Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin

Blood

Volumn 115, Issue 19, 2010, Pages 3980-3988

  Mutch, Nicola J ^a   Engel, Ruchira ^a   De Willige, Shirley Uitte ^b   Philippou, Helen ^b   Ariëns, Robert A S ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; PLASMIN; PLASMINOGEN; POLYPHOSPHATE; PROTEIN DISULFIDE ISOMERASE; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BLOOD CLOTTING; CROSS LINKING; DOWN REGULATION; FIBRINOLYSIS; HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; METABOLISM;

DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIBRIN; FIBRINOLYSIN; FIBRINOLYSIS; HUMANS; PLASMINOGEN; POLYPHOSPHATES; SURFACE PLASMON RESONANCE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 77952974521     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-11-254029     Document Type: Article

References (40)

1. Weisel JW, Stauffacher CV, Bullitt E, Cohen C. A model for fibrinogen: domains and sequence. Science. 1985;230(4732):1388-1391.
2. Doolittle RF, Yang Z, Mochalkin I. Crystal structure studies on fibrinogen and fibrin. Ann N Y Acad Sci. 2001;936:31-43. (Pubitemid 32613891)
3. Weisel JW. Fibrin assembly. Lateral aggregation and the role of the two pairs of fibrinopeptides. Biophys J. 1986;50(6):1079-1093.
4. Shainoff JR, Dardik BN. Fibrinopeptide B in fibrin assembly and metabolism: physiologic significance in delayed release of the peptide. Ann N Y Acad Sci. 1983;408:254-268.
5. Hantgan R, Fowler W, Erickson H, Hermans J. Fibrin assembly: a comparison of electron microscopic and light scattering results. Thromb Haemost. 1980;44(3):119-124. (Pubitemid 11196249)
6. Weisel JW, Nagaswami C. Computer modeling of fibrin polymerization kinetics correlated with electron microscope and turbidity observations: clot structure and assembly are kinetically controlled. Biophys J. 1992;63(1):111-128.
7. Fatah K, Silveira A, Tornvall P, Karpe F, Blomback M, Hamsten A. Proneness to formation of tight and rigid fibrin gel structures in men with myocardial infarction at a young age. Thromb Haemost. 1996;76(4):535-540. (Pubitemid 26372007)
8. Bounameaux H. Factor V Leiden paradox: risk of deep-vein thrombosis but not of pulmonary embolism. Lancet. 2000;356(9225):182-183. (Pubitemid 30446970)
9. Collet JP, Allali Y, Lesty C, et al. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol. 2006;26(11):2567-2573. (Pubitemid 44607482)
10. Lewis SD, Janus TJ, Lorand L, Shafer JA. Regulation of formation of factor XIIIa by its fibrin substrates. Biochemistry. 1985;24(24):6772-6777. (Pubitemid 16170204)
11. Gabriel DA, Muga K, Boothroyd EM. The effect of fibrin structure on fibrinolysis. J Biol Chem. 1992;267(34):24259-24263.
12. Hoylaerts M, Rijken DC, Lijnen HR, Collen D. Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. J Biol Chem. 1982;257(6):2912-2919. (Pubitemid 12118804)
13. Collet JP, Park D, Lesty C, et al. Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arterioscler Thromb Vasc Biol. 2000;20(5):1354-1361. (Pubitemid 30262939)
14. Collet JP, Woodhead JL, Soria J, et al. Fibrinogen Dusart: electron microscopy of molecules, fibers and clots, and viscoelastic properties of clots. Biophys J. 1996;70(1):500-510. (Pubitemid 26021490)
15. Collet JP, Montalescot G, Lesty C, et al. Effects of Abciximab on the architecture of platelet-rich clots in patients with acute myocardial infarction undergoing primary coronary intervention. Circulation. 2001;103(19):2328-2331. (Pubitemid 32448794)
16. Collet JP, Montalescot G, Lesty C, et al. Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis. Arterioscler Thromb Vasc Biol. 2001;21(1):142-148. (Pubitemid 32061939)
17. Collet JP, Montalescot G, Lesty C, Weisel JW. A structural and dynamic investigation of the facilitating effect of glycoprotein IIb/IIIa inhibitors in dissolving platelet-rich clots. Circ Res. 2002;90(4):428-434. (Pubitemid 34633912)
