메뉴 건너뛰기




Volumn 26, Issue 8, 2014, Pages 1057-1069

The role of bile acids in functional GI disorders

Author keywords

Bile acid diarrhea; Bile acid malabsorption; Bile salts; Chronic functional constipation; Elobixibat; Enterohepatic circulation; Ileum; Obeticholic acid

Indexed keywords

6-ETHYLCHENODEOXYCHOLIC ACID; ANTIDIURETIC AGENT; BILE ACID; CHENODEOXYCHOLIC ACID; DIPEPTIDE; ELOBIXIBAT; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; THIAZEPINE DERIVATIVE;

EID: 84904443299     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12370     Document Type: Review
Times cited : (56)

References (124)
  • 1
    • 33646201266 scopus 로고    scopus 로고
    • The functional gastrointestinal disorders and the Rome III process
    • Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130: 1377-90.
    • (2006) Gastroenterology , vol.130 , pp. 1377-1390
    • Drossman, D.A.1
  • 5
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • Russell DW. Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res 2009; 50(Suppl.): S120-5.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Russell, D.W.1
  • 6
  • 7
    • 0016272230 scopus 로고
    • Gastric emptying and secretion of bile acids, cholesterol, and pancreatic enzymes during digestion. Duodenal perfusion studies in healthy subjects
    • Brunner H, Northfield TC, Hofmann AF, Go VL, Summerskill WH. Gastric emptying and secretion of bile acids, cholesterol, and pancreatic enzymes during digestion. Duodenal perfusion studies in healthy subjects. Mayo Clin Proc 1974; 49: 851-60.
    • (1974) Mayo Clin Proc , vol.49 , pp. 851-860
    • Brunner, H.1    Northfield, T.C.2    Hofmann, A.F.3    Go, V.L.4    Summerskill, W.H.5
  • 8
    • 30844460667 scopus 로고    scopus 로고
    • OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology 2005; 42: 1270-9.
    • (2005) Hepatology , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3    Dawson, P.A.4    Soroka, C.J.5    Boyer, J.L.6    Madejczyk, M.S.7    Li, N.8
  • 9
    • 0015921673 scopus 로고
    • Regulation of bile salt pool size in man
    • Low-Beer TS, Pomare EW. Regulation of bile salt pool size in man. Br Med J 1973; 2: 338-40.
    • (1973) Br Med J , vol.2 , pp. 338-340
    • Low-Beer, T.S.1    Pomare, E.W.2
  • 10
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006; 47: 241-59.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 11
    • 0033611305 scopus 로고    scopus 로고
    • The continuing importance of bile acids in liver and intestinal disease
    • Hofmann AF. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 1999; 159: 2647-58.
    • (1999) Arch Intern Med , vol.159 , pp. 2647-2658
    • Hofmann, A.F.1
  • 16
    • 33751115468 scopus 로고    scopus 로고
    • Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
    • Lundasen T, Galman C, Angelin B, Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 2006; 260: 530-6.
    • (2006) J Intern Med , vol.260 , pp. 530-536
    • Lundasen, T.1    Galman, C.2    Angelin, B.3    Rudling, M.4
  • 17
    • 77955697988 scopus 로고    scopus 로고
    • Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19 - mediated down-regulation of cytochrome P450 7A1
    • Triantis V, Saeland E, Bijl N, Oude-Elferink RP, Jansen PLM. Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19 - mediated down-regulation of cytochrome P450 7A1. Hepatology 2010; 52: 656-66.
    • (2010) Hepatology , vol.52 , pp. 656-666
    • Triantis, V.1    Saeland, E.2    Bijl, N.3    Oude-Elferink, R.P.4    Jansen, P.L.M.5
  • 19
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543-53.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 20
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F. The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 2005; 25: 2020-30.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 24
    • 84898011280 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
    • Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG et al. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. Gut 2013; 63: 808-17.
    • (2013) Gut , vol.63 , pp. 808-817
    • Mroz, M.S.1    Keating, N.2    Ward, J.B.3    Sarker, R.4    Amu, S.5    Aviello, G.6    Donowitz, M.7    Fallon, P.G.8
  • 26
    • 80053241181 scopus 로고    scopus 로고
    • A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys
    • Chiang PC, Thompson DC, Ghosh S, Heitmeier MR. A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys. J Pharm Sci 2011; 100: 4722-33.
