메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 131-139

Clinical utility of phentermine/topiramate (Qsymia™) combination for the treatment of obesity

Author keywords

Antiobesity drugs; Combination drug; Obesity; Phentermine; Qsymia; Topiramate; Weight loss

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHENTERMINE; PHENTERMINE PLUS TOPIRAMATE; PLACEBO; TOPIRAMATE; TRIACYLGLYCEROL;

EID: 84876031270     PISSN: 11787007     EISSN: None     Source Type: Journal    
DOI: 10.2147/DMSO.S43403     Document Type: Article
Times cited : (57)

References (57)
  • 1
    • 84967053962 scopus 로고    scopus 로고
    • World Health Organization, Geneva: World Health Organization, Available from, Accessed March 25, 2013
    • World Health Organization. Obesity and overweight [webpage on the Internet]. Geneva: World Health Organization; 2012. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed March 25, 2013.
    • (2012) Obesity and Overweight [webpage On the Internet]
  • 2
    • 40349088822 scopus 로고    scopus 로고
    • The epidemiology of obesity: The size of the problem
    • James WP. The epidemiology of obesity: the size of the problem. J Intern Med. 2008;263(4):336-352.
    • (2008) J Intern Med , vol.263 , Issue.4 , pp. 336-352
    • James, W.P.1
  • 3
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197-1209.
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.2
  • 4
    • 0034630441 scopus 로고    scopus 로고
    • Overweight, obesity, and health risk. National Task Force on the Prevention and Treatment of Obesity
    • Overweight, obesity, and health risk. National Task Force on the Prevention and Treatment of Obesity. Arch Intern Med. 2000;160(7):898-904.
    • (2000) Arch Intern Med , vol.160 , Issue.7 , pp. 898-904
  • 5
    • 0024359327 scopus 로고
    • Long-term follow-up of behavioral treatment for obesity: Patterns of weight regain among men and women
    • Kramer FM, Jeffery RW, Forster JL, Snell MK. Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes. 1989;13(2):123-136.
    • (1989) Int J Obes , vol.13 , Issue.2 , pp. 123-136
    • Kramer, F.M.1    Jeffery, R.W.2    Forster, J.L.3    Snell, M.K.4
  • 6
    • 0034289881 scopus 로고    scopus 로고
    • Long-term efficacy of dietary treatment of obesity: A systematic review of studies published between 1931 and 1999
    • Ayyad C, Andersen T. Long-term efficacy of dietary treatment of obesity: a systematic review of studies published between 1931 and 1999. Obes Rev. 2000;1(2):113-119.
    • (2000) Obes Rev , vol.1 , Issue.2 , pp. 113-119
    • Ayyad, C.1    Andersen, T.2
  • 7
    • 33748344924 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks
    • Gadde KM, Allison DB. Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks. Circulation. 2006;114(9):974-984.
    • (2006) Circulation , vol.114 , Issue.9 , pp. 974-984
    • Gadde, K.M.1    Allison, D.B.2
  • 8
    • 63249114370 scopus 로고    scopus 로고
    • Withdrawal of Rimonabant - walking the tightrope of 21st century pharmaceutical regulation?
    • Taylor D. Withdrawal of Rimonabant - walking the tightrope of 21st century pharmaceutical regulation? Curr Drug Saf. 2009;4(1):2-4.
    • (2009) Curr Drug Saf , vol.4 , Issue.1 , pp. 2-4
    • Taylor, D.1
  • 9
    • 77149170351 scopus 로고    scopus 로고
    • Withdrawal of sibutramine in Europe
    • Williams G. Withdrawal of sibutramine in Europe. BMJ. 2010;340:c824.
    • (2010) BMJ , vol.340
    • Williams, G.1
  • 10
    • 80053516605 scopus 로고    scopus 로고
    • Effectiveness of primary care-relevant treatments for obesity in adults: A systematic evidence review for the US Preventive Services Task Force
    • Leblanc ES, O'Connor E, Whitlock EP, Patnode CD, Kapka T. Effectiveness of primary care-relevant treatments for obesity in adults: a systematic evidence review for the US Preventive Services Task Force. Ann Intern Med. 2011;155(7):434-447.
