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Volumn 119, Issue 12, 2009, Pages 3774-3786

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

Author keywords

[No Author keywords available]

Indexed keywords

MINOR HISTOCOMPATIBILITY ANTIGEN; PROTEIN KINASE C THETA; T LYMPHOCYTE RECEPTOR; ALLOANTIGEN; ISOENZYME; OVA 8; OVA-8; OVALBUMIN; PEPTIDE FRAGMENT; PRKCQ PROTEIN, MOUSE; PROTEIN KINASE C;

EID: 72849123229     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39692     Document Type: Article
Times cited : (66)

References (64)
  • 2
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • DOI 10.1146/annurev.immunol.23.021704.115839
    • Watts, T.H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23:23-68. (Pubitemid 40563164)
    • (2005) Annual Review of Immunology , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 3
    • 34249780834 scopus 로고    scopus 로고
    • Signal 3 availability limits the CD8 T cell response to a solid tumor
    • Curtsinger, J.M., Gerner, M.Y., Lins, D.C., and Mescher, M.F. 2007. Signal 3 availability limits the CD8 T cell response to a solid tumor. J. Immunol. 178:6752-6760.
    • (2007) J. Immunol. , vol.178 , pp. 6752-6760
    • Curtsinger, J.M.1    Gerner, M.Y.2    Lins, D.C.3    Mescher, M.F.4
  • 4
    • 0036221481 scopus 로고    scopus 로고
    • Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins
    • DOI 10.1146/annurev.immunol.20.092601.111357
    • Samelson, L.E. 2002. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20:371-394. (Pubitemid 34293429)
    • (2002) Annual Review of Immunology , vol.20 , pp. 371-394
    • Samelson, L.E.1
  • 5
    • 4444245423 scopus 로고    scopus 로고
    • Protein kinase C and beyond
    • Spitaler, M., and Cantrell, D.A. 2004. Protein kinase C and beyond. Nat. Immunol. 5:785-790.
    • (2004) Nat. Immunol. , vol.5 , pp. 785-790
    • Spitaler, M.1    Cantrell, D.A.2
  • 6
    • 85047682875 scopus 로고    scopus 로고
    • Protien kinase Ctheta in T cell activation
    • DOI 10.1146/annurev.immunol.20.120701.074321
    • Isakov, N., and Altman, A. 2002. Protein kinase C(theta) in T cell activation. Annu. Rev. Immunol. 20:761-794. (Pubitemid 34293439)
    • (2002) Annual Review of Immunology , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 7
    • 18844473151 scopus 로고    scopus 로고
    • PKC-theta is required for TCRinduced NF-kappaB activation in mature but not immature T lymphocytes
    • Sun, Z., et al. 2000. PKC-theta is required for TCRinduced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 404:402-407.
    • (2000) Nature , vol.404 , pp. 402-407
    • Sun, Z.1
  • 8
    • 0038620475 scopus 로고    scopus 로고
    • Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
    • Pfeifhofer, C., et al. 2003. Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J. Exp. Med. 197:1525-1535.
    • (2003) J. Exp. Med. , vol.197 , pp. 1525-1535
    • Pfeifhofer, C.1
  • 9
    • 3142696783 scopus 로고    scopus 로고
    • The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-κB-dependent c-myc expression
    • DOI 10.1016/j.immuni.2004.06.004, PII S1074761304001657
    • Grumont, R., et al. 2004. The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression. Immunity. 21:19-30. (Pubitemid 38925264)
    • (2004) Immunity , vol.21 , Issue.1 , pp. 19-30
    • Grumont, R.1    Lock, P.2    Mollinari, M.3    Shannon, F.M.4    Moore, A.5    Gerondakis, S.6
  • 10
    • 26844551590 scopus 로고    scopus 로고
    • Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells
    • Barouch-Bentov, R., et al. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J. Immunol. 175:5126-5134.
    • (2005) J. Immunol. , vol.175 , pp. 5126-5134
    • Barouch-Bentov, R.1
  • 11
    • 1642299050 scopus 로고    scopus 로고
    • PKCtheta signals activation versus tolerance in vivo
    • Berg-Brown, N.N., et al. 2004. PKCtheta signals activation versus tolerance in vivo. J. Exp. Med. 199:743-752.
