Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells

Journal of Bone and Mineral Metabolism

Volumn 28, Issue 4, 2010, Pages 418-423

  Morimoto, Daiki ^a   Tomita, Tetsuya ^a   Kuroda, Shoko ^a   Higuchi, Chikahisa ^a   Kato, Shinichi ^b   Shiba, Toshikazu ^b   Nakagami, Hironori ^a   Morishita, Ryuichi ^a   Yoshikawa, Hideki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Regenetiss Inc   (Japan)

Author keywords

Bone formation; Human mesenchymal stem cells; Inorganic polyphosphate; Osteoblast

Indexed keywords

ALIZARIN RED S; ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1A; MATRIX PROTEIN; OSTEOCALCIN; POLYPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; POLYMERASE CHAIN REACTION;

ALKALINE PHOSPHATASE; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOCALCIN; POLYMERASE CHAIN REACTION; POLYPHOSPHATES; MESENCHYMAL STROMAL CELLS;

EID: 77956475166     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-010-0157-4     Document Type: Article

References (20)

1. Kornberg A (1995) Inorganic polyphosphate: toward making a forgotten polymer unforgettable. J Bacteriol 177:491-496
2. Shiba T, Tsutsumi K, Ishige K, Noguchi T (2000) Inorganic polyphosphate and polyphosphate kinase: their novel biological functions and applications. Biochemistry (Mosc) 65:315-323
3. Brown MR, Kornberg A (2004) Inorganic polyphosphate in the origin and survival of species. Proc Natl Acad Sci USA 101:16085-16087
4. Wang L, Fraley CD, Faridi J, Kornberg A, Roth RA (2003) Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells. Proc Natl Acad Sci USA 100:11249-11254
5. Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH (2006) Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci USA 103:903-908
6. Han KY, Hong BS, Yoon YJ, Yoon CM, Kim YK, Kwon YG, Gho YS (2007) Polyphosphate blocks tumour metastasis via antiangiogenic activity. Biochem J 406:49-55
7. Yamaoka M, Uematsu T, Shiba T, Matsuura T, Ono Y, Ishizuka M, Naramoto H, Takahashi M, Sugiura-Tomita M, Iguchi K, Yamashita S, Furusawa K (2008) Effect of inorganic polyphosphate in periodontitis in the elderly. Gerodontology 25:10-17
8. Leyhausen G, Lorenz B, Zhu H, Geurtsen W, Bohnensack R, Muller WE, Schroder HC (1998) Inorganic polyphosphate in human osteoblast-like cells. J Bone Miner Res 13:803-812
9. Schroder HC, Kurz L, Muller WE, Lorenz B (2000) Polyphosphate in bone. Biochemistry (Mosc) 65:296-303
10. Kawazoe Y, Shiba T, Nakamura R, Mizuno A, Tsutsumi K, Uematsu T, Yamaoka M, Shindoh M, Kohgo T (2004) Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate. J Dent Res 83:613-618
11. Hacchou Y, Uematsu T, Ueda O, Usui Y, Uematsu S, Takahashi M, Uchihashi T, Kawazoe Y, Shiba T, Kurihara S, Yamaoka M, Furusawa K (2007) Inorganic polyphosphate: a possible stimulant of bone formation. J Dent Res 86:893-897
12. Shiba T, Nishimura D, Kawazoe Y, Onodera Y, Tsutsumi K, Nakamura R, Ohshiro M (2003) Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate. J Biol Chem 278:26788-26792
13. Morimoto D, Kuroda S, Kizawa T, Nomura K, Higuchi C, Yoshikawa H, Tomita T (2009) Equivalent osteoblastic differentiation function of human mesenchymal stem cells from rheumatoid arthritis in comparison with osteoarthritis. Rheumatology 48:643-649
14. Stein GS, Lian JB (1993) Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14: 424-442
15. Siggelkow H, Rebenstorff K, Kurre W, Niedhart C, Engel I, Schulz H, Atkinson MJ, Hufner M (1999) Development of the osteoblast phenotype in primary human osteoblasts in culture: comparison with rat calvarial cells in osteoblast differentiation. J Cell Biochem 75:22-35
16. Kawazoe Y, Katoh S, Onodera Y, Kohgo T, Shindoh M, Shiba T (2008) Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate. Int J Biol Sci 4:37-47
17. Zaidi M (2007) Skeletal remodeling in health and disease. Nat Med 13:791-801
18. Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85:307-310
19. Goldring SR (2003) Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxf) 42:ii11-ii16
20. Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature (Lond) 423:337-342