메뉴 건너뛰기




Volumn 19, Issue 6, 2014, Pages 906-915

Targeting myeloid differentiation 2 for treatment of sepsis

Author keywords

Eritoran; Lipopolysaccharide; Myeloid differentiation 2; Review; Sepsis; Toll like receptor 4

Indexed keywords

DISACCHARIDE; ERITORAN; LIPOPOLYSACCHARIDE; LY96 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN MD 2; SUGAR PHOSPHATE; TOLL LIKE RECEPTOR 4;

EID: 84904287365     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4256     Document Type: Review
Times cited : (33)

References (65)
  • 1
    • 0037389094 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    • Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31 (4): 1250-6 (2003)
    • (2003) Crit Care Med , vol.31 , Issue.4 , pp. 1250-1256
    • Levy, M.M.1    Fink, M.P.2    Marshall, J.C.3    Abraham, E.4    Angus, D.5    Cook, D.6
  • 4
    • 38349058657 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34 (1): 17-60 (2008)
    • (2008) Intensive Care Med , vol.34 , Issue.1 , pp. 17-60
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3    Bion, J.4    Parker, M.M.5    Jaeschke, R.6
  • 5
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348 (16): 1546-54 (2003)
    • (2003) N Engl J Med , vol.348 , Issue.16 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 6
    • 33748072117 scopus 로고    scopus 로고
    • Mechanisms of mortality in early and late sepsis
    • Xiao H, J Siddiqui, DG Remick: Mechanisms of mortality in early and late sepsis. Infect Immun 74 (9): 5227-35 (2006)
    • (2006) Infect Immun , vol.74 , Issue.9 , pp. 5227-5235
    • Xiao, H.1    Siddiqui, J.2    Remick, D.G.3
  • 8
    • 77956064316 scopus 로고    scopus 로고
    • Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: Evidence from human studies and animal models
    • Kumpf O, RR Schumann: Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: evidence from human studies and animal models. J Innate Immun 2 (5): 381-94 (2010)
    • (2010) J Innate Immun , vol.2 , Issue.5 , pp. 381-394
    • Kumpf, O.1    Schumann, R.R.2
  • 9
    • 66749164669 scopus 로고    scopus 로고
    • The sepsis seesaw: Tilting toward immunosuppression
    • Hotchkiss RS, et al: The sepsis seesaw: tilting toward immunosuppression. Nat Med 15 (5): 496-7 (2009)
    • (2009) Nat Med , vol.15 , Issue.5 , pp. 496-497
    • Hotchkiss, R.S.1
  • 10
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, J Tschopp: The inflammasomes. Cell 140 (6): 821-32 (2010)
    • (2010) Cell , vol.140 , Issue.6 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 11
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, S Akira: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11 (5): 373-84 (2010)
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 12
    • 39149097579 scopus 로고    scopus 로고
    • Host-pathogen interactions in sepsis
    • van der Poll T, SM Opal: Host-pathogen interactions in sepsis. Lancet Infect Dis 8 (1): 32-43 (2008)
    • (2008) Lancet Infect Dis , vol.8 , Issue.1 , pp. 32-43
    • Van Der Poll, T.1    Opal, S.M.2
  • 13
    • 3042785468 scopus 로고    scopus 로고
    • Diagnostic and prognostic implications of endotoxemia in critical illness: Results of the MEDIC study
    • Marshall JC, Foster D, Vincent JL, Cook DJ, Cohen J, Dellinger RP: Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis 190 (3): 527-34 (2004)
    • (2004) J Infect Dis , vol.190 , Issue.3 , pp. 527-534
    • Marshall, J.C.1    Foster, D.2    Vincent, J.L.3    Cook, D.J.4    Cohen, J.5    Dellinger, R.P.6
  • 14
    • 78650233801 scopus 로고    scopus 로고
    • Endotoxin removal devices for the treatment of sepsis and septic shock
    • Davies B, J Cohen: Endotoxin removal devices for the treatment of sepsis and septic shock. Lancet Infect Dis 11 (1): 65-71 (2011)
    • (2011) Lancet Infect Dis , vol.11 , Issue.1 , pp. 65-71
    • Davies, B.1    Cohen, J.2
  • 15
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K: MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 (11): 1777-82 (1999)
    • (1999) J Exp Med , vol.189 , Issue.11 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6
  • 16
  • 17
    • 20644450101 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
    • Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A: Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol 6 (6): 571-8 (2005)
    • (2005) Nat Immunol , vol.6 , Issue.6 , pp. 571-578
