270 , pp. 27292-27298
    • George, K.M.1    Yuan, Y.2    Sherman, D.R.3    Barry III, C.E.4
  • 20
    • 0036840641 scopus 로고    scopus 로고
    • Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase
    • A.B. Gerum, J.E. Ulmer, D.P. Jacobus, N.P. Jensen, D.R. Sherman, and C.H. Sibley Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase Antimicrob. Agents Chemother. 46 2002 3362 3369
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3362-3369
    • Gerum, A.B.1    Ulmer, J.E.2    Jacobus, D.P.3    Jensen, N.P.4    Sherman, D.R.5    Sibley, C.H.6
  • 21
    • 80052822481 scopus 로고    scopus 로고
    • Pulmonary tuberculosis: Clinical features and patient management
    • A. Gough, and G. Kaufman Pulmonary tuberculosis: Clinical features and patient management Nurs. Stand. 25 2011 48 56
    • (2011) Nurs. Stand. , vol.25 , pp. 48-56
    • Gough, A.1    Kaufman, G.2
  • 22
    • 77953362042 scopus 로고    scopus 로고
    • Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli
    • N.M. Halliday, K.R. Hardie, P. Williams, K. Winzer, and D.A. Barrett Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli Anal. Biochem. 403 2010 20 29
    • (2010) Anal. Biochem. , vol.403 , pp. 20-29
    • Halliday, N.M.1    Hardie, K.R.2    Williams, P.3    Winzer, K.4    Barrett, D.A.5
  • 23
    • 0027737508 scopus 로고
    • Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors
    • P.G. Hartman Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors J. Chemother. 5 1993 369 376
    • (1993) J. Chemother. , vol.5 , pp. 369-376
    • Hartman, P.G.1
  • 24
    • 37049210882 scopus 로고
    • The "sulfanilamide Effect" of Substances Devoid of Sulfo Groups
    • J. Hirsch The "Sulfanilamide Effect" of Substances Devoid of Sulfo Groups Science 96 1942 139 140
    • (1942) Science , vol.96 , pp. 139-140
    • Hirsch, J.1
  • 25
    • 0029944197 scopus 로고    scopus 로고
    • In search of dihydrofolate reductase
    • F.M. Huennekens In search of dihydrofolate reductase Protein Sci. 5 1996 1201 1208
    • (1996) Protein Sci. , vol.5 , pp. 1201-1208
    • Huennekens, F.M.1
  • 26
    • 70350441681 scopus 로고    scopus 로고
    • A lipid profile typifies the Beijing strains of Mycobacterium tuberculosis: Identification of a mutation responsible for a modification of the structures of phthiocerol dimycocerosates and phenolic glycolipids
    • G. Huet, P. Constant, W. Malaga, M.A. Lanéelle, K. Kremer, D. van Soolingen, M. Daffé, and C. Guilhot A lipid profile typifies the Beijing strains of Mycobacterium tuberculosis: Identification of a mutation responsible for a modification of the structures of phthiocerol dimycocerosates and phenolic glycolipids J. Biol. Chem. 284 2009 27101 27113
    • (2009) J. Biol. Chem. , vol.284 , pp. 27101-27113
    • Huet, G.1    Constant, P.2    Malaga, W.3    Lanéelle, M.A.4    Kremer, K.5    Van Soolingen, D.6    Daffé, M.7    Guilhot, C.8
  • 28
    • 78651137723 scopus 로고
    • The in vitro activity of 4,4′-diaminodiphenyl sulfone against various acid-fast microorganisms
    • A.G. Karlson The in vitro activity of 4,4′-diaminodiphenyl sulfone against various acid-fast microorganisms Int. J. Lepr. 31 1963 183 187
    • (1963) Int. J. Lepr. , vol.31 , pp. 183-187
    • Karlson, A.G.1
  • 29
    • 14844342386 scopus 로고    scopus 로고
    • DNA and RNA synthesis: Antifolates
    • I.M. Kompis, K. Islam, and R.L. Then DNA and RNA synthesis: Antifolates Chem. Rev. 105 2005 593 620
    • (2005) Chem. Rev. , vol.105 , pp. 593-620
    • Kompis, I.M.1    Islam, K.2    Then, R.L.3
