Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 973-982

  Lin, Hao ^a   Wei, Bo ^a   Li, Guangsheng ^a   Zheng, Jinchang ^a   Sun, Jiecong ^a   Chu, Jiaqi ^a   Zeng, Rong ^a   Niu, Yanru ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Glucocorticoid; Nrf2 pathway; Osteoporosis; Sulforaphane

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; DEXAMETHASONE; DNA; GLUCOCORTICOID; ISOTHIOCYANIC ACID; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OSTEOCALCIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RUNX2; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAFAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; FLOW CYTOMETRY; GLUCOCORTICOID INDUCED APOPTOSIS; GROWTH INHIBITION; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; OSTEOBLAST; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; APOPTOSIS; CASPASES; DEXAMETHASONE; GENE SILENCING; GLUCOCORTICOIDS; ISOTHIOCYANATES; L-LACTATE DEHYDROGENASE; MICE; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OSTEOBLASTS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84904610693     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S65410     Document Type: Article

References (33)

1. Hsu WL, Chen CY, Tsauo JY, Yang RS. Balance control in elderly people with osteoporosis. J Formos Med Assoc.2014;113(6): 334-339.
2. Reid IR. Anti-resorptive therapies for osteoporosis. Semin Cell Dev Biol.2008;19(5):473-478.
3. Salam SN, Eastell R, Khwaja A. Fragility fractures and osteoporosis in CKD: pathophysiology and diagnostic methods. Am J Kidney Dis. 2014;S0272-6386(14):499-495.
4. Seibel MJ, Cooper MS, Zhou H. Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives. Lancet Diabetes Endocrinol.2013;1(1):59-70.
5. Brennan-Speranza TC, Henneicke H, Gasparini SJ, et al. Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. J Clin Invest.2012;122(11):4172-4189.
6. Rauch A, Seitz S, Baschant U, et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab.2010;11(6):517-531.
7. den Uyl D, Bultink IE, Lems WF. Advances in glucocorticoid-induced osteoporosis. Curr Rheumatol Rep.2011;13(3):233-240.
8. Weinstein RS. Clinical practice. Glucocorticoid-induced bone disease. N Engl J Med.2011;365(1):62-70.
9. Espina B, Liang M, Russell RG, Hulley PA. Regulation of Bim in glucocorticoid-mediated osteoblast apoptosis. J Cell Physiol. 2008;215(2):488-496.
10. O'Brien CA, Jia D, Plotkin LI, et al. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology.2004;145(4): 1835-1841.
11. Yun SI, Yoon HY, Jeong SY, Chung YS. Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase3beta. J Bone Miner Metab.2009;27(2): 140-148.
12. Choi EM, Kim GH, Lee YS. Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Toxicol In Vitro.2009;23(5): 862-867.
13. Wang Y, Wang WL, Xie WL, et al. Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. Phytomedicine.15,2013;20(10):787-796.
14. Yan XT, Lee SH, Li W, et al. Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume. Food Chem.2014;156:408-415.
15. Zhang JK, Yang L, Meng GL, et al. Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2012;689(1-3):31-37.
16. Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc.2008;67(3):253-256.
17. Gupta P, Kim B, Kim SH, Srivastava SK. Molecular targets of isothiocyanates in cancer: recent advances. Mol Nutr Food Res. Epub February10, 2014.
18. Houghton CA, Fassett RG, Coombes JS. Sulforaphane: translational research from laboratory bench to clinic. Nutr Rev.2013;71(11): 709-726.
19. Xu T, Ren D, Sun X, Yang G. Dual roles of sulforaphane in cancer treatment. Anticancer Agents Med Chem.2012;12(9):1132-1142.
20. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev.2013;2013:415078.
21. Barcelo S, Gardiner JM, Gescher A, Chipman JK. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis.1996;17(2):277-282.
22. Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Eaton DL. Sulforaphane-and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci. 2010;116(2):422-432.
23. Katoch O, Kumar A, Adhikari JS, Dwarakanath BS, Agrawala PK. Sulforaphane mitigates genotoxicity induced by radiation and anticancer drugs in human lymphocytes. Mutat Res.2013;758(1-2):29-34.
24. Fan C, Chen J, Wang Y, et al. Selenocystine potentiates cancer cell apoptosis induced by5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway. Free Radic Biol Med.2013;65:305-316.
25. Su J, Lai H, Chen J, et al. Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage. PLoS One.2013;8(5):e63502.
26. McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol.2013;5(4):a008656.
27. Xu ZS, Wang XY, Xiao DM, et al. Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis. Free Radic Biol Med.2011;50(10): 1314-1323.
28. Nakashima K, Zhou X, Kunkel G, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell.2002;108(1):17-29.
29. Komori T. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem.2006;99(5):1233-1239.
30. Arai M, Shibata Y, Pugdee K, Abiko Y, Ogata Y. Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life.2007;59(1):27-33.
31. Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol.2013;1(1):45-49.
32. Seeman E, Delmas PD. Bone quality: the material and structural basis of bone strength and fragility. N Engl J Med.2006;354(21):2250-2261.
33. Lee NK, Choi YG, Baik JY, et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood.2005; 106(3):852-859