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Volumn 23, Issue 8, 2014, Pages 1055-1066

Investigational drugs in Phase II clinical trials for the treatment of obesity: Implications for future development of novel therapies

Author keywords

Beloranib; Bupropion zonisamide; GSK 2890457; HPP404; Investigational drugs; KD026; Obesity; Patient stratification; Phase II; Remogliflozin etabonate; RM 493

Indexed keywords

AMFEBUTAMONE PLUS ZONISAMIDE; ANTIOBESITY AGENT; GSK 2890457; HPP 404; KD 026; REMOGLIFLOZIN ETABONATE; RM 493; UNCLASSIFIED DRUG; NEW DRUG;

EID: 84904313098     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.918952     Document Type: Review
Times cited : (17)

References (78)
  • 1
    • 77649209853 scopus 로고    scopus 로고
    • Gene-environment interactions in obesity
    • Hetherington MM, Cecil JE. Gene-environment interactions in obesity. Forum Nutr 2010;63: 195-203
    • (2010) Forum Nutr , vol.63 , pp. 195-203
    • Hetherington, M.M.1    Cecil, J.E.2
  • 3
    • 0942279569 scopus 로고    scopus 로고
    • Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology
    • Gale SM, Castracane VD, Mantzoros CS. Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology. J Nutr 2004;134: 295-8
    • (2004) J Nutr , vol.134 , pp. 295-298
    • Gale, S.M.1    Castracane, V.D.2    Mantzoros, C.S.3
  • 4
    • 70349207410 scopus 로고    scopus 로고
    • Annual medical spending attributable to obesity: Payer-And servicespecific estimates
    • Finkelstein EA, Trogdon JG, Cohen JW, et al. Annual medical spending attributable to obesity: Payer-And servicespecific estimates. Health Aff 2009;28: W822-31
    • (2009) Health Aff , vol.28
    • Finkelstein, E.A.1    Trogdon, J.G.2    Cohen, J.W.3
  • 5
    • 12944260424 scopus 로고    scopus 로고
    • Surgical management of morbid obesity
    • Schneider BE, Mun EC. Surgical management of morbid obesity. Diabetes Care 2005;28: 475-80
    • (2005) Diabetes Care , vol.28 , pp. 475-480
    • Schneider, B.E.1    Mun, E.C.2
  • 6
    • 65349194409 scopus 로고    scopus 로고
    • Results of Roux-en-Y gastric bypass in morbidly obese vs superobese patients: Similar body weight loss, correction of comorbidities, and improvement of quality of life
    • discussion 18
    • Suter M, Calmes JM, Paroz A, et al. Results of Roux-en-Y gastric bypass in morbidly obese vs superobese patients: Similar body weight loss, correction of comorbidities, and improvement of quality of life. Arch Surg 2009;144: 312-18.discussion 18
    • (2009) Arch Surg , vol.144 , pp. 312-318
    • Suter, M.1    Calmes, J.M.2    Paroz, A.3
  • 7
    • 84872109705 scopus 로고    scopus 로고
    • A review of late-stage CNS drug candidates for the treatment of obesity
    • Heal DJ, Gosden J, Smith SL. A review of late-stage CNS drug candidates for the treatment of obesity. Int J Obes 2013;37: 107-17
    • (2013) Int J Obes , vol.37 , pp. 107-117
    • Heal, D.J.1    Gosden, J.2    Smith, S.L.3
  • 8
    • 77952584236 scopus 로고    scopus 로고
    • Central and peripheral molecular targets for antiobesity pharmacotherapy
    • Valentino MA, Lin JE, Waldman SA. Central and peripheral molecular targets for antiobesity pharmacotherapy. Clin Pharmacol Ther 2010;87: 652-62
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 652-662
    • Valentino, M.A.1    Lin, J.E.2    Waldman, S.A.3
  • 9
    • 33645468559 scopus 로고    scopus 로고
    • Safety of drug therapies used for weight loss and treatment of obesity
    • Ioannides-Demos LL, Proietto J, Tonkin AM, et al. Safety of drug therapies used for weight loss and treatment of obesity. Drug Saf 2006;29: 277-302
    • (2006) Drug Saf , vol.29 , pp. 277-302
    • Ioannides-Demos, L.L.1    Proietto, J.2    Tonkin, A.M.3
  • 10
    • 84891919414 scopus 로고    scopus 로고