  • 30
    • 79957588857 scopus 로고    scopus 로고
    • Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition
    • A. Kumar, K. Saigal, K. Malhotra, K.M. Sinha, and B. Taneja Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition J. Biol. Chem. 286 2011 19652 19661
    • (2011) J. Biol. Chem. , vol.286 , pp. 19652-19661
    • Kumar, A.1    Saigal, K.2    Malhotra, K.3    Sinha, K.M.4    Taneja, B.5
  • 31
    • 84863088810 scopus 로고    scopus 로고
    • High-throughput screening and sensitized bacteria identify an M. Tuberculosis dihydrofolate reductase inhibitor with whole cell activity
    • A. Kumar, M. Zhang, L. Zhu, R.P. Liao, C. Mutai, S. Hafsat, D.R. Sherman, and M.W. Wang High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity PLoS One 7 2012 e39961
    • (2012) PLoS One , vol.7 , pp. 39961
    • Kumar, A.1    Zhang, M.2    Zhu, L.3    Liao, R.P.4    Mutai, C.5    Hafsat, S.6    Sherman, D.R.7    Wang, M.W.8
  • 33
    • 77955867163 scopus 로고    scopus 로고
    • Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. Coli
    • Y.K. Kwon, M.B. Higgins, and J.D. Rabinowitz Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli ACS Chem. Biol. 5 2010 787 795
    • (2010) ACS Chem. Biol. , vol.5 , pp. 787-795
    • Kwon, Y.K.1    Higgins, M.B.2    Rabinowitz, J.D.3
  • 34
    • 0027527775 scopus 로고
    • Mycobacteriophage L5 integrase-mediated site-specific integration in vitro
    • M.H. Lee, and G.F. Hatfull Mycobacteriophage L5 integrase-mediated site-specific integration in vitro J. Bacteriol. 175 1993 6836 6841
    • (1993) J. Bacteriol. , vol.175 , pp. 6836-6841
    • Lee, M.H.1    Hatfull, G.F.2
  • 35
    • 0034645774 scopus 로고    scopus 로고
    • Three-dimensional structure of M. Tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs
    • R. Li, R. Sirawaraporn, P. Chitnumsub, W. Sirawaraporn, J. Wooden, F. Athappilly, S. Turley, and W.G. Hol Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs J. Mol. Biol. 295 2000 307 323
    • (2000) J. Mol. Biol. , vol.295 , pp. 307-323
    • Li, R.1    Sirawaraporn, R.2    Chitnumsub, P.3    Sirawaraporn, W.4    Wooden, J.5    Athappilly, F.6    Turley, S.7    Hol, W.G.8
  • 36
    • 0037455808 scopus 로고    scopus 로고
    • Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
    • E. Liani, L. Rothem, M.A. Bunni, C.A. Smith, G. Jansen, and Y.G. Assaraf Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines Int. J. Cancer 103 2003 587 599
    • (2003) Int. J. Cancer , vol.103 , pp. 587-599
    • Liani, E.1    Rothem, L.2    Bunni, M.A.3    Smith, C.A.4    Jansen, G.5    Assaraf, Y.G.6
  • 37
    • 84860431572 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon
    • K. Minch, T. Rustad, and D.R. Sherman Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon PLoS One 7 2012 e35935
    • (2012) PLoS One , vol.7 , pp. 35935
    • Minch, K.1    Rustad, T.2    Sherman, D.R.3
  • 39
    • 33745505203 scopus 로고    scopus 로고
    • Foundations of antibiotic resistance in bacterial physiology: The mycobacterial paradigm
    • L. Nguyen, and C.J. Thompson Foundations of antibiotic resistance in bacterial physiology: The mycobacterial paradigm Trends Microbiol. 14 2006 304 312
    • (2006) Trends Microbiol. , vol.14 , pp. 304-312
    • Nguyen, L.1    Thompson, C.J.2
  • 41
    • 78650238422 scopus 로고    scopus 로고
    • Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism
    • N. Parveen, and K.A. Cornell Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism Mol. Microbiol. 79 2011 7 20
    • (2011) Mol. Microbiol. , vol.79 , pp. 7-20
