Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 305-316

  Fan, Cundong ^a   Chen, Jingjing ^a   Wang, Yi ^a   Wong, Yum Shing ^b   Zhang, Yibo ^a   Zheng, Wenjie ^a   Cao, Wenqiang ^a   Chen, Tianfeng ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

5 Fluorouracil; Apoptosis; Chemosensitization; Free radicals; Selenocystine; Synergy

Indexed keywords

FLUOROURACIL; GLUTATHIONE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SELENOCYSTINE; ANTINEOPLASTIC AGENT; CYSTINE; ORGANOSELENIUM DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANALOGS AND DERIVATIVES; CELL SURVIVAL; DRUG EFFECTS; DRUG POTENTIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHYSIOLOGY; TUMOR CELL LINE; TUNEL ASSAY; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTINE; DNA DAMAGE; DRUG SYNERGISM; FLUOROURACIL; HUMANS; IN SITU NICK-END LABELING; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; ORGANOSELENIUM COMPOUNDS; REACTIVE OXYGEN SPECIES;

EID: 84880994920     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.07.002     Document Type: Article

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