Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

Blood

Volumn 122, Issue 22, 2013, Pages 3651-3658

  Pidala, Joseph ^a   Wang, Tao ^b   Haagenson, Michael ^c   Spellman, Stephen R ^c   Askar, Medhat ^d   Battiwalla, Minoo ^e   Baxter Lowe, Lee Ann ^f   Bitan, Menachem ^g   Fernandez Viña, Marcelo ^h   Gandhi, Manish ⁱ   Jakubowski, Ann A ^j   Maiers, Martin ^k   Marino, Susana R ^l   Marsh, Steven G E ^m   Oudshoorn, Machteld ⁿ   Palmer, Jeanne ^o   Prasad, Vinod K ^p   Reddy, Vijay ^q   Ringden, Olle ^r   Saber, Wael ^b   Santarone, Stella ^s   Schultz, Kirk R ^t   Setterholm, Michelle ^k   Trachtenberg, Elizabeth ^u   Turner, E Victoria ^v   Woolfrey, Ann E ^w   Lee, Stephanie J ^w   Anasetti, Claudio ^a   more..

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^h STANFORD UNIVERSITY MEDICAL CENTER   (United States)

ⁱ MAYO CLINIC   (United States)

^j MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^k NATIONAL MARROW DONOR PROGRAM   (United States)

^l UNIVERSITY OF CHICAGO   (United States)

^m UNIVERSITY COLLEGE LONDON   (United Kingdom)

ⁿ LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^o CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^p DUKE UNIVERSITY MEDICAL CENTER   (United States)

^q UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^r KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^s Ospedale Civile BMT Center Pescara   (Italy)

^t BC CHILDREN S HOSPITAL   (Canada)

^u CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^v ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^w Fred Hutchinson Cancer Research Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CHILD; CHRONIC MYELOID LEUKEMIA; DISEASE ASSOCIATION; FEMALE; GENE LOCUS; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOLECULE; MORTALITY; OUTCOME ASSESSMENT; PERIPHERAL BLOOD STEM CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHOOL CHILD;

EID: 84888269622     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-05-501510     Document Type: Article

References (37)

1. Davies SM, Kollman C, Anasetti C, et al. Engraftment and survival after unrelated-donor bone marrow transplantation: a report from the national marrow donor program. Blood. 2000;96(13):4096-4102.
2. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104(7):1923-1930.
3. Lee SJ, Klein J, Haagenson M, et al. Highresolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110(13):4576-4583.
4. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99(11):4200-4206.
5. Petersdorf EW, Longton GM, Anasetti C, et al. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood. 1997;89(5):1818-1823.
6. Sasazuki T, Juji T, Morishima Y, et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med. 1998;339(17):1177-1185.
7. Speiser DE, Tiercy JM, Rufer N, et al. High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation. Blood. 1996;87(10):4455-4462.
8. Woolfrey A, Klein JP, Haagenson M, et al. HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 2011;17(6):885-892.
9. Elsner HA, Blasczyk R. Sequence similarity matching: proposal of a structure-based rating system for bone marrow transplantation. Eur J Immunogenet. 2002;29(3):229-236.
10. Elsner HA, DeLuca D, Strub J, Blasczyk R. HistoCheck: rating of HLA class I and II mismatches by an internet-based software tool. Bone Marrow Transplant. 2004;33(2):165-169.
11. Spellman S, Klein J, Haagenson M, et al. Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012;18(5):739-746.
12. Kawase T, Morishima Y, Matsuo K, et al; Japan Marrow Donor Program. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood. 2007;110(7):2235-2241.
13. Morishima Y, Yabe T, Matsuo K, et al; Japan Marrow Donor Program. Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. Biol Blood Marrow Transplant. 2007;13(3):315-328.
14. Ferrara GB, Bacigalupo A, Lamparelli T, et al. Bone marrow transplantation from unrelated donors: the impact of mismatches with substitutions at position 116 of the human leukocyte antigen class I heavy chain. Blood. 2001;98(10):3150-3155.
15. Fleischhauer K, Shaw BE, Gooley T, et al; International Histocompatibility Working Group in Hematopoietic Cell Transplantation. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncol. 2012;13(4):366-374.
16. Kawase T, Matsuo K, Kashiwase K, et al; Japan Marrow Donor Program. HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. Blood. 2009;113(12):2851-2858.
17. Marino SR, Lin S, Maiers M, et al. Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. Bone Marrow Transplant. 2012;47(2):217-226.
18. Farag SS, Bacigalupo A, Eapen M, et al; KIR Study Group, Center for International Blood and Marrow Transplantation Research. The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry. Biol Blood Marrow Transplant. 2006;12(8):876-884.
19. Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA. Natural killer cell receptors: new biology and insights into the graft-versusleukemia effect. Blood. 2002;100(6):1935-1947.
20. Spellman S, Setterholm M, Maiers M, et al. Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry. Biol Blood Marrow Transplant. 2008;14(9 Suppl):37-44.
21. Shaw BE, Gooley TA, Malkki M, et al. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood. 2007;110(13):4560- 4566.
22. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995;15(6):825-828.
23. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69(2):204-217.
24. Zhang X, Zhang MJ. SAS macros for estimation of direct adjusted cumulative incidence curves under proportional subdistribution hazards models. Comput Methods Programs Biomed. 2011;101(1):87-93.
25. Garrett TP, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature. 1989;342(6250):692-696.
26. Madden DR, Garboczi DN, Wiley DC. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell. 1993;75(4):693-708.
27. Matsumura M, Fremont DH, Peterson PA, Wilson IA. Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science. 1992;257(5072):927-934.
28. Saper MA, Bjorkman PJ, Wiley DC. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol. 1991;219(2):277-319.
29. Guo HC, Jardetzky TS, Garrett TP, Lane WS, Strominger JL, Wiley DC. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature. 1992;360(6402):364-366.
30. Silver ML, Guo HC, Strominger JL, Wiley DC. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature. 1992;360(6402):367- 369.
31. Khanna R, Silins SL, Weng Z, Gatchell D, Burrows SR, Cooper L. Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCR-peptide interaction. Eur J Immunol. 1999;29(5):1587-1597.
32. *5101 binding peptides but does not explain the general affinity difference. Immunogenetics. 1998;47(3):256-263.
33. Mattson DH, Shimojo N, Cowan EP, et al. Differential effects of amino acid substitutions in the beta-sheet floor and alpha-2 helix of HLA-A2 on recognition by alloreactive viral peptidespecific cytotoxic T lymphocytes. J Immunol. 1989;143(4):1101-1107.
34. Shimojo N, Anderson RW, Mattson DH, Turner RV, Coligan JE, Biddison WE. The kinetics of peptide binding to HLA-A2 and the conformation of the peptide-A2 complex can be determined by amino acid side chains on the floor of the peptide binding groove. Int Immunol. 1990;2(3):193-200.
35. Tussey LG, Matsui M, Rowland-Jones S, Warburton R, Frelinger JA, McMichael A. Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition. J Immunol. 1994;152(3):1213-1221.
36. Greinix HT, Faé I, Schneider B, et al. Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors. Bone Marrow Transplant. 2005;35(1):57-62.
37. Ozawa S, Nakaseko C, Nishimura M, et al; Japan Marrow Donor Program. Chronic graft-versushost disease after allogeneic bone marrow transplantation from an unrelated donor: incidence, risk factors and association with relapse. A report from the Japan Marrow Donor Program. Br J Haematol. 2007;137(2):142-151.