    • (2004) J. Exp. Med. , vol.199 , pp. 743-752
    • Berg-Brown, N.N.1
  • 12
    • 33947204489 scopus 로고    scopus 로고
    • TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis
    • Marsland, B.J., et al. 2007. TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis. J. Immunol. 178:3466-3473.
    • (2007) J. Immunol. , vol.178 , pp. 3466-3473
    • Marsland, B.J.1
  • 13
    • 28244464872 scopus 로고    scopus 로고
    • Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis
    • Salek-Ardakani, S., So, T., Halteman, B.S., Altman, A., and Croft, M. 2005. Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J. Immunol. 175:7635-7641. (Pubitemid 41713463)
    • (2005) Journal of Immunology , vol.175 , Issue.11 , pp. 7635-7641
    • Salek-Ardakani, S.1    So, T.2    Halteman, B.S.3    Altman, A.4    Croft, M.5
  • 14
    • 33746210212 scopus 로고    scopus 로고
    • PKC-theta-deficient mice are protected from Th1-dependent antigeninduced arthritis
    • Healy, A.M., et al. 2006. PKC-theta-deficient mice are protected from Th1-dependent antigeninduced arthritis. J. Immunol. 177:1886-1893.
    • (2006) J. Immunol. , vol.177 , pp. 1886-1893
    • Healy, A.M.1
  • 15
    • 3242790172 scopus 로고    scopus 로고
    • Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th-1 cell responses
    • DOI 10.1084/jem.20032229
    • Marsland, B.J., Soos, T.J., Spath, G., Littman, D.R., and Kopf, M. 2004. Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J. Exp. Med. 200:181-189. (Pubitemid 38982177)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.2 , pp. 181-189
    • Marsland, B.J.1    Soos, T.J.2    Spath, G.3    Littman, D.R.4    Kopf, M.5
  • 16
    • 26444476013 scopus 로고    scopus 로고
    • Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses
    • Marsland, B.J., et al. 2005. Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses. Proc. Natl. Acad. Sci. U. S. A. 102:14374-14379.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 14374-14379
    • Marsland, B.J.1
  • 17
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • Shlomchik, W.D. 2007. Graft-versus-host disease. Nat. Rev. Immunol. 7:340-352.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 18
    • 0032613565 scopus 로고    scopus 로고
    • Pathophysiologic mechanisms of acute graft-vs.-host disease
    • Ferrara, J.L., Levy, R., and Chao, N.J. 1999. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biol. Blood Marrow Transplant. 5:347-356.
    • (1999) Biol. Blood Marrow Transplant , vol.5 , pp. 347-356
    • Ferrara, J.L.1    Levy, R.2    Chao, N.J.3
  • 19
    • 34247867901 scopus 로고    scopus 로고
    • Immunobiology of allogeneic hematopoietic stem cell transplantation
    • DOI 10.1146/annurev.immunol.25.022106.141606
    • Welniak, L.A., Blazar, B.R., and Murphy, W.J. 2007. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol. 25:139-170. (Pubitemid 46697905)
    • (2007) Annual Review of Immunology , vol.25 , pp. 139-170
    • Welniak, L.A.1    Blazar, B.R.2    Murphy, W.J.3
  • 20
    • 33746896573 scopus 로고    scopus 로고
    • The persistent challenges of bacterial infections in the transplant recipient
    • DOI 10.1111/j.1399-3062.2006.00168.x
    • Marty, F.M., and Rubin, R.H. 2006. The persistent challenges of bacterial infections in the transplant recipient. Transpl. Infect. Dis. 8:125-127. (Pubitemid 44196178)
    • (2006) Transplant Infectious Disease , vol.8 , Issue.3 , pp. 125-127
    • Marty, F.M.1    Rubin, R.H.2
  • 21
    • 10944241442 scopus 로고    scopus 로고
    • Principles of antimicrobial therapy in the transplant patient
    • Rubin, R.H., and Marty, F.M. 2004. Principles of antimicrobial therapy in the transplant patient. Transpl. Infect. Dis. 6:97-100.
