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Volumn 124, Issue 3, 2014, Pages 363-373

Acute graft-versus-host disease: A bench-to-bedside update

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; BORTEZOMIB; BRENTUXIMAB VEDOTIN; CORTICOSTEROID DERIVATIVE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DENILEUKIN DIFTITOX; ETANERCEPT; INFLIXIMAB; MARAVIROC; METHOTREXATE; PANOBINOSTAT; PENTOSTATIN; RAPAMYCIN; TACROLIMUS; TOCILIZUMAB; TRYPSIN INHIBITOR; VORINOSTAT;

EID: 84904471984     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-01-514786     Document Type: Review
Times cited : (166)

References (158)
  • 1
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therapy
    • Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol. 2012;12(6):443-458.
    • (2012) Nat Rev Immunol , vol.12 , Issue.6 , pp. 443-458
    • Blazar, B.R.1    Murphy, W.J.2    Abedi, M.3
  • 3
    • 84887330998 scopus 로고    scopus 로고
    • The major histocompatibility complex: A model for understanding graft-versus-host disease
    • Petersdorf EW. The major histocompatibility complex: a model for understanding graft-versus-host disease. Blood. 2013;122(11):1863-1872.
    • (2013) Blood , vol.122 , Issue.11 , pp. 1863-1872
    • Petersdorf, E.W.1
  • 4
    • 34948865802 scopus 로고    scopus 로고
    • High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
    • DOI 10.1182/blood-2007-02-072405
    • Kawase T, Morishima Y, Matsuo K, et al Japan Marrow Donor Program. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood. 2007;110(7):2235-2241. (Pubitemid 47523140)
    • (2007) Blood , vol.110 , Issue.7 , pp. 2235-2241
    • Kawase, T.1    Morishima, Y.2    Matsuo, K.3    Kashiwase, K.4    Inoko, H.5    Saji, H.6    Kato, S.7    Juji, T.8    Kodera, Y.9    Sasazuki, T.10
  • 5
    • 84895790901 scopus 로고    scopus 로고
    • Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation
    • HLA working group of the Japan Society for Hematopoietic Cell Transplantation
    • Kanda Y, Kanda J, Atsuta Y, et al; HLA working group of the Japan Society for Hematopoietic Cell Transplantation. Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation. Biol Blood Marrow Transplant. 2014;20(4):526-535.
    • (2014) Biol Blood Marrow Transplant , vol.20 , Issue.4 , pp. 526-535
    • Kanda, Y.1    Kanda, J.2    Atsuta, Y.3
  • 6
    • 84888269622 scopus 로고    scopus 로고
    • Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality
    • Pidala J, Wang T, Haagenson M, et al. Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality. Blood. 2013;122(22):3651-3658.
    • (2013) Blood , vol.122 , Issue.22 , pp. 3651-3658
    • Pidala, J.1    Wang, T.2    Haagenson, M.3
  • 7
    • 84880775816 scopus 로고    scopus 로고
    • Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation
    • Fernández-Viña MA, Klein JP, Haagenson M, et al. Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation. Blood. 2013;121(22):4603-4610.
    • (2013) Blood , vol.121 , Issue.22 , pp. 4603-4610
    • Fernández-Viña, M.A.1    Klein, J.P.2    Haagenson, M.3
  • 8
    • 51849112358 scopus 로고    scopus 로고
    • Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation
    • Stern M, Brand R, de Witte T, et al. Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation. Am J Transplant. 2008;8(10):2149-2157.
    • (2008) Am J Transplant , vol.8 , Issue.10 , pp. 2149-2157
    • Stern, M.1    Brand, R.2    De Witte, T.3
  • 9
    • 84880425257 scopus 로고    scopus 로고
    • Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    • Spierings E, Kim YH, Hendriks M, et al. Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19(8):1244-1253.
    • (2013) Biol Blood Marrow Transplant , vol.19 , Issue.8 , pp. 1244-1253
    • Spierings, E.1    Kim, Y.H.2    Hendriks, M.3
  • 11
    • 84867316465 scopus 로고    scopus 로고
    • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
    • Brennan TV, Lin L, Huang X, et al. Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood. 2012;120(14):2899-2908.
    • (2012) Blood , vol.120 , Issue.14 , pp. 2899-2908
    • Brennan, T.V.1    Lin, L.2    Huang, X.3
  • 12
    • 78649993400 scopus 로고    scopus 로고
    • Graft-versus- host disease is enhanced by extracellular ATP activating P2X7R
    • Wilhelm K, Ganesan J, Müller T, et al. Graft-versus- host disease is enhanced by extracellular ATP activating P2X7R. Nat Med. 2010;16(12):1434-1438.
    • (2010) Nat Med , vol.16 , Issue.12 , pp. 1434-1438
    • Wilhelm, K.1    Ganesan, J.2    Müller, T.3
  • 13
    • 84885447590 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome regulates acute graft-versus-host disease
    • Jankovic D, Ganesan J, Bscheider M, et al. The Nlrp3 inflammasome regulates acute graft-versus-host disease. J Exp Med. 2013;210(10):1899-1910.
    • (2013) J Exp Med , vol.210 , Issue.10 , pp. 1899-1910
    • Jankovic, D.1    Ganesan, J.2    Bscheider, M.3
  • 15
    • 78650310185 scopus 로고    scopus 로고
    • Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant
    • Kinnier CV, Martinu T, Gowdy KM, Nugent JL, Kelly FL, Palmer SM. Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant. Transpl Immunol. 2011;24(2):83-93.
    • (2011) Transpl Immunol , vol.24 , Issue.2 , pp. 83-93
    • Kinnier, C.V.1    Martinu, T.2    Gowdy, K.M.3    Nugent, J.L.4    Kelly, F.L.5    Palmer, S.M.6
  • 16
    • 80052493237 scopus 로고    scopus 로고
    • Danger signals activating innate immunity in graft-versus-host disease
    • Zeiser R, Penack O, Holler E, Idzko M. Danger signals activating innate immunity in graft-versus-host disease. J Mol Med (Berl). 2011;89(9):833-845.
    • (2011) J Mol Med (Berl) , vol.89 , Issue.9 , pp. 833-845
    • Zeiser, R.1    Penack, O.2    Holler, E.3    Idzko, M.4
  • 17
    • 81455141945 scopus 로고    scopus 로고
    • Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity
    • Hossain MS, Jaye DL, Pollack BP, et al. Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. J Immunol. 2011;187(10):5130-5140.
    • (2011) J Immunol , vol.187 , Issue.10 , pp. 5130-5140
    • Hossain, M.S.1    Jaye, D.L.2    Pollack, B.P.3
  • 20
    • 84860317080 scopus 로고    scopus 로고
    • Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction
    • Li H, Demetris AJ, McNiff J, et al. Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. J Immunol. 2012;188(8):3804-3811.
    • (2012) J Immunol , vol.188 , Issue.8 , pp. 3804-3811
    • Li, H.1    Demetris, A.J.2    McNiff, J.3
  • 21
    • 78751531266 scopus 로고    scopus 로고
    • Langerhans cells are not required for graft-versus-host disease
    • Li H, Kaplan DH, Matte-Martone C, et al. Langerhans cells are not required for graft-versus-host disease. Blood. 2011;117(2):697-707.
    • (2011) Blood , vol.117 , Issue.2 , pp. 697-707
    • Li, H.1    Kaplan, D.H.2    Matte-Martone, C.3
  • 22
    • 77955513410 scopus 로고    scopus 로고
    • Recipient B cells are not required for graft-versus-host disease induction
    • Matte-Martone C, Wang X, Anderson B, et al. Recipient B cells are not required for graft-versus-host disease induction. Biol Blood Marrow Transplant. 2010;16(9):1222-1230.
