Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: A retrospective chart review and patient questionnaire

Clinical Therapeutics

Volumn 31, Issue 11, 2009, Pages 2549-2558

  Wedlake, Linda ^a   Thomas, Karen ^a   Lalji, Amyn ^a   Anagnostopoulos, Constantinos ^b   Andreyev, H Jervoise N ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

bile acid; bile acid sequestrant; cholestyramine; colesevelam; colestipol

Indexed keywords

ANTINEOPLASTIC AGENT; COLESEVELAM; COLESTYRAMINE;

ABDOMINAL PAIN; ADULT; ANUS DISEASE; ARTICLE; BILE ACID MALABSORPTION; BLOATING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; CROHN DISEASE; DEFECATION; DIARRHEA; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ELECTRONIC MEDICAL RECORD; FACE EDEMA; FECES INCONTINENCE; FEMALE; FLATULENCE; FOLLOW UP; GASTROINTESTINAL SURGERY; HEARTBURN; HUMAN; INTESTINE RESECTION; LEG EDEMA; LOOSE FECES; MALABSORPTION; MALE; MALIGNANT NEOPLASTIC DISEASE; PRESCRIPTION; QUESTIONNAIRE; RETROSPECTIVE STUDY; SIDE EFFECT; STEATORRHEA; SYMPTOM; WEIGHT GAIN;

ADULT; AGED; AGED, 80 AND OVER; ALLYLAMINE; ANTICHOLESTEREMIC AGENTS; ANTINEOPLASTIC AGENTS; BILE ACIDS AND SALTS; CHOLESTYRAMINE RESIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; MALABSORPTION SYNDROMES; MALE; MIDDLE AGED; NEOPLASMS; QUALITY ASSURANCE, HEALTH CARE; QUESTIONNAIRES; RADIOTHERAPY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 74549201833     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2009.11.027     Document Type: Article

References (16)

1. Eusufzai S. Bile acid malabsorption: Mechanisms and treatment. Dig Dis. 13 (1995) 312-321
2. Smith M.J., Cherian P., Raju G.S., et al. Bile acid malabsorption in persistent diarrhoea. J R Coll Physicians Lond. 34 (2000) 448-451
3. Hofmann A.F., Mangelsdorf D.J., and Kliewer S.A. Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: A new syndrome of defective fibroblast growth factor 19 release. Clin Gastroenterol Hepatol. 7 (2009) 1151-1154
4. Ford G.A., Preece J.D., Davies I.H., and Wilkinson S.P. Use of the SeHCAT test in the investigation of diarrhoea. Postgrad Med J. 68 (1992) 272-276
5. Rössel P., Sortsøe Jensen H., Quist P., and Arvaschoug A. Prognosis of adult-onset idiopathic bile acid malabsorption. Scand J Gastroenterol. 34 (1999) 587-590
6. Hiatt J.G., Shamsie S.G., and Schectman G. Discontinuation rates of cholesterol-lowering medications: Implications for primary care. Am J Manag Care. 5 (1999) 437-444
7. Davidson M.H., Dillon M.A., Gordon B., et al. Colesevelam hydrochloride (cholestagel): A new, potent bile acid sequestrant associated with a low incidence of gastrointestinal side effects. Arch Intern Med. 159 (1999) 1893-1900
8. Donovan J.M., Von Bergmann K., Setchell K.D., et al. Effects of colesevelam HCl on sterol and bile acid excretion in patients with type IIa hypercholesterolemia. Dig Dis Sci. 50 (2005) 1232-1238
9. Insull Jr. W.J. Clinical utility of bile acid sequestrants in the treatment of dyslipidemia: A scientific review. South Med J. 99 (2006) 257-273
10. Jewkes A.J., Windsor C.W., Ward R.S., and Timmins A.E. Relationship between bile acid malabsorption using the 75Se homocholic acid taurine scanning method and diarrhoea following right hemicolectomy. Br J Surg. 76 (1989) 707-708
11. Stryker J.A., and Demers L.M. The effect of pelvic irradiation on the absorption of bile acids. Int J Radiat Oncol Biol Phys. 5 (1979) 935-939
12. Gillespie C., Goode C., Hackett C., and Andreyev H.J. The clinical needs of patients with chronic gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther. 26 (2007) 555-563
13. Andreyev J. Gastrointestinal symptoms after pelvic radiotherapy: A new understanding to improve the management of symptomatic patients. Lancet Oncol. 8 (2007) 1007-1017
14. Wedlake L., A'Hern R., Russell D., et al. Systematic review: The prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoeapredominant irritable bowel syndrome. Aliment Pharmacol Ther. 30 (2009) 707-717
15. Luman W., Williams A.J., Merrick M.V., and Eastwood M.A. Idiopathic bile acid malabsorption: Long-term outcome. Eur J Gastroenterol Hepatol. 7 (1995) 641-645
16. Andreyev H.J., Vlavianos P., Blake P., et al. Gastrointestinal symptoms after pelvic radiotherapy: Role for the gastroenterologist?. Int J Radiol Biol Phys. 62 (2005) 1464-1471