    • (2004) Transpl. Infect. Dis. , vol.6 , pp. 97-100
    • Rubin, R.H.1    Marty, F.M.2
  • 22
    • 30744443483 scopus 로고    scopus 로고
    • A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
    • DOI 10.1038/nm1309, PII NM1309
    • Reddy, P., et al. 2005. A crucial role for antigen-presenting cells and alloantigen expression in graft-versus- leukemia responses. Nat. Med. 11:1244-1249. (Pubitemid 43093673)
    • (2005) Nature Medicine , vol.11 , Issue.11 , pp. 1244-1249
    • Reddy, P.1    Maeda, Y.2    Liu, C.3    Krijanovski, O.I.4    Korngold, R.5    Ferrara, J.L.M.6
  • 23
    • 0026452044 scopus 로고
    • CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion
    • Harty, J.T., Schreiber, R.D., and Bevan, M.J. 1992. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc. Natl. Acad. Sci. U. S. A. 89:11612-11616.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 11612-11616
    • Harty, J.T.1    Schreiber, R.D.2    Bevan, M.J.3
  • 24
    • 45949104245 scopus 로고    scopus 로고
    • Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis
    • Sakowicz-Burkiewicz, M., et al. 2008. Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J. Immunol. 180:5601-5612.
    • (2008) J. Immunol. , vol.180 , pp. 5601-5612
    • Sakowicz-Burkiewicz, M.1
  • 25
    • 0344406188 scopus 로고    scopus 로고
    • + T cells reveals an essential requirement for nuclear factor κB in regulating mature T cell survival and in vivo function
    • DOI 10.1084/jem.20021610
    • Zheng, Y., Vig, M., Lyons, J., Van Parijs, L., and Beg, A.A. 2003. Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for NF-kB in regulating mature T cell survival and in vivo function. J. Exp. Med. 197:861-874. (Pubitemid 36437863)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.7 , pp. 861-874
    • Zheng, Y.1    Vig, M.2    Lyons, J.3    Van Parijs, L.4    Beg, A.A.5
  • 26
    • 41149167494 scopus 로고    scopus 로고
    • T-cell fate and function: PKC-theta and beyond
    • Marsland, B.J., and Kopf, M. 2008. T-cell fate and function: PKC-theta and beyond. Trends Immunol. 29:179-185.
    • (2008) Trends Immunol. , vol.29 , pp. 179-185
    • Marsland, B.J.1    Kopf, M.2
  • 27
    • 33744913796 scopus 로고    scopus 로고
    • Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells
    • Yu, X.Z., et al. 2006. Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells. J. Immunol. 176:7394-7401.
    • (2006) J. Immunol. , vol.176 , pp. 7394-7401
    • Yu, X.Z.1
  • 28
    • 38349188886 scopus 로고    scopus 로고
    • 2 integrins separates graft-versus-host disease and graft-versus-leukemia effect
    • Liang, Y., et al. 2007. {beta}2 integrins separates graft-versus-host disease and graft-versus-leukemia effect. Blood. 111:954-962.
    • (2007) Blood , vol.111 , pp. 954-962
    • Liang, Y.1
  • 29
    • 0030762736 scopus 로고    scopus 로고
    • Recent advances in graft-versus-host disease (GVHD) prevention
    • DOI 10.1111/j.1600-065X.1997.tb00976.x
    • Blazar, B.R., Korngold, R., and Vallera, D.A. 1997. Recent advances in graft-versus-host disease (GVHD) prevention. Immunol. Rev. 157:79-109. (Pubitemid 27303123)
    • (1997) Immunological Reviews , vol.157 , pp. 79-109
    • Blazar, B.R.1    Korngold, R.2    Vallera, D.A.3
  • 30
    • 47949130474 scopus 로고    scopus 로고
    • A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection
    • Manicassamy, S., et al. 2008. A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection. J. Immunol. 181:513-520.
