Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 744-751

  Sule, Shantanu V ^a   Cheung, Jason K ^b   Antochshuk, Valentyn ^b   Bhalla, Amardeep S ^b   Narasimhan, Chakravarthy ^b   Blaisdell, Steven ^b   Shameem, Mohammed ^b   Tessier, Peter M ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

aggregation; opalescence; osmotic second virial coefficient; solubility; viscosity

Indexed keywords

MONOCLONAL ANTIBODY;

ARTICLE; CONCENTRATION (PARAMETERS); CROSSING OVER; HUMAN; IONIC STRENGTH; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN INTERACTION; SOLUBILITY; VISCOSITY;

ANTIBODIES, MONOCLONAL; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; VISCOSITY;

EID: 84859368104     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200448j     Document Type: Article

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