    • Parveen, N.1    Cornell, K.A.2
  • 42
    • 58249121979 scopus 로고    scopus 로고
    • Aqueous normal-phase retention of nucleotides on silica hydride columns
    • J.J. Pesek, M.T. Matyska, M.T. Hearn, and R.I. Boysen Aqueous normal-phase retention of nucleotides on silica hydride columns J. Chromatogr. A 1216 2009 1140 1146
    • (2009) J. Chromatogr. A , vol.1216 , pp. 1140-1146
    • Pesek, J.J.1    Matyska, M.T.2    Hearn, M.T.3    Boysen, R.I.4
  • 43
    • 0017405215 scopus 로고
    • Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds
    • J.R. Piper, and J.A. Montgomery Preparation of 6-(bromomethyl)-2,4- pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds J. Org. Chem. 42 1977 208 211
    • (1977) J. Org. Chem. , vol.42 , pp. 208-211
    • Piper, J.R.1    Montgomery, J.A.2
  • 45
    • 21944444385 scopus 로고    scopus 로고
    • Challenges of target/compound data integration from disease to chemistry: A case study of dihydrofolate reductase inhibitors
    • S.J. Potts, D.J. Edwards, and R. Hoffman Challenges of target/compound data integration from disease to chemistry: A case study of dihydrofolate reductase inhibitors Curr. Drug Discov. Technol. 2 2005 75 87
    • (2005) Curr. Drug Discov. Technol. , vol.2 , pp. 75-87
    • Potts, S.J.1    Edwards, D.J.2    Hoffman, R.3
  • 46
    • 77956634721 scopus 로고    scopus 로고
    • Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: A non-conventional hemolysin and a ribosomal RNA methyl transferase
    • A. Rahman, S.S. Srivastava, A. Sneh, N. Ahmed, and M.V. Krishnasastry Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: A non-conventional hemolysin and a ribosomal RNA methyl transferase BMC Biochem. 11 2010 35
    • (2010) BMC Biochem. , vol.11 , pp. 35
    • Rahman, A.1    Srivastava, S.S.2    Sneh, A.3    Ahmed, N.4    Krishnasastry, M.V.5
  • 47
    • 56749102479 scopus 로고    scopus 로고
    • Crystal structures of Mycobacterium tuberculosis S-adenosyl-L- homocysteine hydrolase in ternary complex with substrate and inhibitors
    • M.C. Reddy, G. Kuppan, N.D. Shetty, J.L. Owen, T.R. Ioerger, and J.C. Sacchettini Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors Protein Sci. 17 2008 2134 2144
    • (2008) Protein Sci. , vol.17 , pp. 2134-2144
    • Reddy, M.C.1    Kuppan, G.2    Shetty, N.D.3    Owen, J.L.4    Ioerger, T.R.5    Sacchettini, J.C.6
  • 48
    • 0015901102 scopus 로고
    • Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3′,5′-dichloromethotrexate by direct esterification
    • A. Rosowsky Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3′,5′- dichloromethotrexate by direct esterification J. Med. Chem. 16 1973 1190 1193
    • (1973) J. Med. Chem. , vol.16 , pp. 1190-1193
    • Rosowsky, A.1
  • 49
    • 0017799711 scopus 로고
    • Methotrexate analogues. 11. Unambiguous chemical synthesis and in vitro biological evaluation of alpha- and gamma-monoesters as potential prodrugs
    • A. Rosowsky, G.P. Beardsley, W.D. Ensminger, H. Lazarus, and C.S. Yu Methotrexate analogues. 11. Unambiguous chemical synthesis and in vitro biological evaluation of alpha- and gamma-monoesters as potential prodrugs J. Med. Chem. 21 1978 380 386
    • (1978) J. Med. Chem. , vol.21 , pp. 380-386
    • Rosowsky, A.1    Beardsley, G.P.2    Ensminger, W.D.3    Lazarus, H.4    Yu, C.S.5
  • 50
    • 43049182981 scopus 로고    scopus 로고
    • The enduring hypoxic response of Mycobacterium tuberculosis
    • T.R. Rustad, M.I. Harrell, R. Liao, and D.R. Sherman The enduring hypoxic response of Mycobacterium tuberculosis PLoS One 3 2008 e1502