    • Divanovic, S.1    Trompette, A.2    Atabani, S.F.3    Madan, R.4    Golenbock, D.T.5    Visintin, A.6
  • 18
    • 0036493503 scopus 로고    scopus 로고
    • Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide
    • Nagai Y, Shimazu R, Ogata H, Akashi S, Sudo K, Yamasaki H: Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood 99 (5): 1699-705 (2002)
    • (2002) Blood , vol.99 , Issue.5 , pp. 1699-1705
    • Nagai, Y.1    Shimazu, R.2    Ogata, H.3    Akashi, S.4    Sudo, K.5    Yamasaki, H.6
  • 19
    • 0035834135 scopus 로고    scopus 로고
    • Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
    • Visintin A, Mazzoni A, Spitzer JA, Segal DM: Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc Natl Acad Sci U S A 98 (21): 12156-61 (2001)
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.21 , pp. 12156-12161
    • Visintin, A.1    Mazzoni, A.2    Spitzer, J.A.3    Segal, D.M.4
  • 20
    • 33745305542 scopus 로고    scopus 로고
    • Analysis of TLR4 polymorphic variants: New insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling
    • Rallabhandi P, Bell J, Boukhvalova MS, Medvedev A, Lorenz E, Arditi M: Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol 177 (1): 322-32 (2006)
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 322-332
    • Rallabhandi, P.1    Bell, J.2    Boukhvalova, M.S.3    Medvedev, A.4    Lorenz, E.5    Arditi, M.6
  • 21
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
    • Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130 (5): 906-17 (2007)
    • (2007) Cell , vol.130 , Issue.5 , pp. 906-917
    • Kim, H.M.1    Park, B.S.2    Kim, J.I.3    Kim, S.E.4    Lee, J.5    Oh, S.C.6
  • 22
    • 9144271703 scopus 로고    scopus 로고
    • Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
    • Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M: Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J Immunol 173 (11): 6949-54 (2004)
    • (2004) J Immunol , vol.173 , Issue.11 , pp. 6949-6954
    • Hyakushima, N.1    Mitsuzawa, H.2    Nishitani, C.3    Sano, H.4    Kuronuma, K.5    Konishi, M.6
  • 24
    • 33845982600 scopus 로고    scopus 로고
    • Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: Importance of CYS29 and CYS40
    • Nishitani C, Mitsuzawa H, Sano H, Shimizu T, Matsushima N, Kuroki Y: Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40. J Biol Chem 281 (50): 38322-9 (2006)
    • (2006) J Biol Chem , vol.281 , Issue.50 , pp. 38322-38329
    • Nishitani, C.1    Mitsuzawa, H.2    Sano, H.3    Shimizu, T.4    Matsushima, N.5    Kuroki, Y.6
  • 25
    • 0242495481 scopus 로고    scopus 로고
    • Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
    • Re F, Strominger JL: Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol 171 (10): 5272-6 (2003)
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5272-5276
    • Re, F.1    Strominger, J.L.2
  • 26
    • 79959447465 scopus 로고    scopus 로고
    • Structural biology of the Toll-like receptor family
    • Kang JY, Lee JO: Structural biology of the Toll-like receptor family. Annu Rev Biochem 80: 917-41 (2011)
    • (2011) Annu Rev Biochem , vol.80 , pp. 917-941
    • Kang, J.Y.1    Lee, J.O.2
  • 27
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO: The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458 (7242): 1191-5 (2009)
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 28
    • 67649386535 scopus 로고    scopus 로고
    • Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin
    • Resman N, Vasl J, Oblak A, Pristovsek P, Gioannini TL, Weiss JP: Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J Biol Chem 284 (22): 15052-60 (2009)
    • (2009) J Biol Chem , vol.284 , Issue.22 , pp. 15052-15060
    • Resman, N.1    Vasl, J.2    Oblak, A.3    Pristovsek, P.4    Gioannini, T.L.5    Weiss, J.P.6
  • 29
    • 27644578690 scopus 로고    scopus 로고
    • Conserved mechanisms of signal transduction by Toll and Toll-like receptors
    • Gangloff M, AN Weber, NJ Gay: Conserved mechanisms of signal transduction by Toll and Toll-like receptors. J Endotoxin Res 11 (5): p294-8 (2005)
    • (2005) J Endotoxin Res , vol.11 , Issue.5 , pp. 294-298
    • Gangloff, M.1    Weber, A.N.2    Gay, N.J.3
  • 30
    • 33749065328 scopus 로고    scopus 로고
    • Roles for accessory molecules in microbial recognition by Toll-like receptors
    • Miyake, K: Roles for accessory molecules in microbial recognition by Toll-like receptors. J Endotoxin Res12 (4): 195-204 (2006)