    • (2011) Ann Intern Med , vol.155 , Issue.7 , pp. 434-447
    • Leblanc, E.S.1    O'Connor, E.2    Whitlock, E.P.3    Patnode, C.D.4    Kapka, T.5
  • 11
    • 0019842317 scopus 로고
    • Limitations of behavioral treatment of obesity: Review and analysis
    • Foreyt JP, Goodrick GK, Gotto AM. Limitations of behavioral treatment of obesity: review and analysis. J Behav Med. 1981;4(2):159-174.
    • (1981) J Behav Med , vol.4 , Issue.2 , pp. 159-174
    • Foreyt, J.P.1    Goodrick, G.K.2    Gotto, A.M.3
  • 12
    • 0024957479 scopus 로고
    • Treatment of obesity by very low calorie diet, behavior therapy, and their combination: A five-year perspective
    • Wadden TA, Sternberg JA, Letizia KA, Stunkard AJ, Foster GD. Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective. Int J Obes. 1989; 13 Suppl 2:39-46.
    • (1989) Int J Obes , vol.13 , Issue.2 SUPPL. , pp. 39-46
    • Wadden, T.A.1    Sternberg, J.A.2    Letizia, K.A.3    Stunkard, A.J.4    Foster, G.D.5
  • 14
    • 0027483751 scopus 로고
    • Methods for voluntary weight loss and control. NIH Technology Assessment Conference Panel. Consensus Development Conference, March 30 to April 1, 1992
    • Methods for voluntary weight loss and control. NIH Technology Assessment Conference Panel. Consensus Development Conference, March 30 to April 1, 1992. Ann Intern Med. 1993;119(7 Pt 2):764-770.
    • (1993) Ann Intern Med , vol.119 , Issue.7 PT. 2 , pp. 764-770
  • 15
    • 0000182485 scopus 로고    scopus 로고
    • National Task Force on the Prevention and Treatment of Obesity
    • Long-term pharmacotherapy in the management of obesity
    • Long-term pharmacotherapy in the management of obesity. National Task Force on the Prevention and Treatment of Obesity. JAMA. 1996;276(23):1907-1915.
    • (1996) JAMA , vol.276 , Issue.23 , pp. 1907-1915
  • 16
    • 67649631173 scopus 로고    scopus 로고
    • Combination pharmaceutical therapies for obesity
    • Gadde KM, Allison DB. Combination pharmaceutical therapies for obesity. Expert Opin Pharmacother. 2009;10(6):921-925.
    • (2009) Expert Opin Pharmacother , vol.10 , Issue.6 , pp. 921-925
    • Gadde, K.M.1    Allison, D.B.2
  • 17
    • 69349104834 scopus 로고    scopus 로고
    • Combination therapy for obesity and metabolic disease
    • Gadde KM, Allison DB. Combination therapy for obesity and metabolic disease. Curr Opin Endocrinol Diabetes Obes. 2009;16(5):353-358.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , Issue.5 , pp. 353-358
    • Gadde, K.M.1    Allison, D.B.2
  • 18
    • 66149175444 scopus 로고    scopus 로고
    • Pharmacotherapy for the obese patient
    • Dickerson LM, Carek PJ. Pharmacotherapy for the obese patient. Prim Care. 2009;36(2):407-415.
    • (2009) Prim Care , vol.36 , Issue.2 , pp. 407-415
    • Dickerson, L.M.1    Carek, P.J.2
  • 19
    • 84876047441 scopus 로고    scopus 로고
    • Qsymia™ (phentermine and topiramate extended-release) [prescribing information]. Mountain View, CA: VIVIUS, Inc
    • Qsymia™ (phentermine and topiramate extended-release) [prescribing information]. Mountain View, CA: VIVIUS, Inc; 2012.