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.9 , pp. 1222-1230
    • Matte-Martone, C.1    Wang, X.2    Anderson, B.3
  • 23
    • 79956068261 scopus 로고    scopus 로고
    • Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
    • Hashimoto D, Chow A, Greter M, et al. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med. 2011;208(5):1069-1082.
    • (2011) J Exp Med , vol.208 , Issue.5 , pp. 1069-1082
    • Hashimoto, D.1    Chow, A.2    Greter, M.3
  • 24
    • 84855546719 scopus 로고    scopus 로고
    • Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease
    • Koyama M, Kuns RD, Olver SD, et al. Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nat Med. 2012;18(1):135-142.
    • (2012) Nat Med , vol.18 , Issue.1 , pp. 135-142
    • Koyama, M.1    Kuns, R.D.2    Olver, S.D.3
  • 25
    • 84880569064 scopus 로고    scopus 로고
    • Dual receptor T cells mediate pathologic alloreactivity in patients with acute graft-versus-host disease
    • Morris GP, Uy GL, Donermeyer D, Dipersio JF, Allen PM. Dual receptor T cells mediate pathologic alloreactivity in patients with acute graft-versus-host disease. Sci Transl Med. 2013;5(188):188ra174.
    • (2013) Sci Transl Med , vol.5 , Issue.188
    • Morris, G.P.1    Uy, G.L.2    Donermeyer, D.3    Dipersio, J.F.4    Allen, P.M.5
  • 26
    • 84861579314 scopus 로고    scopus 로고
    • T-cell costimulatory molecules in acute-graft-versus host disease: Therapeutic implications
    • Briones J, Novelli S, Sierra J. T-cell costimulatory molecules in acute-graft-versus host disease: therapeutic implications. Bone Marrow Res. 2011;2011:976793.
    • (2011) Bone Marrow Res , vol.2011 , pp. 976793
    • Briones, J.1    Novelli, S.2    Sierra, J.3
  • 27
    • 33746932816 scopus 로고    scopus 로고
    • An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues
    • Chakraverty R, Côtê D, Buchli J, et al. An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med. 2006;203(8):2021-2031.
    • (2006) J Exp Med , vol.203 , Issue.8 , pp. 2021-2031
    • Chakraverty, R.1    Côtê, D.2    Buchli, J.3
  • 30
    • 22044439846 scopus 로고    scopus 로고
    • + T-cell-mediated acute graft-versus-host disease responses
    • DOI 10.1182/blood-2004-08-2996
    • Varona R, Cadenas V, Gómez L, Martínez-A C, Márquez G. CCR6 regulates CD41 T-cell-mediated acute graft-versus-host disease responses. Blood. 2005;106(1):18-26. (Pubitemid 40967169)
    • (2005) Blood , vol.106 , Issue.1 , pp. 18-26
    • Varona, R.1    Cadenas, V.2    Gomez, L.3    Martinez-A, C.4    Marquez, G.5
  • 31
    • 33747597069 scopus 로고    scopus 로고
    • + T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy
    • DOI 10.1038/sj.leu.2404308, PII 2404308
    • Yakoub-Agha I, Saule P, Depil S, et al. A high proportion of donor CD41 T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy. Leukemia. 2006; 20(9):1557-1565. (Pubitemid 44264099)
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1557-1565
    • Yakoub-Agha, I.1    Saule, P.2    Depil, S.3    Micol, J.-B.4    Grutzmacher, C.5    Boulanger-Villard, F.6    Bauters, F.7    Jouet, J.-P.8    Dessaint, J.-P.9    Labalette, M.10
  • 32
    • 78650704919 scopus 로고    scopus 로고
    • The chemokine system: A possible therapeutic target in acute graft versus host disease
    • Kittan NA, Hildebrandt GC. The chemokine system: a possible therapeutic target in acute graft versus host disease. Curr Top Microbiol Immunol. 2010;341:97-120.
    • (2010) Curr Top Microbiol Immunol , vol.341 , pp. 97-120
    • Kittan, N.A.1    Hildebrandt, G.C.2
  • 33
    • 84870737851 scopus 로고    scopus 로고
    • Decreased levels of circulating IL17-producing CD161+CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation
    • van der Waart AB, van der Velden WJ, van Halteren AG, et al. Decreased levels of circulating IL17-producing CD161+CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation. PLoS ONE. 2012;7(12):e50896.
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Van Der Waart, A.B.1    Van Der Velden, W.J.2    Van Halteren, A.G.3
  • 34
    • 33748580715 scopus 로고    scopus 로고
    • + human T lymphocytes expressing beta7 integrin correlate with the occurrence of intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    • DOI 10.1016/j.exphem.2006.06.006, PII S0301472X0600381X
    • Avanzini MA, Maccario R, Locatelli F, et al. Low percentages of circulating CD8(+)/CD45RA(+) human T lymphocytes expressing beta7 integrin correlate with the occurrence of intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Exp Hematol. 2006;34(10):1429-1434. (Pubitemid 44374842)
    • (2006) Experimental Hematology , vol.34 , Issue.10 , pp. 1429-1434
    • Avanzini, M.A.1    Maccario, R.2    Locatelli, F.3    Giebel, S.4    Santos, C.D.5    Bernardo, M.E.6    Pagliara, D.7    Montagna, D.8    Longo, S.9    Amendola, G.10    Marconi, M.11
  • 35
    • 84876409364 scopus 로고    scopus 로고
    • Expression of α4b7 integrin on memory CD8(+) T cells at the presentation of acute intestinal GVHD
    • Chen YB, McDonough S, Chen H, et al. Expression of α4b7 integrin on memory CD8(+) T cells at the presentation of acute intestinal GVHD. Bone Marrow Transplant. 2013;48(4):598-603.
    • (2013) Bone Marrow Transplant , vol.48 , Issue.4 , pp. 598-603
    • Chen, Y.B.1    McDonough, S.2    Chen, H.3
  • 37
    • 38449089930 scopus 로고    scopus 로고
    • Naive and memory T cells induce different types of graft-versus-host disease
    • Dutt S, Tseng D, Ermann J, et al. Naive and memory T cells induce different types of graft-versus-host disease. J Immunol. 2007;179(10):6547-6554.
    • (2007) J Immunol , vol.179 , Issue.10 , pp. 6547-6554
    • Dutt, S.1    Tseng, D.2    Ermann, J.3
  • 38
    • 33947573126 scopus 로고    scopus 로고
    • Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse
    • DOI 10.1182/blood-2006-04-016410
    • Chen BJ, Deoliveira D, Cui X, et al. Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood. 2007;109(7):3115-3123. (Pubitemid 46482115)
    • (2007) Blood , vol.109 , Issue.7 , pp. 3115-3123
    • Chen, B.J.1    Deoliveira, D.2    Cui, X.3    Le, N.T.4    Son, J.5    Whitesides, J.F.6    Chao, N.J.7
  • 39
    • 84866182776 scopus 로고    scopus 로고
    • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice
    • Zhang P, Wu J, Deoliveira D, Chao NJ, Chen BJ. Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. Biol Blood Marrow Transplant. 2012;18(10):1488-1499.
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.10 , pp. 1488-1499
    • Zhang, P.1    Wu, J.2    Deoliveira, D.3    Chao, N.J.4    Chen, B.J.5
  • 40
    • 80052173275 scopus 로고    scopus 로고
    • A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells
    • Juchem KW, Anderson BE, Zhang C, et al. A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. Blood. 2011;118(23):6209-6219.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6209-6219
    • Juchem, K.W.1    Anderson, B.E.2    Zhang, C.3
  • 41
    • 78650070717 scopus 로고    scopus 로고
    • GVHD after haploidentical transplantation: A novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression
    • Miller WP, Srinivasan S, Panoskaltsis-Mortari A, et al. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010;116(24):5403-5418.
