Engineering bacterial phenylalanine 4-hydroxylase for microbial synthesis of human neurotransmitter precursor 5-hydroxytryptophan

ACS Synthetic Biology

Volumn 3, Issue 7, 2014, Pages 497-505

  Lin, Yuheng ^a   Sun, Xinxiao ^b   Yuan, Qipeng ^b   Yan, Yajun ^a  

^a University of Georgia   (United States)

^b BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

5 hydroxytryptophan; antidepressant; metabolic engineering; microbial production; phenylalanine 4 hydroxylase; protein engineering

Indexed keywords

5 HYDROXYTRYPTOPHAN; PHENYLALANINE 4 MONOOXYGENASE; TRYPTOPHAN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; RECOMBINANT PROTEIN;

ARTICLE; BIOTRANSFORMATION; CRYSTAL STRUCTURE; CUPRIAVIDUS NECATOR; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GRIFFONIA; METABOLIC ENGINEERING; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS FLUORESCENS; PSEUDOMONAS PUTIDA; WHOLE CELL; XANTHOMONAS CAMPESTRIS; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PSEUDOMONAS;

5-HYDROXYTRYPTOPHAN; ESCHERICHIA COLI; HUMANS; METABOLIC ENGINEERING; NEUROTRANSMITTER AGENTS; PHENYLALANINE HYDROXYLASE; PHYLOGENY; PROTEIN ENGINEERING; PSEUDOMONAS; RECOMBINANT PROTEINS; TRYPTOPHAN;

EID: 84904566164     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb5002505     Document Type: Article

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