MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: Effect of acylation state

American Journal of Respiratory Cell and Molecular Biology

Volumn 38, Issue 6, 2008, Pages 647-654

  Hacina, Suzana ^a   Weiss, Jerrold P ^a   McCray Jr , Paul B ^a,b   Kulhankova, Katarina ^a   Thorne, Peter S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Endotoxin; Inhalation; Lipooligosaccharide; Pulmonary inflammation

Indexed keywords

CHEMOKINE; CYTOKINE; ENDOTOXIN; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOOLIGOSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PROTEIN MD 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IMMUNE RESPONSE; INFLAMMATION; KINETICS; LUNG LAVAGE; MALE; MOUSE; NEISSERIA MENINGITIDIS; NEUTROPHIL; NONHUMAN; PNEUMONIA; PROTEIN FUNCTION;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL3; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LUNG; LYMPHOCYTE ANTIGEN 96; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEISSERIA MENINGITIDIS, SEROGROUP B; NEUTROPHILS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; NEISSERIA MENINGITIDIS;

EID: 45249083643     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0418OC     Document Type: Article

References (40)

1. Heumann D, Roger T. Initial responses to endotoxins and Gram-negative bacteria. Clin Chim Acta 2002;323:59-72.
2. Schwartz DA, Thorne PS, Yagla SJ, Burmeister LF, Olenchock SA, Watt JL, Quinn TJ. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med 1995;152:603-608.
3. Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol 2000;12:20-26.
4. Alexander C, Rietschel ET. Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 2001;7:167-202.
5. Giardina PC, Gioannini T, Buscher BA, Zaleski A, Zheng DS, Stoll L, Teghanemt A, Apicella MA, Weiss J. Construction of acetate auxotrophs of Neisseria meningitidis to study host-meningococcal endotoxin interactions. J Biol Chem 2001;276:5883-5891.
6. Gioannini TL, Teghanemt A, Zhang D, Coussens NP, Dockstader W, Ramaswamy S, Weiss JP. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc Natl Acad Sci USA 2004;101:4186-4191.
7. Jia HP, Kline JN, Penisten A, Apicella MA, Gioannini TL, Weiss J, McCray PB Jr. Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol 2004;287:L428-L437.
8. Gioannini TL, Teghanemt A, Zhang D, Levis EN, Weiss JP. Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation. J Endotoxin Res 2005;11:117-123.
9. Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss JP, Gioannini TL. Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain. J Biol Chem 2007;282:1010-1017.
10. Post DM, Zhang D, Eastvold JS, Teghanemt A, Gibson BW, Weiss JP. Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B. J Biol Chem 2005;280:38383-38394.
11. Weiss J. Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Biochem Soc Trans 2003;31:785-790.
12. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol 2006;24:353-389.
13. Brandenburg K, Wiese A. Endotoxins: relationships between structure, function, and activity. Curr Top Med Chem 2004;4:1127-1146.
14. Dixon DR, Darveau RP. Lipopolysaccharide heterogeneity: innate host responses to bacterial modification of lipid a structure. J Dent Res 2005;84:584-595.
15. Miller SI, Ernst RK, Bader MW. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol 2005;3:36-46.
16. Munford RS. Detoxifying endotoxin: time, place and person. J Endotoxin Res 2005;11:69-84.
17. Teghanemt A, Zhang D, Levis EN, Weiss JP, Gioannini TL. Molecular basis of reduced potency of underacylated endotoxins. J Immunol 2005;175:4669-4676.
18. Munford RS, Varley AW. Shield as signal: lipopolysaccharides and the evolution of immunity to gram-negative bacteria. PLoS Pathog 2006;2:e67.
19. Coats SR, Pham TT, Bainbridge BW, Reife RA, Darveau RP. MD-2 mediates the ability of tetra-acylated and penta-acylated lipopolysaccharides to antagonize Escherichia coli lipopolysaccharide at the TLR4 signaling complex. J Immunol 2005;175:4490-4498.
20. Ernst RK, Yi EC, Guo L, Lim KB, Burns JL, Hackett M, Miller SI. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science 1999;286:1561-1565.
21. Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K, Stead CM, Trent MS, Miller SI. The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. J Bacteriol 2006;188:191-201.
22. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F, Conlon JE, Fukase K, Kusumoto S, Sweet C, Miyake K, et al. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol 2006;7:1066-1073.
23. HaCina S, Thorne PS, Kulhankova K, McCray PBJ, Weiss JP. Lipooligosaccharide inhalation produces dose- and time-dependant lung inflammation and cytokine release in mice [abstract]. J Allergy Clin Immunol 2006;117:S149.
24. HaCina S, Thorne PS, McCray PBJ, Weiss JP. Lung inflammation depends on the acylation of lipooligosaccharide (LOS) [abstract]. Eur Respir J 2006;S227.
25. HaCina S, Weiss JP, McCray PBJ, Widstrom R, Thorne PS. The importance of MD-2 in the induction of TLR-4 signaling and release of inflammatory cytokines in lungs [abstract]. Am J Respir Crit Care Med 2007;175:A311.
26. Thorne PS. Inhalation toxicology models of endotoxin- and bioaerosol-induced inflammation. Toxicology 2000;152:13-23.
27. Hornung RW, Reed LD. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 1990;5:46-51.
28. Brass DM, Savov JD, Whitehead GS, Maxwell AB, Schwartz DA. LPS binding protein is important in the airway response to inhaled endotoxin. J Allergy Clin Immunol 2004;114:586-592.
29. Hollingsworth JW, Chen BJ, Brass DM, Berman K, Gunn MD, Cook DN, Schwartz DA. The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. Am J Respir Crit Care Med 2005;171:806-813.
30. Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 2005;73:1754-1763.
31. Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, Miyake K. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 2002;3:667-672.
32. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996;110:263-270.
33. Deetz DC, Jagielo PJ, Quinn TJ, Thorne PS, Bleuer SA, Schwartz DA. The kinetics of grain dust-induced inflammation of the lower respiratory tract. Am J Respir Crit Care Med 1997;155:254-259.
34. Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 1999;160:297-303.
35. Jagielo PJ, Thorne PS, Kern JA, Quinn TJ, Schwartz DA. Role of endotoxin in grain dust-induced lung inflammation in mice. Am J Physiol 1996;270:L1052-L1059.
36. Thorne PS, DeKoster JA. Pulmonary effects of machining fluids in guinea pigs and mice. Am Ind Hyg Assoc J 1996;57:1168-1172.
37. Thorne PS, McCray PB, Howe TS, O'Neill MA. Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammation. Am J Respir Cell Mol Biol 1999;20:1155-1164.
38. Thorne PS, Adamcakova-Dodd A, Kelly KM, O'Neill ME, Duchaine C. Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice. Am J Respir Crit Care Med 2006;173:759-768.
39. Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. Am J Physiol Lung Cell Mol Physiol 2001;281:L1106-L1114.
40. Skerrett SJ, Wilson CB, Liggitt HD, Hajjar AM. Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 2007;292:L312-L322.