    • (2010) Blood , vol.116 , Issue.24 , pp. 5403-5418
    • Miller, W.P.1    Srinivasan, S.2    Panoskaltsis-Mortari, A.3
  • 43
    • 1442265964 scopus 로고    scopus 로고
    • Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: A study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    • Ringdén O, Labopin M, Gorin NC, et al. Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2004;22(3):416-423.
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 416-423
    • Ringdén, O.1    Labopin, M.2    Gorin, N.C.3
  • 44
    • 78650269478 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor induced acute and chronic graft-versus-host disease
    • Ringden O, Hassan Z, Karlsson H, et al. Granulocyte colony-stimulating factor induced acute and chronic graft-versus-host disease. Transplantation. 2010;90(9):1022-1029.
    • (2010) Transplantation , vol.90 , Issue.9 , pp. 1022-1029
    • Ringden, O.1    Hassan, Z.2    Karlsson, H.3
  • 45
    • 70349230993 scopus 로고    scopus 로고
    • Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation
    • Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS. Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol. 2009;183(5):3219-3228.
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3219-3228
    • Olson, J.A.1    Zeiser, R.2    Beilhack, A.3    Goldman, J.J.4    Negrin, R.S.5
  • 46
    • 0023242444 scopus 로고
    • Graft-versus-host reactions in the beige mouse. An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease
    • Ghayur T, Seemayer TA, Kongshavn PA, Gartner JG, Lapp WS. Graft-versus-host reactions in the beige mouse. An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease. Transplantation. 1987;44(2):261-267. (Pubitemid 17158347)
    • (1987) Transplantation , vol.44 , Issue.2 , pp. 261-267
    • Ghayur, T.1    Seemayer, T.A.2    Kongshavn, P.A.L.3
  • 47
    • 84859809525 scopus 로고    scopus 로고
    • The impact of the dose of natural killer cells in the graft on severe acute graft-versus-host disease after unrelated bone marrow transplantation
    • Tanaka M, Kobayashi S, Numata A, et al. The impact of the dose of natural killer cells in the graft on severe acute graft-versus-host disease after unrelated bone marrow transplantation. Leuk Res. 2012;36(6):699-703.
    • (2012) Leuk Res , vol.36 , Issue.6 , pp. 699-703
    • Tanaka, M.1    Kobayashi, S.2    Numata, A.3
  • 48
    • 0029112701 scopus 로고
    • Requirement for B cells in T cell priming to minor histocompatibility antigens and development of graft-versus-host disease
    • Schultz KR, Paquet J, Bader S, HayGlass KT. Requirement for B cells in T cell priming to minor histocompatibility antigens and development of graft-versus-host disease. Bone Marrow Transplant. 1995;16(2):289-295.
    • (1995) Bone Marrow Transplant , vol.16 , Issue.2 , pp. 289-295
    • Schultz, K.R.1    Paquet, J.2    Bader, S.3    HayGlass, K.T.4
  • 49
    • 80051470064 scopus 로고    scopus 로고
    • Prior rituximab administration is associated with reduced rate of acute GVHD after in vivo T-cell depleted transplantation in lymphoma patients
    • Crocchiolo R, Castagna L, El-Cheikh J, et al. Prior rituximab administration is associated with reduced rate of acute GVHD after in vivo T-cell depleted transplantation in lymphoma patients. Exp Hematol. 2011;39(9):892-896.
    • (2011) Exp Hematol , vol.39 , Issue.9 , pp. 892-896
    • Crocchiolo, R.1    Castagna, L.2    El-Cheikh, J.3
  • 50
    • 66749129586 scopus 로고    scopus 로고
    • Center for International Blood and Marrow Transplant Research, Milwaukee, WI. Prior rituximab correlates with less acute graft-versus-host disease and better survival in B-cell lymphoma patients who received allogeneic peripheral blood stem cell transplantation
    • Ratanatharathorn V, Logan B, Wang D, et al; Center for International Blood and Marrow Transplant Research, Milwaukee, WI. Prior rituximab correlates with less acute graft-versus-host disease and better survival in B-cell lymphoma patients who received allogeneic peripheral blood stem cell transplantation. Br J Haematol. 2009;145(6):816-824.
    • (2009) Br J Haematol , vol.145 , Issue.6 , pp. 816-824
    • Ratanatharathorn, V.1    Logan, B.2    Wang, D.3
  • 51
    • 85047695131 scopus 로고    scopus 로고
    • Macrophage migratory inhibitory factor (MIF) expression in acute graft-versus-host disease (GVHD) in allogeneic hemopoietic stem cell transplant recipients
    • DOI 10.1038/sj.bmt.1703639
    • Lo JW, Leung AY, Huang XR, et al. Macrophage migratory inhibitory factor (MIF) expression in acute graft-versus-host disease (GVHD) in allogeneic hemopoietic stem cell transplant recipients. Bone Marrow Transplant. 2002;30(6):375-380. (Pubitemid 35203510)
    • (2002) Bone Marrow Transplantation , vol.30 , Issue.6 , pp. 375-380
    • Lo, J.W.S.1    Leung, A.Y.H.2    Huang, X.R.3    Lie, A.K.W.4    Metz, C.5    Bucala, R.6    Liang, R.7    Lan, H.Y.8
  • 52
    • 0037025943 scopus 로고    scopus 로고
    • + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • DOI 10.1084/jem.20020399
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196(3):389-399. (Pubitemid 34875667)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.3 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Garrison, F.C.4    Strober, S.5
  • 53
    • 0037093217 scopus 로고    scopus 로고
    • + immune regulatory cells inhibits graft-versus-host disease lethality
    • DOI 10.1182/blood.V99.10.3493
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99(10):3493-3499. (Pubitemid 34534513)
    • (2002) Blood , vol.99 , Issue.10 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 54
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117(3):1061-1070.
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 56
    • 84893148757 scopus 로고    scopus 로고
    • Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression
    • Sawitzki B, Brunstein C, Meisel C, et al. Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression. Biol Blood Marrow Transplant. 2014;20(2):173-182.
    • (2014) Biol Blood Marrow Transplant , vol.20 , Issue.2 , pp. 173-182
    • Sawitzki, B.1    Brunstein, C.2    Meisel, C.3
  • 57
    • 84872607599 scopus 로고    scopus 로고
    • Profile of Toll-like receptors on peripheral blood cells in relation to acute graft-versus-host disease after allogeneic stem cell transplantation
    • Skert C, Fogli M, Perucca S, et al. Profile of Toll-like receptors on peripheral blood cells in relation to acute graft-versus-host disease after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19(2):227-234.
    • (2013) Biol Blood Marrow Transplant , vol.19 , Issue.2 , pp. 227-234
    • Skert, C.1    Fogli, M.2    Perucca, S.3
  • 58
    • 84882676700 scopus 로고    scopus 로고
    • Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
    • Mangus CW, Massey PR, Fowler DH, Amarnath S. Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity. PLoS ONE. 2013;8(8):e72305.
    • (2013) PLoS ONE , vol.8 , Issue.8
    • Mangus, C.W.1    Massey, P.R.2    Fowler, D.H.3    Amarnath, S.4
  • 59
    • 78650474985 scopus 로고    scopus 로고
    • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    • Highfill SL, Rodriguez PC, Zhou Q, et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood. 2010;116(25):5738-5747.
    • (2010) Blood , vol.116 , Issue.25 , pp. 5738-5747
    • Highfill, S.L.1    Rodriguez, P.C.2    Zhou, Q.3
  • 60
    • 84873569840 scopus 로고    scopus 로고
    • Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation
    • Mougiakakos D, Jitschin R, von Bahr L, et al. Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation. Leukemia. 2013;27(2):377-388.