18. Campbell RA, Overmyer KA, Bagnell CR, Wolberg AS. Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface. Arterioscler Thromb Vasc Biol. 2008;28(12):2247-2254.
19. Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004;279(43):44250-44257. (Pubitemid 39430828)
20. Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH. Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A. 2006;103(4):903-908. (Pubitemid 43212194)
21. Lorenz B, Marme S, Muller WE, Unger K, Schroder HC. Preparation and use of polyphosphate-modified zirconia for purification of nucleic acids and proteins. Anal Biochem. 1994;216(1):118-126. (Pubitemid 24036841)
22. Becker DL, Fredenburgh JC, Stafford AR, Weitz JI. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. J Biol Chem. 1999;274(10):6226-6233.
23. Ariëns RA, Philippou H, Nagaswami C, Weisel JW, Lane DA, Grant PJ. The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure. Blood. 2000;96(3):988-995. (Pubitemid 30616865)
24. Standeven KF, Grant PJ, Carter AM, Scheiner T, Weisel JW, Ariens RA. Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function. Circulation. 2003;107(18):2326-2330. (Pubitemid 36578503)
25. Cooper AV, Standeven KF, Ariens RA. Fibrinogen gamma-chain splice variant gamma' alters fibrin formation and structure. Blood. 2003;102(2):535-540.
26. Dunn EJ, Philippou H, Ariens RA, Grant PJ. Molecular mechanisms involved in the resistance of fibrin to clot lysis by plasmin in subjects with type 2 diabetes mellitus. Diabetologia. 2006;49(5):1071-1080.
27. Smith SA, Morrissey JH. Polyphosphate enhances fibrin clot structure. Blood. 2008;112(7):2810-2816.
28. Müller F, Mutch NJ, Schenk WA, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139(6):1143-1156.
29. Carr ME, Jr., Hermans J. Size and density of fibrin fibers from turbidity. Macromolecules. 1978;11(1):46-50.
30. Chernysh IN, Weisel JW. Dynamic imaging of fibrin network formation correlated with other measures of polymerization. Blood. 2008;111(10):4854-4861.
31. Litvinov RI, Yakovlev S, Tsurupa G, Gorkun OV, Medved L, Weisel JW. Direct evidence for specific interactions of the fibrinogen alphaC-domains with the central E region and with each other. Biochemistry. 2007;46(31):9133-9142. (Pubitemid 47237388)
32. Sugo T, Endo H, Matsuda M, et al. A classification of the fibrin network structures formed from the hereditary dysfibrinogens. J Thromb Haemost. 2006;4(8):1738-1746. (Pubitemid 44144801)
33. Carr ME Jr, Cromartie R, Gabriel DA. Effect of homo poly(L-amino acids) on fibrin assembly: role of charge and molecular weight. Biochemistry. 1989;28(3):1384-1388. (Pubitemid 19058716)
34. Odrljin TM, Shainoff JR, Lawrence SO, Simpson-Haidaris PJ. Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain. Blood. 1996;88(6):2050-2061. (Pubitemid 26307907)
35. Yakovlev S, Gorlatov S, Ingham K, Medved L. Interaction of fibrin(ogen) with heparin: further characterization and localization of the heparin-binding site. Biochemistry. 2003;42(25):7709-7716. (Pubitemid 36758936)
36. Parise P, Morini M, Agnelli G, Ascani A, Nenci GG. Effects of low molecular weight heparins on fibrin polymerization and clot sensitivity to t-PA-induced lysis. Blood Coagul Fibrinolysis. 1993;4(5):721-727. (Pubitemid 23343395)
37. Collet JP, Lesty C, Montalescot G, Weisel JW. Dynamic changes of fibrin architecture during fibrin formation and intrinsic fibrinolysis of fibrin-rich clots. J Biol Chem. 2003;278(24):21331-21335. (Pubitemid 36792527)
38. Kostelansky MS, Lounes KC, Ping LF, Dickerson SK, Gorkun OV, Lord ST. Calcium-binding site beta 2, adjacent to the "b" polymerization site, modulates lateral aggregation of protofibrils during fibrin polymerization. Biochemistry. 2004;43(9):2475-2483.
39. Kornberg A. Inorganic polyphosphate: a molecule of many functions. Prog Mol Subcell Biol. 1999;23:1-18. (Pubitemid 29449188)
40. Lorenz B, Leuck J, Kohl D, Muller WE, Schroder HC. Anti-HIV-1 activity of inorganic polyphosphates. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14(2):110-118.