-
1
-
-
34247857432
-
Pathways of signal transduction employed by vertebrate Hedgehogs
-
N.A. Riobo, and D.R. Manning Pathways of signal transduction employed by vertebrate Hedgehogs Biochem J 403 2007 369 379
-
(2007)
Biochem J
, vol.403
, pp. 369-379
-
-
Riobo, N.A.1
Manning, D.R.2
-
2
-
-
33746879125
-
Patched2 modulates tumorigenesis in patched1 heterozygous mice
-
Y. Lee, H.L. Miller, H.R. Russell, K. Boyd, T. Curran, and P.J. McKinnon Patched2 modulates tumorigenesis in patched1 heterozygous mice Cancer Res 66 2006 6964 6971
-
(2006)
Cancer Res
, vol.66
, pp. 6964-6971
-
-
Lee, Y.1
Miller, H.L.2
Russell, H.R.3
Boyd, K.4
Curran, T.5
McKinnon, P.J.6
-
4
-
-
57049085407
-
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signaling
-
S.K. Ogden, D.L. Fei, N.S. Schilling, Y.F. Ahmed, J. Hwa, and D.J. Robbins G protein Galphai functions immediately downstream of Smoothened in Hedgehog signaling Nature 456 2008 967 970
-
(2008)
Nature
, vol.456
, pp. 967-970
-
-
Ogden, S.K.1
Fei, D.L.2
Schilling, N.S.3
Ahmed, Y.F.4
Hwa, J.5
Robbins, D.J.6
-
5
-
-
36049033946
-
Hedgehog regulates smoothened activity by inducing a conformational switch
-
Y. Zao, C. Tong, and J. Jiang Hedgehog regulates smoothened activity by inducing a conformational switch Nature 450 2007 252 258
-
(2007)
Nature
, vol.450
, pp. 252-258
-
-
Zao, Y.1
Tong, C.2
Jiang, J.3
-
6
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened
-
Y. Chen, N. Sasai, G. Ma, T. Yue, J. Jia, J. Briscoe, and J. Jiang Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened PLoS Biol 9 2011 e1001083
-
(2011)
PLoS Biol
, vol.9
, pp. 1001083
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
Briscoe, J.6
Jiang, J.7
-
7
-
-
84863012714
-
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
-
S. Li, Y. Chen, Q. Shi, T. Yue, B. Wnag, and J. Jiang Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila PLoS Biol 10 2012 e1001239
-
(2012)
PLoS Biol
, vol.10
, pp. 1001239
-
-
Li, S.1
Chen, Y.2
Shi, Q.3
Yue, T.4
Wnag, B.5
Jiang, J.6
-
8
-
-
84863252342
-
Non-canonical Hedgehog signaling
-
D. Brennan, X. Chen, K. Cheng, M. Mahoney, and N.A. Riobo Non-canonical Hedgehog signaling Vitam Horm 88 2012 55 72
-
(2012)
Vitam Horm
, vol.88
, pp. 55-72
-
-
Brennan, D.1
Chen, X.2
Cheng, K.3
Mahoney, M.4
Riobo, N.A.5
-
9
-
-
0032959871
-
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
-
R.J. Wechsler-Reya, and M.P. Scott Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog Neuron 22 1999 103 114
-
(1999)
Neuron
, vol.22
, pp. 103-114
-
-
Wechsler-Reya, R.J.1
Scott, M.P.2
-
10
-
-
33745869471
-
Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis
-
J.X. Zhou, L.W. Jia, W.M. Liu, C.L. Miao, S. Liu, Y.J. Cao, and E.K. Duan Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis Hum Reprod 21 2006 1698 1704
-
(2006)
Hum Reprod
, vol.21
, pp. 1698-1704
-
-
Zhou, J.X.1
Jia, L.W.2
Liu, W.M.3
Miao, C.L.4
Liu, S.5
Cao, Y.J.6
Duan, E.K.7
-
11
-
-
21644458019
-
Hedgehog signaling in murine vasculogenesis and angiogenesis
-
N. Byrd, and L. Grabel Hedgehog signaling in murine vasculogenesis and angiogenesis Trends Cardiovasc Med 14 2004 308 313
-
(2004)
Trends Cardiovasc Med
, vol.14
, pp. 308-313
-
-
Byrd, N.1
Grabel, L.2
-
12
-
-
77951932085
-
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
-
P. Chinchilla, L. Xiao, M.G. Kazanietz, and N.A. Riobo Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways Cell Cycle 9 2001 570 579
-
(2001)
Cell Cycle
