Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis

Gastroenterology

Volumn 129, Issue 5, 2005, Pages 1445-1453

  Gälman, Cecilia ^a   Angelin, Bo ^a   Rudling, Mats ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; CHOLEST 4 EN 3 ONE; LATHOSTEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BILE ACID SYNTHESIS; CHOLECYSTECTOMY; CHOLESTEROL SYNTHESIS; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; HUMAN; LIPID BLOOD LEVEL; MALE; NIGHT; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; STANDARDIZATION;

EID: 27744516236     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.09.009     Document Type: Article

References (41)

1. D.W. Russell, K.D. Setchell Bile acid biosynthesis Biochemistry 31 1992 4737 4749
2. M. Fuchs Bile acid regulation of hepatic physiology: III. Regulation of bile acid synthesis: past progress and future challenges Am J Physiol Gastrointest Liver Physiol 284 2003 G551 G557
3. G.A. Kullak-Ublick, B. Stieger, P.J. Meier Enterohepatic bile salt transporters in normal physiology and liver disease Gastroenterology 126 2004 322 342
4. M.C. Carey, W.C. Duane Enterohepatic circulation I.M. Arias J.L. Boyer N. Fausto W.B. Jacoby D.A. Schachter D.A. Shafritz The liver biology and pathobiology 3rd ed. 1994 Raven Press New York 719 767
5. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease JAMA 251 1984 351 364
6. S. Zanlungo, F. Nervi The molecular and metabolic basis of biliary cholesterol secretion and gallstone disease Front Biosci 8 2003 s1166 s1174
7. C. Galman, J.F. Miquel, R.M. Perez, C. Einarsson, L. Stahle, G. Marshall, F. Nervi, M. Rudling Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians Gastroenterology 126 2004 741 748
8. D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.M. Lobaccaro, R.E. Hammer, D.J. Mangelsdorf Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 1998 693 704
9. J.Y. Chen, B. Levy-Wilson, S. Goodart, A.D. Cooper Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet J Biol Chem 277 2002 42588 42595
10. J.Y. Chiang, R. Kimmel, D. Stroup Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha) Gene 262 2001 257 265
11. B. Hamprecht, C. Nussler, F. Lynen Rhythmic changes of hydroxymethylglutaryl coenzyme a reductase activity in livers of fed and fasted rats FEBS Lett 4 1969 117 121
12. D.J. Shapiro, V.W. Rodwell Diurnal variation and cholesterol regulation of hepatic HMG-CoA reductase activity Biochem Biophys Res Commun 37 1969 867 872
13. P.A. Edwards, H. Muroya, R.G. Gould In vivo demonstration of the circadian rhythm of cholesterol biosynthesis in the liver and intestine of the rat J Lipid Res 13 1972 396 401
14. S.S. Sundseth, D.J. Waxman Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback J Biol Chem 265 1990 15090 15095
15. C. Galman, I. Arvidsson, B. Angelin, M. Rudling Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood J Lipid Res 44 2003 859 866
16. M. Noshiro, M. Nishimoto, K. Okuda Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm J Biol Chem 265 1990 10036 10041
17. D.J. Lavery, U. Schibler Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP Genes Dev 7 1993 1871 1884
18. Y.H. Lee, J.A. Alberta, F.J. Gonzalez, D.J. Waxman Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression J Biol Chem 269 1994 14681 14689
19. P.A. Pooler, W.C. Duane Effects of bile acid administration on bile acid synthesis and its circadian rhythm in man Hepatology 8 1988 1140 1146
20. W.C. Duane, D.G. Levitt, S.M. Mueller, J.C. Behrens Regulation of bile acid synthesis in man. Presence of a diurnal rhythm J Clin Invest 72 1983 1930 1936
