Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation

Phytomedicine

Volumn 20, Issue 10, 2013, Pages 787-796

  Wang, Yue ^a,b   Wang, Wen Liang ^c   Xie, Wen Li ^b   Li, Ling Zhi ^a,b   Sun, Jing ^b   Sun, Wei Jia ^b   Gong, Hai Ying ^b  

^a Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^c Chinese People's Armed Police Force   (China)

Author keywords

Differentiation; Osteoblast; Proliferation; Puerarin; Survival

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN; DOUBLE STRANDED RNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B; PUERARIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RNA INTERFERENCE; UPREGULATION;

DIFFERENTIATION; OSTEOBLAST; PROLIFERATION; PUERARIN; SURVIVAL;

ALKALINE PHOSPHATASE; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; COLLAGEN; FEMALE; HUMANS; ISOFLAVONES; MAP KINASE SIGNALING SYSTEM; OSTEOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN; VASODILATOR AGENTS;

PUERARIA MONTANA VAR. LOBATA; RATTUS;

EID: 84879890020     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.03.005     Document Type: Article

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