The effect of arginine glutamate on the stability of monoclonal antibodies in solution

International Journal of Pharmaceutics

Volumn 473, Issue 1-2, 2014, Pages 126-133

  Kheddo, Priscilla ^a   Tracka, Malgorzata ^b   Armer, Jonathan ^b   Dearman, Rebecca J ^a   Uddin, Shahid ^b   Van Der Walle, Christopher F ^b   Golovanov, Alexander P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

Excipients; mAbs formulation; Physical characterization; Physical stability; Protein aggregation

Indexed keywords

ARGININE GLUTAMATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1; MONOCLONAL ANTIBODY 2; MONOCLONAL ANTIBODY 3; MONOCLONAL ANTIBODY 4; MONOMER; UNCLASSIFIED DRUG; DIPEPTIDE; EXCIPIENT; IMMUNOGLOBULIN G; PROTEIN AGGREGATE; SOLUTION AND SOLUBILITY;

ARTICLE; CONFORMATION; CONTROLLED STUDY; FLUORESCENCE; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MELTING POINT; OSMOLALITY; PH; PRIORITY JOURNAL; SIZE EXCLUSION HIGH PRESSURE LIQUID CHROMATOGRAPHY; STORAGE; TEMPERATURE; THERMOSTABILITY; CHEMISTRY; OSMOLARITY; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; SOLUTION AND SOLUBILITY;

ANTIBODIES, MONOCLONAL; DIPEPTIDES; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; OSMOLAR CONCENTRATION; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; SOLUTIONS; TEMPERATURE;

EID: 84904317616     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.06.053     Document Type: Article

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