    • (2006) J Endotoxin Res , vol.12 , Issue.4 , pp. 195-204
    • Miyake, K.1
  • 31
    • 27744516113 scopus 로고    scopus 로고
    • Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2
    • Visintin A, Halmen KA, Latz E, Monks BG, Golenbock DT: Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2. J Immunol 175 (10): 6465-72 (2005)
    • (2005) J Immunol , vol.175 , Issue.10 , pp. 6465-6472
    • Visintin, A.1    Halmen, K.A.2    Latz, E.3    Monks, B.G.4    Golenbock, D.T.5
  • 32
    • 4544254589 scopus 로고    scopus 로고
    • Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling
    • Ohta S, Bahrun U, Tanaka M, Kimoto M: Identification of a novel isoform of MD-2 that downregulates lipopolysaccharide signaling. Biochem Biophys Res Commun 323 (3): 1103-8 (2004)
    • (2004) Biochem Biophys Res Commun , vol.323 , Issue.3 , pp. 1103-1108
    • Ohta, S.1    Bahrun, U.2    Tanaka, M.3    Kimoto, M.4
  • 33
    • 84870519222 scopus 로고    scopus 로고
    • Significance of MD-2 and MD-2B expression in rat liver during acute cholangitis
    • Miao HL, Qiu ZD, Hao FL, Bi YH, Li MY, Chen M: Significance of MD-2 and MD-2B expression in rat liver during acute cholangitis. World J Hepatol 2 (6): 233-8 (2010)
    • (2010) World J Hepatol , vol.2 , Issue.6 , pp. 233-238
    • Miao, H.L.1    Qiu, Z.D.2    Hao, F.L.3    Bi, Y.H.4    Li, M.Y.5    Chen, M.6
  • 34
    • 0037619127 scopus 로고    scopus 로고
    • MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface
    • Ohnishi T, M. Muroi, and K. Tanamoto: MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface. Clin Diagn Lab Immunol 10 (3): 405-10 (2003)
    • (2003) Clin Diagn Lab Immunol , vol.10 , Issue.3 , pp. 405-410
    • Ohnishi, T.1    Muroi, M.2    Tanamoto, K.3
  • 35
    • 70349506775 scopus 로고    scopus 로고
    • Mutational analysis of Cys (88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression
    • Nishitani C, Takahashi M, Mitsuzawa H, Shimizu T, Ariki S, Matsushima N: Mutational analysis of Cys (88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression. Int Immunol 21 (8): 925-34 (2009)
    • (2009) Int Immunol , vol.21 , Issue.8 , pp. 925-934
    • Nishitani, C.1    Takahashi, M.2    Mitsuzawa, H.3    Shimizu, T.4    Ariki, S.5    Matsushima, N.6
  • 36
    • 84885373130 scopus 로고    scopus 로고
    • MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface
    • Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M: MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface. Biochem Biophys Res Commun 440 (1): 31-6 (2013)
    • (2013) Biochem Biophys Res Commun , vol.440 , Issue.1 , pp. 31-36
    • Tsukamoto, H.1    Ihara, H.2    Ito, R.3    Ukai, I.4    Suzuki, N.5    Kimoto, M.6
  • 37
    • 33746214788 scopus 로고    scopus 로고
    • A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4
    • Wakabayashi Y, Kobayashi M, Akashi-Takamura S, Tanimura N, Konno K, Takahashi K: A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. J Immunol 177 (3): 1772-9 (2006)
    • (2006) J Immunol , vol.177 , Issue.3 , pp. 1772-1779
    • Wakabayashi, Y.1    Kobayashi, M.2    Akashi-Takamura, S.3    Tanimura, N.4    Konno, K.5    Takahashi, K.6
  • 38
    • 77950274021 scopus 로고    scopus 로고
    • Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway
    • Park JE, YI Kim, Yi AK: Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol 182 (10): 6316-27 (2009)
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6316-6327
    • Park, J.E.1    Kim, Y.I.2    Yi, A.K.3
  • 39
    • 84856498328 scopus 로고    scopus 로고
    • Myeloid differentiation 2 as a therapeutic target of inflammatory disorders
    • Park SH, Kim ND, Jung JK, Lee CK, Han SB, Kim Y: Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Pharmacol Ther 133 (3): 291-8 (2012)
    • (2012) Pharmacol Ther , vol.133 , Issue.3 , pp. 291-298
    • Park, S.H.1    Kim, N.D.2    Jung, J.K.3    Lee, C.K.4    Han, S.B.5    Kim, Y.6
  • 40
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill LA, Bowie AG: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 (5): 353-64 (2007)
    • (2007) Nat Rev Immunol , vol.7 , Issue.5 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 41
    • 36348932904 scopus 로고    scopus 로고
    • IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
    • Keating SE, Maloney GM, Moran EM, Bowie AG.: IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. J Biol Chem 282 (46): 33435-43 (2007)
