PhhB, a Pseudomonas aeruginosa homolog of mammalian pterin 4a- carbinolamine dehydratase/DCoH, does not regulate expression of phenylalanine hydroxylase at the transcriptional level

Journal of Bacteriology

Volumn 181, Issue 9, 1999, Pages 2789-2796

  Song, Jian ^a,b   Xia, Tianhui ^a   Jensen, Roy A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPTERIN; HYDROLYASE; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; PTERIN 4A CARBINOLAMINE DEHYDRATASE; REGULATOR PROTEIN; TRANS ACTING FACTOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ISOLATION; ENZYME MECHANISM; ENZYME REGULATION; ESCHERICHIA COLI; GROWTH INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; TRANSCRIPTION REGULATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA; PROKARYOTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; TRIXIS;

EID: 0032953634     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.9.2789-2796.1999     Document Type: Article

References (34)

1. Baldwin, G. S., and B. E. Davidson. 1981. A kinetic and structural comparison of chorismate mutase/prephenate dehydratase from mutant strains of Escherichia coli K-12 defective in the pheA gene. Arch. Biochem. Biophys. 211:66-75.
2. Chang, A. C. Y., and S. N. Cohen. 1978. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the p15A cryptic miniplasmid. J. Bacteriol. 134:1141-1156.
3. Citron, B. A., M. D. Davis, S. Milstien, J. Gutierrez, D. B. Mendel, G. R. Crabtree, and S. Kaufman. 1992. Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. Proc. Natl. Acad. Sci. USA 89:11891-11894.
4. Curtius, H. C., C. Adler, I. Rebrin, C. Heizmann, and S. Ghisla. 1990. 7-Substituted pterins: formation during phenylalanine hydroxylation in the absence of dehydratase. Biochem. Biophys. Res. Commun. 172:1060-1066.
5. DeFeyter, R., C. I. Kado, and D. W. Gabriel. 1990. Small, stable shuttle vectors for use in Xanthomonas. Gene 88:65-72.
6. Endrizzi, J. A., J. F. Cronk, W. Wang, G. R. Crabtree, and T. Alber. 1995. Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Science 268:556-559.
7. Ficner, R., U. H. Sauer, G. Stier, and D. Suck. 1995. Three-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcriptional factor HNF1. EMBO J. 14:2034-2042.
8. Gu, W., J. Song, C. A. Bonner, G. Xie, and R. A. Jensen. 1998. PhhC, an essential aminotransferase for aromatic amino acid catabolism in Pseudomonas aeruginosa. Microbiology 144:3127-3134.
9. Heatwole, V. M., and R. L. Somerville. 1991. The tryptophan-specific permease gene, mtr, is differentially regulated by the tryptophan and tyrosine repressors in Escherichia coli K-12. J. Bacteriol. 173:3601-3604.
10. Holloway, B. W. 1955. Genetic recombination in Pseudomonas aeruginosa. J. Gen. Microbiol. 13:572-581.
11. Huang, C. Y., E. E. Max, and S. Kaufman. 1973. Purification and characterization of phenylalanine hydroxylase-stimulating protein from rat liver. J. Biol. Chem. 248:4235-4241.
12. Kaufman, S., B. A. Citron, M. Davis, and S. Milstien. 1993. The isolation and characterization of clones of 4a-hydroxytetrahydrobiopterin dehydratase. Adv. Exp. Med. Biol. 338:97-102.
13. Kaufman, S., and D. B. Fisher. 1970. Purification and some physical properties of phenylalanine hydroxylase from rat liver. J. Biol. Chem. 245:4745-4750.
14. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
15. Lazarus, R. A., S. J. Benkovic, and S. Kaufman. 1983. Phenylalanine hydroxylase stimulation protein is a 4a-carbinolamine dehydratase. J. Biol. Chem. 258:10960-10962.
16. Mendel, D. B., and G. R. Crabtree. 1991. HNF1, a member of a novel class of dimerizing homeodomain proteins. J. Biol. Chem. 266:677-680.
17. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
18. Nakata, H., T. Yamauchi, and H. Fujisawa. 1979. Phenylalanine hydroxylase from Chromobacterium violaceum: purification and characterization. J. Biol. Chem. 266:18454-18459.
19. Nikolov, D. B., S. H. Hu, J. Lin, A. Gasch, A. Hoffmann, M. Horikoshi, N. H. Chua, R. G. Roeder, and S. K. Burley. 1992. Crystal structure of TFIID TATA-box binding protein. Nature 360:40-46.
20. Pogge von Strandmann, E., and G. U. Ryffel. 1995. Developmental expression of the maternal protein XDCoH, the dimerization cofactor of the homeoprotein LFB1 (HNF1). Development 121:1217-1226.
21. Rosentel, J. K., F. Healy, J. A. Maupin-Furlow, J. H. Lee, and K. T. Shanmugam. 1995. Molybdate and regulation of mod (molybdate transport), fdhF, and hyc (formate hydrogenlyase) operons in Escherichia coli. J. Bacteriol. 177:4857-4864.
22. Rebrin, I., J. E. Ayling, J. Song, and R. A. Jensen. 1997. Mechanistic studies of 4a-hydroxytetrahydropterin dehydratase from Pseudomonas aeruginosa, p. 631-634. In W. Pfleiderer and H. Rokas (ed.), Chemistry and biology of pteridines and folates. Blackwell Scientific, Oxford, United Kingdom.
23. Rhee, K.-H., G. Stier, P. B. Becker, D. Suck, and R. Sandaltzopoulos. 1997. The bifunctional protein DcoH modulates interactions of the homoeodomain transcription factor HNF1 with nucleic acids. J. Mol. Biol. 265:20-29.
24. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
25. Schallreuter, K. U., J. M. Wood, M. R. Pittelkow, M. Gutlich, K. R. Lemke, W. Rodl, N. N. Swanson, K. Hitzemann, and I. Ziegler. 1994. Regulation of melanin biosynthesis in the human epidermis by tetahydrobiopterin. Science 263:1444-1446.
26. Schweizer, H. P. 1993. Two plasmids, X1918 and Z1918, for easy recovery of the xy/E and lacZ reporter genes. Gene 134:89-91.
27. Simons, R. W., F. Houman, and N. Kleckner. 1983. Improved single and multicopy lac-based cloning vectors for protein and operon fusions. Gene 53:85-96.
28. Song, J., and R. A. Jensen. 1996. PhhR, a divergently transcribed activator of the phenylalanine hydroxylase gene cluster of Pseudomonas aeruginosa. Mol. Microbiol. 22:497-507.
29. Thöny, B., F. Neuheiser, L. Kierat, M. Blaskovics, P. H. Arn, P. Ferreira, I. Rebrin, J. Ayling, and N. Blau. 1998. Hyperphenylalaninemia with high levels of 7-biopterin is associated with mutations in the PCBD gene encoding the bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DcoH). Am. J. Hum. Genet. 62:1302-1311.
30. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
31. Vasudevan, S. G., D. C. Shaw, and W. L. F. Armarego. 1988. Dihydropteridine reductase from Escherichia coli. Biochem. J. 255:581-588.
32. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC vectors. Gene 33:103-119.
33. Yu, X.-M, and W. S. Reznikoff. 1984. Deletion analysis of the CAP-cAMP binding site of the Escherichia coli lactose promoter. Nucleic Acids Res. 12:5449-5464.
34. Zhao, G., T. Xia, J. Song, and R. A. Jensen. 1994. Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4a-carbinolamine dehydratase/DCoH as part of a three-component gene cluster. Proc. Natl. Acad. Sci. USA 91:1366-1370.