-
1
-
-
0037069690
-
Rho GTPases in cell biology.
-
Etienne-Manneville S, Hall A. 2002. Rho GTPases in cell biology. Nature 420:629-635. http://dx.doi.org/10.1038/nature01148.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
2
-
-
30044445761
-
RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling.
-
Canguilhem B, Pradines A, Baudouin C, Boby C, Lajoie-Mazenc I, Charveron M, Favre G. 2005. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. J. Biol. Chem. 280:43257-43263. http://dx.doi.org/10.1074/jbc. M508650200.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 43257-43263
-
-
Canguilhem, B.1
Pradines, A.2
Baudouin, C.3
Boby, C.4
Lajoie-Mazenc, I.5
Charveron, M.6
Favre, G.7
-
3
-
-
0028849261
-
The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments
-
Fritz G, Kaina B, Aktories K. 1995. The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments. J. Biol. Chem. 270:25172-25177. http://dx.doi.org/10.1074/jbc.270.42.25172.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25172-25177
-
-
Fritz, G.1
Kaina, B.2
Aktories, K.3
-
4
-
-
0035992372
-
Suppression of rho B expression in invasive carcinoma from head and neck cancer patients.
-
Adnane J, Muro-Cacho C, Mathews L, Sebti SM, Munoz-Antonia T. 2002. Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. Clin. Cancer Res. 8:2225-2232.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2225-2232
-
-
Adnane, J.1
Muro-Cacho, C.2
Mathews, L.3
Sebti, S.M.4
Munoz-Antonia, T.5
-
5
-
-
38849203044
-
Epigenetic regulation of RhoB loss of expression in lung cancer.
-
Mazieres J, Tovar D, He B, Nieto-Acosta J, Marty-Detraves C, Clanet C, Pradines A, Jablons D, Favre G. 2007. Epigenetic regulation of RhoB loss of expression in lung cancer. BMC Cancer 7:220. http://dx.doi.org/10.1186/1471-2407-7-220.
-
(2007)
BMC Cancer
, vol.7
, pp. 220
-
-
Mazieres, J.1
Tovar, D.2
He, B.3
Nieto-Acosta, J.4
Marty-Detraves, C.5
Clanet, C.6
Pradines, A.7
Jablons, D.8
Favre, G.9
-
6
-
-
78650746714
-
A distinct role of RhoB in gastric cancer suppression
-
Zhou J, Zhu Y, Zhang G, Liu N, Sun L, Liu M, Qiu M, Luo D, Tang Q, Liao Z, Zheng Y, Bi F. 2011. A distinct role of RhoB in gastric cancer suppression. Int. J. Cancer 128:1057-1068. http://dx.doi.org/10.1002/ijc.25445.
-
(2011)
Int. J. Cancer
, vol.128
, pp. 1057-1068
-
-
Zhou, J.1
Zhu, Y.2
Zhang, G.3
Liu, N.4
Sun, L.5
Liu, M.6
Qiu, M.7
Luo, D.8
Tang, Q.9
Liao, Z.10
Zheng, Y.11
Bi, F.12
-
7
-
-
68049144964
-
Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1
-
Bousquet E, Mazieres J, Privat M, Rizzati V, Casanova A, Ledoux A, Mery E, Couderc B, Favre G, Pradines A. 2009. Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1. Cancer Res. 69:6092-6099. http://dx.doi.org/10.1158/0008-5472.CAN-08-4147.
-
(2009)
Cancer Res.
, vol.69
, pp. 6092-6099
-
-
Bousquet, E.1
Mazieres, J.2
Privat, M.3
Rizzati, V.4
Casanova, A.5
Ledoux, A.6
Mery, E.7
Couderc, B.8
Favre, G.9
Pradines, A.10
-
9
-
-
57149136324
-
GammaH2AX and cancer
-
Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y. 2008. GammaH2AX and cancer. Nat. Rev. Cancer 8:957-967. http://dx.doi.org/10.1038/nrc2523.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 957-967
-
-
Bonner, W.M.1
Redon, C.E.2
Dickey, J.S.3
Nakamura, A.J.4
Sedelnikova, O.A.5
Solier, S.6
Pommier, Y.7
-
10
-
-
36749022214
-
The DNA damage response: ten years after
-
Harper JW, Elledge SJ. 2007. The DNA damage response: ten years after. Mol. Cell 28:739-745. http://dx.doi.org/10.1016/j.molcel.2007.11.015.