    • (2012)
  • 20
    • 68949165946 scopus 로고    scopus 로고
    • Appetite suppressants, cardiac valve disease and combination pharmacotherapy
    • Rothman RB, Baumann MH. Appetite suppressants, cardiac valve disease and combination pharmacotherapy. Am J Ther. 2009;16(4):354-364.
    • (2009) Am J Ther , vol.16 , Issue.4 , pp. 354-364
    • Rothman, R.B.1    Baumann, M.H.2
  • 21
    • 15244345390 scopus 로고    scopus 로고
    • Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis
    • Alexander M, Rothman RB, Baumann MH, Endres CJ, Brasić JR, Wong DF. Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis. Synapse. 2005;56(2):94-99.
    • (2005) Synapse , vol.56 , Issue.2 , pp. 94-99
    • Alexander, M.1    Rothman, R.B.2    Baumann, M.H.3    Endres, C.J.4    Brasić, J.R.5    Wong, D.F.6
  • 22
    • 84876045639 scopus 로고    scopus 로고
    • Adipex-P (phenteramine) [prescribing information]. Philadelphia, PA: Teva Pharmaceuticals USA, Inc
    • Adipex-P (phenteramine) [prescribing information]. Philadelphia, PA: Teva Pharmaceuticals USA, Inc; 2012.
    • (2012)
  • 24
    • 0346593400 scopus 로고    scopus 로고
    • A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity
    • Bray GA, Hollander P, Klein S, et al. A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res. 2003;11(6):722-733.
    • (2003) Obes Res , vol.11 , Issue.6 , pp. 722-733
    • Bray, G.A.1    Hollander, P.2    Klein, S.3
  • 25
    • 16644400954 scopus 로고    scopus 로고
    • Topiramate: Long-term maintenance of weight loss induced by a low-calorie diet in obese subjects
    • Astrup A, Caterson I, Zelissen P, et al. Topiramate: long-term maintenance of weight loss induced by a low-calorie diet in obese subjects. Obes Res. 2004;12(10):1658-1669.
    • (2004) Obes Res , vol.12 , Issue.10 , pp. 1658-1669
    • Astrup, A.1    Caterson, I.2    Zelissen, P.3
  • 26
    • 34249899669 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients
    • for OBD-202 Study Group
    • Rosenstock J, Hollander P, Gadde KM, Sun X, Strauss R, Leung A; for OBD-202 Study Group. A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients. Diabetes Care. 2007;30(6):1480-1486.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1480-1486
    • Rosenstock, J.1    Hollander, P.2    Gadde, K.M.3    Sun, X.4    Strauss, R.5    Leung, A.6
  • 27
    • 33947668881 scopus 로고    scopus 로고
    • Topiramate in the treatment of obese subjects with drug-naive type 2 diabetes
    • OBDM-003 Study Group
    • Stenlöf K, Rössner S, Vercruysse F, Kumar A, Fitchet M, Sjöström L; OBDM-003 Study Group. Topiramate in the treatment of obese subjects with drug-naive type 2 diabetes. Diabetes Obes Metab. 2007;9(3): 360-368.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.3 , pp. 360-368
    • Stenlöf, K.1    Rössner, S.2    Vercruysse, F.3    Kumar, A.4    Fitchet, M.5    Sjöström, L.6
  • 28
    • 34250842579 scopus 로고    scopus 로고
    • Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: Randomized double-blind placebo-controlled trial
    • Eliasson B, Gudbjörnsdottir S, Cederholm J, Liang T, Vercruysse F, Smith U. Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: randomized double-blind placebo-controlled trial. Int J Obes (Lond). 2007;31(7):1140-1147.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.7 , pp. 1140-1147
    • Eliasson, B.1    Gudbjörnsdottir, S.2    Cederholm, J.3    Liang, T.4    Vercruysse, F.5    Smith, U.6
  • 29
    • 22144479432 scopus 로고    scopus 로고
    • Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension
    • Tonstad S, Tykarski A, Weissgarten J, et al. Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension. Am J Cardiol. 2005;96(2):243-251.