    • Long-Term drug treatment for obesity: A systematic and clinical review
    • Yanovski SZ, Yanovski JA. Long-Term drug treatment for obesity: A systematic and clinical review. J Am Med Assoc 2014;311: 74-86
    • (2014) J Am Med Assoc , vol.311 , pp. 74-86
    • Yanovski, S.Z.1    Yanovski, J.A.2
  • 11
    • 80053427920 scopus 로고    scopus 로고
    • Evaluation of efficacy and safety of orlistat in obese patients
    • Jain SS, Ramanand SJ, Ramanand JB, et al. Evaluation of efficacy and safety of orlistat in obese patients. Indian J Endocrinol Metab 2011;15: 99-104
    • (2011) Indian J Endocrinol Metab , vol.15 , pp. 99-104
    • Jain, S.S.1    Ramanand, S.J.2    Ramanand, J.B.3
  • 12
    • 84898490591 scopus 로고    scopus 로고
    • The new weight-loss drugs, lorcaserin and phentermine-Topiramate: Slim pickings
    • Woloshin S, Schwartz LM. The new weight-loss drugs, lorcaserin and phentermine-Topiramate: Slim pickingš JAMA Intern Med 2014;174: 615-19
    • (2014) JAMA Intern Med , vol.174 , pp. 615-619
    • Woloshin, S.1    Schwartz, L.M.2
  • 13
    • 84887155139 scopus 로고    scopus 로고
    • Evaluation of phentermine and topiramate versus phentermine/ topiramate extended-release in obese adults
    • Aronne LJ, Wadden TA, Peterson C, et al. Evaluation of phentermine and topiramate versus phentermine/ topiramate extended-release in obese adults. Obesity (Silver Spring) 2013;21: 2163-71
    • (2013) Obesity (Silver Spring , vol.21 , pp. 2163-2171
    • Aronne, L.J.1    Wadden, T.A.2    Peterson, C.3
  • 14
    • 84876031270 scopus 로고    scopus 로고
    • Clinical utility of phentermine/topiramate (Qsymia) combination for the treatment of obesity
    • Shin JH, Gadde KM. Clinical utility of phentermine/topiramate (Qsymia) combination for the treatment of obesity. Diabetes Metab Syndr Obes 2013;6: 131-9
    • (2013) Diabetes Metab Syndr Obes , vol.6 , pp. 131-139
    • Shin, J.H.1    Gadde, K.M.2
  • 15
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rossner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study. Lancet 2009;374: 1606-16
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rossner, S.2    Van Gaal, L.3
  • 16
    • 84879324574 scopus 로고    scopus 로고
    • A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II
    • Apovian CM, Aronne L, Rubino D, et al. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring) 2013;21: 935-43
    • (2013) Obesity (Silver Spring , vol.21 , pp. 935-943
    • Apovian, C.M.1    Aronne, L.2    Rubino, D.3
  • 17
    • 73949084345 scopus 로고    scopus 로고
    • Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: Comparison with orlistat (Xenical
    • Kopelman P, Groot Gde H, Rissanen A, et al. Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: Comparison with orlistat (Xenical). Obesity (Silver Spring) 2010;18: 108-15
    • (2010) Obesity (Silver Spring , vol.18 , pp. 108-115
    • Kopelman, P.1    Groot Gde, H.2    Rissanen, A.3
  • 19
    • 79961165599 scopus 로고    scopus 로고
    • Current and future drug targets in weight management
    • Witkamp RF. Current and future drug targets in weight management. Pharm Res 2011;28: 1792-818
    • (2011) Pharm Res , vol.28 , pp. 1792-1818
    • Witkamp, R.F.1
  • 20
    • 34248342673 scopus 로고    scopus 로고
    • Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss
    • Erondu N, Wadden T, Gantz I, et al. Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss. Obesity (Silver Spring) 2007;15: 895-905
    • (2007) Obesity (Silver Spring , vol.15 , pp. 895-905
    • Erondu, N.1    Wadden, T.2    Gantz, I.3
  • 21
    • 80053193844 scopus 로고    scopus 로고
    • Neuropsychiatric adverse effects of centrally acting antiobesity drugs
    • Nathan PJ, O'Neill BV, Napolitano A, et al. Neuropsychiatric adverse effects of centrally acting antiobesity drugs. CNS Neurosci Ther 2011;17: 490-505