    • (2013) Leukemia , vol.27 , Issue.2 , pp. 377-388
    • Mougiakakos, D.1    Jitschin, R.2    Von Bahr, L.3
  • 61
    • 0032080398 scopus 로고    scopus 로고
    • Suppression of graft-versus-host disease and amplification of graft- versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation
    • Asai O, Longo DL, Tian ZG, et al. Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J Clin Invest. 1998;101(9):1835-1842. (Pubitemid 28226101)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.9 , pp. 1835-1842
    • Asai, O.1    Longo, D.L.2    Tian, Z.-G.3    Hornung, R.L.4    Taub, D.D.5    Ruscetti, F.W.6    Murphy, W.J.7
  • 62
    • 84860652954 scopus 로고    scopus 로고
    • Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation
    • Chaidos A, Patterson S, Szydlo R, et al. Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. Blood. 2012;119(21):5030-5036.
    • (2012) Blood , vol.119 , Issue.21 , pp. 5030-5036
    • Chaidos, A.1    Patterson, S.2    Szydlo, R.3
  • 63
    • 21244479319 scopus 로고    scopus 로고
    • Cutting edge: The link between lymphocyte deficiency and autoimmunity: Roles of endogenous T and B lymphocytes in tolerance
    • Knoechel B, Lohr J, Kahn E, Abbas AK. The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J Immunol. 2005;175(1):21-26. (Pubitemid 40884296)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 21-26
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Abbas, A.K.4
  • 64
    • 84875239728 scopus 로고    scopus 로고
    • The possible diagnostic and prognostic use of systemic chemokine profiles in clinical medicine - The experience in acute myeloid leukemia from disease development and diagnosis via conventional chemotherapy to allogeneic stem cell transplantation
    • Reikvam H, Fredly H, Kittang AO, Bruserud O. The possible diagnostic and prognostic use of systemic chemokine profiles in clinical medicine - the experience in acute myeloid leukemia from disease development and diagnosis via conventional chemotherapy to allogeneic stem cell transplantation. Toxins (Basel). 2013;5(2):336-362.
    • (2013) Toxins (Basel) , vol.5 , Issue.2 , pp. 336-362
    • Reikvam, H.1    Fredly, H.2    Kittang, A.O.3    Bruserud, O.4
  • 65
    • 70449494642 scopus 로고    scopus 로고
    • Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease
    • Yi T, Chen Y, Wang L, et al. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood. 2009;114(14):3101-3112.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3101-3112
    • Yi, T.1    Chen, Y.2    Wang, L.3
  • 66
    • 77954687870 scopus 로고    scopus 로고
    • Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses
    • Das R, Komorowski R, Hessner MJ, et al. Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses. Blood. 2010;115(25):5249-5258.
    • (2010) Blood , vol.115 , Issue.25 , pp. 5249-5258
    • Das, R.1    Komorowski, R.2    Hessner, M.J.3
  • 67
    • 84897018784 scopus 로고    scopus 로고
    • Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease
    • Br̈uggen MC, Klein I, Greinix H, et al. Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease. Blood. 2014;123(2):290-299.
    • (2014) Blood , vol.123 , Issue.2 , pp. 290-299
    • Br̈uggen, M.C.1    Klein, I.2    Greinix, H.3
  • 68
    • 77956062895 scopus 로고    scopus 로고
    • A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation
    • Hübel K, Cremer B, Heuser E, von Strandmann EP, Hallek M, Hansen HP. A prospective study of serum soluble CD30 in allogeneic hematopoietic stem cell transplantation. Transpl Immunol. 2010;23(4):215-219.
    • (2010) Transpl Immunol , vol.23 , Issue.4 , pp. 215-219
    • Hübel, K.1    Cremer, B.2    Heuser, E.3    Von Strandmann, E.P.4    Hallek, M.5    Hansen, H.P.6
  • 69
    • 77952962428 scopus 로고    scopus 로고
    • Elafin is a biomarker of graft-versus-host disease of the skin
    • Paczesny S, Braun TM, Levine JE, et al. Elafin is a biomarker of graft-versus-host disease of the skin. Sci Transl Med. 2010;2(13):13ra2.
    • (2010) Sci Transl Med , vol.2 , Issue.13
    • Paczesny, S.1    Braun, T.M.2    Levine, J.E.3
  • 70
    • 84055177580 scopus 로고    scopus 로고
    • Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease
    • Ferrara JL, Harris AC, Greenson JK, et al. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood. 2011;118(25):6702-6708.
    • (2011) Blood , vol.118 , Issue.25 , pp. 6702-6708
    • Ferrara, J.L.1    Harris, A.C.2    Greenson, J.K.3
  • 72
    • 84888246020 scopus 로고    scopus 로고
    • Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease
    • Xiao B, Wang Y, Li W, et al. Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. Blood. 2013;122(19): 3365-3375.
    • (2013) Blood , vol.122 , Issue.19 , pp. 3365-3375
    • Xiao, B.1    Wang, Y.2    Li, W.3
  • 73
    • 84873044177 scopus 로고    scopus 로고
    • Discovery and validation of graft-versus- host disease biomarkers
    • Paczesny S. Discovery and validation of graft-versus- host disease biomarkers. Blood. 2013;121(4):585-594.
    • (2013) Blood , vol.121 , Issue.4 , pp. 585-594
    • Paczesny, S.1
  • 74
    • 80051918483 scopus 로고    scopus 로고
    • Increased numbers of circulating ECs are associated with systemic GVHD
    • Yan Z, Zeng L, Jia L, Xu S, Ding S. Increased numbers of circulating ECs are associated with systemic GVHD. Int J Lab Hematol. 2011;33(5):507-515.
    • (2011) Int J Lab Hematol , vol.33 , Issue.5 , pp. 507-515
    • Yan, Z.1    Zeng, L.2    Jia, L.3    Xu, S.4    Ding, S.5
  • 75
    • 80051604321 scopus 로고    scopus 로고
    • Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system
    • Luft T, Dietrich S, Falk C, et al. Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. Blood. 2011;118(6):1685-1692.
    • (2011) Blood , vol.118 , Issue.6 , pp. 1685-1692
    • Luft, T.1    Dietrich, S.2    Falk, C.3
  • 77
    • 22544453628 scopus 로고    scopus 로고
    • Prognostic factors identifiable at the time of onset of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
    • Lee KH, Choi SJ, Lee JH, et al. Prognostic factors identifiable at the time of onset of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation. Haematologica. 2005;90(7):939-948.
    • (2005) Haematologica , vol.90 , Issue.7 , pp. 939-948
    • Lee, K.H.1    Choi, S.J.2    Lee, J.H.3
  • 78
    • 76749094563 scopus 로고    scopus 로고
    • Eosinophilia predicts better overall survival after acute graft-versus-host-disease
    • Imahashi N, Miyamura K, Seto A, et al. Eosinophilia predicts better overall survival after acute graft-versus-host-disease. Bone Marrow Transplant. 2010;45(2):371-377.
    • (2010) Bone Marrow Transplant , vol.45 , Issue.2 , pp. 371-377
    • Imahashi, N.1    Miyamura, K.2    Seto, A.3
  • 79
    • 79960172161 scopus 로고    scopus 로고
    • Delayed platelet recovery after allogeneic transplantation: A predictor of increased treatment-related mortality and poorer survival
    • Ramírez P, Brunstein CG, Miller B, Defor T, Weisdorf D. Delayed platelet recovery after allogeneic transplantation: a predictor of increased treatment-related mortality and poorer survival. Bone Marrow Transplant. 2011;46(7):981-986.
