Effective protocol for the investigation of physicochemical and conformational stability and aggregation kinetics measurements of therapeutic IgG2 monoclonal antibody

Journal of Immunological Methods

Volumn 405, Issue , 2014, Pages 154-166

  Aboel Dahab, Ali ^a   El Hag, Dhia ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Absorbance; Aggregation; IgG2a; Monoclonal antibodies (mAbs); Stability; Turbidity and circular dichroism

Indexed keywords

IMMUNOGLOBULIN G2A ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IMMUNOGLOBULIN G2A; POLYSORBATE 80; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTICLE; CIRCULAR DICHROISM; CLINICAL PROTOCOL; COMPUTER PROGRAM; IMMUNOGENICITY; KINETICS; LIGHT SCATTERING; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RESPONSE TIME; THERMOSTABILITY; TURBIDITY;

ABSORBANCE; AGGREGATION; IGG2A; MONOCLONAL ANTIBODIES (MABS); STABILITY; TURBIDITY AND CIRCULAR DICHROISM;

ANTIBODIES, MONOCLONAL; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; KINETICS; MODELS, MOLECULAR; PHYSICOCHEMICAL PHENOMENA; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE;

EID: 84897114776     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2014.01.016     Document Type: Article

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