-
(2007)
Mol. Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
11
-
-
36949030242
-
DNA double-strand breaks: their cellular and clinical impact?
-
Jeggo PA, Lobrich M. 2007. DNA double-strand breaks: their cellular and clinical impact? Oncogene 26:7717-7719. http://dx.doi.org/10.1038/sj.onc.1210868.
-
(2007)
Oncogene
, vol.26
, pp. 7717-7719
-
-
Jeggo, P.A.1
Lobrich, M.2
-
12
-
-
80053555789
-
More than just a focus: the chromatin response to DNA damage and its role in genome integrity maintenance
-
Lukas J, Lukas C, Bartek J. 2011. More than just a focus: the chromatin response to DNA damage and its role in genome integrity maintenance. Nat. Cell Biol. 13:1161-1169. http://dx.doi.org/10.1038/ncb2344.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1161-1169
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
13
-
-
33745823159
-
The ATM-mediated DNA-damage response: taking shape
-
Shiloh Y. 2006. The ATM-mediated DNA-damage response: taking shape. Trends Biochem. Sci. 31:402-410. http://dx.doi.org/10.1016/j.tibs.2006.05.004.
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 402-410
-
-
Shiloh, Y.1
-
14
-
-
77956833348
-
Phosphatases in the cellular response to DNA damage.
-
Freeman AK, Monteiro AN. 2010. Phosphatases in the cellular response to DNA damage. Cell Commun. Signal. 8:27. http://dx.doi.org/10.1186/1478-811X-8-27.
-
(2010)
Cell Commun. Signal.
, vol.8
, pp. 27
-
-
Freeman, A.K.1
Monteiro, A.N.2
-
15
-
-
28444483130
-
Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
-
Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. 2005. Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 20:801-809. http://dx.doi.org/10.1016/j.molcel.2005.10.003.
-
(2005)
Mol. Cell
, vol.20
, pp. 801-809
-
-
Chowdhury, D.1
Keogh, M.C.2
Ishii, H.3
Peterson, C.L.4
Buratowski, S.5
Lieberman, J.6
-
16
-
-
84871198111
-
Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition
-
Kalev P, Simicek M, Vazquez I, Munck S, Chen L, Soin T, Danda N, Chen W, Sablina A. 2012. Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. Cancer Res. 72:6414-6424. http://dx.doi.org/10.1158/0008-5472.CAN -12-1667.
-
(2012)
Cancer Res.
, vol.72
, pp. 6414-6424
-
-
Kalev, P.1
Simicek, M.2
Vazquez, I.3
Munck, S.4
Chen, L.5
Soin, T.6
Danda, N.7
Chen, W.8
Sablina, A.9
-
17
-
-
70149108072
-
A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.
-
Wang Q, Gao F, Wang T, Flagg T, Deng X. 2009. A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair. Neoplasia 11:1012-1021.
-
(2009)
Neoplasia
, vol.11
, pp. 1012-1021
-
-
Wang, Q.1
Gao, F.2
Wang, T.3
Flagg, T.4
Deng, X.5
-
18
-
-
33749034730
-
Topoisomerase I inhibitors: camptothecins and beyond
-
Pommier Y. 2006. Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer 6:789-802. http://dx.doi.org/10.1038/nrc1977.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 789-802
-
-
Pommier, Y.1
-
19
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replicationdependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y. 2003. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replicationdependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 278:20303-20312. http://dx.doi.org/10.1074/jbc. M300198200.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
Aune, G.J.4
Redon, C.5
Sedelnikova, O.A.6
Pilch, D.R.7
Rogakou, E.P.8
Celeste, A.9
Chen, H.T.10
Nussenzweig, A.11
Aladjem, M.I.12
Bonner, W.M.13
Pommier, Y.14
-
20
-
-
68249083044
-
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks
-
Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y. 2009. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep. 10:887-893. http://dx.doi.org/10.1038/embor.2009.97.
-
(2009)
EMBO Rep.
