DSF method optimization and its application in predicting protein thermal aggregation kinetics

Journal of Pharmaceutical Sciences

Volumn 102, Issue 8, 2013, Pages 2471-2483

  Shi, Shuai ^a   Semple, Andrew ^a   Cheung, Jason ^a   Shameem, Mohammed ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aggregation kinetics; Analytical biochemistry; Biopharmaceuticals characterization; Biotechnology; Differential scanning calorimetry; Differential scanning fluorimetry; Protein aggregation; Protein formulation; Surfactant

Indexed keywords

MONOCLONAL ANTIBODY; SURFACTANT;

ARTICLE; CONCENTRATION RESPONSE; DIFFERENTIAL SCANNING CALORIMETRY; DIFFERENTIAL SCANNING FLUORIMETRY; FLUOROMETRY; GEL PERMEATION CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; KINETICS; PROCESS OPTIMIZATION; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN UNFOLDING; QUALITY CONTROL; THERMAL ANALYSIS; THERMOSTABILITY; TRANSITION TEMPERATURE; ULTRACENTRIFUGATION;

EID: 84881001310     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23633     Document Type: Article

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