    • (2011) Bone Marrow Transplant , vol.46 , Issue.7 , pp. 981-986
    • Ramírez, P.1    Brunstein, C.G.2    Miller, B.3    Defor, T.4    Weisdorf, D.5
  • 80
    • 41949090993 scopus 로고    scopus 로고
    • Clinical molecular imaging in intestinal graft-versus-host disease: Mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography
    • Stelljes M, Hermann S, Albring J, et al. Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography. Blood. 2008;111(5):2909-2918.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2909-2918
    • Stelljes, M.1    Hermann, S.2    Albring, J.3
  • 81
    • 84870509087 scopus 로고    scopus 로고
    • Mapping immune processes in intact tissues at cellular resolution
    • Brede C, Friedrich M, Jordán-Garrote AL, et al. Mapping immune processes in intact tissues at cellular resolution. J Clin Invest. 2012;122(12):4439-4446.
    • (2012) J Clin Invest , vol.122 , Issue.12 , pp. 4439-4446
    • Brede, C.1    Friedrich, M.2    Jordán-Garrote, A.L.3
  • 82
    • 84885102672 scopus 로고    scopus 로고
    • Pathways mediating resolution of inflammation: When enough is too much
    • Fullerton JN, O'Brien AJ, Gilroy DW. Pathways mediating resolution of inflammation: when enough is too much. J Pathol. 2013;231(1):8-20.
    • (2013) J Pathol , vol.231 , Issue.1 , pp. 8-20
    • Fullerton, J.N.1    O'Brien, A.J.2    Gilroy, D.W.3
  • 83
    • 78751541111 scopus 로고    scopus 로고
    • Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract
    • Bouazzaoui A, Spacenko E, Mueller G, et al. Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract. Exp Hematol. 2011;39(2):238-249.e1.
    • (2011) Exp Hematol , vol.39 , Issue.2
    • Bouazzaoui, A.1    Spacenko, E.2    Mueller, G.3
  • 84
    • 84860345135 scopus 로고    scopus 로고
    • Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: A Blood and Marrow Transplant Clinical Trials Network study
    • Levine JE, Logan BR, Wu J, et al. Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. Blood. 2012;119(16):3854-3860.
    • (2012) Blood , vol.119 , Issue.16 , pp. 3854-3860
    • Levine, J.E.1    Logan, B.R.2    Wu, J.3
  • 85
    • 84873591805 scopus 로고    scopus 로고
    • Lymphocyte phenotype during therapy for acute graft-versus-host disease: A brief report from BMT-CTN 0302
    • Blood and Marrow Transplant Clinical Trials Network
    • Bolaños-Meade J, Wu J, Logan BR, et al; Blood and Marrow Transplant Clinical Trials Network. Lymphocyte phenotype during therapy for acute graft-versus-host disease: a brief report from BMT-CTN 0302. Biol Blood Marrow Transplant. 2013;19(3):481-485.
    • (2013) Biol Blood Marrow Transplant , vol.19 , Issue.3 , pp. 481-485
    • Bolaños-Meade, J.1    Wu, J.2    Logan, B.R.3
  • 86
    • 44249084010 scopus 로고    scopus 로고
    • Vascular endothelium as 'novel' target of graft-versus-host disease
    • DOI 10.1016/j.beha.2008.02.002, PII S1521692608000042
    • Tichelli A, Gratwohl A. Vascular endothelium as 'novel' target of graft-versus-host disease. Best Pract Res Clin Haematol. 2008;21(2):139-148. (Pubitemid 351720432)
    • (2008) Best Practice and Research: Clinical Haematology , vol.21 , Issue.2 , pp. 139-148
    • Tichelli, A.1    Gratwohl, A.2
  • 87
    • 77953074174 scopus 로고    scopus 로고
    • Immune reconstitution: How it should work, what's broken, and why it matters
    • Gress RE, Emerson SG, Drobyski WR. Immune reconstitution: how it should work, what's broken, and why it matters. Biol Blood Marrow Transplant. 2010;16:suppl 1S133-S137.
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.SUPPL. 1
    • Gress, R.E.1    Emerson, S.G.2    Drobyski, W.R.3
  • 89
    • 0036048349 scopus 로고    scopus 로고
    • Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: Comparison of grading systems
    • MacMillan ML, Weisdorf DJ, Wagner JE, et al. Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems. Biol Blood Marrow Transplant. 2002;8(7):387-394.
    • (2002) Biol Blood Marrow Transplant , vol.8 , Issue.7 , pp. 387-394
    • MacMillan, M.L.1    Weisdorf, D.J.2    Wagner, J.E.3
  • 90
    • 84855296444 scopus 로고    scopus 로고
    • Steroid-refractory acute GVHD: Predictors and outcomes
    • Westin JR, Saliba RM, De Lima M, et al. Steroid-refractory acute GVHD: predictors and outcomes. Adv Hematol. 2011;2011:601953.
    • (2011) Adv Hematol , vol.2011 , pp. 601953
    • Westin, J.R.1    Saliba, R.M.2    De Lima, M.3
  • 91
    • 84861527625 scopus 로고    scopus 로고
    • What predicts high risk acute graft-versus-host disease (GVHD) at onset? Identification of those at highest risk by a novel acute GVHD risk score
    • MacMillan ML, DeFor TE, Weisdorf DJ. What predicts high risk acute graft-versus-host disease (GVHD) at onset? Identification of those at highest risk by a novel acute GVHD risk score. Br J Haematol. 2012;157(6):732-741.
    • (2012) Br J Haematol , vol.157 , Issue.6 , pp. 732-741
    • MacMillan, M.L.1    DeFor, T.E.2    Weisdorf, D.J.3
  • 92
    • 84881256541 scopus 로고    scopus 로고
    • ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death
    • Vander Lugt MT, Braun TM, Hanash S, et al. ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med. 2013;369(6):529-539.
    • (2013) N Engl J Med , vol.369 , Issue.6 , pp. 529-539
    • Vander Lugt, M.T.1    Braun, T.M.2    Hanash, S.3
  • 93
    • 84883375670 scopus 로고    scopus 로고
    • Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation
    • Jitschin R, Mougiakakos D, Von Bahr L, et al. Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation. Stem Cells. 2013;31(8):1715-1725.
    • (2013) Stem Cells , vol.31 , Issue.8 , pp. 1715-1725
    • Jitschin, R.1    Mougiakakos, D.2    Von Bahr, L.3
  • 94
    • 70449509133 scopus 로고    scopus 로고
    • Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: A clue to refractory graft-versus-host disease
    • Nishiwaki S, Terakura S, Ito M, et al. Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: a clue to refractory graft-versus-host disease. Blood. 2009;114(14):3113-3116.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3113-3116
    • Nishiwaki, S.1    Terakura, S.2    Ito, M.3
  • 95
    • 0015114945 scopus 로고
    • Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs
    • Thomas ED, Buckner CD, Rudolph RH, et al. Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs. Blood. 1971;38(3):267-287.
    • (1971) Blood , vol.38 , Issue.3 , pp. 267-287
    • Thomas, E.D.1    Buckner, C.D.2    Rudolph, R.H.3
  • 96
    • 0023930031 scopus 로고
    • Acute graft-versus-host disease: Clinical characteristics in the cyclosporine era
    • Vogelsang GB, Hess AD, Santos GW. Acute graft-versus-host disease: clinical characteristics in the cyclosporine era. Medicine (Baltimore). 1988;67(3):163-174.
    • (1988) Medicine (Baltimore) , vol.67 , Issue.3 , pp. 163-174
    • Vogelsang, G.B.1    Hess, A.D.2    Santos, G.W.3
  • 98
    • 77953051955 scopus 로고    scopus 로고
    • Should methotrexate plus calcineurin inhibitors be considered standard of care for prophylaxis of acute graft-versus- host disease?