    • (2011) J Pharm Sci , vol.100 , pp. 4722-4733
    • Chiang, P.C.1    Thompson, D.C.2    Ghosh, S.3    Heitmeier, M.R.4
  • 28
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147-91.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 29
    • 52449085809 scopus 로고    scopus 로고
    • Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    • Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R. Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants. Am J Physiol Gastrointest Liver Physiol 2008; 295: G260-72.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Kidd, M.1    Modlin, I.M.2    Gustafsson, B.I.3    Drozdov, I.4    Hauso, O.5    Pfragner, R.6
  • 33
    • 80053909415 scopus 로고    scopus 로고
    • Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders
    • e458.
    • Camilleri M, Vazquez-Roque MI, Carlson P, Burton D, Wong BS, Zinsmeister AR. Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders. Neurogastroenterol Motil 2011; 23: 995-9, e458.
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 995-999
    • Camilleri, M.1    Vazquez-Roque, M.I.2    Carlson, P.3    Burton, D.4    Wong, B.S.5    Zinsmeister, A.R.6
  • 35
    • 84895520482 scopus 로고    scopus 로고
    • The bile acid TGR5 membrane receptor: from basic research to clinical application
    • Duboc H, Tache Y, Hofmann AF. The bile acid TGR5 membrane receptor: from basic research to clinical application. Dig Liver Dis 2014; 46: 302-12.
    • (2014) Dig Liver Dis , vol.46 , pp. 302-312
    • Duboc, H.1    Tache, Y.2    Hofmann, A.F.3
  • 36
    • 84860253913 scopus 로고    scopus 로고
    • Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
    • Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, Higuchi H, Matsuoka K, Watanabe M et al. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 2012; 136: 153-62.
    • (2012) Immunology , vol.136 , pp. 153-162
    • Ichikawa, R.1    Takayama, T.2    Yoneno, K.3    Kamada, N.4    Kitazume, M.T.5    Higuchi, H.6    Matsuoka, K.7    Watanabe, M.8
  • 38
    • 0030931230 scopus 로고    scopus 로고
    • Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota
    • Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997; 112: 1448-56.
    • (1997) Gastroenterology , vol.112 , pp. 1448-1456
    • Locke III, G.R.1    Talley, N.J.2    Fett, S.L.3    Zinsmeister, A.R.4    Melton III, L.J.5
  • 39
    • 84865020294 scopus 로고    scopus 로고
    • Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors
    • Sifrim D, Zerbib F. Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 2012; 61: 1340-54.
    • (2012) Gut , vol.61 , pp. 1340-1354
    • Sifrim, D.1    Zerbib, F.2
  • 40
    • 0031052721 scopus 로고    scopus 로고
    • The relationship between acid and bile reflux and symptoms in gastro-oesophageal reflux disease
    • Marshall RE, Anggiansah A, Owen WA, Owen WJ. The relationship between acid and bile reflux and symptoms in gastro-oesophageal reflux disease. Gut 1997; 40: 182-7.
    • (1997) Gut , vol.40 , pp. 182-187
    • Marshall, R.E.1    Anggiansah, A.2    Owen, W.A.3    Owen, W.J.4
  • 41
    • 0141621818 scopus 로고    scopus 로고
    • Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs
    • Inadomi JM, McIntyre L, Bernard L, Fendrick AM. Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs. Am J Gastroenterol 2003; 98: 1940-4.
    • (2003) Am J Gastroenterol , vol.98 , pp. 1940-1944
    • Inadomi, J.M.1    McIntyre, L.2    Bernard, L.3    Fendrick, A.M.4
  • 42
    • 0141757445 scopus 로고    scopus 로고
    • Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors
    • Koek GH, Sifrim D, Lerut T, Janssens J, Tack J. Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors. Gut 2003; 52: 1397-402.
    • (2003) Gut , vol.52 , pp. 1397-1402
    • Koek, G.H.1    Sifrim, D.2    Lerut, T.3    Janssens, J.4    Tack, J.5
  • 43
    • 14544279375 scopus 로고    scopus 로고
    • Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects
    • Siddiqui A, Rodriguez-Stanley S, Zubaidi S, Miner PB Jr. Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects. Dig Dis Sci 2005; 50: 81-5.