, vol.10
, pp. 887-893
-
-
Sordet, O.1
Redon, C.E.2
Guirouilh-Barbat, J.3
Smith, S.4
Solier, S.5
Douarre, C.6
Conti, C.7
Nakamura, A.J.8
Das, B.B.9
Nicolas, E.10
Kohn, K.W.11
Bonner, W.M.12
Pommier, Y.13
-
21
-
-
79956053314
-
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
-
Zhang YW, Regairaz M, Seiler JA, Agama KK, Doroshow JH, Pommier Y. 2011. Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res. 39:3607-3620. http://dx.doi.org/10.1093/nar/gkq1304.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 3607-3620
-
-
Zhang, Y.W.1
Regairaz, M.2
Seiler, J.A.3
Agama, K.K.4
Doroshow, J.H.5
Pommier, Y.6
-
22
-
-
84857216401
-
Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762
-
Aris SM, Pommier Y. 2012. Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762. Cancer Res. 72:979-989. http://dx.doi.org/10.1158/0008-5472.CAN-11-2579.
-
(2012)
Cancer Res.
, vol.72
, pp. 979-989
-
-
Aris, S.M.1
Pommier, Y.2
-
23
-
-
35649021338
-
Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456
-
Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C. 2007. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J. Biol. Chem. 282:30311-30321. http://dx.doi.org/10.1074/jbc. M704642200.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 30311-30321
-
-
Kass, E.M.1
Ahn, J.2
Tanaka, T.3
Freed-Pastor, W.A.4
Keezer, S.5
Prives, C.6
-
24
-
-
0034808219
-
RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
-
Liu AX, Rane N, Liu JP, Prendergast GC. 2001. RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol. Cell. Biol. 21:6906-6912. http://dx.doi.org/10.1128/MCB.21.20.6906-6912.2001.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6906-6912
-
-
Liu, A.X.1
Rane, N.2
Liu, J.P.3
Prendergast, G.C.4
-
25
-
-
76549260925
-
Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
-
Aasen T, Izpisua Belmonte JC. 2010. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat. Protoc. 5:371-382. http://dx.doi.org/10.1038/nprot.2009.241.
-
(2010)
Nat. Protoc.
, vol.5
, pp. 371-382
-
-
Aasen, T.1
Izpisua Belmonte, J.C.2
-
26
-
-
33745089168
-
Bax and Bid, two proapoptotic Bcl-2 family members, inhibit homologous recombination, independently of apoptosis regulation
-
Dumay A, Laulier C, Bertrand P, Saintigny Y, Lebrun F, Vayssiere JL, Lopez BS. 2006. Bax and Bid, two proapoptotic Bcl-2 family members, inhibit homologous recombination, independently of apoptosis regulation. Oncogene 25:3196-3205. http://dx.doi.org/10.1038/sj.onc.1209344.
-
(2006)
Oncogene
, vol.25
, pp. 3196-3205
-
-
Dumay, A.1
Laulier, C.2
Bertrand, P.3
Saintigny, Y.4
Lebrun, F.5
Vayssiere, J.L.6
Lopez, B.S.7
-
27
-
-
68249138694
-
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
-
Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS. 2009. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat. Struct. Mol. Biol. 16:819-824. http://dx.doi.org/10.1038/nsmb.1641.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 819-824
-
-
Rass, E.1
Grabarz, A.2
Plo, I.3
Gautier, J.4
Bertrand, P.5
Lopez, B.S.6
-
28
-
-
80053976182
-
HuR-dependent loading of miRNA RISC to the mRNA encoding the Rasrelated small GTPase RhoB controls its translation during UV-induced apoptosis
-
Glorian V, Maillot G, Poles S, Iacovoni JS, Favre G, Vagner S. 2011. HuR-dependent loading of miRNA RISC to the mRNA encoding the Rasrelated small GTPase RhoB controls its translation during UV-induced apoptosis. Cell Death Differ. 18:1692-1701. http://dx.doi.org/10.1038/cdd.2011.35.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1692-1701
-
-
Glorian, V.1
Maillot, G.2
Poles, S.3
Iacovoni, J.S.4
Favre, G.5
Vagner, S.6
-
29
-
-
42949163674
-
MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling
-
Lajoie-Mazenc I, Tovar D, Penary M, Lortal B, Allart S, Favard C, Brihoum M, Pradines A, Favre G. 2008. MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. J. Biol. Chem. 283:4155-4164. http://dx.doi.org/10.1074/jbc. M709639200.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4155-4164
-
-
Lajoie-Mazenc, I.1
Tovar, D.2
Penary, M.3
Lortal, B.4
Allart, S.5
Favard, C.6
Brihoum, M.7
Pradines, A.8
Favre, G.9
-
30
-
-
84862908473
-
Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.