, vol.9
, pp. 570-579
-
-
Chinchilla, P.1
Xiao, L.2
Kazanietz, M.G.3
Riobo, N.A.4
-
13
-
-
15844381336
-
Human homolog of patched, a candidate for basal cell nevus syndrome
-
R.L. Johnson, A.L. Rothman, J. Xie, L.V. Goodrich, J.W. Bare, J.M. Bonifas, A.G. Quinn, R.M. Myers, D.R. Cox, E.H. Epstein Jr., and M.P. Scott Human homolog of patched, a candidate for basal cell nevus syndrome Science 272 1996 1668 1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, Jr.E.H.10
Scott, M.P.11
-
14
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevus basal cell carcinoma syndrome
-
H. Hahn, C. Wicking, P.G. Zaphiropoulous, M.R. Gailani, S. Shanley, A. Chidambaram, I. Vorechovsky, E. Holmberg, A.B. Unden, and S. Gillies Mutations of the human homolog of Drosophila patched in the nevus basal cell carcinoma syndrome Cell 85 1996 841 851
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
-
15
-
-
0031036694
-
Sporadic medulloblastomas contain PTCH mutations
-
C. Raffel, R.B. Jenkins, L. Frederick, D. Hebrink, B. Alderete, D.W. Fults, and C.D. James Sporadic medulloblastomas contain PTCH mutations Cancer Res 57 1997 842 845
-
(1997)
Cancer Res
, vol.57
, pp. 842-845
-
-
Raffel, C.1
Jenkins, R.B.2
Frederick, L.3
Hebrink, D.4
Alderete, B.5
Fults, D.W.6
James, C.D.7
-
16
-
-
0030874617
-
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumors
-
I. Vorechovský, O. Tingby, M. Hartman, B. Strömberg, M. Nister, V.P. Collins, and R. Toftgård Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumors Oncogene 15 1997 361 366
-
(1997)
Oncogene
, vol.15
, pp. 361-366
-
-
Vorechovský, I.1
Tingby, O.2
Hartman, M.3
Strömberg, B.4
Nister, M.5
Collins, V.P.6
Toftgård, R.7
-
17
-
-
0029841366
-
Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PTCH inactivation
-
A.B. Unden, E. Holmberg, B. Lundh-Rozell, M. Stähle-Bäckdahl, P.G. Zaphiropoulos, R. Toftgård, and I. Vorechovsky Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation Cancer Res 56 1996 4562 4565
-
(1996)
Cancer Res
, vol.56
, pp. 4562-4565
-
-
Unden, A.B.1
Holmberg, E.2
Lundh-Rozell, B.3
Stähle-Bäckdahl, M.4
Zaphiropoulos, P.G.5
Toftgård, R.6
Vorechovsky, I.7
-
18
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
M.D. Taylor, L. Liu, C. Raffel, C.C. Hui, T.G. Mainprize, X. Zhang, R. Agatep, S. Chiappa, L. Gao, and A. Lowrance Mutations in SUFU predispose to medulloblastoma Nat Genet 31 2002 306 310
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
Hui, C.C.4
Mainprize, T.G.5
Zhang, X.6
Agatep, R.7
Chiappa, S.8
Gao, L.9
Lowrance, A.10
-
19
-
-
84863979877
-
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age
-
L. Brugières, A. Remenieras, G. Pierron, P. Varlet, S. Forget, V. Byrde, J. Bombled, S. Puget, O. Caron, and C. Dufour High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age J Clin Oncol 30 2012 2087 2093
-
(2012)
J Clin Oncol
, vol.30
, pp. 2087-2093
-
-
Brugières, L.1
Remenieras, A.2
Pierron, G.3
Varlet, P.4
Forget, S.5
Byrde, V.6
Bombled, J.7
Puget, S.8
Caron, O.9
Dufour, C.10
-
20
-
-
0033590605
-
A frequent activated smoothened mutation in sporadic basal cell carcinomas
-
C.W. Lam, J. Xie, K.F. To, H.K. Ng, K.C. Lee, N.W. Yuen, P.L. Lim, L.Y. Chan, S.F. Tong, and F. McCormick A frequent activated smoothened mutation in sporadic basal cell carcinomas Oncogene 18 1999 833 836
-
(1999)
Oncogene
, vol.18
, pp. 833-836
-
-
Lam, C.W.1
Xie, J.2
To, K.F.3
Ng, H.K.4
Lee, K.C.5
Yuen, N.W.6
Lim, P.L.7
Chan, L.Y.8