    • (2005) Dig Dis Sci , vol.50 , pp. 81-85
    • Siddiqui, A.1    Rodriguez-Stanley, S.2    Zubaidi, S.3    Miner Jr, P.B.4
  • 44
    • 1542399542 scopus 로고    scopus 로고
    • The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro
    • Jenkins GJ, Harries K, Doak SH, Wilmes A, Griffiths AP, Baxter JN, Parry JM. The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis 2004; 25: 317-23.
    • (2004) Carcinogenesis , vol.25 , pp. 317-323
    • Jenkins, G.J.1    Harries, K.2    Doak, S.H.3    Wilmes, A.4    Griffiths, A.P.5    Baxter, J.N.6    Parry, J.M.7
  • 45
    • 79959378981 scopus 로고    scopus 로고
    • Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia
    • McQuaid KR, Laine L, Fennerty MB, Souza R, Spechler SJ. Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. Aliment Pharmacol Ther 2011; 34: 146-65.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 146-165
    • McQuaid, K.R.1    Laine, L.2    Fennerty, M.B.3    Souza, R.4    Spechler, S.J.5
  • 46
    • 84884722289 scopus 로고    scopus 로고
    • Pathophysiology of gastro-esophageal reflux disease: a role for mucosa integrity?
    • Farre R. Pathophysiology of gastro-esophageal reflux disease: a role for mucosa integrity? Neurogastroenterol Motil 2013; 25: 783-99.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 783-799
    • Farre, R.1
  • 48
    • 84872855413 scopus 로고    scopus 로고
    • Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice
    • Cipriani S, Mencarelli A, Bruno A, Renga B, Distrutti E, Santucci L, Baldelli F, Fiorucci S. Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice. Br J Pharmacol 2013; 168: 225-37.
    • (2013) Br J Pharmacol , vol.168 , pp. 225-237
    • Cipriani, S.1    Mencarelli, A.2    Bruno, A.3    Renga, B.4    Distrutti, E.5    Santucci, L.6    Baldelli, F.7    Fiorucci, S.8
  • 50
    • 84858214623 scopus 로고    scopus 로고
    • The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia
    • Atak I, Ozdil K, Yucel M, Caliskan M, Kilic A, Erdem H, Alimoglu O. The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia. Hepatogastroenterology 2012; 59: 59-61.
    • (2012) Hepatogastroenterology , vol.59 , pp. 59-61
    • Atak, I.1    Ozdil, K.2    Yucel, M.3    Caliskan, M.4    Kilic, A.5    Erdem, H.6    Alimoglu, O.7
  • 52
    • 84875223369 scopus 로고    scopus 로고
    • Changes in gastrointestinal tract function and structure in functional dyspepsia
    • Vanheel H, Farre R. Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013; 10: 142-9.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 142-149
    • Vanheel, H.1    Farre, R.2
  • 53
    • 33846785471 scopus 로고    scopus 로고
    • Luminal stimuli acutely sensitize visceromotor responses to distension of the rat stomach
    • Lamb K, Gebhart GF, Bielefeldt K. Luminal stimuli acutely sensitize visceromotor responses to distension of the rat stomach. Dig Dis Sci 2007; 52: 488-94.
    • (2007) Dig Dis Sci , vol.52 , pp. 488-494
    • Lamb, K.1    Gebhart, G.F.2    Bielefeldt, K.3
  • 54
    • 84870302483 scopus 로고    scopus 로고
    • Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects
    • Psichas A, Little T, Lal S, McLaughlin J. Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects. Neurogastroenterol Motil 2012; 24: 1095-101.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 1095-1101
    • Psichas, A.1    Little, T.2    Lal, S.3    McLaughlin, J.4
  • 55
    • 0030462843 scopus 로고    scopus 로고
    • Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids
    • Koop I, Schindler M, Bosshammer A, Scheibner J, Stange E, Koop H. Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids. Gut 1996; 39: 661-7.
    • (1996) Gut , vol.39 , pp. 661-667
    • Koop, I.1    Schindler, M.2    Bosshammer, A.3    Scheibner, J.4    Stange, E.5    Koop, H.6
  • 56
    • 0015105518 scopus 로고
    • Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man
    • Mekjian HS, Phillips SF, Hofmann AF. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest 1971; 50: 1569-77.