-
Regairaz M, Zhang YW, Fu H, Agama KK, Tata N, Agrawal S, Aladjem MI, Pommier Y. 2011. Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J. Cell Biol. 195: 739-749. http://dx.doi.org/10.1083/jcb.201104003.
-
(2011)
J. Cell Biol.
, vol.195
, pp. 739-749
-
-
Regairaz, M.1
Zhang, Y.W.2
Fu, H.3
Agama, K.K.4
Tata, N.5
Agrawal, S.6
Aladjem, M.I.7
Pommier, Y.8
-
31
-
-
84883543030
-
Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer.
-
Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, Rameseder J, Chen CC, D'Andrea AD, Kozono D. 2013. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8:e73710. http://dx.doi.org/10.1371/journal.pone.0073710.
-
(2013)
PLoS One
, vol.8
-
-
Cron, K.R.1
Zhu, K.2
Kushwaha, D.S.3
Hsieh, G.4
Merzon, D.5
Rameseder, J.6
Chen, C.C.7
D'Andrea, A.D.8
Kozono, D.9
-
32
-
-
84856513068
-
Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors
-
Lagarde P, Perot G, Kauffmann A, Brulard C, Dapremont V, Hostein I, Neuville A, Wozniak A, Sciot R, Schoffski P, Aurias A, Coindre JM, Debiec-Rychter M, Chibon F. 2012. Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors. Clin. Cancer Res. 18:826-838. http://dx.doi.org/10.1158/1078-0432.CCR-11-1610.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 826-838
-
-
Lagarde, P.1
Perot, G.2
Kauffmann, A.3
Brulard, C.4
Dapremont, V.5
Hostein, I.6
Neuville, A.7
Wozniak, A.8
Sciot, R.9
Schoffski, P.10
Aurias, A.11
Coindre, J.M.12
Debiec-Rychter, M.13
Chibon, F.14
-
33
-
-
33845420563
-
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress
-
Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW. 2006. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr. Biol. 16:2466-2472. http://dx.doi.org/10.1016/j.cub.2006.10.056.
-
(2006)
Curr. Biol.
, vol.16
, pp. 2466-2472
-
-
Ongusaha, P.P.1
Kim, H.G.2
Boswell, S.A.3
Ridley, A.J.4
Der, C.J.5
Dotto, G.P.6
Kim, Y.B.7
Aaronson, S.A.8
Lee, S.W.9
-
34
-
-
73449114926
-
Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells
-
Kim CH, Won M, Choi CH, Ahn J, Kim BK, Song KB, Kang CM, Chung KS. 2010. Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells. Biochem. Biophys. Res. Commun. 391:1182-1186. http://dx.doi.org/10.1016/j.bbrc.2009.12.012.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.391
, pp. 1182-1186
-
-
Kim, C.H.1
Won, M.2
Choi, C.H.3
Ahn, J.4
Kim, B.K.5
Song, K.B.6
Kang, C.M.7
Chung, K.S.8
-
35
-
-
13244268269
-
RhoB mRNA is stabilized by HuR after UV light
-
Westmark CJ, Bartleson VB, Malter JS. 2005. RhoB mRNA is stabilized by HuR after UV light. Oncogene 24:502-511. http://dx.doi.org/10.1038/sj.onc.1208224.
-
(2005)
Oncogene
, vol.24
, pp. 502-511
-
-
Westmark, C.J.1
Bartleson, V.B.2
Malter, J.S.3
-
36
-
-
0035099573
-
HuR and mRNA stability
-
Brennan CM, Steitz JA. 2001. HuR and mRNA stability. Cell. Mol. Life Sci. 58:266-277. http://dx.doi.org/10.1007/PL00000854.
-
(2001)
Cell. Mol. Life Sci.
, vol.58
, pp. 266-277
-
-
Brennan, C.M.1
Steitz, J.A.2
-
37
-
-
79952754428
-
Global dissociation of HuRmRNA complexes promotes cell survival after ionizing radiation
-
Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, Selimyan R, Martindale JL, Yang X, Lehrmann E, Zhang Y, Becker KG, Wang JY, Kim HH, Gorospe M. 2011. Global dissociation of HuRmRNA complexes promotes cell survival after ionizing radiation. EMBO J. 30:1040-1053. http://dx.doi.org/10.1038/emboj.2011.24.