Tong, S.F.9
McCormick, F.10
-
21
-
-
33750543972
-
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway
-
J. Mao, K.L. Ligon, E.Y. Rakhlin, S.P. Thayer, R.T. Bronson, D. Rowitch, and A.P. McMahon A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway Cancer Res 66 2006 10171 10178
-
(2006)
Cancer Res
, vol.66
, pp. 10171-10178
-
-
Mao, J.1
Ligon, K.L.2
Rakhlin, E.Y.3
Thayer, S.P.4
Bronson, R.T.5
Rowitch, D.6
McMahon, A.P.7
-
22
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
D.M. Berman, S.S. Karhadkar, A. Maitra, R. Montes De Oca, M.R. Gerstenblith, K. Briggs, A.R. Parker, Y. Shimada, J.R. Eshleman, D.N. Watkins, and P.A. Beachy Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 2003 846 851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
Parker, A.R.7
Shimada, Y.8
Eshleman, J.R.9
Watkins, D.N.10
Beachy, P.A.11
-
23
-
-
0242669237
-
Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer
-
D.N. Watkins, D.M. Berman, S.G. Burkholder, B. Wang, P.A. Beachy, and S.B. Baylin Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer Nature 422 2003 313 317
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
24
-
-
6044243650
-
Hedgehog signaling in prostate regeneration, neoplasias and metastasis
-
S.S. Karhadkar, G.S. Bova, N. Abdallah, S. Dhara, D. Gardner, A. Maitra, J.T. Isaacs, D.M. Berman, and P.A. Beachy Hedgehog signaling in prostate regeneration, neoplasias and metastasis Nature 431 2004 707 712
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
26
-
-
34547683699
-
Essential role of stromally induced hedgehog signaling in B-cell malignancies
-
C. Dierks, J. Grbic, K. Zirlik, R. Beigi, N.P. Englund, G.R. Guo, H. Veelken, M. Engelhardt, R. Mertelsmann, and J.F. Kelleher Essential role of stromally induced hedgehog signaling in B-cell malignancies Nat Med 13 2007 944 951
-
(2007)
Nat Med
, vol.13
, pp. 944-951
-
-
Dierks, C.1
Grbic, J.2
Zirlik, K.3
Beigi, R.4
Englund, N.P.5
Guo, G.R.6
Veelken, H.7
Engelhardt, M.8
Mertelsmann, R.9
Kelleher, J.F.10
-
27
-
-
77749249596
-
Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells
-
K. Nakamura, J. Sasajima, Y. Mizukami, Y. Sugiyama, M. Yamazaki, R. Fujii, T. Kawamoto, K. Koizumi, K. Sato, and M. Fujiya Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells PLoS One 5 2010 e8824
-
(2010)
PLoS One
, vol.5
, pp. 8824
-
-
Nakamura, K.1
Sasajima, J.2
Mizukami, Y.3
Sugiyama, Y.4
Yamazaki, M.5
Fujii, R.6
Kawamoto, T.7
Koizumi, K.8
Sato, K.9
Fujiya, M.10
-
28
-
-
0029844192
-
Cholesterol modification of hedgehog signaling proteins in animal development
-
J.A. Porter, K.E. Young, and P.A. Beachy Cholesterol modification of hedgehog signaling proteins in animal development Science 274 1996 255 259
-
(1996)
Science
, vol.274
, pp. 255-259
-
-
Porter, J.A.1
Young, K.E.2
Beachy, P.A.3
-
29
-
-
15444359695
-
Identification of a palmitic acid-modified form of human Sonic Hedgehog
-
R.B. Pepinsky, C. Zeng, D. Wen, P. Rayhorn, D.P. Baker, K.P. Williams, S.A. Bixler, C.M. Ambrose, E.A. Garber, and K. Miatkowski Identification of a palmitic acid-modified form of human Sonic Hedgehog J Biol Chem 273 1998 14037 14045
-
(1998)
J Biol Chem
, vol.273
, pp. 14037-14045
-
-
Pepinsky, R.B.1
Zeng, C.2
Wen, D.3
Rayhorn, P.4
Baker, D.P.5
Williams, K.P.6
Bixler, S.A.7
Ambrose, C.M.8
Garber, E.A.9
Miatkowski, K.10
-
30
-
-
0037020216
-
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
-