    • (1971) J Clin Invest , vol.50 , pp. 1569-1577
    • Mekjian, H.S.1    Phillips, S.F.2    Hofmann, A.F.3
  • 57
    • 0017744731 scopus 로고
    • Effect of glycochenodeoxycholic acid on unidirectional transepithelial fluxes of electrolytes in the perfused human ileum
    • Oddsson E, Rask-Madsen J, Krag E. Effect of glycochenodeoxycholic acid on unidirectional transepithelial fluxes of electrolytes in the perfused human ileum. Scand J Gastroenterol 1977; 12: 199-204.
    • (1977) Scand J Gastroenterol , vol.12 , pp. 199-204
    • Oddsson, E.1    Rask-Madsen, J.2    Krag, E.3
  • 62
    • 0026317183 scopus 로고
    • Efficacy and safety of ursodeoxycholic acid for dissolution of gallstone fragments: comparison with the combination of ursodeoxycholic acid and chenodeoxycholic acid
    • Sackmann M, Pauletzki J, Aydemir U, Holl J, Sauerbruch T, Hasford J, Paumgartner G. Efficacy and safety of ursodeoxycholic acid for dissolution of gallstone fragments: comparison with the combination of ursodeoxycholic acid and chenodeoxycholic acid. Hepatology 1991; 14: 1136-41.
    • (1991) Hepatology , vol.14 , pp. 1136-1141
    • Sackmann, M.1    Pauletzki, J.2    Aydemir, U.3    Holl, J.4    Sauerbruch, T.5    Hasford, J.6    Paumgartner, G.7
  • 64
    • 84881621285 scopus 로고    scopus 로고
    • Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells
    • Ao M, Sarathy J, Domingue J, Alrefai WA, Rao MC. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol 2013; 305: C447-56.
    • (2013) Am J Physiol Cell Physiol , vol.305
    • Ao, M.1    Sarathy, J.2    Domingue, J.3    Alrefai, W.A.4    Rao, M.C.5
  • 66
    • 0018860487 scopus 로고
    • Dose-related effects of chenodeoxycholic acid in the rabbit colon
    • Camilleri M, Murphy R, Chadwick VS. Dose-related effects of chenodeoxycholic acid in the rabbit colon. Dig Dis Sci 1980; 25: 433-8.
    • (1980) Dig Dis Sci , vol.25 , pp. 433-438
    • Camilleri, M.1    Murphy, R.2    Chadwick, V.S.3
  • 69
    • 0031799380 scopus 로고    scopus 로고
    • Lithocholyltaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach
    • Raufman JP, Zimniak P, Bartoszko-Malik A. Lithocholyltaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach. Am J Physiol 1998; 274: G997-1004.
    • (1998) Am J Physiol , vol.274
    • Raufman, J.P.1    Zimniak, P.2    Bartoszko-Malik, A.3
  • 71
    • 1242295305 scopus 로고    scopus 로고
    • Enteric neurones modulate the colonic permeability response to luminal bile acids in rat colon in vivo
    • Sun Y, Fihn BM, Sjovall H, Jodal M. Enteric neurones modulate the colonic permeability response to luminal bile acids in rat colon in vivo. Gut 2004; 53: 362-7.
    • (2004) Gut , vol.53 , pp. 362-367
    • Sun, Y.1    Fihn, B.M.2    Sjovall, H.3    Jodal, M.4
  • 72
    • 80055090450 scopus 로고    scopus 로고
    • The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
    • Cipriani S, Mencarelli A, Chini MG, Distrutti E, Renga B, Bifulco G, Baldelli F, Donini A et al. The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 2011; 6: e25637.
    • (2011) PLoS ONE , vol.6
    • Cipriani, S.1    Mencarelli, A.2    Chini, M.G.3    Distrutti, E.4    Renga, B.5    Bifulco, G.6    Baldelli, F.7    Donini, A.8
  • 73
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 2009; 183: 6251-61.
    • (2009) J Immunol , vol.183 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3    Distrutti, E.4    Fiorucci, S.5
  • 74
    • 0034495248 scopus 로고    scopus 로고
    • Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors
    • Chen X, Yang D, Shen W, Dong HF, Wang JM, Oppenheim JJ, Howard OMZ et al. Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors. Inflamm Res 2000; 49: 744-55.
