TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 12, 2013, Pages 4714-4719

  Kondo, Yuji ^a   Ikeda, Kazutaka ^b   Tokuda, Noriyo ^a   Nishitani, Chiaki ^c   Ohto, Umeharu ^d   Akashi Takamura, Sachiko ^d   Ito, Yasutomo ^a   Uchikawa, Makoto ^e   Kuroki, Yoshio ^c   Taguchi, Ryo ^f   Miyake, Kensuke ^d   Zhang, Qing ^a   Furukawa, Keiko ^a,f   Furukawa, Koichi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e JAPANESE RED CROSS SOCIETY   (Japan)

^f CHUBU UNIVERSITY   (Japan)

Author keywords

Innate immunity; Sepsis

Indexed keywords

CERAMIDE DERIVATIVE; COMPLEMENTARY DNA; GALACTOSYLTRANSFERASE; GLOBOTETRAOSYLCERAMIDE; GLYCOSPHINGOLIPID; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; LIPID RAFT; MALE; MOLECULAR DOCKING; MORTALITY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; WILD TYPE;

ANIMALS; GALACTOSYLTRANSFERASES; GENE EXPRESSION REGULATION; GLOBOSIDES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE MICRODOMAINS; MICE; MICE, MUTANT STRAINS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; SHOCK, SEPTIC; TOLL-LIKE RECEPTOR 4;

EID: 84875253357     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218508110     Document Type: Article

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