    • (2008) J. Immunol. , vol.181 , pp. 513-520
    • Manicassamy, S.1
  • 31
    • 33644848095 scopus 로고    scopus 로고
    • Alloantigen affinity and CD4 help determine severity of graft-versus-host disease mediated by CD8 donor T cells
    • Yu, X.Z., Albert, M.H., and Anasetti, C. 2006. Alloantigen affinity and CD4 help determine severity of graft-versus-host disease mediated by CD8 donor T cells. J. Immunol. 176:3383-3390. (Pubitemid 43363985)
    • (2006) Journal of Immunology , vol.176 , Issue.6 , pp. 3383-3390
    • Yu, X.-Z.1    Albert, M.H.2    Anasetti, C.3
  • 32
    • 0034192104 scopus 로고    scopus 로고
    • CD28-specific antibody prevents graft-versus-host disease in mice
    • Yu, X.Z., Bidwell, S.J., Martin, P.J., and Anasetti, C. 2000. CD28-specific antibody prevents graft-versushost disease in mice. J. Immunol. 164:4564-4568. (Pubitemid 30238053)
    • (2000) Journal of Immunology , vol.164 , Issue.9 , pp. 4564-4568
    • Yu, X.-Z.1    Bidwell, S.J.2    Martin, P.J.3    Anasetti, C.4
  • 33
    • 0023724209 scopus 로고
    • Positive and negative selection of an antigen receptor on T cells in transgenic mice
    • DOI 10.1038/336073a0
    • Sha, W.C., et al. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 336:73-76. (Pubitemid 18262137)
    • (1988) Nature , vol.336 , Issue.6194 , pp. 73-76
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 34
    • 0023785318 scopus 로고
    • Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
    • DOI 10.1038/335271a0
    • Sha, W.C., et al. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 335:271-274. (Pubitemid 18224875)
    • (1988) Nature , vol.335 , Issue.6187 , pp. 271-274
    • Sha, W.C.1    Nelson, C.A.2    Newberry, R.D.3    Kranz, D.M.4    Russell, J.H.5    Loh, D.Y.6
  • 35
    • 0028120414 scopus 로고
    • T cell receptor-MHC class I peptide interactions: Affinity, kinetics, and specificity
    • Corr, M., et al. 1994. T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science. 265:946-949.
    • (1994) Science , vol.265 , pp. 946-949
    • Corr, M.1
  • 36
    • 0029996649 scopus 로고    scopus 로고
    • + T cells in vitro
    • DOI 10.1084/jem.183.5.2247
    • Cai, Z., and Sprent, J. 1996. Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro. J. Exp. Med. 183:2247-2257. (Pubitemid 26158916)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.5 , pp. 2247-2257
    • Cai, Z.1    Sprent, J.2
  • 38
    • 33747092261 scopus 로고    scopus 로고
    • Altered Peptide Ligands Induce Delayed CD8-T Cell Receptor Interaction-a Role for CD8 in Distinguishing Antigen Quality
    • DOI 10.1016/j.immuni.2006.05.015, PII S1074761306003189
    • Yachi, P.P., Ampudia, J., Zal, T., and Gascoigne, N.R. 2006. Altered peptide ligands induce delayed CD8- T cell receptor interaction - a role for CD8 in distinguishing antigen quality. Immunity. 25:203-211. (Pubitemid 44224141)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 203-211
    • Yachi, P.P.1    Ampudia, J.2    Zal, T.3    Gascoigne, N.R.J.4
  • 39
    • 0032754034 scopus 로고    scopus 로고
    • + T cells in the graft-versus-host reaction
    • Yu, X.Z., Bidwell, S., Martin, P.J., and Anasetti, C. 1999. Visualization, fate, and pathogenicity of antigen- specific CD8+ T cells in the graft-versus-host reaction. J. Immunol. 163:4780-4787. (Pubitemid 29501240)
    • (1999) Journal of Immunology , vol.163 , Issue.9 , pp. 4780-4787
    • Yu, X.-Z.1    Bidwell, S.2    Martin, P.J.3    Anasetti, C.4
  • 40
    • 1642362512 scopus 로고    scopus 로고
    • Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN
    • Ahonen, C.L., et al. 2004. Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J. Exp. Med. 199:775-784.
    • (2004) J. Exp. Med. , vol.199 , pp. 775-784
    • Ahonen, C.L.1
  • 41
    • 42449147062 scopus 로고    scopus 로고
    • Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines
    • Ahonen, C.L., et al. 2008. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 111:3116-3125.
