The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug Trimethoprim

BMC Genomics

Volumn 12, Issue , 2011, Pages

  Sangurdekar, Dipen P ^a   Zhang, Zhigang ^b,c   Khodursky, Arkady B ^b  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Metabolix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBOSE; THYMIDYLATE SYNTHASE; THYMINE; TRIMETHOPRIM; ANTIINFECTIVE AGENT; FOLIC ACID ANTAGONIST; NUCLEOTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; DRUG MECHANISM; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; MICROARRAY ANALYSIS; MODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; REGULON; REPRESSOR GENE; BACTERIAL GENE; DNA MICROARRAY; DNA REPAIR; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ANTI-BACTERIAL AGENTS; DNA DAMAGE; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; GENES, BACTERIAL; NUCLEOTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPERON; SOS RESPONSE (GENETICS); TRIMETHOPRIM;

EID: 82155203018     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-12-583     Document Type: Article

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