-
(2011)
EMBO J.
, vol.30
, pp. 1040-1053
-
-
Masuda, K.1
Abdelmohsen, K.2
Kim, M.M.3
Srikantan, S.4
Lee, E.K.5
Tominaga, K.6
Selimyan, R.7
Martindale, J.L.8
Yang, X.9
Lehrmann, E.10
Zhang, Y.11
Becker, K.G.12
Wang, J.Y.13
Kim, H.H.14
Gorospe, M.15
-
38
-
-
77950527724
-
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer.
-
Calaluce R, Gubin MM, Davis JW, Magee JD, Chen J, Kuwano Y, Gorospe M, Atasoy U. 2010. The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer 10:126. http://dx.doi.org/10.1186/1471-2407-10-126.
-
(2010)
BMC Cancer
, vol.10
, pp. 126
-
-
Calaluce, R.1
Gubin, M.M.2
Davis, J.W.3
Magee, J.D.4
Chen, J.5
Kuwano, Y.6
Gorospe, M.7
Atasoy, U.8
-
39
-
-
22944462043
-
Targeting chk2 kinase: molecular interaction maps and therapeutic rationale
-
Pommier Y, Sordet O, Rao VA, Zhang H, Kohn KW. 2005. Targeting chk2 kinase: molecular interaction maps and therapeutic rationale. Curr. Pharm. Des. 11:2855-2872. http://dx.doi.org/10.2174/1381612054546716.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 2855-2872
-
-
Pommier, Y.1
Sordet, O.2
Rao, V.A.3
Zhang, H.4
Kohn, K.W.5
-
40
-
-
33847035824
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
-
Abdelmohsen K, Pullmann R, Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. 2007. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol. Cell 25:543-557. http://dx.doi.org/10.1016/j.molcel.2007.01.011.
-
(2007)
Mol. Cell
, vol.25
, pp. 543-557
-
-
Abdelmohsen, K.1
Pullmann Jr., R.2
Lal, A.3
Kim, H.H.4
Galban, S.5
Yang, X.6
Blethrow, J.D.7
Walker, M.8
Shubert, J.9
Gillespie, D.A.10
Furneaux, H.11
Gorospe, M.12
-
41
-
-
73949111960
-
Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation
-
Liu L, Rao JN, Zou T, Xiao L, Wang PY, Turner DJ, Gorospe M, Wang JY. 2009. Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Mol. Biol. Cell 20:4885-4898. http://dx.doi.org/10.1091/mbc. E09-07-0550.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 4885-4898
-
-
Liu, L.1
Rao, J.N.2
Zou, T.3
Xiao, L.4
Wang, P.Y.5
Turner, D.J.6
Gorospe, M.7
Wang, J.Y.8
-
42
-
-
80455129693
-
Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function.
-
Yu TX, Wang PY, Rao JN, Zou T, Liu L, Xiao L, Gorospe M, Wang JY. 2011. Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Nucleic Acids Res. 39:8472-8487. http://dx.doi.org/10.1093/nar/gkr567.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 8472-8487
-
-
Yu, T.X.1
Wang, P.Y.2
Rao, J.N.3
Zou, T.4
Liu, L.5
Xiao, L.6
Gorospe, M.7
Wang, J.Y.8
-
43
-
-
33749028012
-
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
-
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y. 2006. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J. Biol. Chem. 281: 30814-30823. http://dx.doi.org/10.1074/jbc. M603747200.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30814-30823
-
-
Takemura, H.1
Rao, V.A.2
Sordet, O.3
Furuta, T.4
Miao, Z.H.5
Meng, L.6
Zhang, H.7
Pommier, Y.8
-
44
-
-
0034306332
-
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
-
Melchionna R, Chen XB, Blasina A, McGowan CH. 2000. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat. Cell Biol. 2:762-765. http://dx.doi.org/10.1038/35036406.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 762-765
-
-
Melchionna, R.1
Chen, X.B.2
Blasina, A.3
McGowan, C.H.4
-
45
-
-
77953166592
-
GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
-
Lobrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. 2010. GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle 9:662-669. http://dx.doi.org/10.4161/cc.9.4.10764.
