메뉴 건너뛰기




Volumn 55, Issue 10-11, 2003, Pages 599-603

Mitochondrial Nitric-oxide Synthase: Role in Pathophysiology

Author keywords

Free radicals; Mitochondria; Mitochondrial metabolism; Nitric oxide; Nitric oxide synthase; Oxygen consumption

Indexed keywords

FREE RADICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYHEMOGLOBIN;

EID: 0347622944     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540310001628681     Document Type: Review
Times cited : (52)

References (46)
  • 1
    • 0025191219 scopus 로고
    • Isolation of nitric oxide synthase, a calmodulin-requiring enzyme
    • Bredt, D. S., and Snyder, S. H. (1990) Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A. 87, 682-685.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 682-685
    • Bredt, D.S.1    Snyder, S.H.2
  • 2
    • 0025572626 scopus 로고
    • 2+ calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin
    • 2+ calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin. FEBS Lett. 277, 215-219.
    • (1990) FEBS Lett. , vol.277 , pp. 215-219
    • Mayer, B.1    John, M.2    Bohme, E.3
  • 4
    • 0026565840 scopus 로고
    • Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: Inhibition by transforming growth factor-beta
    • Förstermann, U., Schmidt, H. H. H. W., Kohlhaas, K. L., and Murad, F. (1992) Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-beta. Eur. J. Pharmacol. 225, 161-165.
    • (1992) Eur. J. Pharmacol. , vol.225 , pp. 161-165
    • Förstermann, U.1    Schmidt, H.H.H.W.2    Kohlhaas, K.L.3    Murad, F.4
  • 5
    • 0023928184 scopus 로고
    • Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function
    • Moncada, S., Radomski, M. W., and Palmer, R. M. (1988) Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacol. 37, 2495-2501.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2495-2501
    • Moncada, S.1    Radomski, M.W.2    Palmer, R.M.3
  • 6
    • 0024537028 scopus 로고
    • Endothelium-derived nitric oxide: Actions and properties
    • Ignarro, L. J. (1989) Endothelium-derived nitric oxide: actions and properties. FASEB J. 3, 31-36.
    • (1989) FASEB J. , vol.3 , pp. 31-36
    • Ignarro, L.J.1
  • 8
    • 0026570890 scopus 로고
    • Nitric oxide, a novel neuronal messenger
    • Bredt, D. S., and Snyder, S. H. (1992) Nitric oxide, a novel neuronal messenger. Neuron 8, 3-11.
    • (1992) Neuron , vol.8 , pp. 3-11
    • Bredt, D.S.1    Snyder, S.H.2
  • 9
    • 0023250888 scopus 로고
    • Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma
    • Stuehr, D. J., and Marletta, M. A. (1987) Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. J. Immunol. 139, 518-525.
    • (1987) J. Immunol. , vol.139 , pp. 518-525
    • Stuehr, D.J.1    Marletta, M.A.2
  • 10
    • 0028134892 scopus 로고
    • Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
    • Brown, G. C., and Cooper, C. E. (1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 356, 295-298.
    • (1994) FEBS Lett. , vol.356 , pp. 295-298
    • Brown, G.C.1    Cooper, C.E.2
  • 11
    • 28044464985 scopus 로고
    • Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
    • Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., and Schapira, A. H. V. (1994) Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345, 50-54.
    • (1994) FEBS Lett. , vol.345 , pp. 50-54
    • Cleeter, M.W.J.1    Cooper, J.M.2    Darley-Usmar, V.M.3    Moncada, S.4    Schapira, A.H.V.5
  • 12
    • 0029986691 scopus 로고    scopus 로고
    • Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles
    • Poderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., and Boveris, A. (1996) Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 328, 85-92.
    • (1996) Arch. Biochem. Biophys. , vol.328 , pp. 85-92
    • Poderoso, J.J.1    Carreras, M.C.2    Lisdero, C.3    Riobó, N.4    Schöpfer, F.5    Boveris, A.6
  • 13
    • 0030029056 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase: A ubiquitous regulator of oxidative phosphorylation
    • Bates, T. E., Loesch, A., Burnstock, G., and Clark, J. B. (1996) Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation. Biochem. Biophys. Res. Commun. 218, 40-44.
    • (1996) Biochem. Biophys. Res. Commun. , vol.218 , pp. 40-44
    • Bates, T.E.1    Loesch, A.2    Burnstock, G.3    Clark, J.B.4
  • 14
    • 0032526039 scopus 로고    scopus 로고
    • Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism
    • Giulivi, C. (1998) Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism. Biochem. J. 332, 673-679.
    • (1998) Biochem. J. , vol.332 , pp. 673-679
