Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Sutcliffe, Jane S ^a   Beaumont, Vahri ^b   Watson, James M ^a   Chew, Chang Sing ^a   Beconi, Maria ^b   Hutcheson, Daniel M ^a   Dominguez, Celia ^b   Munoz Sanjuan, Ignacio ^b  

^a Singapore Science Park II   (Singapore)

^b CHDI MANAGEMENT CHDI FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

D 159687; D 159797; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG; BENZHYDRYL DERIVATIVE; CARBANILAMIDE DERIVATIVE; D159687; NOOTROPIC AGENT; PHOSPHODIESTERASE IV;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG RESPONSE; FEMALE; INFORMATION RETRIEVAL; MACACA FASCICULARIS; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CLEARANCE; RETCHING; SALIVATION; TASK PERFORMANCE; TIME TO MAXIMUM PLASMA CONCENTRATION; ALLOSTERISM; ANIMAL; CROSSOVER PROCEDURE; INTRAVENOUS DRUG ADMINISTRATION; PRECLINICAL STUDY;

ADMINISTRATION, INTRAVENOUS; ALLOSTERIC REGULATION; ANIMALS; AREA UNDER CURVE; BENZHYDRYL COMPOUNDS; CROSS-OVER STUDIES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG EVALUATION, PRECLINICAL; FEMALE; MACACA FASCICULARIS; NOOTROPIC AGENTS; PHENYLUREA COMPOUNDS; PHOSPHODIESTERASE 4 INHIBITORS; ROLIPRAM;

EID: 84904632632     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102449     Document Type: Article

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