    • Storb R, Antin JH, Cutler C. Should methotrexate plus calcineurin inhibitors be considered standard of care for prophylaxis of acute graft-versus- host disease? Biol Blood Marrow Transplant. 2010;16(suppl1):S18-S27.
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.SUPPL. 1
    • Storb, R.1    Antin, J.H.2    Cutler, C.3
  • 100
    • 84870455529 scopus 로고    scopus 로고
    • A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation
    • Pidala J, Kim J, Jim H, et al. A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation. Haematologica. 2012;97(12):1882-1889.
    • (2012) Haematologica , vol.97 , Issue.12 , pp. 1882-1889
    • Pidala, J.1    Kim, J.2    Jim, H.3
  • 101
    • 58149388343 scopus 로고    scopus 로고
    • Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation
    • Cutler C, Stevenson K, Kim HT, et al. Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation. Blood. 2008;112(12):4425-4431.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4425-4431
    • Cutler, C.1    Stevenson, K.2    Kim, H.T.3
  • 102
    • 84889559995 scopus 로고    scopus 로고
    • Tacrolimus/sirolimus vs. tacrolimus/methotrexate for graft-vs.-host disease prophylaxis after HLA-matched, related donor hematopoietic stem cell transplantation: Results of Blood and Marrow Transplant Clinical Trials Network Trial 0402
    • [abstract] Abstract 739
    • Cutler C, Logan BR, Makamura R, et al. Tacrolimus/sirolimus vs. tacrolimus/methotrexate for graft-vs.-host disease prophylaxis after HLA-matched, related donor hematopoietic stem cell transplantation: results of Blood and Marrow Transplant Clinical Trials Network Trial 0402 [abstract]. Blood. 2012; 122(21). Abstract 739.
    • (2012) Blood , vol.122 , Issue.21
    • Cutler, C.1    Logan, B.R.2    Makamura, R.3
  • 103
    • 84868207569 scopus 로고    scopus 로고
    • Negative depletion of CD3(+) and TcRαβ(+) T cells
    • Handgretinger R. Negative depletion of CD3(+) and TcRαβ(+) T cells. Curr Opin Hematol. 2012; 19(6):434-439.
    • (2012) Curr Opin Hematol , vol.19 , Issue.6 , pp. 434-439
    • Handgretinger, R.1
  • 104
    • 84890082174 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide
    • Kanakry CG, Ganguly S, Zahurak M, et al. Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Sci Transl Med. 2013;5(211):211ra157.
    • (2013) Sci Transl Med , vol.5 , Issue.211
    • Kanakry, C.G.1    Ganguly, S.2    Zahurak, M.3
  • 105
    • 80053046392 scopus 로고    scopus 로고
    • Treatment of hematological malignancies with nonmyeloablative, HLA-haploidentical bone marrow transplantation and high dose, posttransplantation cyclophosphamide
    • Munchel AT, Kasamon YL, Fuchs EJ. Treatment of hematological malignancies with nonmyeloablative, HLA-haploidentical bone marrow transplantation and high dose, posttransplantation cyclophosphamide. Best Pract Res Clin Haematol. 2011;24(3):359-368.
    • (2011) Best Pract Res Clin Haematol , vol.24 , Issue.3 , pp. 359-368
    • Munchel, A.T.1    Kasamon, Y.L.2    Fuchs, E.J.3
  • 106
    • 84876089274 scopus 로고    scopus 로고
    • T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation
    • Bashey A, Zhang X, Sizemore CA, et al. T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation. J Clin Oncol. 2013;31(10):1310-1316.
    • (2013) J Clin Oncol , vol.31 , Issue.10 , pp. 1310-1316
    • Bashey, A.1    Zhang, X.2    Sizemore, C.A.3
  • 107
    • 84863680262 scopus 로고    scopus 로고
    • Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease
    • Reshef R, Luger SM, Hexner EO, et al. Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. N Engl J Med. 2012;367(2):135-145.
    • (2012) N Engl J Med , vol.367 , Issue.2 , pp. 135-145
    • Reshef, R.1    Luger, S.M.2    Hexner, E.O.3
  • 108
    • 84866546465 scopus 로고    scopus 로고
    • Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation
    • Koreth J, Stevenson KE, Kim HT, et al. Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation. J Clin Oncol. 2012;30(26):3202-3208.
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3202-3208
    • Koreth, J.1    Stevenson, K.E.2    Kim, H.T.3
  • 110
    • 84863012446 scopus 로고    scopus 로고
    • Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
    • He S, Wang J, Kato K, et al. Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood. 2012;119(5):1274-1282.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1274-1282
    • He, S.1    Wang, J.2    Kato, K.3
  • 111
    • 84891372385 scopus 로고    scopus 로고
    • Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: A phase 1/2 trial
    • Choi SW, Braun T, Chang L, et al. Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol. 2014;15(1):87-95.
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 87-95
    • Choi, S.W.1    Braun, T.2    Chang, L.3
  • 112
    • 84862137300 scopus 로고    scopus 로고
    • First-and second-line systemic treatment of acute graft-versus-host disease: Recommendations of the American Society of Blood and Marrow Transplantation
    • Martin PJ, Rizzo JD, Wingard JR, et al. First-and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2012;18(8):1150-1163.
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.8 , pp. 1150-1163
    • Martin, P.J.1    Rizzo, J.D.2    Wingard, J.R.3
  • 113
    • 63849343227 scopus 로고    scopus 로고
    • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes
    • Mielcarek M, Storer BE, Boeckh M, et al. Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. Blood. 2009;113(13):2888-2894.
    • (2009) Blood , vol.113 , Issue.13 , pp. 2888-2894
    • Mielcarek, M.1    Storer, B.E.2    Boeckh, M.3
  • 114
    • 84904465261 scopus 로고    scopus 로고
    • Efficacy and safety of lower-dose glucocorticoids for initial treatment of acute graft-versus-host disease: A randomized controlled trial
    • [abstract] Abstract 703
    • Mielcarek MD, Furlong T, Storer BE, et al. Efficacy and safety of lower-dose glucocorticoids for initial treatment of acute graft-versus-host disease: a randomized controlled trial [abstract]. Blood. 2013;122(21). Abstract 703.
    • (2013) Blood , vol.122 , Issue.21
    • Mielcarek, M.D.1    Furlong, T.2    Storer, B.E.3
  • 115
    • 34248356010 scopus 로고    scopus 로고
    • How I treat refractory acute GVHD
    • DOI 10.1182/blood-2006-12-041889
    • Deeg HJ. How I treat refractory acute GVHD. Blood. 2007;109(10):4119- 4126. (Pubitemid 46743372)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4119-4126
    • Deeg, H.J.1
  • 117
    • 84893088279 scopus 로고    scopus 로고
    • A multi-center, randomized, double blind, phase III clinical trial comparing steroids/placebo vs. steroids/mycophenolate mofetil as initial therapy for acute graft-versus-host disease
    • Blood and Marrow Transplant Clinical Trials Network Study 0802
    • Bolaños-Meade J, Logan BR, Alousi AM, et al. A multi-center, randomized, double blind, phase III clinical trial comparing steroids/placebo vs. steroids/mycophenolate mofetil as initial therapy for acute graft-versus-host disease. Blood and Marrow Transplant Clinical Trials Network Study 0802. Biol Blood Marrow Transplant. 2013;19(suppl 2):S137.
    • (2013) Biol Blood Marrow Transplant , vol.19 , Issue.SUPPL. 2
    • Bolaños-Meade, J.1    Logan, B.R.2    Alousi, A.M.3
  • 118
    • 77955902702 scopus 로고    scopus 로고
    • The best endpoint for acute GVHD treatment trials
    • MacMillan ML, DeFor TE, Weisdorf DJ. The best endpoint for acute GVHD treatment trials. Blood. 2010;115(26):5412-5417.