    • Giulivi, C.1
  • 15
    • 0030697859 scopus 로고    scopus 로고
    • Nitric oxide synthase activity in mitochondria
    • Ghafourifar, P., and Richter, C. (1997) Nitric oxide synthase activity in mitochondria. FEBS Lett. 418, 291-296.
    • (1997) FEBS Lett. , vol.418 , pp. 291-296
    • Ghafourifar, P.1    Richter, C.2
  • 16
    • 0032079478 scopus 로고    scopus 로고
    • Production of nitric oxide by mitochondria
    • Giulivi, C., Poderoso, J. J., and Boveris, A. (1998) Production of nitric oxide by mitochondria. J. Biol. Chem. 273, 11038-11043.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11038-11043
    • Giulivi, C.1    Poderoso, J.J.2    Boveris, A.3
  • 17
    • 0032079851 scopus 로고    scopus 로고
    • Purification and characterization of a nitric-oxide synthase from rat liver mitochondria
    • Tatoyan, A., and Giulivi, C. (1998) Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J. Biol. Chem. 273, 11044-11048.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11044-11048
    • Tatoyan, A.1    Giulivi, C.2
  • 18
    • 0034979539 scopus 로고    scopus 로고
    • Nitric oxide synthase in porcine heart mitochondria: Evidence for low physiological activity
    • French, S., Giulivi, C., and Balaban, R.S. (2001) Nitric oxide synthase in porcine heart mitochondria: evidence for low physiological activity. J. Physiol. Heart Circ. Physiol. 280, H2863-H2867.
    • (2001) J. Physiol. Heart Circ. Physiol. , vol.280
    • French, S.1    Giulivi, C.2    Balaban, R.S.3
  • 19
    • 0037441389 scopus 로고    scopus 로고
    • Characterization and function of mitochondrial nitric-oxide synthase
    • Giulivi, C. (2003) Characterization and function of mitochondrial nitric-oxide synthase. Free Radical Biol. Med. 34, 397-408.
    • (2003) Free Radical Biol. Med. , vol.34 , pp. 397-408
    • Giulivi, C.1
  • 20
    • 0029086659 scopus 로고
    • Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver
    • Bates, T. E., Loesch, A., Burnstock, G., and Clark, J. B. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem. Biophys. Res. Commun. 213, 896-898.
    • (1995) Biochem. Biophys. Res. Commun. , vol.213 , pp. 896-898
    • Bates, T.E.1    Loesch, A.2    Burnstock, G.3    Clark, J.B.4
  • 25
    • 0032560572 scopus 로고    scopus 로고
    • Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
    • Clementi, E., Brown, G. C., Feelisch, M., and Moncada, S. (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl. Acad. Sci. USA 95, 7631-7636.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7631-7636
    • Clementi, E.1    Brown, G.C.2    Feelisch, M.3    Moncada, S.4
  • 26
    • 0035831466 scopus 로고    scopus 로고
    • The modulation of oxygen radical production by nitric oxide in mitochondria
    • Sarkela, T. M., Berthiaume, J., Elfering, S., Gybina, A. A., and Giulivi, C. (2001) The modulation of oxygen radical production by nitric oxide in mitochondria. J. Biol. Chem. 276, 6945-6949.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6945-6949
    • Sarkela, T.M.1    Berthiaume, J.2    Elfering, S.3    Gybina, A.A.4    Giulivi, C.5
  • 27
    • 0033615544 scopus 로고    scopus 로고
    • Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
    • Ghafourifar, P., Schenk, U., Klein, S. D., and Richter, C. (1999) Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J. Biol Chem. 274, 31185-31188.
    • (1999) J. Biol Chem. , vol.274 , pp. 31185-31188
    • Ghafourifar, P.1    Schenk, U.2    Klein, S.D.3    Richter, C.4
  • 28
    • 0346341254 scopus 로고    scopus 로고
    • Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric-oxide synthase
    • in press
    • Elfering, S. L., Haynes, V., Traaseth, N., Ettl, A., and Giulivi, C. (2003) Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric-oxide synthase. Am. J. Physiol., in press.
    • (2003) Am. J. Physiol.
    • Elfering, S.L.1    Haynes, V.2    Traaseth, N.3    Ettl, A.4    Giulivi, C.5
  • 30
    • 0037064058 scopus 로고    scopus 로고
    • Biochemistry of nitric-oxide synthase
    • Elfering, S. L., Sarkela, T. M., and Giulivi, C. (2002) Biochemistry of nitric-oxide synthase. J. Biol. Chem. 277, 38079-38086.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38079-38086
    • Elfering, S.L.1    Sarkela, T.M.2    Giulivi, C.3
  • 32
    • 0029933799 scopus 로고    scopus 로고
    • Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle
    • Silvagno, F., Xia, H., and Bredt, D. S. (1996) Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle J. Biol. Chem. 271, 11204-11208.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11204-11208