    • (2011) CNS Neurosci Ther , vol.17 , pp. 490-505
    • Nathan, P.J.1    O'Neill, B.V.2    Napolitano, A.3
  • 22
    • 84866108680 scopus 로고    scopus 로고
    • Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons
    • Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: The critical role of hunger-promoting neurons. Nat Rev Drug Discov 2012;11: 675-91
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 675-691
    • Dietrich, M.O.1    Horvath, T.L.2
  • 23
    • 31944452253 scopus 로고    scopus 로고
    • The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
    • King BM. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav 2006;87: 221-44
    • (2006) Physiol Behav , vol.87 , pp. 221-244
    • King, B.M.1
  • 24
    • 0035757969 scopus 로고    scopus 로고
    • Adrenoceptors, uncoupling proteins, and energy expenditure
    • Collins S, Cao W, Daniel KW, et al. Adrenoceptors, uncoupling proteins, and energy expenditure. Exp Biol Med 2001;226: 982-90
    • (2001) Exp Biol Med , vol.226 , pp. 982-990
    • Collins, S.1    Cao, W.2    Daniel, K.W.3
  • 25
    • 33745872950 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonists for treatment of obesity and prevention of comorbid metabolic disorders
    • Antel J, Gregory PC, Nordheim U. CB1 cannabinoid receptor antagonists for treatment of obesity and prevention of comorbid metabolic disorders. J Med Chem 2006;49: 4008-16
    • (2006) J Med Chem , vol.49 , pp. 4008-4016
    • Antel, J.1    Gregory, P.C.2    Nordheim, U.3
  • 26
    • 33646889517 scopus 로고    scopus 로고
    • Cannabinoids, opioids and eating behavior: The molecular face of hedonism
    • Cota D, Tschop MH, Horvath TL, et al. Cannabinoids, opioids and eating behavior: The molecular face of hedonism? Brain Res Rev 2006;51: 85-107
    • (2006) Brain Res Rev , vol.51 , pp. 85-107
    • Cota, D.1    Tschop, M.H.2    Horvath, T.L.3
  • 27
    • 78650752631 scopus 로고    scopus 로고
    • Reward, dopamine and the control of food intake: Implications for obesity
    • Volkow ND, Wang G-J, Baler RD. Reward, dopamine and the control of food intake: Implications for obesity. Trends Cogn Sci 2011;15: 37-46
    • (2011) Trends Cogn Sci , vol.15 , pp. 37-46
    • Volkow, N.D.1    Wang, G.-J.2    Baler, R.D.3
  • 28
    • 62649127050 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin-A receptors With Gl181771X: A failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake
    • Roses AD. Stimulation of cholecystokinin-A receptors With Gl181771X: A failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake. Clin Pharmacol Ther 2009;85: 362-5
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 362-365
    • Roses, A.D.1
  • 29
    • 51549104158 scopus 로고    scopus 로고
    • Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents
    • Santoro N, del Giudice EM, Grandone A, et al. Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. J Hypertens 2008;26: 1590-4
    • (2008) J Hypertens , vol.26 , pp. 1590-1594
    • Santoro, N.1    Del Giudice, E.M.2    Grandone, A.3
  • 30
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults, A randomized, controlled, dose-escalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults, A randomized, controlled, dose-escalation trial. JAMA 1999;282: 1568-75
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 31
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/ metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA, et al. Enhanced weight loss with pramlintide/ metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring) 2009;17: 1736-43
    • (2009) Obesity (Silver Spring , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 32
    • 80555135931 scopus 로고    scopus 로고
    • Novel strategy for the use of leptin for obesity therapy
