Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid

Microbiology

Volumn 158, Issue 2, 2012, Pages 308-318

  Fivian Hughes, Amanda S ^a,b   Houghton, Joanna ^a   Davis, Elaine O ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINOSALICYLIC ACID; DNA; GUANINE; THREONINE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE A; THYMIDYLATE SYNTHASE X; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; IN VITRO STUDY; MOUSE; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PURIFICATION; SOUTHERN BLOTTING;

AMINOSALICYLIC ACID; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; FEMALE; GENE DELETION; HUMANS; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; THYMIDYLATE SYNTHASE; THYMINE; TUBERCULOSIS;

CORYNEBACTERINEAE; MURINAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84856754603     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.053983-0     Document Type: Article

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