21. R.R. Kopito, S.B. Weinstock, L.E. Freed, D.M. Murray, H. Brunengraber Metabolism of plasma mevalonate in rats and humans J Lipid Res 23 1982 577 583
22. A.S. Pappu, D.R. Illingworth Diurnal variations in the plasma concentrations of mevalonic acid in patients with abetalipoproteinaemia Eur J Clin Invest 24 1994 698 702
23. T.A. Miettinen Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins J Lipid Res 23 1982 466 473
24. T.S. Parker, D.J. McNamara, C. Brown, O. Garrigan, R. Kolb, H. Batwin, E.H. Ahrens Jr Mevalonic acid in human plasma relationship of concentration and circadian rhythm to cholesterol synthesis rates in man Proc Natl Acad Sci U S A 79 1982 3037 3041
25. L.K. Cella, E. Van Cauter, D.A. Schoeller Effect of meal timing on diurnal rhythm of human cholesterol synthesis Am J Physiol 269 1995 E878 E883
26. L. Pettersson, C.G. Eriksson Reversed-phase high-performance liquid chromatographic determination of 7 alpha-hydroxy-4-cholesten-3-one in human serum J Chromatogr B Biomed Appl 657 1994 31 36
27. E. Lund, L. Sisfontes, E. Reihner, I. Bjorkhem Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry Scand J Clin Lab Invest 49 1989 165 171
28. M. Rudling, B. Angelin Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo J Clin Invest 91 1993 2796 2805
29. S. Skrede, I. Bjorkhem Biosynthesis of cholestanol from intestinal 7 alpha-hydroxy-4-cholesten-3-one J Biol Chem 257 1982 8363 8367
30. B. Angelin, I. Bjorkhem, K. Einarsson, S. Ewerth Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum J Clin Invest 70 1982 724 731
31. B. Angelin, I. Bjorkhem Postprandial serum bile acids in healthy man. Evidence for differences in absorptive pattern between individual bile acids Gut 18 1977 606 609
32. S.W. Schalm, N.F. LaRusso, A.F. Hofmann, N.E. Hoffman, G.P. van Berge-Henegouwen, M.G. Korman Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid Gut 19 1978 1006 1014
33. L.K. Cella, E. Van Cauter, D.A. Schoeller Diurnal rhythmicity of human cholesterol synthesis normal pattern and adaptation to simulated "jet lag" Am J Physiol 269 1995 E489 E498
34. M. Axelson, A. Aly, J. Sjovall Levels of 7 alpha-hydroxy-4-cholesten-3- one in plasma reflect rates of bile acid synthesis in man FEBS Lett 239 1988 324 328
35. M. Axelson, I. Bjorkhem, E. Reihner, K. Einarsson The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man FEBS Lett 284 1991 216 218
36. G. Sauter, F. Berr, U. Beuers, S. Fischer, G. Paumgartner Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans Hepatology 24 1996 123 126
37. T. Yoshida, A. Honda, N. Tanaka, Y. Matsuzaki, J. Shoda, B. He, T. Osuga, H. Miyazaki Determination of 7 alpha-hydroxy-4-cholesten-3-one level in plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in humans as an index of bile acid biosynthesis J Chromatogr B Biomed Appl 655 1994 179 187
38. J.R. Li, D.N. Kim, K.T. Lee, J.M. Reiner, W.A. Thomas Effect of clofibrate, cholestyramine, cholesterol and feeding pattern on the diurnal variation of cholesterol 7 alpha-hydroxylation in swine Exp Mol Pathol 32 1980 52 60
39. B. Angelin, I. Bjorkhem, K. Einarsson, S. Ewerth Cholestyramine treatment reduces postprandial but not fasting serum bile acid levels in humans Gastroenterology 83 1982 1097 1101
40. J.A. Holt, G. Luo, A.N. Billin, J. Bisi, Y.Y. McNeill, K.F. Kozarsky, M. Donahee, Y. Wang da, T.A. Mansfield, S.A. Kliewer, B. Goodwin, S.A. Jones Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis Genes Dev 17 2003 1581 1591
41. J. Van Cantfort, J.E. Gielen Comparison of rat and mouse circadian rhythm of cholesterol-7 alpha-hydroxylase activity J Steroid Biochem 10 1979 647 651