    • (2000) Inflamm Res , vol.49 , pp. 744-755
    • Chen, X.1    Yang, D.2    Shen, W.3    Dong, H.F.4    Wang, J.M.5    Oppenheim, J.J.6    Howard, O.M.Z.7
  • 75
    • 24344479257 scopus 로고    scopus 로고
    • Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors
    • Cheng K, Raufman JP. Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem Pharmacol 2005; 70: 1035-47.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1035-1047
    • Cheng, K.1    Raufman, J.P.2
  • 77
    • 67649410738 scopus 로고    scopus 로고
    • Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells
    • Yui S, Kanamoto R, Saeki T. Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells. Nutr Cancer 2009; 61: 374-80.
    • (2009) Nutr Cancer , vol.61 , pp. 374-380
    • Yui, S.1    Kanamoto, R.2    Saeki, T.3
  • 79
    • 77955011833 scopus 로고    scopus 로고
    • Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis
    • Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Moyer MP, Bernstein H. Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis. Nutr Cancer 2010; 62: 825-40.
    • (2010) Nutr Cancer , vol.62 , pp. 825-840
    • Payne, C.M.1    Crowley-Skillicorn, C.2    Bernstein, C.3    Holubec, H.4    Moyer, M.P.5    Bernstein, H.6
  • 80
    • 84884355706 scopus 로고    scopus 로고
    • Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome
    • e1.
    • Shin A, Camilleri M, Vijayvargiya P, Busciglio I, Burton D, Ryks M, Rhoten D, Lueke A et al. Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2013; 11: 1270-5 e1.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1270-1275
    • Shin, A.1    Camilleri, M.2    Vijayvargiya, P.3    Busciglio, I.4    Burton, D.5    Ryks, M.6    Rhoten, D.7    Lueke, A.8
  • 81
    • 56749182268 scopus 로고    scopus 로고
    • Altered bile acid metabolism in patients with constipation-predominat irritable bowel syndrome and functional constipation
    • Abrahamsson H, Ostlund-Lindqvist A-M, Nilsson R, Simren M, Gillberg P-G. Altered bile acid metabolism in patients with constipation-predominat irritable bowel syndrome and functional constipation. Scand J Gastroenterol 2008; 43: 1483-8.
    • (2008) Scand J Gastroenterol , vol.43 , pp. 1483-1488
    • Abrahamsson, H.1    Ostlund-Lindqvist, A.-M.2    Nilsson, R.3    Simren, M.4    Gillberg, P.-G.5
  • 82
  • 83
    • 82955195427 scopus 로고    scopus 로고
    • Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation
    • Wong BS, Camilleri M, McKinzie S, Burton D, Graffner H, Zinsmeister AR. Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. Am J Gastroenterol 2011; 106: 2154-64.
    • (2011) Am J Gastroenterol , vol.106 , pp. 2154-2164
    • Wong, B.S.1    Camilleri, M.2    McKinzie, S.3    Burton, D.4    Graffner, H.5    Zinsmeister, A.R.6
  • 84
    • 80053912847 scopus 로고    scopus 로고
    • A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation
    • Chey WD, Camilleri M, Chang L, Rikner L, Graffner H. A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation. Am J Gastroenterol 2011; 106: 1803-12.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1803-1812
    • Chey, W.D.1    Camilleri, M.2    Chang, L.3    Rikner, L.4    Graffner, H.5
  • 85
    • 0014071178 scopus 로고
    • The syndrome of ileal disease and the broken enterohepatic circulation: cholerhetic enteropathy
    • Hofmann AF. The syndrome of ileal disease and the broken enterohepatic circulation: cholerhetic enteropathy. Gastroenterology 1967; 52: 752-7.
    • (1967) Gastroenterology , vol.52 , pp. 752-757
    • Hofmann, A.F.1
  • 86
    • 0017036391 scopus 로고
    • Idiopathic bile acid catharsis
    • Thaysen EH, Pedersen L. Idiopathic bile acid catharsis. Gut 1976; 17: 965-70.