    • (2005) Am J Cardiol , vol.96 , Issue.2 , pp. 243-251
    • Tonstad, S.1    Tykarski, A.2    Weissgarten, J.3
  • 30
    • 8344272013 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects
    • OBES-002 Study Group
    • Wilding J, Van Gaal L, Rissanen A, Vercruysse F, Fitchet M; OBES-002 Study Group. A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects. Int J Obes Relat Metab Disord. 2004;28(11):1399-1410.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.11 , pp. 1399-1410
    • Wilding, J.1    van Gaal, L.2    Rissanen, A.3    Vercruysse, F.4    Fitchet, M.5
  • 31
    • 33845750696 scopus 로고    scopus 로고
    • Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Toplak H, Hamann A, Moore R, et al. Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Int J Obes (Lond). 2007;31(1):138-146.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.1 , pp. 138-146
    • Toplak, H.1    Hamann, A.2    Moore, R.3
  • 32
    • 0033781367 scopus 로고    scopus 로고
    • Influence of topiramate in the regulation of energy balance
    • Richard D, Ferland J, Lalonde J, Samson P, Deshaies Y. Influence of topiramate in the regulation of energy balance. Nutrition. 2000;16(10): 961-966.
    • (2000) Nutrition , vol.16 , Issue.10 , pp. 961-966
    • Richard, D.1    Ferland, J.2    Lalonde, J.3    Samson, P.4    Deshaies, Y.5
  • 34
    • 0034576649 scopus 로고    scopus 로고
    • Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats
    • Picard F, Deshaies Y, Lalonde J, Samson P, Richard D. Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats. Obes Res. 2000;8(9):656-663.
    • (2000) Obes Res , vol.8 , Issue.9 , pp. 656-663
    • Picard, F.1    Deshaies, Y.2    Lalonde, J.3    Samson, P.4    Richard, D.5
  • 35
    • 0042840536 scopus 로고    scopus 로고
    • Predictors of weight loss in adults with topiramate-treated epilepsy
    • Ben-Menachem E, Axelsen M, Johanson EH, Stagge A, Smith U. Predictors of weight loss in adults with topiramate-treated epilepsy. Obes Res. 2003;11(4):556-562.
    • (2003) Obes Res , vol.11 , Issue.4 , pp. 556-562
    • Ben-Menachem, E.1    Axelsen, M.2    Johanson, E.H.3    Stagge, A.4    Smith, U.5
  • 36
    • 33846416927 scopus 로고    scopus 로고
    • The effect of topiramate on energy balance in obese men: A 6-month double-blind randomized placebo-controlled study with a 6-month open-label extension
    • Tremblay A, Chaput JP, Bérubé-Parent S, et al. The effect of topiramate on energy balance in obese men: a 6-month double-blind randomized placebo-controlled study with a 6-month open-label extension. Eur J Clin Pharmacol. 2007;63(2):123-134.
    • (2007) Eur J Clin Pharmacol , vol.63 , Issue.2 , pp. 123-134
    • Tremblay, A.1    Chaput, J.P.2    Bérubé-Parent, S.3
  • 37
    • 34547755883 scopus 로고    scopus 로고
    • Topiramate-induced weight loss is possibly due to the blockade of conditioned and automatic processes
    • author reply 893
    • Khazaal Y, Zullino DF. Topiramate-induced weight loss is possibly due to the blockade of conditioned and automatic processes. Eur J Clin Pharmacol. 2007;63(9):891-892; author reply 893.
    • (2007) Eur J Clin Pharmacol , vol.63 , Issue.9 , pp. 891-892
    • Khazaal, Y.1    Zullino, D.F.2
  • 38
    • 0037315937 scopus 로고    scopus 로고
    • Topiramate in the treatment of binge eating disorder associated with obesity: A randomized, placebo-controlled trial
    • McElroy SL, Arnold LM, Shapira NA, et al. Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial. Am J Psychiatry. 2003;160(2):255-261.