    • (2008) Blood , vol.111 , pp. 3116-3125
    • Ahonen, C.L.1
  • 42
    • 57149086082 scopus 로고    scopus 로고
    • In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells
    • Assudani, D., Cho, H.I., DeVito, N., Bradley, N., and Celis, E. 2008. In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells. Cancer Res. 68:9892-9899.
    • (2008) Cancer Res. , vol.68 , pp. 9892-9899
    • Assudani, D.1    Cho, H.I.2    Devito, N.3    Bradley, N.4    Celis, E.5
  • 43
    • 54049153247 scopus 로고    scopus 로고
    • TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
    • Taylor, P.A., et al. 2008. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood. 112:3508-3516.
    • (2008) Blood , vol.112 , pp. 3508-3516
    • Taylor, P.A.1
  • 44
    • 34248334250 scopus 로고    scopus 로고
    • Chronic GvHD decreases antiviral immune responses in allogeneic BMT
    • Hossain, M.S., et al. 2007. Chronic GvHD decreases antiviral immune responses in allogeneic BMT. Blood. 109:4548-4556.
    • (2007) Blood , vol.109 , pp. 4548-4556
    • Hossain, M.S.1
  • 45
    • 45549092411 scopus 로고    scopus 로고
    • Host and donor immune responses contribute to antiviral effects of amotosalen-treated donor lymphocytes following early posttransplant cytomegalovirus infection
    • Hossain, M.S., Roback, J.D., Wang, F., and Waller, E.K. 2008. Host and donor immune responses contribute to antiviral effects of amotosalen-treated donor lymphocytes following early posttransplant cytomegalovirus infection. J. Immunol. 180:6892-6902.
    • (2008) J. Immunol. , vol.180 , pp. 6892-6902
    • Hossain, M.S.1    Roback, J.D.2    Wang, F.3    Waller, E.K.4
  • 46
    • 0022621521 scopus 로고
    • Risk factors for cytomegalovirus infection after human marrow transplantation
    • Meyers, J.D., Flournoy, N., and Thomas, E.D. 1986. Risk factors for cytomegalovirus infection after human marrow transplantation. J. Infect. Dis. 153:478-488. (Pubitemid 16135651)
    • (1986) Journal of Infectious Diseases , vol.153 , Issue.3 , pp. 478-488
    • Meyers, J.D.1    Flournoy, N.2    Thomas, E.D.3
  • 47
    • 0037026001 scopus 로고    scopus 로고
    • + immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • DOI 10.1084/jem.20020090
    • Cohen, J.L., Trenado, A., Vasey, D., Klatzmann, D., and Salomon, B.L. 2002. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus- host disease. J. Exp. Med. 196:401-406. (Pubitemid 34875668)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.3 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 48
    • 54349086262 scopus 로고    scopus 로고
    • Differential requirement of PKC-theta in the development and function of natural regulatory T cells
    • Gupta, S., et al. 2008. Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol. Immunol. 46:213-224.
    • (2008) Mol. Immunol. , vol.46 , pp. 213-224
    • Gupta, S.1
  • 49
    • 32644449066 scopus 로고    scopus 로고
    • Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
    • Waldman, E., et al. 2006. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 107:1703-1711.
    • (2006) Blood , vol.107 , pp. 1703-1711
    • Waldman, E.1
  • 50
    • 10744230688 scopus 로고    scopus 로고
    • LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graftversus- Host disease
    • Petrovic, A., et al. 2004. LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graftversus- host disease. Blood. 103:1542-1547.
    • (2004) Blood , vol.103 , pp. 1542-1547
    • Petrovic, A.1
  • 51
    • 36148994331 scopus 로고    scopus 로고
    • CCR1/CCL5 (RANTES) receptor- Ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
    • Choi, S.W., et al. 2007. CCR1/CCL5 (RANTES) receptor- ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood. 110:3447-3455.