    • (1976) Gut , vol.17 , pp. 965-970
    • Thaysen, E.H.1    Pedersen, L.2
  • 88
    • 69949136438 scopus 로고    scopus 로고
    • Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome
    • Wedlake L, A'Hern R, Russell D, Thomas K, Walters JR, Andreyev HJ. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2009; 30: 707-17.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 707-717
    • Wedlake, L.1    A'Hern, R.2    Russell, D.3    Thomas, K.4    Walters, J.R.5    Andreyev, H.J.6
  • 89
    • 0022540277 scopus 로고
    • Use of 23-selena-25-homocholyltaurine to detect bile acid malabsorption in patients with illeal dysfunction or diarrhea
    • Sciarretta G, Vicini G, Fagioli G, Verri A, Ginevra A, Malaguti P. Use of 23-selena-25-homocholyltaurine to detect bile acid malabsorption in patients with illeal dysfunction or diarrhea. Gastroenterology 1986; 91: 1-9.
    • (1986) Gastroenterology , vol.91 , pp. 1-9
    • Sciarretta, G.1    Vicini, G.2    Fagioli, G.3    Verri, A.4    Ginevra, A.5    Malaguti, P.6
  • 90
    • 0023228639 scopus 로고
    • 75Se HCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit
    • Sciarretta G, Fagioli G, Furno A, Vicini G, Cecchetti L, Grigolo B, Verri A, Malaguti P. 75Se HCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit. Gut 1987; 28: 970-5.
    • (1987) Gut , vol.28 , pp. 970-975
    • Sciarretta, G.1    Fagioli, G.2    Furno, A.3    Vicini, G.4    Cecchetti, L.5    Grigolo, B.6    Verri, A.7    Malaguti, P.8
  • 91
    • 84926261067 scopus 로고    scopus 로고
    • Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS
    • Bajor A, Tornblom H, Rudling M, Ung KA, Simren M. Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS. Gut 2014.
    • (2014) Gut
    • Bajor, A.1    Tornblom, H.2    Rudling, M.3    Ung, K.A.4    Simren, M.5
  • 93
    • 0027245469 scopus 로고
    • Serum 7 alpha-hydroxy-4-cholesten-3-one concentrations in the evaluation of bile acid malabsorption in patients with diarrhoea: correlation to SeHCAT test
    • Eusufzai S, Axelson M, Angelin B, Einarsson K. Serum 7 alpha-hydroxy-4-cholesten-3-one concentrations in the evaluation of bile acid malabsorption in patients with diarrhoea: correlation to SeHCAT test. Gut 1993; 34: 698-701.
    • (1993) Gut , vol.34 , pp. 698-701
    • Eusufzai, S.1    Axelson, M.2    Angelin, B.3    Einarsson, K.4
  • 94
    • 0032917843 scopus 로고    scopus 로고
    • Bile acid malabsorption as a cause of chronic diarrhea: diagnostic value of 7alpha-hydroxy-4-cholesten-3-one in serum
    • Sauter GH, Munzing W, von Ritter C, Paumgartner G. Bile acid malabsorption as a cause of chronic diarrhea: diagnostic value of 7alpha-hydroxy-4-cholesten-3-one in serum. Dig Dis Sci 1999; 44: 14-9.
    • (1999) Dig Dis Sci , vol.44 , pp. 14-19
    • Sauter, G.H.1    Munzing, W.2    von Ritter, C.3    Paumgartner, G.4
  • 95
    • 27744516236 scopus 로고    scopus 로고
    • Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis
    • Galman C, Angelin B, Rudling M. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology 2005; 129: 1445-53.
    • (2005) Gastroenterology , vol.129 , pp. 1445-1453
    • Galman, C.1    Angelin, B.2    Rudling, M.3
  • 96
    • 67650480494 scopus 로고    scopus 로고
    • Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry
    • Camilleri M, Nadeau A, Tremaine WJ, Lamsam J, Burton D, Odunsi S, Sweetser S, Singh R. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil 2009; 21: 734-e43.
    • (2009) Neurogastroenterol Motil , vol.21
    • Camilleri, M.1    Nadeau, A.2    Tremaine, W.J.3    Lamsam, J.4    Burton, D.5    Odunsi, S.6    Sweetser, S.7    Singh, R.8
  • 98
    • 0026165709 scopus 로고
    • Primary bile acid diarrhoea without an ileal carrier defect: quantification of active bile acid transport across the ileal brush border membrane
    • van Tilburg AJ, de Rooij FW, van den Berg JW, van Blankenstein M. Primary bile acid diarrhoea without an ileal carrier defect: quantification of active bile acid transport across the ileal brush border membrane. Gut 1991; 32: 500-3.