    • (2003) Am J Psychiatry , vol.160 , Issue.2 , pp. 255-261
    • McElroy, S.L.1    Arnold, L.M.2    Shapira, N.A.3
  • 39
    • 61849127278 scopus 로고    scopus 로고
    • GABA(A) receptors in the lateral hypothalamus as mediators of satiety and body weight regulation
    • Turenius CI, Htut MM, Prodon DA, et al. GABA(A) receptors in the lateral hypothalamus as mediators of satiety and body weight regulation. Brain Res. 2009;1262:16-24.
    • (2009) Brain Res , vol.1262 , pp. 16-24
    • Turenius, C.I.1    Htut, M.M.2    Prodon, D.A.3
  • 40
    • 42149099900 scopus 로고    scopus 로고
    • Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
    • De Simone G, Di Fiore A, Supuran CT. Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? Curr Pharm Des. 2008;14(7):655-660.
    • (2008) Curr Pharm Des , vol.14 , Issue.7 , pp. 655-660
    • De Simone, G.1    Di Fiore, A.2    Supuran, C.T.3
  • 41
    • 0034115766 scopus 로고    scopus 로고
    • Topiramate as an inhibitor of carbonic anhydrase isoenzymes
    • Dodgson SJ, Shank RP, Maryanoff BE. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41(Suppl 1): S35-S39.
    • (2000) Epilepsia , vol.41 , Issue.1 SUPPL.
    • Dodgson, S.J.1    Shank, R.P.2    Maryanoff, B.E.3
  • 43
    • 0041922327 scopus 로고    scopus 로고
    • Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: Implications for mood-stabilizing and weight loss-inducing effects
    • Husum H, Van Kammen D, Termeer E, Bolwig G, Mathé A. Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects. Neuropsychopharmacology. 2003;28(7): 1292-1299.
    • (2003) Neuropsychopharmacology , vol.28 , Issue.7 , pp. 1292-1299
    • Husum, H.1    van Kammen, D.2    Termeer, E.3    Bolwig, G.4    Mathé, A.5
  • 44
    • 13844265654 scopus 로고    scopus 로고
    • Topiramate as an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats
    • Wilkes JJ, Nelson E, Osborne M, Demarest KT, Olefsky JM. Topiramate as an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. Am J Physiol Endocrinol Metab. 2005;288(3):E617-E624.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , Issue.3
    • Wilkes, J.J.1    Nelson, E.2    Osborne, M.3    Demarest, K.T.4    Olefsky, J.M.5
  • 45
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784-1792.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 46
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): A randomised, placebo-controlled, phase 3 trial
    • Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377(9774):1341-1352.
    • (2011) Lancet , vol.377 , Issue.9774 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3
  • 47
    • 4644327804 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of topiramate
    • Bialer M, Doose DR, Murthy B, et al. Pharmacokinetic interactions of topiramate. Clin Pharmacokinet. 2004;43(12):763-780.
    • (2004) Clin Pharmacokinet , vol.43 , Issue.12 , pp. 763-780
    • Bialer, M.1    Doose, D.R.2    Murthy, B.3
  • 48
    • 84856579231 scopus 로고    scopus 로고
    • Food and Drug Administration. July 15, Silver Spring, MD: Division of Metabolism and Endocrinology Products (DMEP) Office of Drug Evaluation II Center for Drug Evaluation and Research, US Food and Drug Administration; 2010. Available from, Accessed March 25, 2013
    • Food and Drug Administration. July 15, 2010, Advisory Committee Meeting for Phentermine/Topiramate (Qnexa). Silver Spring, MD: Division of Metabolism and Endocrinology Products (DMEP) Office of Drug Evaluation II Center for Drug Evaluation and Research, US Food and Drug Administration; 2010. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommitee/UCM218824.pdf. Accessed March 25, 2013.
