Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress

Cellular Signalling

Volumn 26, Issue 10, 2014, Pages 2122-2130

  Park, Dohyun ^a   Lee, Mi Nam ^a   Jeong, Heeyoon ^a   Koh, Ara ^a   Yang, Yong Ryoul ^b   Suh, Pann Ghill ^b   Ryu, Sung Ho ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

Mitochondrial stress; MTOR; MTORC1; Parkin; Ubiquitination

Indexed keywords

ARGININE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PARKIN; PROTEASOME; PROTEIN K2066; PROTEIN K2306; UNCLASSIFIED DRUG; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CARBONYLCYANIDE 4-CHLOROPHENYLHYDRAZONE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN BINDING; RAPAMYCIN; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRIAL STRESS; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; HEK293 CELLS; HUMANS; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIROLIMUS; TOR SERINE-THREONINE KINASES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84904430677     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.06.010     Document Type: Article

References (41)

1. Pilsl A., Winklhofer K.F. Acta Neuropathol. 2012, 123:173-188.
2. Vafai S.B., Mootha V.K. Nature 2012, 491:374-383.
3. Novak I. Antioxid. Redox Signal. 2012, 17:794-802.
4. Li Z.Y., Yang Y., Ming M., Liu B. Biochem. Biophys. Res. Commun. 2011, 414:5-8.
5. Laplante M., Sabatini D.M. J. Cell Sci. 2009, 122:3589-3594.
6. Budanov A.V., Karin M. Cell 2008, 134:451-460.
7. Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., Witters L.A., Ellisen L.W., Kaelin W.G. Genes Dev. 2004, 18:2893-2904.
8. Inoki K., Zhu T., Guan K.L. Cell 2003, 115:577-590.
9. Kim S.G., Hoffman G.R., Poulogiannis G., Buel G.R., Jang Y.J., Lee K.W., Kim B.Y., Erikson R.L., Cantley L.C., Choo A.Y., Blenis J. Mol. Cell 2013, 49:172-185.
10. Dennis P.B., Jaeschke A., Saitoh M., Fowler B., Kozma S.C., Thomas G. Science (New York, N.Y.) 2001, 294:1102-1105.
11. Kwon K.Y., Viollet B., Yoo O.J. Biochem. Biophys. Res. Commun. 2011, 416:343-348.
12. Narendra D., Tanaka A., Suen D.F., Youle R.J. J. Cell Biol. 2008, 183:795-803.
13. Van Humbeeck C., Cornelissen T., Hofkens H., Mandemakers W., Gevaert K., De Strooper B., Vandenberghe W. J. Neurosci. Off. J. Soc. Neurosci. 2011, 31:10249-10261.
14. Ding W.X., Yin X.M. Biol. Chem. 2012, 393:547-564.
15. Kuroda Y., Mitsui T., Kunishige M., Shono M., Akaike M., Azuma H., Matsumoto T. Hum. Mol. Genet. 2006, 15:883-895.
16. Shin J.H., Ko H.S., Kang H., Lee Y., Lee Y.I., Pletinkova O., Troconso J.C., Dawson V.L., Dawson T.M. Cell 2011, 144:689-702.
17. Kang Y.J., Lu M.K., Guan K.L. Cell Death Differ. 2011, 18:133-144.
18. Cunningham J.T., Rodgers J.T., Arlow D.H., Vazquez F., Mootha V.K., Puigserver P. Nature 2007, 450:736-740.
19. Morita M., Gravel S.P., Chenard V., Sikstrom K., Zheng L., Alain T., Gandin V., Avizonis D., Arguello M., Zakaria C., McLaughlan S., Nouet Y., Pause A., Pollak M., Gottlieb E., Larsson O., St-Pierre J., Topisirovic I., Sonenberg N. Cell Metab. 2013, 18:698-711.
20. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Cell 2002, 110:163-175.
21. Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. Curr. Biol. 2004, 14:1296-1302.
22. Sarraf S.A., Raman M., Guarani-Pereira V., Sowa M.E., Huttlin E.L., Gygi S.P., Harper J.W. Nature 2013, 496:372-376.
23. Winklhofer K.F. Trends Cell Biol. 2014, 24(6):332-341.
24. Chen D., Gao F., Li B., Wang H., Xu Y., Zhu C., Wang G. J. Biol. Chem. 2010, 285:38214-38223.
25. Tanaka A., Cleland M.M., Xu S., Narendra D.P., Suen D.F., Karbowski M., Youle R.J. J. Cell Biol. 2010, 191:1367-1380.
26. Wang X., Winter D., Ashrafi G., Schlehe J., Wong Y.L., Selkoe D., Rice S., Steen J., Lavoie M.J., Schwarz T.L. Cell 2011, 147:893-906.
27. Baker B.M., Nargund A.M., Sun T., Haynes C.M. PLoS Genet. 2012, 8:e1002760.
28. McLeod L.E., Proud C.G. FEBS Lett. 2002, 531:448-452.
29. Matsuda N., Sato S., Shiba K., Okatsu K., Saisho K., Gautier C.A., Sou Y.S., Saiki S., Kawajiri S., Sato F., Kimura M., Komatsu M., Hattori N., Tanaka K. J. Cell Biol. 2010, 189:211-221.
30. Narendra D.P., Jin S.M., Tanaka A., Suen D.F., Gautier C.A., Shen J., Cookson M.R., Youle R.J. PLoS Biol. 2010, 8:e1000298.
31. Ng S., Wu Y.T., Chen B., Zhou J., Shen H.M. Autophagy 2011, 7:1173-1186.
32. Qiu F., Chen Y.R., Liu X., Chu C.Y., Shen L.J., Xu J., Gaur S., Forman H.J., Zhang H., Zheng S., Yen Y., Huang J., Kung H.J., Ann D.K. Sci. Signal. 2014, 7:ra31.
33. Reynolds IV T.H., Bodine S.C., Lawrence J.C. J. Biol. Chem. 2002, 277:17657-17662.
34. Soliman G.A., Acosta-Jaquez H.A., Dunlop E.A., Ekim B., Maj N.E., Tee A.R., Fingar D.C. J. Biol. Chem. 2010, 285:7866-7879.
35. Ekim B., Magnuson B., Acosta-Jaquez H.A., Keller J.A., Feener E.P., Fingar D.C. Mol. Cell. Biol. 2011, 31:2787-2801.
36. Mao J.H., Kim I.J., Wu D., Climent J., Kang H.C., DelRosario R., Balmain A. Science (New York, N.Y.) 2008, 321:1499-1502.
37. Linares J.F., Duran A., Yajima T., Pasparakis M., Moscat J., Diaz-Meco M.T. Mol. Cell 2013, 51:283-296.
38. Oshiro N., Yoshino K., Hidayat S., Tokunaga C., Hara K., Eguchi S., Avruch J., Yonezawa K. Genes Cells 2004, 9:359-366.
39. Yilmaz O.H., Valdez R., Theisen B.K., Guo W., Ferguson D.O., Wu H., Morrison S.J. Nature 2006, 441:475-482.
40. Kharas M.G., Okabe R., Ganis J.J., Gozo M., Khandan T., Paktinat M., Gilliland D.G., Gritsman K. Blood 2010, 115:1406-1415.
41. Kalaitzidis D., Sykes S.M., Wang Z., Punt N., Tang Y., Ragu C., Sinha A.U., Lane S.W., Souza A.L., Clish C.B., Anastasiou D., Gilliland D.G., Scadden D.T., Guertin D.A., Armstrong S.A. Cell Stem Cell 2012, 11:429-439.