    • Tam CS, Lecoultre V, Ravussin E. Novel strategy for the use of leptin for obesity therapy. Expert Opin Biol Ther 2011;11: 1677-85
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1677-1685
    • Tam, C.S.1    Lecoultre, V.2    Ravussin, E.3
  • 33
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382: 250-2
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 34
    • 0036093071 scopus 로고    scopus 로고
    • Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    • Rosenbaum M, Murphy EM, Heymsfield SB, et al. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 2002;87: 2391-4
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3
  • 35
    • 19444379385 scopus 로고    scopus 로고
    • General pharmacology of CKD-732, a new anticancer agent: Effects on central nervous, cardiovascular, and respiratory system
    • Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: Effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull 2005;28: 217-23
    • (2005) Biol Pharm Bull , vol.28 , pp. 217-223
    • Kim, E.J.1    Shin, W.H.2
  • 36
    • 34248143523 scopus 로고    scopus 로고
    • Assessment of the anti-obesity effects of the TNP-470 analog CKD-732
    • Kim YM, An JJ, Jin Y-J, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol 2007;38: 455-65
    • (2007) J Mol Endocrinol , vol.38 , pp. 455-465
    • Kim, Y.M.1    An, J.J.2    Jin, Y.-J.3
  • 38
    • 13244265583 scopus 로고    scopus 로고
    • Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model
    • Chun E, Han CK, Yoon JH, et al. Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model. Int J Cancer 2005;114: 124-30
    • (2005) Int J Cancer , vol.114 , pp. 124-130
    • Chun, E.1    Han, C.K.2    Yoon, J.H.3
  • 40
    • 84884905713 scopus 로고    scopus 로고
    • Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women
    • Hughes TE, Kim DD, Marjason J, et al. Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women. Obesity (Silver Spring) 2013;21: 1782-8
    • (2013) Obesity (Silver Spring , vol.21 , pp. 1782-1788
    • Hughes, T.E.1    Kim, D.D.2    Marjason, J.3
  • 41
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • Rossi J, Balthasar N, Olson D, et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 2011;13: 195-204
    • (2011) Cell Metab , vol.13 , pp. 195-204
    • Rossi, J.1    Balthasar, N.2    Olson, D.3
  • 42
    • 58249087146 scopus 로고    scopus 로고
    • Modulation of blood pressure by central melanocortinergic pathways
    • Greenfield JR, Miller JW, Keogh JM, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 2009;360: 44-52
    • (2009) N Engl J Med , vol.360 , pp. 44-52
    • Greenfield, J.R.1    Miller, J.W.2    Keogh, J.M.3
  • 43
    • 70450245171 scopus 로고    scopus 로고
    • Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: Energy intake predicts lack of weight loss efficacy
    • Krishna R, Gumbiner B, Stevens C, et al. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: Energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther 2009;86: 659-66
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 659-666
    • Krishna, R.1    Gumbiner, B.2    Stevens, C.3
  • 45
    • 84873301711 scopus 로고    scopus 로고
    • Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons
    • Sohn J-W, Harris LE, Berglund ED, et al. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell 2013;152: 612-19
    • (2013) Cell , vol.152 , pp. 612-619
    • Sohn, J.-W.1    Harris, L.E.2    Berglund, E.D.3
  • 46
    • 84873053314 scopus 로고    scopus 로고
    • Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques
    • Kievit P, Halem H, Marks DL, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes 2013;62: 490-7
    • (2013) Diabetes , vol.62 , pp. 490-497
    • Kievit, P.1    Halem, H.2    Marks, D.L.3
  • 47
  • 48