-
(2010)
Cell Cycle
, vol.9
, pp. 662-669
-
-
Lobrich, M.1
Shibata, A.2
Beucher, A.3
Fisher, A.4
Ensminger, M.5
Goodarzi, A.A.6
Barton, O.7
Jeggo, P.A.8
-
46
-
-
47349107760
-
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
-
Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Lobrich M, Jeggo PA. 2008. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31:167-177. http://dx.doi.org/10.1016/j.molcel.2008.05.017.
-
(2008)
Mol. Cell
, vol.31
, pp. 167-177
-
-
Goodarzi, A.A.1
Noon, A.T.2
Deckbar, D.3
Ziv, Y.4
Shiloh, Y.5
Lobrich, M.6
Jeggo, P.A.7
-
47
-
-
0035093737
-
DNA double-strand breaks: signaling, repair and the cancer connection
-
Khanna KK, Jackson SP. 2001. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:247-254. http://dx.doi.org/10.1038/85798.
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
48
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
Pierce AJ, Johnson RD, Thompson LH, Jasin M. 1999. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 13:2633-2638. http://dx.doi.org/10.1101/gad.13.20.2633.
-
(1999)
Genes Dev.
, vol.13
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
49
-
-
2942525595
-
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells
-
Guirouilh-Barbat J, Huck S, Bertrand P, Pirzio L, Desmaze C, Sabatier L, Lopez BS. 2004. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol. Cell 14:611-623. http://dx.doi.org/10.1016/j.molcel.2004.05.008.
-
(2004)
Mol. Cell
, vol.14
, pp. 611-623
-
-
Guirouilh-Barbat, J.1
Huck, S.2
Bertrand, P.3
Pirzio, L.4
Desmaze, C.5
Sabatier, L.6
Lopez, B.S.7
-
50
-
-
38049187905
-
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
-
Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS. 2007. Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proc. Natl. Acad. Sci. U. S. A. 104:20902-20907. http://dx.doi.org/10.1073/pnas.0708541104.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 20902-20907
-
-
Guirouilh-Barbat, J.1
Rass, E.2
Plo, I.3
Bertrand, P.4
Lopez, B.S.5
-
51
-
-
84904483319
-
ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.
-
in press.
-
Al-Khalaf HH, Aboussekhra A. ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner. Mol. Carcinog., in press.
-
Mol. Carcinog
-
-
Al-Khalaf, H.H.1
Aboussekhra, A.2
-
52
-
-
80053986419
-
Regulation of HuR by DNA damage response kinases.
-
Kim HH, Abdelmohsen K, Gorospe M. 2010. Regulation of HuR by DNA damage response kinases. J. Nucleic Acids 2010:981487. http://dx.doi.org/10.4061/2010/981487.
-
(2010)
J. Nucleic Acids
, pp. 981487
-
-
Kim, H.H.1
Abdelmohsen, K.2
Gorospe, M.3
-
53
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
Sorensen CS, Hansen LT, Dziegielewski J, Syljuasen RG, Lundin C, Bartek J, Helleday T. 2005. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat. Cell Biol. 7:195-201. http://dx.doi.org/10.1038/ncb1212.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 195-201
-
-
Sorensen, C.S.1
Hansen, L.T.2
Dziegielewski, J.3
Syljuasen, R.G.4
Lundin, C.5
Bartek, J.6
Helleday, T.7
-
54
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress.
-
Ward IM, Chen J. 2001. Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress. J. Biol. Chem. 276: 47759-47762.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
55
-
-
0037039463
-
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization
-
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE. 2002. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization. Proc. Natl. Acad. Sci. U. S. A. 99:233-238. http://dx.doi.org/10.1073/pnas.231611798.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 233-238
-
-
Limoli, C.L.1
Giedzinski, E.2
Bonner, W.M.3
Cleaver, J.E.4
-
56
-
-
22144458661
-
Cisplatin-mediated DNA double-strand breaks in replicating but not in quiescent cells of the yeast Saccharomyces cerevisiae
-
Frankenberg-Schwager M, Kirchermeier D, Greif G, Baer K, Becker M, Frankenberg D. 2005. Cisplatin-mediated DNA double-strand breaks in replicating but not in quiescent cells of the yeast Saccharomyces cerevisiae. Toxicology 212:175-184. http://dx.doi.org/10.1016/j.tox.2005.04.015.