    • (1991) Gut , vol.32 , pp. 500-503
    • van Tilburg, A.J.1    de Rooij, F.W.2    van den Berg, J.W.3    van Blankenstein, M.4
  • 100
    • 0030944084 scopus 로고    scopus 로고
    • Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
    • Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest 1997; 99: 1880-7.
    • (1997) J Clin Invest , vol.99 , pp. 1880-1887
    • Oelkers, P.1    Kirby, L.C.2    Heubi, J.E.3    Dawson, P.A.4
  • 101
    • 0034878273 scopus 로고    scopus 로고
    • Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption
    • Montagnani M, Love MW, Rossel P, Dawson PA, Qvist P. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand J Gastroenterol 2001; 36: 1077-80.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 1077-1080
    • Montagnani, M.1    Love, M.W.2    Rossel, P.3    Dawson, P.A.4    Qvist, P.5
  • 102
    • 42149145538 scopus 로고    scopus 로고
    • Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea
    • Balesaria S, Pell RJ, Abbott LJ, Tasleem A, Chavele K-M, Barley NF, Khair U, Simon A et al. Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea. Eur J Gastroenterol Hepatol 2008; 20: 413-22.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 413-422
    • Balesaria, S.1    Pell, R.J.2    Abbott, L.J.3    Tasleem, A.4    Chavele, K.-M.5    Barley, N.F.6    Khair, U.7    Simon, A.8
  • 105
    • 84864459266 scopus 로고    scopus 로고
    • Fibroblast growth factor 19 and 7alpha-hydroxy-4-cholesten-3-one in the diagnosis of patients with possible bile acid diarrhea
    • Pattni SS, Brydon WG, Dew T, Walters JR. Fibroblast growth factor 19 and 7alpha-hydroxy-4-cholesten-3-one in the diagnosis of patients with possible bile acid diarrhea. Clin Transl Gastroenterol 2012; 3: e18.
    • (2012) Clin Transl Gastroenterol , vol.3
    • Pattni, S.S.1    Brydon, W.G.2    Dew, T.3    Walters, J.R.4
  • 109
  • 111
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson E, Fu L, John L, Hultgren B, Huang X, Renz M, Stephan JP, Tsai SP et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 2002; 143: 1741-7.
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3    Hultgren, B.4    Huang, X.5    Renz, M.6    Stephan, J.P.7    Tsai, S.P.8
  • 112
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
    • Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev 2012; 26: 312-24.
    • (2012) Genes Dev , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 113
    • 84861201380 scopus 로고    scopus 로고
    • Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
    • e246-7.
    • Duboc H, Rainteau D, Rajca S, Humbert L, Farabos D, Maubert M, Grondin V, Jouet P et al. Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 2012; 24: 513-20, e246-7.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 513-520
    • Duboc, H.1    Rainteau, D.2    Rajca, S.3    Humbert, L.4    Farabos, D.5    Maubert, M.6    Grondin, V.7    Jouet, P.8
  • 114
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin SI, Wahlstrom A, Felin J, Jantti S, Marschall HU, Bamberg K, Angelin B, Hyotylainen T et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013; 17: 225-35.
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.I.1    Wahlstrom, A.2    Felin, J.3    Jantti, S.4    Marschall, H.U.5    Bamberg, K.6    Angelin, B.7    Hyotylainen, T.8
  • 115
    • 0014686822 scopus 로고
    • Cholestyramine treatment of diarrhea associated with ileal resection
    • Hofmann AF, Poley JR. Cholestyramine treatment of diarrhea associated with ileal resection. N Engl J Med 1969; 281: 397-402.
    • (1969) N Engl J Med , vol.281 , pp. 397-402
    • Hofmann, A.F.1    Poley, J.R.2
  • 116
    • 84904424329 scopus 로고    scopus 로고
    • Effect of cholestyramine on gastrointestinal transit in patients with idiopathic bile acid diarrhea: a prospective, open-label study
    • Stotzer P-O, Abrahamsson H, Bajor A, Sadik R. Effect of cholestyramine on gastrointestinal transit in patients with idiopathic bile acid diarrhea: a prospective, open-label study. Neuroenterology 2013; 2.