    • 84904282384 scopus 로고    scopus 로고
    • National Institutes of Health Washington, DC Available from
    • Effects of RM-493 on energy expenditure in obese individuals. National Institutes of Health, Washington, DC; 2014. Available from: Http: //clinicaltrials. gov/ct2/show/NCT01867437?term=RM-493&rank=2
    • (2014) Effects of RM-493 on energy expenditure in obese individuals
  • 52
    • 84904280153 scopus 로고    scopus 로고
    • Societe de Conseils de Recherches et D'Applications Scientifiques S.A.S. Fr.Louisiana State University and Agriculture and Mechanical College; Ipsen Pharma. WO2009061411A2
    • Societe de Conseils de Recherches et D'Applications Scientifiques S.A.S., Fr.; Louisiana State University and Agriculture and Mechanical College; Ipsen Pharma. Use of melanocortin receptor agonist peptide compounds to treat insulin resistance. WO2009061411A2; 2009
    • (2009) Use of melanocortin receptor agonist peptide compounds to treat insulin resistance
  • 55
    • 78651111374 scopus 로고    scopus 로고
    • Histamine H3 receptor as a drug discovery target
    • Berlin M, Boyce CW, de Lera Ruiz M. Histamine H3 receptor as a drug discovery target. J Med Chem 2011;54: 26-53
    • (2011) J Med Chem , vol.54 , pp. 26-53
    • Berlin, M.1    Boyce, C.W.2    De Lera Ruiz, M.3
  • 56
    • 84885172697 scopus 로고    scopus 로고
    • Bicyclic and tricyclic heterocycle derivatives as histamine H3 receptor antagonists for the treatment of obesity
    • de Lera Ruiz M, Zheng J, Berlin MY, et al. Bicyclic and tricyclic heterocycle derivatives as histamine H3 receptor antagonists for the treatment of obesity. Bioorg Med Chem Lett 2013;23: 6004-9
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 6004-6009
    • De Lera Ruiz, M.1    Zheng, J.2    Berlin, M.Y.3
  • 58
    • 79956202758 scopus 로고    scopus 로고
    • A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: Biochemical, pharmacodynamic, pharmacokinetic, and safety profile
    • Kim E, Campbell S, Schueller O, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: Biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther 2011;337: 775-85
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 775-785
    • Kim, E.1    Campbell, S.2    Schueller, O.3
  • 60
    • 84904355592 scopus 로고    scopus 로고
    • Kadmon Available from
    • Clinical pipeline. Kadmon, 2014. Available from: Http: //kadmon. com/docs/science-pipeline
    • (2014) Clinical pipeline
  • 61
    • 84880133265 scopus 로고    scopus 로고
    • Microsomal transfer protein inhibition in humans
    • Cuchel M, Rader DJ. Microsomal transfer protein inhibition in humans. Curr Opin Lipidol 2013;24: 246-50
    • (2013) Curr Opin Lipidol , vol.24 , pp. 246-250
    • Cuchel, M.1    Rader, D.J.2
  • 62
    • 34249802297 scopus 로고    scopus 로고
    • Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs
    • Wren JA, King VL, Campbell SL, et al. Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs. J Vet Pharmacol Ther 2007;30: 33-42
    • (2007) J Vet Pharmacol Ther , vol.30 , pp. 33-42
    • Wren, J.A.1    King, V.L.2    Campbell, S.L.3
  • 63
    • 79956333142 scopus 로고    scopus 로고
    • JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats
    • Hata T, Mera Y, Kawai T, et al. JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats. Diabetes Obes Metab 2011;13: 629-38
    • (2011) Diabetes Obes Metab , vol.13 , pp. 629-638
    • Hata, T.1    Mera, Y.2    Kawai, T.3
  • 64
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-Affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I, et al. Remogliflozin etabonate, in a novel category of selective low-Affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther 2008;327: 268-76
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3
  • 65
    • 84880643826 scopus 로고    scopus 로고
