메뉴 건너뛰기




Volumn 5, Issue 188, 2013, Pages

Dual receptor T cells mediate pathologic alloreactivity in patients with acute graft-versus-host disease

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOSUPPRESSIVE AGENT; MAJOR HISTOCOMPATIBILITY ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 84880569064     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3005452     Document Type: Article
Times cited : (30)

References (40)
  • 1
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • W. D. Shlomchik, Graft-versus-host disease. Nat. Rev. Immunol. 7, 340-352 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 2
    • 79953123445 scopus 로고    scopus 로고
    • Effector CD4+ T cells, the cytokines they generate, and GVHD: Something old and something new
    • J. M. Coghill, S. Sarantopoulos, T. P. Moran, W. J. Murphy, B. R. Blazar, J. S. Serody, Effector CD4+ T cells, the cytokines they generate, and GVHD: Something old and something new. Blood 117, 3268-3276 (2011).
    • (2011) Blood , vol.117 , pp. 3268-3276
    • Coghill, J.M.1    Sarantopoulos, S.2    Moran, T.P.3    Murphy, W.J.4    Blazar, B.R.5    Serody, J.S.6
  • 3
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therapy
    • B. R. Blazar, W. J. Murphy, M. Abedi, Advances in graft-versus-host disease biology and therapy. Nat. Rev. Immunol. 12, 443-458 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 443-458
    • Blazar, B.R.1    Murphy, W.J.2    Abedi, M.3
  • 4
    • 13944258549 scopus 로고    scopus 로고
    • Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: Efficacy and side effects
    • A. Bacigalupo, Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: Efficacy and side effects. Bone Marrow Transplant. 35, 225-231 (2005).
    • (2005) Bone Marrow Transplant , vol.35 , pp. 225-231
    • Bacigalupo, A.1
  • 5
    • 33646119401 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation
    • E. A. Copelan, Hematopoietic stem-cell transplantation. N. Engl. J. Med. 354, 1813-1826 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 1813-1826
    • Copelan, E.A.1
  • 8
    • 84855957129 scopus 로고    scopus 로고
    • How the TCR balances sensitivity and specificity for the recognition of self and pathogens
    • G. P. Morris, P. M. Allen, How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat. Immunol. 13, 121-128 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 121-128
    • Morris, G.P.1    Allen, P.M.2
  • 10
    • 0028822771 scopus 로고
    • Allelic exclusion of mouse T cell receptor a chains occurs at the time of thymocyte TCR up-regulation
    • S. M. Alam, I. N. Crispe, N. R. Gascoigne, Allelic exclusion of mouse T cell receptor a chains occurs at the time of thymocyte TCR up-regulation. Immunity 3, 449-458 (1995).
    • (1995) Immunity , vol.3 , pp. 449-458
    • Alam, S.M.1    Crispe, I.N.2    Gascoigne, N.R.3
  • 12
    • 0024280910 scopus 로고
    • A T cell clone expresses two T cell receptor a genes but uses one ab heterodimer for allorecognition and self MHC-restricted antigen recognition
    • M. Malissen, J. Trucy, F. Letourneur, N. Rebaï, D. E. Dunn, F. W. Fitch, L. Hood, B. Malissen, A T cell clone expresses two T cell receptor a genes but uses one ab heterodimer for allorecognition and self MHC-restricted antigen recognition. Cell 55, 49-59 (1988).
    • (1988) Cell , vol.55 , pp. 49-59
    • Malissen, M.1    Trucy, J.2    Letourneur, F.3    Rebaï, N.4    Dunn, D.E.5    Fitch, F.W.6    Hood, L.7    Malissen, B.8
  • 14
    • 67449149805 scopus 로고    scopus 로고
    • Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease
    • G. P. Morris, P. M. Allen, Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease. J. Immunol. 182, 6639-6643 (2009).
    • (2009) J. Immunol , vol.182 , pp. 6639-6643
    • Morris, G.P.1    Allen, P.M.2
  • 15
    • 0029810903 scopus 로고    scopus 로고
    • Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
    • T. Zal, S. Weiss, A. Mellor, B. Stockinger, Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. U.S.A. 93, 9102-9107 (1996).
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9102-9107
    • Zal, T.1    Weiss, S.2    Mellor, A.3    Stockinger, B.4
  • 16
    • 77953758560 scopus 로고    scopus 로고
    • Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
    • Q. Ji, A. Perchellet, J. M. Goverman, Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat. Immunol. 11, 628-634 (2010).
    • (2010) Nat. Immunol , vol.11 , pp. 628-634
    • Ji, Q.1    Perchellet, A.2    Goverman, J.M.3
  • 18
    • 0029968758 scopus 로고    scopus 로고
    • Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation
    • K. Kubo, K. Yamanaka, H. Kiyoi, H. Fukutani, M. Ito, R. Hayakawa, R. Ohno, T. Naoe, Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation. Blood 87, 3019-3026 (1996).
    • (1996) Blood , vol.87 , pp. 3019-3026
    • Kubo, K.1    Yamanaka, K.2    Kiyoi, H.3    Fukutani, H.4    Ito, M.5    Hayakawa, R.6    Ohno, R.7    Naoe, T.8