    • (2013) Neuroenterology , vol.2
    • Stotzer, P.-O.1    Abrahamsson, H.2    Bajor, A.3    Sadik, R.4
  • 117
    • 80855132773 scopus 로고    scopus 로고
    • Bile acid malabsorption investigated by selenium-75-homocholic acid taurine ((75)SeHCAT) scans: causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea
    • Borghede MK, Schlutter JM, Agnholt JS, Christensen LA, Gormsen LC, Dahlerup JF. Bile acid malabsorption investigated by selenium-75-homocholic acid taurine ((75)SeHCAT) scans: causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea. Eur J Intern Med 2011; 22: e137-40.
    • (2011) Eur J Intern Med , vol.22
    • Borghede, M.K.1    Schlutter, J.M.2    Agnholt, J.S.3    Christensen, L.A.4    Gormsen, L.C.5    Dahlerup, J.F.6
  • 118
    • 33846838863 scopus 로고    scopus 로고
    • Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice
    • Kamal-Bahl SJ, Burke T, Watson D, Wentworth C. Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice. Am J Cardiol 2007; 99: 530-4.
    • (2007) Am J Cardiol , vol.99 , pp. 530-534
    • Kamal-Bahl, S.J.1    Burke, T.2    Watson, D.3    Wentworth, C.4
  • 119
    • 0021804353 scopus 로고
    • Effect of enterocoated cholestyramine on bowel habit after ileal resection: a double blind crossover study
    • Jacobsen O, Hojgaard L, Moller EH, Weilandt TO, Thale M, Jarnum S, Krag E. Effect of enterocoated cholestyramine on bowel habit after ileal resection: a double blind crossover study. Br Med J 1985; 290: 1315-8.
    • (1985) Br Med J , vol.290 , pp. 1315-1318
    • Jacobsen, O.1    Hojgaard, L.2    Moller, E.H.3    Weilandt, T.O.4    Thale, M.5    Jarnum, S.6    Krag, E.7
  • 120
    • 70349515826 scopus 로고    scopus 로고
    • Quantitative structure-property relationships modeling to predict in vitro and in vivo binding of drugs to the bile sequestrant, colesevelam (Welchol)
    • Walker JR, Brown K, Rohatagi S, Bathala MS, Xu C, Wickremasingha PK, Salazar DE, Mager DE. Quantitative structure-property relationships modeling to predict in vitro and in vivo binding of drugs to the bile sequestrant, colesevelam (Welchol). J Clin Pharmacol 2009; 49: 1185-95.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1185-1195
    • Walker, J.R.1    Brown, K.2    Rohatagi, S.3    Bathala, M.S.4    Xu, C.5    Wickremasingha, P.K.6    Salazar, D.E.7    Mager, D.E.8
  • 121
    • 74549201833 scopus 로고    scopus 로고
    • Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: a retrospective chart review and patient questionnaire
    • Wedlake L, Thomas K, Lalji A, Anagnostopoulos C, Andreyev HJ. Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: a retrospective chart review and patient questionnaire. Clin Ther 2009; 31: 2549-58.
    • (2009) Clin Ther , vol.31 , pp. 2549-2558
    • Wedlake, L.1    Thomas, K.2    Lalji, A.3    Anagnostopoulos, C.4    Andreyev, H.J.5
  • 122
    • 84886632403 scopus 로고    scopus 로고
    • A new therapy for chronic diarrhea? A proof of concept study of the FXR agonist obeticholic acid in patients with primary bile acid diarrhea
    • Johnston IM, Nolan JD, Dew T, Shapiro D, Walters JRF. A new therapy for chronic diarrhea? A proof of concept study of the FXR agonist obeticholic acid in patients with primary bile acid diarrhea. Dig Dis Week Orlando FL 2013; 144: s-60.
    • (2013) Dig Dis Week Orlando FL , vol.144
    • Johnston, I.M.1    Nolan, J.D.2    Dew, T.3    Shapiro, D.4    Walters, J.R.F.5
  • 123
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • e1.
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-82 e1.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6
  • 124
    • 33845490017 scopus 로고    scopus 로고
    • Budesonide treatment is associated with increased bile acid absorption in collagenous colitis
    • Bajor A, Kilander A, Galman C, Rudling M, Ung KA. Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. Aliment Pharmacol Ther 2006; 24: 1643-9.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1643-1649
    • Bajor, A.1    Kilander, A.2    Galman, C.3    Rudling, M.4    Ung, K.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.