    • First human doseescalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus
    • Kapur A, O'Connor-Semmes R, Hussey EK, et al. First human doseescalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus. BMC Pharmacol Toxicol 2013;14: 26
    • (2013) BMC Pharmacol Toxicol , vol.14 , pp. 26
    • Kapur, A.1    O'Connor-Semmes, R.2    Hussey, E.K.3
  • 66
    • 84904295149 scopus 로고    scopus 로고
    • BHV Pharma-Our pipeline. Available from
    • BHV Pharma-Our pipeline. BHV Pharma, 2014. Available from: Http: //www.bhvpharma.com/pipeline/
    • (2014) BHV Pharma
  • 67
    • 84897447957 scopus 로고    scopus 로고
    • Canagliflozin: Effects in overweight and obese subjects without diabetes mellitus
    • Bays HE, Weinstein R, Law G, et al. Canagliflozin: Effects in overweight and obese subjects without diabetes mellitus. Obesity (Silver Spring) 2014;22: 1042-9
    • (2014) Obesity (Silver Spring , vol.22 , pp. 1042-1049
    • Bays, H.E.1    Weinstein, R.2    Law, G.3
  • 68
    • 84893844270 scopus 로고    scopus 로고
    • Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition
    • Cefalu WT. Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition. J Clin Invest 2014;124: 485-7
    • (2014) J Clin Invest , vol.124 , pp. 485-487
    • Cefalu, W.T.1
  • 70
    • 79958282647 scopus 로고    scopus 로고
    • Naltrexone SR/ bupropion SR (Contrave): A new approach to weight loss in obese adults
    • Ornellas T, Chavez B. Naltrexone SR/ bupropion SR (Contrave): A new approach to weight loss in obese adults. P T 2011;36: 255-62
    • (2011) P T , vol.36 , pp. 255-262
    • Ornellas, T.1    Chavez, B.2
  • 71
    • 84904309715 scopus 로고    scopus 로고
    • Available from
    • Empatic. Orexigen; 2014. Available from: Http: //www. orexigen.com/product-candidates/ empatic.html
    • (2014) Empatic Orexigen
  • 72
    • 84904361526 scopus 로고    scopus 로고
    • National Institutes of Health, Washington DC Available from
    • Exenatide in extreme pediatric obesity. National Institutes of Health, Washington, DC; 2014. Available from: Http: //clinicaltrials. gov/ct2/show/NCT01237197? term=exenatide+and+Minnesota&rank=2
    • (2014) Exenatide in extreme pediatric obesity
  • 73
    • 84904298529 scopus 로고    scopus 로고
    • National Institutes of Health, Washington DC Available from
    • Topiramate in adolescents with severe obesity. National Institutes of Health, Washington, DC; 2014. Available from: Http: //clinicaltrials. gov/ct2/show/NCT01859013? term=topiramate+and+minnesota&rank=1
    • (2014) Topiramate in adolescents with severe obesity
  • 75
    • 0842348094 scopus 로고    scopus 로고
    • American Diabetes Association American Psychiatric Association American Association of Clinical Endocrinologists. et al. Consensus development conference on antipsychotic drugs and obesity and diabetes
    • American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists. et al. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care 2004;27: 596-601
    • (2004) Diabetes Care , vol.27 , pp. 596-601
  • 77
    • 84904331399 scopus 로고    scopus 로고
    • National Institutes of Health, Washington DC Available from
    • Amlexanox for type 2 diabetes and obesity. National Institutes of Health, Washington, DC; 2014. Available from: Http: //clinicaltrials. gov/ct2/show/NCT01842282? term=amlexanox&rank=2
    • (2014) Amlexanox for type 2 diabetes and obesity
  • 78
    • 84875179301 scopus 로고    scopus 로고
    • An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice
    • Reilly SM, Chiang SH, Decker SJ, et al. An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice. Nat Med 2013;19: 313-21.
    • (2013) Nat Med , vol.19 , pp. 313-321
    • Reilly, S.M.1    Chiang, S.H.2    Decker, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.