Natural Borneol, a Monoterpenoid Compound, Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular Carcinoma Cells by Enhancement of Cellular Uptake and Activation of ROS-Mediated DNA Damage

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Su, Jianyu ^a   Lai, Haoqiang ^b   Chen, Jianping ^a   Li, Lin ^a   Wong, Yum Shing ^c   Chen, Tianfeng ^b   Li, Xiaoling ^b  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b JINAN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CASPASE 8; CASPASE 9; DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL BORNEOL; PEPTIDES AND PROTEINS; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN P53; PROTEIN TBID; REACTIVE OXYGEN METABOLITE; SELENOCYSTINE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HEPG2; COMET ASSAY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA STRAND BREAKAGE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BORNANES; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL PROLIFERATION; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SELENOCYSTEINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877910517     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063502     Document Type: Article

References (51)

1. Lau WY, Lai ECH, (2008) Hepatocellular carcinoma: current management and recent advances. Hepatob Pancreat Dis 7: 237-257.
2. Cabrera R, Nelson DR, (2010) Review article: the management of hepatocellular carcinoma. Aliment Pharm Ther 31: 461-476.
3. Guo X, Yin S, Dong Y, Fan L, Ye M, et al.(2012) Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of Mcl-1 and FAK. Mol Carcinogen: Wiley Online Library 1-11.
4. Yamaguchi K, Uzzo RG, Pimkina J, Makhov P, Golovine K, et al. (2005) Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Oncogene 24: 5868-5877.
5. Rayman MP, (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. P Nutr Soc 64: 527-542.
6. Lee JS, Hong EK, (2010) Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett 297: 144-154.
7. Li S, Zhou Y, Wang R, Zhang H, Dong Y, et al. (2007) Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther 6: 1031-1038.
8. Fan JG, Farrell GC, (2009) Prevention of hepatocellular carcinoma in nonviral-related liver diseases. J Gastroen Hepatol 24: 712-719.
9. Bjorkhem-Bergman L, Torndal UB, Eken S, Nystrom C, Capitanio A, et al. (2005) Selenium prevents tumor development in a rat model for chemical carcinogenesis. Carcinogenesis 26: 125-131.
10. Katzenellenbogen M, Mizrahi L, Pappo O, Klopstock N, Olam D, et al. (2007) Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice. Mol Cancer Ther 6: 1283-1291.
11. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C, (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364: 1219-1228.
12. Chen TF, Wong YS, (2009) Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells. Biomed Pharmacother 63: 105-113.
13. Chen TF, Wong YS, (2008) Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cell Mol Life Sci 65: 2763-2775.
14. Chen TF, Wong YS, (2008) Selenocystine Induces S-Phase Arrest and Apoptosis in Human Breast Adenocarcinoma MCF-7 Cells by Modulating ERK and Akt Phosphorylation. J Agr Food Chem 56: 10574-10581.
15. Horvathova E, Slamenova D, Marsalkova L, Sramkova M, Wsolova L, (2009) Effects of borneol on the level of DNA damage induced in primary rat hepatocytes and testicular cells by hydrogen peroxide. Food Chem Toxicol 47: 1318-1323.
16. Lu Y, Du SY, Chen XL, Wu Q, Song X, et al. (2011) Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration. J Zhejiang Univ-Sc B 12: 143-148.
17. Hikita H, Takehara T, Shimizu S, Kodama T, Li W, et al. (2009) Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver. Hepatology 2050: 1217-1226.
18. Zhou Y, Li W, Chen L, Ma S, Ping L, et al. (2010) Enhancement of intestinal absorption of akebia saponin D by borneol and probenecid in situ and in vitro. Environ Toxicol Pharmacol 29: 229-234.
19. Shen Q, Li X, Li W, Zhao X, (2011) Enhanced intestinal absorption of daidzein by borneol/menthol eutectic mixture and microemulsion. AAPS Pharm Sci Tech 12: 1044-1049.
20. Chen TF, Zheng WJ, Wong YS, Yang F, (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomed Pharmacother 62: 77-84.