-
(2005)
Toxicology
, vol.212
, pp. 175-184
-
-
Frankenberg-Schwager, M.1
Kirchermeier, D.2
Greif, G.3
Baer, K.4
Becker, M.5
Frankenberg, D.6
-
57
-
-
0347994029
-
Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts
-
Ader I, Delmas C, Bonnet J, Rochaix P, Favre G, Toulas C, Cohen- Jonathan-Moyal E. 2003. Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts. Oncogene 22:8861-8869. http://dx.doi.org/10.1038/sj.onc.1207095.
-
(2003)
Oncogene
, vol.22
, pp. 8861-8869
-
-
Ader, I.1
Delmas, C.2
Bonnet, J.3
Rochaix, P.4
Favre, G.5
Toulas, C.6
Cohen-Jonathan-Moyal, E.7
-
58
-
-
33846618797
-
Identification of proteins interacting with the catalytic subunit of PP2A by proteomics
-
Lee WJ, Kim DU, Lee MY, Choi KY. 2007. Identification of proteins interacting with the catalytic subunit of PP2A by proteomics. Proteomics 7:206-214. http://dx.doi.org/10.1002/pmic.200600480.
-
(2007)
Proteomics
, vol.7
, pp. 206-214
-
-
Lee, W.J.1
Kim, D.U.2
Lee, M.Y.3
Choi, K.Y.4
-
59
-
-
78651406669
-
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes
-
Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP. 2011. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature 469:245-249. http://dx.doi.org/10.1038/nature09585.
-
(2011)
Nature
, vol.469
, pp. 245-249
-
-
Helmink, B.A.1
Tubbs, A.T.2
Dorsett, Y.3
Bednarski, J.J.4
Walker, L.M.5
Feng, Z.6
Sharma, G.G.7
McKinnon, P.J.8
Zhang, J.9
Bassing, C.H.10
Sleckman, B.P.11
-
60
-
-
38349190654
-
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
-
Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW. 2008. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J. Biol. Chem. 283:1882-1892. http://dx.doi.org/10.1074/jbc. M709585200.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1882-1892
-
-
Kuo, Y.C.1
Huang, K.Y.2
Yang, C.H.3
Yang, Y.S.4
Lee, W.Y.5
Chiang, C.W.6
-
61
-
-
56449128931
-
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51
-
Plo I, Laulier C, Gauthier L, Lebrun F, Calvo F, Lopez BS. 2008. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. Cancer Res. 68:9404-9412. http://dx.doi.org/10.1158/0008-5472.CAN-08-0861.
-
(2008)
Cancer Res.
, vol.68
, pp. 9404-9412
-
-
Plo, I.1
Laulier, C.2
Gauthier, L.3
Lebrun, F.4
Calvo, F.5
Lopez, B.S.6
-
62
-
-
46149117962
-
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication
-
Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J. 2008. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol. Cell 31:33-46. http://dx.doi.org/10.1016/j.molcel.2008.05.016.
-
(2008)
Mol. Cell
, vol.31
, pp. 33-46
-
-
Chowdhury, D.1
Xu, X.2
Zhong, X.3
Ahmed, F.4
Zhong, J.5
Liao, J.6
Dykxhoorn, D.M.7
Weinstock, D.M.8
Pfeifer, G.P.9
Lieberman, J.10
-
63
-
-
84891041861
-
RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness
-
Meyer N, Peyret-Lacombe A, Canguilhem B, Medale-Giamarchi C, Mamouni K, Cristini A, Monferran S, Lamant L, Filleron T, Pradines A, Sordet O, Favre G. 2014. RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness. J. Investig. Dermatol. 134:203-212. http://dx.doi.org/10.1038/jid.2013.278.
-
(2014)
J. Investig. Dermatol.
, vol.134
, pp. 203-212
-
-
Meyer, N.1
Peyret-Lacombe, A.2
Canguilhem, B.3
Medale-Giamarchi, C.4
Mamouni, K.5
Cristini, A.6
Monferran, S.7
Lamant, L.8
Filleron, T.9
Pradines, A.10
Sordet, O.11
Favre, G.12
-
64
-
-
0141704306
-
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.
-
Wu X, Chen J. 2003. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J. Biol. Chem. 278: 36163-36168. http://dx.doi.org/10.1074/jbc. M303795200.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36163-36168
-
-
Wu, X.1
Chen, J.2
|