    • Silvagno, F.1    Xia, H.2    Bredt, D.S.3
  • 33
    • 0030983197 scopus 로고    scopus 로고
    • Regulation of neuronal nitric oxide synthase through alternative transcripts
    • Brenman, J. E., Xia, H., Chao, D. S., Black, S. M., and Bredt, D. S. (1997) Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev. Neurosci. 19, 224-231.
    • (1997) Dev. Neurosci. , vol.19 , pp. 224-231
    • Brenman, J.E.1    Xia, H.2    Chao, D.S.3    Black, S.M.4    Bredt, D.S.5
  • 34
    • 0028361984 scopus 로고
    • Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase
    • Liu, J., and Sessa, W. (1994) Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase. J. Biol. Chem. 269, 11691-11694.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11691-11694
    • Liu, J.1    Sessa, W.2
  • 35
    • 0027414849 scopus 로고
    • Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization
    • Busconi, L., and Michel, T. (1993) Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J. Biol. Chem. 268, 8410-8413.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8410-8413
    • Busconi, L.1    Michel, T.2
  • 36
    • 0027289468 scopus 로고
    • Phosphorylation and subcellular translocation of endothelial nitric oxide synthase
    • Michel, T., Li, G. K., and Busconi, L. (1993) Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 90, 6252-6256.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6252-6256
    • Michel, T.1    Li, G.K.2    Busconi, L.3
  • 37
    • 0035912784 scopus 로고    scopus 로고
    • Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase
    • Shiva, S., Brookes, P. S., Patel, R. P., Anderson, P. G., and Darley-Usmar, V. (2001) Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc. Natl. Acad. Sci. USA 98, 7212-7217.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7212-7217
    • Shiva, S.1    Brookes, P.S.2    Patel, R.P.3    Anderson, P.G.4    Darley-Usmar, V.5
  • 39
    • 0001748145 scopus 로고
    • Diffusion coefficients of neon, krypton, xenon, carbon monoxide, and nitric oxide in water at 10-60°C
    • Wise, D. L., and Houghton, G. (1968) Diffusion coefficients of neon, krypton, xenon, carbon monoxide, and nitric oxide in water at 10-60°C. Chem. Eng. Sci. 23, 1211-1216.
    • (1968) Chem. Eng. Sci. , vol.23 , pp. 1211-1216
    • Wise, D.L.1    Houghton, G.2
  • 40
    • 0001487324 scopus 로고
    • The diffusion coefficients of ten slightly soluble gases in water at 10-60°C
    • Wise, D. L., and Houghton, G. (1966) The diffusion coefficients of ten slightly soluble gases in water at 10-60°C. Chem. Eng. Sci. 21, 999-1010.
    • (1966) Chem. Eng. Sci. , vol.21 , pp. 999-1010
    • Wise, D.L.1    Houghton, G.2
  • 41
    • 0344071850 scopus 로고
    • Reaction of oxygen with the respiratory chain in cells and tissues
    • Chance, B. (1965) Reaction of oxygen with the respiratory chain in cells and tissues. J. Gen. Physiol. 49, 163-118.
    • (1965) J. Gen. Physiol. , vol.49 , pp. 163-118
    • Chance, B.1
  • 42
    • 0001773501 scopus 로고
    • The oxygen pressure field of the brain and its significance for the normal and critical oxygen supply of the brain
    • (Lubbers, D. W., Luft, U. C., Thews, G. and Witzels, E., eds) Theime, Stuttgart
    • Lübbers, D. W. (1968) The oxygen pressure field of the brain and its significance for the normal and critical oxygen supply of the brain. In Oxygen transport in blood and tissues (Lubbers, D. W., Luft, U. C., Thews, G. and Witzels, E., eds). pp. 124-139, Theime, Stuttgart.
    • (1968) Oxygen Transport in Blood and Tissues , pp. 124-139
    • Lübbers, D.W.1
  • 44
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman, J. S., and Koppenol, W. H. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271, C1424-C1437.
    • (1996) Am. J. Physiol. , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 45
    • 0032715834 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: A personal view of recent controversies
    • Halliwell, B., Zhao, K., and Whiteman, M. (1999) Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radical Res. 31, 651-669.
    • (1999) Free Radical Res. , vol.31 , pp. 651-669
    • Halliwell, B.1    Zhao, K.2    Whiteman, M.3
  • 46
    • 0032147208 scopus 로고    scopus 로고
    • Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
    • Ischiropoulos, H. (1998) Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch. Biochem. Biophys. 356, 1-11.
    • (1998) Arch. Biochem. Biophys. , vol.356 , pp. 1-11
    • Ischiropoulos, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.