21. Donovan M, Cotter TG, (2004) Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. BBA-Mol Cell Res 1644: 133-147.
22. Chen TF, Wong YS, (2009) Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation. Int J Biochem Cell B 41: 666-676.
23. Manning BD, Cantley LC, (2007) AKT/PKB signaling: Navigating downstream. Cell 129: 1261-1274.
24. Pelicano H, Carney D, Huang P, (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Update 7: 97-110.
25. Kaufmann SH, Earnshaw WC, (2000) Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256: 42-49.
26. Kopper L, Petak I, (2008) Apoptosis and cancer. Cancer Growth and Progression-Dordrecht. 11: 103-113.
27. Varma MVS, Khandavilli S, Ashokraj Y, Jain A, Dhanikula A, et al. (2004) Biopharmaceutic classification system: A scientific framework for pharmacokinetic optimization in drug research. Curr Drug Metab 5: 375-388.
28. Gao Y, He L, Katsumi H, Sakane T, Fujita T, et al. (2008) Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: Intestinal mucosal toxicity and absorption-enhancing mechanism of spermine. Int J Pharmaceut 354: 126-134.
29. Wu C, Huang Q, Qi H, Guo P, Hou S, (2005) Ocular toxicity of borneol in rabbits. Chinese Pharmaceut J 40: 1710.
30. Breier A, Gibalova L, Seres M, Barancik M, Sulova Z, (2013) New Insight into P-Glycoprotein as a Drug Target. Anticancer Agents Med Chem 13: 159-172.
31. Chan JYW, Chu ACY, Fung KP, (2000) Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA. Life Sci 67: 2117-2124.
32. Hait WN, Yang JM, (2005) Clinical management of recurrent breast cancer: Development of multidrug resistance (MDR) and strategies to circumvent it. Semin Oncol 32: S16-S21.
33. Chen YM, Wang NS, (2003) Effect of borneol on P-glycoprotein. Tradit Chin Drug Res Clin Pharmacol 14: 96-99.
34. Cai Z, Hou S, Li Y, Zhao B, Yang Z, et al. (2008) Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. J Drug Target 16: 178-184.
35. Rikiishi H, (2007) Apoptotic cellular events for selenium compounds involved in cancer prevention. J Bioenerg Biomembr 39: 91-98.
36. Martinou JC, Youle RJ, (2011) Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21: 92-101.
37. Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, et al. (2011) Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol. Cell: Elsevier. 104-116.
38. Hikita H, Takehara T, Shimizu S, Kodama T, Li W, et al. (2009) Mcl-1 and Bcl-xL Cooperatively Maintain Integrity of Hepatocytes in Developing and Adult Murine Liver. Hepatology: Wiley Online Library. 1217-1226.
39. Chen J, Jin S, Abraham V, Huang X, Liu B, et al. (2011) The Bcl-2/Bcl-XL/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther AACR. 2340-2349.
40. Abrams SL, Steelman LS, Shelton JG, Wong EWT, Chappell WH, et al. (2010) The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell Cycle 9: 1781-1791.
41. Manning BD, Cantley LC, (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
42. Boldt S, Weidle UH, Kolch W, (2002) The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis 23: 1831-1838.
43. Yang JY, Michod D, Walicki J, Widmann C (2004) Surviving the kiss of death. Biochem Pharmacol: Elsevier. 1027-1031.
44. Konopleva M, Milella M, Ruvolo P, Watts JC, Ricciardi MR, et al. (2011) MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex. Leukemia 26: 778-787.
45. Makin G, Dive C, (2001) Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy? Breast Cancer Res 3: 150-153.
46. Meier F, Busch S, Lasithiotakis K, Kulms D, Garbe C, et al. (2007) Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Brit J Dermatol 156: 1204-1213.
47. Circu ML, Aw TY, (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Bio Med 48: 749-762.
48. Haupt S, Berger M, Goldberg Z, Haupt Y, (2003) Apoptosis- the p53 network. J Cell Sci 116: 4077-4085.
49. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, et al. (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590.
50. Yalcin S, Marinkovic D, Mungamuri SK, Zhang X, Tong W, et al. (2010) ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3-/- mice. EMBO J 29: 4118-4131.
51. Cao J, Xu D, Wang D, Wu R, Zhang L, et al. (2009) ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free Radical Bio Med 47: 536-547.