    • (2008) PLoS One , vol.3 , pp. 1502
    • Rustad, T.R.1    Harrell, M.I.2    Liao, R.3    Sherman, D.R.4
  • 51
    • 82155203018 scopus 로고    scopus 로고
    • The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim
    • D.P. Sangurdekar, Z. Zhang, and A.B. Khodursky The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim BMC Genomics 12 2011 583
    • (2011) BMC Genomics , vol.12 , pp. 583
    • Sangurdekar, D.P.1    Zhang, Z.2    Khodursky, A.B.3
  • 53
    • 84866328705 scopus 로고    scopus 로고
    • The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis
    • C. Vilchèze, and W.R. Jacobs Jr. The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis Antimicrob. Agents Chemother. 56 2012 5142 5148
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5142-5148
    • Vilchèze, C.1    Jacobs, Jr.W.R.2
  • 54
    • 0023023318 scopus 로고
    • Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth
    • R.J. Wallace Jr., D.R. Nash, L.C. Steele, and V. Steingrube Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth J. Clin. Microbiol. 24 1986 976 981
    • (1986) J. Clin. Microbiol. , vol.24 , pp. 976-981
    • Wallace, Jr.R.J.1    Nash, D.R.2    Steele, L.C.3    Steingrube, V.4
  • 55
    • 0030589083 scopus 로고    scopus 로고
    • Electroporation at elevated temperatures substantially improves transformation efficiency of slow-growing mycobacteria
    • B.J. Wards, and D.M. Collins Electroporation at elevated temperatures substantially improves transformation efficiency of slow-growing mycobacteria FEMS Microbiol. Lett. 145 1996 101 105
    • (1996) FEMS Microbiol. Lett. , vol.145 , pp. 101-105
    • Wards, B.J.1    Collins, D.M.2
  • 56
    • 1542381036 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase
    • E.L. White, L.J. Ross, A. Cunningham, and V. Escuyer Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase FEMS Microbiol. Lett. 232 2004 101 105
    • (2004) FEMS Microbiol. Lett. , vol.232 , pp. 101-105
    • White, E.L.1    Ross, L.J.2    Cunningham, A.3    Escuyer, V.4
  • 57
    • 34248636300 scopus 로고    scopus 로고
    • Current strategies for identifying and validating targets for new treatment-shortening drugs for TB
    • K.J. Williams, and K. Duncan Current strategies for identifying and validating targets for new treatment-shortening drugs for TB Curr. Mol. Med. 7 2007 297 307
    • (2007) Curr. Mol. Med. , vol.7 , pp. 297-307
    • Williams, K.J.1    Duncan, K.2
  • 58
    • 0030969974 scopus 로고    scopus 로고
    • Effects of dual combinations of antifolates with atovaquone or dapsone on nucleotide levels in Plasmodium falciparum
    • A.E. Yeo, K.K. Seymour, K.H. Rieckmann, and R.I. Christopherson Effects of dual combinations of antifolates with atovaquone or dapsone on nucleotide levels in Plasmodium falciparum Biochem. Pharmacol. 53 1997 943 950
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 943-950
    • Yeo, A.E.1    Seymour, K.K.2    Rieckmann, K.H.3    Christopherson, R.I.4
  • 59
    • 84888645566 scopus 로고    scopus 로고
    • WHO's 2013 global report on tuberculosis: Successes, threats, and opportunities
    • Baroness Masham of Ilton
    • A. Zumla, A. George, V. Sharma, N. Herbert Baroness Masham of Ilton WHO's 2013 global report on tuberculosis: Successes, threats, and opportunities Lancet 382 2013 1765 1767
    • (2013) Lancet , vol.382 , pp. 1765-1767
    • Zumla, A.1    George, A.2    Sharma, V.3    Herbert, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.