    • (2010) Blood , vol.115 , Issue.26 , pp. 5412-5417
    • MacMillan, M.L.1    DeFor, T.E.2    Weisdorf, D.J.3
  • 119
    • 84893731028 scopus 로고    scopus 로고
    • Six-month freedom from treatment failure is an important end point for acute GVHD clinical trials
    • Sengsayadeth S, Savani BN, Jagasia M, et al. Six-month freedom from treatment failure is an important end point for acute GVHD clinical trials. Bone Marrow Transplant. 2014;49(2):236-240.
    • (2014) Bone Marrow Transplant , vol.49 , Issue.2 , pp. 236-240
    • Sengsayadeth, S.1    Savani, B.N.2    Jagasia, M.3
  • 120
    • 70149109879 scopus 로고    scopus 로고
    • Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: A randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network
    • Blood and Marrow Transplant Clinical Trials Network
    • Alousi AM, Weisdorf DJ, Logan BR, et al Blood and Marrow Transplant Clinical Trials Network. Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network. Blood. 2009;114(3):511-517.
    • (2009) Blood , vol.114 , Issue.3 , pp. 511-517
    • Alousi, A.M.1    Weisdorf, D.J.2    Logan, B.R.3
  • 122
    • 84889098906 scopus 로고    scopus 로고
    • Limited benefit of pentostatin salvage therapy for steroid-refractory grade III-IV acute graft-versus-host disease
    • Alam N, Atenafu EG, Tse G, et al. Limited benefit of pentostatin salvage therapy for steroid-refractory grade III-IV acute graft-versus-host disease. Clin Transplant. 2013;27(6):930-937.
    • (2013) Clin Transplant , vol.27 , Issue.6 , pp. 930-937
    • Alam, N.1    Atenafu, E.G.2    Tse, G.3
  • 123
    • 84879382652 scopus 로고    scopus 로고
    • Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: A multicenter comparative analysis
    • Jagasia M, Greinix H, Robin M, et al. Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: a multicenter comparative analysis. Biol Blood Marrow Transplant. 2013;19(7):1129-1133.
    • (2013) Biol Blood Marrow Transplant , vol.19 , Issue.7 , pp. 1129-1133
    • Jagasia, M.1    Greinix, H.2    Robin, M.3
  • 124
    • 84891904273 scopus 로고    scopus 로고
    • Adult adherent stromal cells in the management of graft-versus-host disease
    • Newell LF, Deans RJ, Maziarz RT. Adult adherent stromal cells in the management of graft-versus-host disease. Expert Opin Biol Ther. 2014;14(2):231-246.
    • (2014) Expert Opin Biol Ther , vol.14 , Issue.2 , pp. 231-246
    • Newell, L.F.1    Deans, R.J.2    Maziarz, R.T.3
  • 125
    • 72849123229 scopus 로고    scopus 로고
    • PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice
    • Valenzuela JO, Iclozan C, Hossain MS, et al. PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest. 2009;119(12):3774-3786.
    • (2009) J Clin Invest , vol.119 , Issue.12 , pp. 3774-3786
    • Valenzuela, J.O.1    Iclozan, C.2    Hossain, M.S.3
  • 126
    • 84887761550 scopus 로고    scopus 로고
    • Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice
    • Haarberg KM, Li J, Heinrichs J, et al. Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood. 2013;122(14):2500-2511.
    • (2013) Blood , vol.122 , Issue.14 , pp. 2500-2511
    • Haarberg, K.M.1    Li, J.2    Heinrichs, J.3
  • 128
    • 77955900102 scopus 로고    scopus 로고
    • In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia
    • Choi J, Ritchey J, Prior JL, et al. In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood. 2010;116(1):129-139.
    • (2010) Blood , vol.116 , Issue.1 , pp. 129-139
    • Choi, J.1    Ritchey, J.2    Prior, J.L.3
  • 129
    • 84859582203 scopus 로고    scopus 로고
    • Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)
    • Goodyear OC, Dennis M, Jilani NY, et al. Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). Blood. 2012;119(14):3361-3369.
    • (2012) Blood , vol.119 , Issue.14 , pp. 3361-3369
    • Goodyear, O.C.1    Dennis, M.2    Jilani, N.Y.3
  • 130
    • 84885458195 scopus 로고    scopus 로고
    • Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration
    • Aoyama K, Saha A, Tolar J, et al. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Blood. 2013;122(12):2125-2134.
    • (2013) Blood , vol.122 , Issue.12 , pp. 2125-2134
    • Aoyama, K.1    Saha, A.2    Tolar, J.3
  • 131
    • 84864129808 scopus 로고    scopus 로고
    • Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
    • Veenstra RG, Taylor PA, Zhou Q, et al. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012;120(3):682-690.
    • (2012) Blood , vol.120 , Issue.3 , pp. 682-690
    • Veenstra, R.G.1    Taylor, P.A.2    Zhou, Q.3
  • 132
    • 82655184651 scopus 로고    scopus 로고
    • The PDL1-PD1 axis converts human TH1 cells into regulatory T cells
    • Amarnath S, Mangus CW, Wang JC, et al. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med. 2011;3(111):111ra120.
    • (2011) Sci Transl Med , vol.3 , Issue.111
    • Amarnath, S.1    Mangus, C.W.2    Wang, J.C.3
  • 133
    • 42449097698 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
    • Jasperson LK, Bucher C, Panoskaltsis-Mortari A, et al. Indoleamine 2, 3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood. 2008;111(6):3257-3265.
    • (2008) Blood , vol.111 , Issue.6 , pp. 3257-3265
    • Jasperson, L.K.1    Bucher, C.2    Panoskaltsis-Mortari, A.3
  • 135
    • 77954733523 scopus 로고    scopus 로고
    • MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease
    • Heimesaat MM, Nogai A, Bereswill S, et al. MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut. 2010;59(8):1079-1087.
    • (2010) Gut , vol.59 , Issue.8 , pp. 1079-1087
    • Heimesaat, M.M.1    Nogai, A.2    Bereswill, S.3
  • 136
    • 84875837518 scopus 로고    scopus 로고
    • Blockade of individual Notch ligands and receptors controls graft-versus-host disease
    • Tran IT, Sandy AR, Carulli AJ, et al. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest. 2013;123(4):1590-1604.
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1590-1604
    • Tran, I.T.1    Sandy, A.R.2    Carulli, A.J.3
  • 137
    • 33646710170 scopus 로고    scopus 로고
    • Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1
    • DOI 10.1016/j.exphem.2006.02.014, PII S0301472X06001226
    • Leng C, Gries M, Ziegler J, et al. Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. Exp Hematol. 2006;34(6):776-787. (Pubitemid 43737091)
    • (2006) Experimental Hematology , vol.34 , Issue.6 , pp. 776-787
    • Leng, C.1    Gries, M.2    Ziegler, J.3    Lokshin, A.4    Mascagni, P.5    Lentzsch, S.6    Mapara, M.Y.7
  • 138
    • 84893812843 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
    • Jaekel N, Behre G, Behning A, et al. Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib. Bone Marrow Transplant. 2014;49(2):179-184.
    • (2014) Bone Marrow Transplant , vol.49 , Issue.2 , pp. 179-184
    • Jaekel, N.1    Behre, G.2    Behning, A.3
  • 139
    • 84879265773 scopus 로고    scopus 로고
    • Curcumin attenuates acute graft-versus-host disease severity via in vivo regulations on Th1, Th17 and regulatory T cells
    • Park MJ, Moon SJ, Lee SH, et al. Curcumin attenuates acute graft-versus-host disease severity via in vivo regulations on Th1, Th17 and regulatory T cells. PLoS ONE. 2013;8(6):e67171.