    • (2010) Advisory Committee Meeting For Phentermine/Topiramate (Qnexa)
  • 49
    • 34249775328 scopus 로고    scopus 로고
    • A 24-week randomized controlled trial of VI-0521, a combination weight loss therapy, in obese adults [abstract]
    • Gadde KM, Yonish GM, Foust MS, et al. A 24-week randomized controlled trial of VI-0521, a combination weight loss therapy, in obese adults [abstract]. Obes Res. 2006;14:A17.
    • (2006) Obes Res , vol.14
    • Gadde, K.M.1    Yonish, G.M.2    Foust, M.S.3
  • 50
    • 84856246606 scopus 로고    scopus 로고
    • Controlled-release phentermine/topiramate in severely obese adults: A randomized controlled trial (EQUIP)
    • Allison DB, Gadde KM, Garvey WT, et al. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring). 2012;20(2):330-342.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.2 , pp. 330-342
    • Allison, D.B.1    Gadde, K.M.2    Garvey, W.T.3
  • 51
    • 84856388467 scopus 로고    scopus 로고
    • Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): A randomized, placebo-controlled, phase 3 extension study
    • Garvey WT, Ryan DH, Look M, et al. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr. 2012;95(2):297-308.
    • (2012) Am J Clin Nutr , vol.95 , Issue.2 , pp. 297-308
    • Garvey, W.T.1    Ryan, D.H.2    Look, M.3
  • 52
    • 84868277159 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of an oral, extended-release formulation of phetermine/topiramate for the treatment of obstructive sleep apnea in obese adults
    • Winslow DH, Bowden CH, DiDonato K, McCullough PA. A randomized, double-blind, placebo-controlled study of an oral, extended-release formulation of phetermine/topiramate for the treatment of obstructive sleep apnea in obese adults. Sleep. 2012;35(11):1529-1539.
    • (2012) Sleep , vol.35 , Issue.11 , pp. 1529-1539
    • Winslow, D.H.1    Bowden, C.H.2    Didonato, K.3    McCullough, P.A.4
  • 53
    • 50549083309 scopus 로고    scopus 로고
    • UK Epilepsy and Pregnancy Register. Topiramate in pregnancy: Preliminary experience from the UK Epilepsy and Pregnancy Register
    • Hunt S, Russell A, Smithson WH, et al; UK Epilepsy and Pregnancy Register. Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology. 2008;71(4):272-276.
    • (2008) Neurology , vol.71 , Issue.4 , pp. 272-276
    • Hunt, S.1    Russell, A.2    Smithson, W.H.3
  • 54
    • 84876038380 scopus 로고    scopus 로고
    • Food and Drug Administration, February 22, New Drug Application 22580: VI-052 Qnexa (phentermine/topiramate). Silver Spring, MD: Food and Drug Administration; 2012 Available from, Accessed March 25, 2013
    • Food and Drug Administration. Clinical Briefing Document, Endocrine and Metabolic Drugs Advisory Committee Meeting, February 22, 2012. New Drug Application 22580: VI-052 Qnexa (phentermine/topiramate). Silver Spring, MD: Food and Drug Administration; 2012 Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM292315.pdf. Accessed March 25, 2013.
    • (2012) Clinical Briefing Document, Endocrine and Metabolic Drugs Advisory Committee Meeting
  • 55
    • 0033004178 scopus 로고    scopus 로고
    • Heart rate and the rate-pressure product as determinants of cardiovascular risk in patients with hypertension
    • White WB. Heart rate and the rate-pressure product as determinants of cardiovascular risk in patients with hypertension. Am J Hypertens. 1999;12(2 Pt 2):50S-55S.
    • (1999) Am J Hypertens , vol.12 , Issue.2 PT. 2
    • White, W.B.1
  • 56
    • 1342309941 scopus 로고    scopus 로고
    • The new antiepileptic drugs: Scientific review
    • LaRoche SM, Helmers SL. The new antiepileptic drugs: scientific review. JAMA. 2004;291(5):605-614.
    • (2004) JAMA , vol.291 , Issue.5 , pp. 605-614
    • Laroche, S.M.1    Helmers, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.