Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells

Journal of Immunology

Volumn 174, Issue 1, 2005, Pages 551-556

  Hashimoto, Daigo ^a   Asakura, Shoji ^a   Miyake, Sachiko ^b   Yamamura, Takashi ^b   Van Kaer, Luc ^c   Liu, Chen ^d   Tanimoto, Mitsune ^a   Teshima, Takanori ^e  

^a OKAYAMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GLYCOLIPID; INTERLEUKIN 4; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRAFT REJECTION; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STIMULATION; CYTOKINE PRODUCTION; DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HOST CELL; IMMUNOREGULATION; MORBIDITY; MORTALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROPHYLAXIS; REGULATORY MECHANISM; STATISTICAL ANALYSIS; T LYMPHOCYTE; TH2 CELL;

EID: 10844271455     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.1.551     Document Type: Article

References (51)

1. Childs, R., A. Chernoff, N. Contentin, E. Bahceci, D. Schrump, S. Leitman, E. J. Read, J. Tisdale, C. Dunbar, W. M. Linehan, N. S. Young, and A. J. Barrett. 2000. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N. Engl. J. Med. 343:750.
2. Burt, R. K., A. E. Traynor, R. Craig, and A. M. Marmont. 2003. The promise of hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant. 31:521.
3. Teshima, T., and J. L. Ferrara. 2002. Understanding the alloresponse: new approaches to graft-versus-host disease prevention. Semin. Hematol. 39:15.
4. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
5. Blazar, B. R., P. A. Taylor, S. Smith, and D. A. Vallera. 1995. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood 85:842.
6. Atkinson, K., C. Matias, A. Guiffre, R. Seymour, M. Cooley, J. Biggs, V. Munro, and S. Gillis. 1991. In vivo administration of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, interleukin-1 (IL-1), and 1L-4, alone and in combination, after allogeneic murine hematopoietic stem cell transplantation. Blood 77:1376.
7. Krenger, W., K. Snyder, S. Smith, and J. L. Ferrara. 1994. Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens. Transplantation 58:1251.
8. Nikolic, B., S. Lee, R. T. Bronson, M. J. Grusby, and M. Sykes. 2000. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J. Clin. Invest. 105:1289.
9. Hill, G. R., and J. L. Ferrara. 2000. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 95:2754.
10. + donor T cells fail to induce experimental acute graft-versus-host disease. J. Immunol. 155:585.
11. Krenger, W., K. R. Cooke, J. M. Crawford, S. T. Sonis, R. Simmons, L. Pan, J. Delmonte, Jr., M. Karandikar, and J. L. Ferrara. 1996. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation 62:1278.
12. Fowler, D. H., K. Kurasawa, R. Smith, M. A. Eckhaus, and R. E. Gress. 1994. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84:3540.
13. Reid, S. D., G. Penna, and L. Adorini. 2000. The control of T cell responses by dendritic cell subsets. Curr. Opin. Immunol. 12:114.
14. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
15. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:557.
16. Godfrey, D. I., H. R. MacDonald, M. Kronenberg, M. J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4:231.
17. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191:1895.
18. Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483.
19. + T cells in a TH2 response and in immunoglobulin E production. Science 270:1845.
20. Bendelac, A., R. D. Hunziker, and O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:1285.
21. Smiley, S. T., M. H. Kaplan, and M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275:977.
22. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. Van Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
23. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459.
24. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182:2091.
25. + cells. J. Immunol. 164:2412.
26. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, H. Koseki, and M. Taniguchi. 1997. CD1d-restricted and TCR-mediated activation of vα14 NKT cells by glycosylceramides. Science 278:1626.
27. Miyamoto, K., S. Miyake, and T. Yamamura. 2001. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413:531.
28. Wall, D. A., S. D. Hamberg, D. S. Reynolds, S. J. Burakoff, A. K. Abbas, and J. L. Ferrara. 1988. Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression. J. Immunol. 140:2970.
29. Cooke, K. R., L. Kobzik, T. R. Martin, J. Brewer, J. Delmonte, Jr., J. M. Crawford, and J. L. Ferrara. 1996. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation. I. The roles of minor H antigens and endotoxin. Blood 88:3230.
30. Kobayashi, E., K. Motoki, T. Uchida, H. Fukushima, and Y. Koezuka. 1995. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol. Res. 7:529.
31. Oki, S., A. Chiba, T. Yamamura, and S. Miyake. 2004. The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J. Clin. Invest. 113:1631.
32. Teshima, T., N. Mach, G. R. Hill, L. Pan, S. Gillessen, G. Dranoff, and J. L. Ferrara. 2001. Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation. Cancer Res. 61:162.
33. Hill, G. R., K. R. Cooke, T. Teshima, J. M. Crawford, J. C. Keith, Jr., Y. S. Brinson, D. Bungard, and J. L. Ferrara. 1998. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Clin. Invest. 102:115.
34. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
35. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
36. + T cells reciprocally regulate acute graft versus host disease. J. Exp. Med. 189:1073.
37. Teshima, T., R. Ordemann, P. Reddy, S. Gagin, C. Liu, K. R. Cooke, and J. L. Ferrara. 2002. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat. Med. 8:575.
38. Reiner, S. L. 2001. Helper T cell differentiation, inside and out. Curr. Opin. Immunol. 13:351.
39. Farrar, J. D., H. Asnagli, and K. M. Murphy. 2002. T helper subset development: roles of instruction, selection, and transcription. J. Clin. Invest. 109:431.
40. + T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. J. Immunol. 167:2087.
41. + cells. Blood 101:2024.
42. Lan, F., D. Zeng, M. Higuchi, J. P. Higgins, and S. Strober. 2003. Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells. Biol. Blood Marrow Transplant. 9:355.
43. Morita, Y., J. Yang, R. Gupta, K. Shimizu, E. A. Shelden, J. Endres, J. J. Mule, K. T. McDonagh, and D. A. Fox. 2001. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J. Clin. Invest. 107:1275.
44. Reddy, P., T. Teshima, G. Hildebrandt, D. L. Williams, C. Liu, K. R. Cooke, and J. L. Ferrara. 2003. Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood 101:2877.
45. Fowler, D. H., and R. E. Gress. 2000. Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leak. Lymphoma 38:221.
46. Teshima, T., G. R. Hill, L. Pan, Y. S. Brinson, M. R. van den Brink, K. R. Cooke, and J. L. Ferrara. 1999. IL-11 separates graft-versus-Ieukemia effects from graft-versus-host disease after bone marrow transplantation. J. Clin. Invest. 104:317.
47. + cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model. J. Immunol. 161:2421.
48. Pan, L., J. Delmonte, Jr., C. K. Jalonen, and J. L. Ferrara. 1995. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 86:4422.
49. Morecki, S., S. Panigrahi, G. Pizov, E. Yacovlev, Y. Gelfand, O. Eizik, and S. Slavin. 2004. Effect of KRN7000 on induced graft-versus-host disease Exp. Hematol. 32:630.
50. + NKT cells by repeated stimulation with KRN7000. J. Immunol. Methods 285:197.
51. Giaccone, G., C. J. Punt, Y. Ando, R. Ruijter, N. Nishi, M. Peters, B. M. von Blomberg, R. J. Scheper, H. J. van der Vliet, A. J. van den Eertwegh, et al. 2002. A phase I study of the natural killer T-cell ligand α-galactosylceramide (KRN7000) in patients with solid tumors. Clin. Cancer Res. 8:3702.