    • (2013) PLoS ONE , vol.8 , Issue.6
    • Park, M.J.1    Moon, S.J.2    Lee, S.H.3
  • 140
    • 73949116753 scopus 로고    scopus 로고
    • IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
    • Bucher C, Koch L, Vogtenhuber C, et al. IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood. 2009;114(26):5375-5384.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5375-5384
    • Bucher, C.1    Koch, L.2    Vogtenhuber, C.3
  • 141
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
    • Hanash AM, Dudakov JA, Hua G, et al. Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012;37(2):339-350.
    • (2012) Immunity , vol.37 , Issue.2 , pp. 339-350
    • Hanash, A.M.1    Dudakov, J.A.2    Hua, G.3
  • 142
    • 84860888650 scopus 로고    scopus 로고
    • Ustekinumab demonstrates activity in glucocorticoid-refractory acute GVHD
    • Pidala J, Perez L, Beato F, Anasetti C. Ustekinumab demonstrates activity in glucocorticoid-refractory acute GVHD. Bone Marrow Transplant. 2012;47(5):747-748.
    • (2012) Bone Marrow Transplant , vol.47 , Issue.5 , pp. 747-748
    • Pidala, J.1    Perez, L.2    Beato, F.3    Anasetti, C.4
  • 143
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma - does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau J. The mesenchymal stromal cells dilemma - does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy. 2013;15(1):2-8.
    • (2013) Cytotherapy , vol.15 , Issue.1 , pp. 2-8
    • Galipeau, J.1
  • 144
    • 84898972471 scopus 로고    scopus 로고
    • Comparison of phenotypic markers and neural differentiation potential of multipotent adult progenitor cells and mesenchymal stem cells
    • Singh SP, Tripathy NK, Nityanand S. Comparison of phenotypic markers and neural differentiation potential of multipotent adult progenitor cells and mesenchymal stem cells. World J Stem Cells. 2013;5(2):53-60.
    • (2013) World J Stem Cells , vol.5 , Issue.2 , pp. 53-60
    • Singh, S.P.1    Tripathy, N.K.2    Nityanand, S.3
  • 145
    • 70149119503 scopus 로고    scopus 로고
    • Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming
    • Highfill SL, Kelly RM, O'Shaughnessy MJ, et al. Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood. 2009;114(3):693-701.
    • (2009) Blood , vol.114 , Issue.3 , pp. 693-701
    • Highfill, S.L.1    Kelly, R.M.2    O'Shaughnessy, M.J.3
  • 146
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117(14):3921-3928.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 147
    • 84878541023 scopus 로고    scopus 로고
    • Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity
    • Ghosh A, Dogan Y, Moroz M, et al. Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. J Clin Invest. 2013;123(6):2654-2662.
    • (2013) J Clin Invest , vol.123 , Issue.6 , pp. 2654-2662
    • Ghosh, A.1    Dogan, Y.2    Moroz, M.3
  • 148
    • 34147184372 scopus 로고    scopus 로고
    • Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
    • DOI 10.1182/blood-2006-05-024315
    • Lundqvist A, McCoy JP, Samsel L, Childs R. Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors. Blood. 2007;109(8):3603-3606. (Pubitemid 46572556)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3603-3606
    • Lundqvist, A.1    McCoy, J.P.2    Samsel, L.3    Childs, R.4
  • 149
    • 75749149739 scopus 로고    scopus 로고
    • Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation
    • Yang J, Gao L, Liu Y, et al. Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation. Transfusion. 2010;50(2):407-417.
    • (2010) Transfusion , vol.50 , Issue.2 , pp. 407-417
    • Yang, J.1    Gao, L.2    Liu, Y.3
  • 150
    • 84888410860 scopus 로고    scopus 로고
    • Third-party tolerogenic dendritic cells reduce allo-reactivity in vitro and ameliorate the severity of acute graft-versus-host disease in allo-bone marrow transplantation
    • Yang J, Li R, Ren Y, Yang Y, Xie R, Fan H. Third-party tolerogenic dendritic cells reduce allo-reactivity in vitro and ameliorate the severity of acute graft-versus-host disease in allo-bone marrow transplantation. Scand J Immunol. 2013; 78(6):486-496.
    • (2013) Scand J Immunol , vol.78 , Issue.6 , pp. 486-496
    • Yang, J.1    Li, R.2    Ren, Y.3    Yang, Y.4    Xie, R.5    Fan, H.6
  • 151
    • 84863582194 scopus 로고    scopus 로고
    • Graft-versus- host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins
    • Eriguchi Y, Takashima S, Oka H, et al. Graft-versus- host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood. 2012;120(1):223-231.
    • (2012) Blood , vol.120 , Issue.1 , pp. 223-231
    • Eriguchi, Y.1    Takashima, S.2    Oka, H.3
  • 152
    • 84861539347 scopus 로고    scopus 로고
    • Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
    • Jenq RR, Ubeda C, Taur Y, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med. 2012;209(5):903-911.
    • (2012) J Exp Med , vol.209 , Issue.5 , pp. 903-911
    • Jenq, R.R.1    Ubeda, C.2    Taur, Y.3
  • 154
    • 10844271455 scopus 로고    scopus 로고
    • Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells
    • Hashimoto D, Asakura S, Miyake S, et al. Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J Immunol. 2005;174(1):551-556. (Pubitemid 40007446)
    • (2005) Journal of Immunology , vol.174 , Issue.1 , pp. 551-556
    • Hashimoto, D.1    Asakura, S.2    Miyake, S.3    Yamamura, T.4    Van Kaer, L.5    Liu, C.6    Tanimoto, M.7    Teshima, T.8
  • 155
    • 84880941717 scopus 로고    scopus 로고
    • Production of α-galactosylceramide by a prominent member of the human gut microbiota
    • Wieland Brown LC, Penaranda C, Kashyap PC, et al. Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol. 2013;11(7):e1001610.
    • (2013) PLoS Biol , vol.11 , Issue.7
    • Wieland Brown, L.C.1    Penaranda, C.2    Kashyap, P.C.3
  • 156
    • 51349107721 scopus 로고    scopus 로고
    • Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease
    • Ellison CA, Makar BM, Wiseman JM, Gheorghiu I, Taniguchi M, Gartner JG. Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol. 2008;28(5):600-615.
    • (2008) J Clin Immunol , vol.28 , Issue.5 , pp. 600-615
    • Ellison, C.A.1    Makar, B.M.2    Wiseman, J.M.3    Gheorghiu, I.4    Taniguchi, M.5    Gartner, J.G.6
  • 157
    • 49449083795 scopus 로고    scopus 로고
    • Long-term follow-up of a phase I/II randomized, placebo-controlled trial of palifermin to prevent graft-versus-host disease (GVHD) after related donor allogeneic hematopoietic cell transplantation (HCT)
    • Levine JE, Blazar BR, DeFor T, Ferrara JL, Weisdorf DJ. Long-term follow-up of a phase I/II randomized, placebo-controlled trial of palifermin to prevent graft-versus-host disease (GVHD) after related donor allogeneic hematopoietic cell transplantation (HCT). Biol Blood Marrow Transplant. 2008;14(9):1017-1021.
    • (2008) Biol Blood Marrow Transplant , vol.14 , Issue.9 , pp. 1017-1021
    • Levine, J.E.1    Blazar, B.R.2    DeFor, T.3    Ferrara, J.L.4    Weisdorf, D.J.5
  • 158
    • 77949500938 scopus 로고    scopus 로고
    • Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation
    • Rotta M, Storer BE, Storb RF, et al. Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation. Blood. 2010;115(6):1288-1295.
    • (2010) Blood , vol.115 , Issue.6 , pp. 1288-1295
    • Rotta, M.1    Storer, B.E.2    Storb, R.F.3


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