    • (2007) Blood , vol.110 , pp. 3447-3455
    • Choi, S.W.1
  • 52
    • 22044439846 scopus 로고    scopus 로고
    • + T-cell-mediated acute graft-versus-host disease responses
    • DOI 10.1182/blood-2004-08-2996
    • Varona, R., Cadenas, V., Gomez, L., Martinez, A.C., and Marquez, G. 2005. CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses. Blood. 106:18-26. (Pubitemid 40967169)
    • (2005) Blood , vol.106 , Issue.1 , pp. 18-26
    • Varona, R.1    Cadenas, V.2    Gomez, L.3    Martinez-A, C.4    Marquez, G.5
  • 53
    • 27644442438 scopus 로고    scopus 로고
    • CCR2 is required for CD8-induced graft-versus-host disease
    • Terwey, T.H., et al. 2005. CCR2 is required for CD8-induced graft-versus-host disease. Blood. 106:3322-3330.
    • (2005) Blood , vol.106 , pp. 3322-3330
    • Terwey, T.H.1
  • 54
    • 0036721158 scopus 로고    scopus 로고
    • Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: Influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    • Wagner, J.E., et al. 2002. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 100:1611-1618.
    • (2002) Blood , vol.100 , pp. 1611-1618
    • Wagner, J.E.1
  • 55
    • 12844273651 scopus 로고    scopus 로고
    • Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    • Barker, J.N., et al. 2005. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 105:1343-1347.
    • (2005) Blood , vol.105 , pp. 1343-1347
    • Barker, J.N.1
  • 56
    • 64049100784 scopus 로고    scopus 로고
    • Acute graft-versushost disease after unrelated donor umbilical cord blood transplantation: Analysis of risk factors
    • MacMillan, M.L., et al. 2009. Acute graft-versushost disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors. Blood. 113:2410-2415.
    • (2009) Blood , vol.113 , pp. 2410-2415
    • MacMillan, M.L.1
  • 57
    • 33846665903 scopus 로고    scopus 로고
    • Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role
    • DOI 10.1189/jlb.0206109
    • Grybko, M.J., Pores-Fernando, A.T., Wurth, G.A., and Zweifach, A. 2007. Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role. J. Leukoc. Biol. 81:509-519. (Pubitemid 46198403)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.2 , pp. 509-519
    • Grybko, M.J.1    Pores-Fernando, A.T.2    Wurth, G.A.3    Zweifach, A.4
  • 58
    • 33845921462 scopus 로고    scopus 로고
    • The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis
    • Manicassamy, S., and Sun, Z. 2007. The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis. J. Immunol. 178:312-319. (Pubitemid 46033614)
    • (2007) Journal of Immunology , vol.178 , Issue.1 , pp. 312-319
    • Manicassamy, S.1    Sun, Z.2
  • 59
    • 0035353187 scopus 로고    scopus 로고
    • Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versusleukemia effect
    • Schmaltz, C., et al. 2001. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versusleukemia effect. Blood. 97:2886-2895.
    • (2001) Blood , vol.97 , pp. 2886-2895
    • Schmaltz, C.1
  • 60
    • 0036914180 scopus 로고    scopus 로고
    • T cells require TRAIL for optimal graft-versus-tumor activity
    • Schmaltz, C., et al. 2002. T cells require TRAIL for optimal graft-versus-tumor activity. Nat. Med. 8:1433-1437.
    • (2002) Nat. Med. , vol.8 , pp. 1433-1437
    • Schmaltz, C.1
  • 61
    • 58149393273 scopus 로고    scopus 로고
    • PKC-theta selectively controls the adhesion-stimulating molecule Rap1
    • Letschka, T., et al. 2008. PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood. 112:4617-4627.
    • (2008) Blood , vol.112 , pp. 4617-4627
    • Letschka, T.1
  • 62
    • 0034671644 scopus 로고    scopus 로고
    • CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants
    • Fischbein, M.P., et al. 2000. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants. J. Immunol. 165:7316-7322.
    • (2000) J. Immunol. , vol.165 , pp. 7316-7322
    • Fischbein, M.P.1
  • 63
    • 0037018094 scopus 로고    scopus 로고
    • Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus
    • Mueller, S.N., Jones, C.M., Smith, C.M., Heath, W.R., and Carbone, F.R. 2002. Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. J. Exp. Med. 195:651-656.
    • (2002) J. Exp. Med. , vol.195 , pp. 651-656
    • Mueller, S.N.1    Jones, C.M.2    Smith, C.M.3    Heath, W.R.4    Carbone, F.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.