    • (2007) J Biol Chem , vol.282 , Issue.46 , pp. 33435-33443
    • Keating, S.E.1    Maloney, G.M.2    Moran, E.M.3    Bowie, A.G.4
  • 42
    • 44049097129 scopus 로고    scopus 로고
    • Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
    • Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y: Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol9 (6): 684-91 (2008)
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 684-691
    • Kawagoe, T.1    Sato, S.2    Matsushita, K.3    Kato, H.4    Matsui, K.5    Kumagai, Y.6
  • 43
    • 0042679529 scopus 로고    scopus 로고
    • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    • Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424 (6950): 743-8 (2003)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 743-748
    • Hoebe, K.1    Du, X.2    Georgel, P.3    Janssen, E.4    Tabeta, K.5    Kim, S.O.6
  • 44
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 (5633): 640-3 (2003)
    • (2003) Science , vol.301 , Issue.5633 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Hoshino, K.4    Kaisho, T.5    Sanjo, H.6
  • 45
    • 0038714270 scopus 로고    scopus 로고
    • Poly (I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR
    • Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X: Poly (I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278 (19): 16713-9 (2003)
    • (2003) J Biol Chem , vol.278 , Issue.19 , pp. 16713-16719
    • Jiang, Z.1    Zamanian-Daryoush, M.2    Nie, H.3    Silva, A.M.4    Williams, B.R.5    Li, X.6
  • 46
    • 2442642691 scopus 로고    scopus 로고
    • RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    • Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M: RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 5 (5): 503-7 (2004)
    • (2004) Nat Immunol , vol.5 , Issue.5 , pp. 503-507
    • Meylan, E.1    Burns, K.2    Hofmann, K.3    Blancheteau, V.4    Martinon, F.5    Kelliher, M.6
  • 47
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    • Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B: Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439 (7073): 208-11 (2006)
    • (2006) Nature , vol.439 , Issue.7073 , pp. 208-211
    • Oganesyan, G.1    Saha, S.K.2    Guo, B.3    He, J.Q.4    Shahangian, A.5    Zarnegar, B.6
  • 48
    • 45249083643 scopus 로고    scopus 로고
    • MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: Effect of acylation state
    • Hadina S, Weiss JP, McCray PB Jr, Kulhankova K, Thorne PS: MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol 38 (6): 647-54 (2008)
    • (2008) Am J Respir Cell Mol Biol , vol.38 , Issue.6 , pp. 647-654
    • Hadina, S.1    Weiss, J.P.2    McCray Jr., P.B.3    Kulhankova, K.4    Thorne, P.S.5
  • 49
    • 10244229656 scopus 로고    scopus 로고
    • Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
    • Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I: Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 104 (13): 4071-9 (2004)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4071-4079
    • Pugin, J.1    Stern-Voeffray, S.2    Daubeuf, B.3    Matthay, M.A.4    Elson, G.5    Dunn-Siegrist, I.6
  • 50
    • 0035211130 scopus 로고    scopus 로고
    • Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition
    • Akashi S, Nagai Y, Ogata H, Oikawa M, Fukase K, Kusumoto S: Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. Int Immunol13 (12): 1595-9 (2001)
    • (2001) Int Immunol , vol.13 , Issue.12 , pp. 1595-1599
    • Akashi, S.1    Nagai, Y.2    Ogata, H.3    Oikawa, M.4    Fukase, K.5    Kusumoto, S.6
  • 51
    • 33646829832 scopus 로고    scopus 로고
    • Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa
    • Muroi, M. and K. Tanamoto: Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa. J Biol Chem281 (9): 5484-91 (2006)
    • (2006) J Biol Chem , vol.281 , Issue.9 , pp. 5484-5491
    • Muroi, M.1    Tanamoto, K.2
  • 52
    • 8344251963 scopus 로고    scopus 로고
    • Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling
    • Saitoh S, Akashi S, Yamada T, Tanimura N, Matsumoto F: Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling. J Endotoxin Res 10 (4): 257-60 (2004)
    • (2004) J Endotoxin Res , vol.10 , Issue.4 , pp. 257-260
    • Saitoh, S.1    Akashi, S.2    Yamada, T.3    Tanimura, N.4    Matsumoto, F.5
  • 53
    • 77956241008 scopus 로고    scopus 로고
    • MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    • Meng J, Drolet JR, Monks BG, Golenbock DT: MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA. J Biol Chem 285 (36): 27935-43 (2010)
    • (2010) J Biol Chem , vol.285 , Issue.36 , pp. 27935-27943
    • Meng, J.1    Drolet, J.R.2    Monks, B.G.3    Golenbock, D.T.4
  • 54
    • 84860832650 scopus 로고    scopus 로고
    • Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
    • Ohto U, Fukase K, Miyake K, Shimizu T: Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc Natl Acad Sci U S A 109 (19): 7421-6 (2012)
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.19 , pp. 7421-7426
    • Ohto, U.1    Fukase, K.2    Miyake, K.3    Shimizu, T.4
  • 55
    • 84887938025 scopus 로고    scopus 로고
    • Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide
    • Artner D, Oblak A, Ittig S, Garate JA, Horvat S, Arrieumerlou C: Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide. ACS Chem Biol 8 (11):2423-32. (2013)
    • (2013) ACS Chem Biol , vol.8 , Issue.11 , pp. 2423-2432
    • Artner, D.1    Oblak, A.2    Ittig, S.3    Garate, J.A.4    Horvat, S.5    Arrieumerlou, C.6
  • 56
    • 3142713223 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by synthetic TLR4 antagonists
    • Hawkins, L.D., W.J. Christ, and D.P. Rossignol: Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem 4 (11): 1147-71. (2004)
    • (2004) Curr Top Med Chem , vol.4 , Issue.11 , pp. 1147-1171
    • Hawkins, L.D.1    Christ, W.J.2    Rossignol, D.P.3
  • 58
    • 74049125175 scopus 로고    scopus 로고
    • Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis
    • Tidswell M, Tillis W, Larosa SP, Lynn M, Wittek AE, Kao R: Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med 38 (1): 72-83 (2010)
    • (2010) Crit Care Med , vol.38 , Issue.1 , pp. 72-83
    • Tidswell, M.1    Tillis, W.2    Larosa, S.P.3    Lynn, M.4    Wittek, A.E.5    Kao, R.6
  • 59
    • 84875124740 scopus 로고    scopus 로고
    • Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial
    • Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP: Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 309 (11): 1154-62 (2013)
    • (2013) JAMA , vol.309 , Issue.11 , pp. 1154-1162
    • Opal, S.M.1    Laterre, P.F.2    Francois, B.3    LaRosa, S.P.4    Angus, D.C.5    Mira, J.P.6
  • 61
    • 84880256950 scopus 로고    scopus 로고
    • Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus
    • Liu B, Fu Y, Feng S, Zhang X, Liu Z, Cao Y: Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Scand J Immunol 78 (1): 8-16 (2013)
    • (2013) Scand J Immunol , vol.78 , Issue.1 , pp. 8-16
    • Liu, B.1    Fu, Y.2    Feng, S.3    Zhang, X.4    Liu, Z.5    Cao, Y.6
  • 62
    • 84875253357 scopus 로고    scopus 로고
    • TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide
    • Kondo Y, et al :TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide. Proc Natl Acad Sci U S A 110 (12): 4714-9 (2013)
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.12 , pp. 4714-4719
    • Kondo, Y.1
  • 63
    • 84880470388 scopus 로고    scopus 로고
    • Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2
    • Kondo Y, Ikeda K, Tokuda N, Nishitani C, Ohto U, Akashi-Takamura S: Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2. Biochem Biophys Res Commun434 (3): 600-5 (2013)
    • (2013) Biochem Biophys Res Commun , vol.434 , Issue.3 , pp. 600-605
    • Kondo, Y.1    Ikeda, K.2    Tokuda, N.3    Nishitani, C.4    Ohto, U.5    Akashi-Takamura, S.6
  • 64
    • 0034672088 scopus 로고    scopus 로고
    • Cutting edge: Naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling
    • Iwami KI, Matsuguchi T, Masuda A, Kikuchi T, Musikacharoen T, Yoshikai Y: Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J Immunol 165 (12): 6682-6 (2000)
    • (2000) J Immunol , vol.165 , Issue.12 , pp. 6682-6686
    • Iwami, K.I.1    Matsuguchi, T.2    Masuda, A.3    Kikuchi, T.4    Musikacharoen, T.5    Yoshikai, Y.6
  • 65
    • 33751584426 scopus 로고    scopus 로고
    • Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
    • Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H: Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol 177 (11): 8133-9 (2006)
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 8133-8139
    • Mitsuzawa, H.1    Nishitani, C.2    Hyakushima, N.3    Shimizu, T.4    Sano, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.