  • 20
    • 0035863825 scopus 로고    scopus 로고
    • Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question
    • E. J. Suchin, P. B. Langmuir, E. Palmer, M. H. Sayegh, A. D. Wells, L. A. Turka, Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question. J. Immunol. 166, 973-981 (2001).
    • (2001) J. Immunol , vol.166 , pp. 973-981
    • Suchin, E.J.1    Langmuir, P.B.2    Palmer, E.3    Sayegh, M.H.4    Wells, A.D.5    Turka, L.A.6
  • 21
    • 54049083468 scopus 로고    scopus 로고
    • Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vb use: A new paradigm for designer allogeneic blood and marrow transplantation
    • T. M. Friedman, K. Goldgirsh, S. A. Berger, J. Zilberberg, J. Filicko-O'Hara, N. Flomenberg, M. Donato, S. D. Rowley, R. Korngold, Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vb use: A new paradigm for designer allogeneic blood and marrow transplantation. Blood 112, 3517-3525 (2008).
    • (2008) Blood , vol.112 , pp. 3517-3525
    • Friedman, T.M.1    Goldgirsh, K.2    Berger, S.A.3    Zilberberg, J.4    Filicko-O'Hara, J.5    Flomenberg, N.6    Donato, M.7    Rowley, S.D.8    Korngold, R.9
  • 23
    • 0030935007 scopus 로고    scopus 로고
    • The MHC reactivity of the T cell repertoire prior to positive and negative selection
    • J. Zerrahn, W. Held, D. H. Raulet, The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627-636 (1997).
    • (1997) Cell , vol.88 , pp. 627-636
    • Zerrahn, J.1    Held, W.2    Raulet, D.H.3
  • 24
    • 34548128306 scopus 로고    scopus 로고
    • Structural evidence for a germlineencoded T cell receptor-major histocompatibility complex interaction 'codon'
    • D. Feng, C. J. Bond, L. K. Ely, J. Maynard, K. C. Garcia, Structural evidence for a germlineencoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat. Immunol. 8, 975-983 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 975-983
    • Feng, D.1    Bond, C.J.2    Ely, L.K.3    Maynard, J.4    Garcia, K.C.5
  • 26
    • 67349280397 scopus 로고    scopus 로고
    • Germline-encoded amino acids in the ab T-cell receptor control thymic selection
    • J. P. Scott-Browne, J. White, J. W. Kappler, L. Gapin, P. Marrack, Germline-encoded amino acids in the ab T-cell receptor control thymic selection. Nature 458, 1043-1046 (2009).
    • (2009) Nature , vol.458 , pp. 1043-1046
    • Scott-Browne, J.P.1    White, J.2    Kappler, J.W.3    Gapin, L.4    Marrack, P.5
  • 28
    • 79952740613 scopus 로고    scopus 로고
    • Alloreactivity is limited by the endogenous peptide repertoire
    • G. P. Morris, P. P. Ni, P. M. Allen, Alloreactivity is limited by the endogenous peptide repertoire. Proc. Natl. Acad. Sci. U.S.A. 108, 3695-3700 (2011).
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 3695-3700
    • Morris, G.P.1    Ni, P.P.2    Allen, P.M.3
  • 29
    • 36448937145 scopus 로고    scopus 로고
    • Specificity of T-cell alloreactivity
    • N. J. Felix, P. M. Allen, Specificity of T-cell alloreactivity. Nat. Rev. Immunol. 7, 942-953 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 942-953
    • Felix, N.J.1    Allen, P.M.2
  • 36
    • 79959529827 scopus 로고    scopus 로고
    • Thymic T-cell development in allogeneic stem cell transplantation
    • W. Krenger, B. R. Blazar, G. A. Holländer, Thymic T-cell development in allogeneic stem cell transplantation. Blood 117, 6768-6776 (2011).
    • (2011) Blood , vol.117 , pp. 6768-6776
    • Krenger, W.1    Blazar, B.R.2    Holländer, G.A.3
  • 37
    • 33845472626 scopus 로고    scopus 로고
    • Most human thymic and peripheral-blood CD4+ CD25+ regulatory T cells express 2 T-cell receptors
    • H. Tuovinen, J. T. Salminen, T. P. Arstila, Most human thymic and peripheral-blood CD4+ CD25+ regulatory T cells express 2 T-cell receptors. Blood 108, 4063-4070 (2006).
    • (2006) Blood , vol.108 , pp. 4063-4070
    • Tuovinen, H.1    Salminen, J.T.2    Arstila, T.P.3
  • 38
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • C. S. Hsieh, H. M. Lee, C. W. Lio, Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 12, 157-167 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 39
    • 14244273313 scopus 로고    scopus 로고
    • The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state Acta Crystallogr
    • C. S. Clements, L. Kjer-Nielsen, W. A. MacDonald, A. G. Brooks, A. W. Purcell, J. McCluskey, J. Rossjohn, The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state. Acta Crystallogr. D Biol. Crystallogr. 58, 2131-2134 (2002).
    • (2002) D Biol. Crystallogr , vol.58 , pp. 2131-2134
    • Clements, C.S.1    Kjer-Nielsen, L.2    Macdonald, W.A.3    Brooks, A.G.4    Purcell, A.W.5    McCluskey, J.6    Rossjohn, J.7
  • 40
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • G. Köhler, C. Milstein, Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497 (1975).
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.