An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 47, 2004, Pages 16399-16400

  Bahnson, Brian J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; CYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; HYPOCHOLESTEROLEMIC AGENT;

ACETYLATION; CATALYSIS; COLD TREATMENT; CRYOGENICS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR DYNAMICS; NOTE; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN INTERACTION; THERMODYNAMICS; X RAY DIFFRACTION;

ANIMALS; CATALYSIS; COENZYME A LIGASES; CRYSTALLOGRAPHY, X-RAY; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS;

EID: 9344242392     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407418101     Document Type: Note

References (19)

1. Campobasso, N., Patel, M., Wilding, I. E., Kallender, H., Rosenberg, M. & Gwynn, M. N. (2004) J. Biol. Chem. 279, 44883-44888.
2. Chun, K. Y., Vinarov, D. A., Zajicek, J. & Miziorko, H. M. (2000) J. Biol. Chem. 275, 17946-17953.
3. Chun, K. Y., Vinarov, D. A. & Miziorko, H. M. (2000) Biochemistry 39, 14670-14681.
4. Greenspan, M. D., Yudkovitz, J. B., Lo, C. Y., Chen, J. S., Alberts, A. W., Hunt, V. M., Chang, M. N., Yang, S. S., Thompson, K. L. & Chiang, Y. C. (1987) Proc. Natl. Acad. Sci. USA 84, 7488-7492.
5. Miziorko, H. M. & Lane, M. D. (1977) J. Biol. Chem. 252, 1414-1420.
6. Teo, K. K. & Burton, J. R. (2002) Drugs 62, 1707-1715.
7. Theisen, M. J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H. M. & Harrison, D. H. T. (2004) Proc. Natl. Acad. Sci. USA 101, 16442-16447.
8. Gerlt, J. A. & Gassman, P. G. (1993) Biochemistry 32, 11943-11952.
9. Anderson, V. E., Bahnson, B. J., Wlassics, I. D. & Walsh, C. T. (1990) J. Biol. Chem. 265, 6255-6261.
10. Bahnson, B. J., Anderson, V. E. & Petsko, G. A. (2002) Biochemistry 41, 2621-2629.
11. Wlassics, I. D. & Anderson, V. E. (1989) Biochemistry 28, 1627-1633.
12. Stoddard, B. L. (1999) Biochem. Soc. Trans. 27, 42-48.
13. Schlichting, I., Berendzen, J., Chu, K., Stock, A. M., Maves, S. A., Benson, D. E., Sweet, R. M., Ringe, D., Petsko, G. A. & Sugar, S. G. (2000) Science 287, 1615-1622.
14. Lahiri, S. D., Zhang, G., Dunaway-Mariano, D. & Allen, K. N. (2003) Science 299, 2067-2071.
15. Bolduc, J. M., Dyer, D. H., Scott, W. G., Singer, P., Sweet, R. M., Koshland, D. E., Jr. & Stoddard, B. L. (1995) Science 268, 1312-1318.
16. Knowles, J. (2003) Science 299, 2002-2003.
17. Karplus, M. & McCammon, J. A. (2002) Nat. Struct. Biol. 9, 646-652.
18. Luo, J. & Bruice, T. C. (2004) Proc. Natl. Acad. Sci. USA 101, 13152-13156.
19. Stoddard, B. L., Dean, A. & Bash, P. A. (1996) Nat. Struct. Biol. 3, 590-595.