Y. Ma, A. Erkner, R. Gong, S. Yao, J. Taipale, K. Basler, and P.A. Beachy Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched Cell 111 2002 63 75
-
(2002)
Cell
, vol.111
, pp. 63-75
-
-
Ma, Y.1
Erkner, A.2
Gong, R.3
Yao, S.4
Taipale, J.5
Basler, K.6
Beachy, P.A.7
-
31
-
-
0037125938
-
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling
-
T. Caspary, M.J. García-García, D. Huangfu, J.T. Eggenschwiler, M.R. Wyler, A.S. Rakeman, H.L. Alcorn, and K.V. Anderson Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling Curr Biol 12 2002 1628 1632
-
(2002)
Curr Biol
, vol.12
, pp. 1628-1632
-
-
Caspary, T.1
García-García, M.J.2
Huangfu, D.3
Eggenschwiler, J.T.4
Wyler, M.R.5
Rakeman, A.S.6
Alcorn, H.L.7
Anderson, K.V.8
-
32
-
-
0035822098
-
A freely diffusible form of Sonic hedgehog mediates long-range signaling
-
X. Zeng, J.A. Goetz, L.M. Suber, W.J. Scott Jr., C.M. Schreiner, and D.J. Robbins A freely diffusible form of Sonic hedgehog mediates long-range signaling Nature 411 2001 716 720
-
(2001)
Nature
, vol.411
, pp. 716-720
-
-
Zeng, X.1
Goetz, J.A.2
Suber, L.M.3
Scott, Jr.W.J.4
Schreiner, C.M.5
Robbins, D.J.6
-
33
-
-
18344378499
-
Lipoprotein particles are required for Hedgehog and Wingless signaling
-
D. Panáková, H. Sprong, E. Marois, C. Thiele, and S. Eaton Lipoprotein particles are required for Hedgehog and Wingless signaling Nature 435 2005 58 65
-
(2005)
Nature
, vol.435
, pp. 58-65
-
-
Panáková, D.1
Sprong, H.2
Marois, E.3
Thiele, C.4
Eaton, S.5
-
34
-
-
78149400975
-
Human plasma very low density lipoprotein carries Indian hedgehog
-
K.C. Queiroz, R.A. Tio, C.J. Zeebregts, M.F. Bijlsma, F. Zijlstra, B. Badlou, M. de Vries, C.V. Ferreira, C.A. Spek, M.P. Peppelenbosch, and F. Rezaee Human plasma very low density lipoprotein carries Indian hedgehog J Proteome Res 9 2010 6052 6059
-
(2010)
J Proteome Res
, vol.9
, pp. 6052-6059
-
-
Queiroz, K.C.1
Tio, R.A.2
Zeebregts, C.J.3
Bijlsma, M.F.4
Zijlstra, F.5
Badlou, B.6
De Vries, M.7
Ferreira, C.V.8
Spek, C.A.9
Peppelenbosch, M.P.10
Rezaee, F.11
-
35
-
-
84857764655
-
Sonic hedgehog on microparticles and neovascularization
-
R. Soleti, and M.C. Martinez Sonic hedgehog on microparticles and neovascularization Vitam Horm 88 2012 395 428
-
(2012)
Vitam Horm
, vol.88
, pp. 395-428
-
-
Soleti, R.1
Martinez, M.C.2
-
36
-
-
77449105629
-
The full-length unprocessed hedgehog protein is an active signaling molecule
-
R. Tokhunts, S. Singh, T. Chu, G. D'Angelo, V. Baubet, J.A. Goetz, Z. Huang, Z. Yuan, M. Ascano, and Y. Zavros The full-length unprocessed hedgehog protein is an active signaling molecule J Biol Chem 285 2010 2562 2568
-
(2010)
J Biol Chem
, vol.285
, pp. 2562-2568
-
-
Tokhunts, R.1
Singh, S.2
Chu, T.3
D'Angelo, G.4
Baubet, V.5
Goetz, J.A.6
Huang, Z.7
Yuan, Z.8
Ascano, M.9
Zavros, Y.10
-
37
-
-
38949218488
-
Patched, the receptor of Hedgehog, is a lipoprotein receptor
-
A. Callejo, J. Culi, and I. Guerrero Patched, the receptor of Hedgehog, is a lipoprotein receptor Proc Natl Acad Sci U S A 105 2008 912 917
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 912-917
-
-
Callejo, A.1
Culi, J.2
Guerrero, I.3
-
38
-
-
84857003746
-
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals
-
A. Christ, A. Christa, E. Kur, O. Lioubinski, S. Bachmann, T.E. Willnow, and A. Hammes LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals Dev Cell 22 2012 268 278
-
(2012)
Dev Cell
, vol.22
, pp. 268-278
-
-
Christ, A.1
Christa, A.2
Kur, E.3
Lioubinski, O.4
Bachmann, S.5
Willnow, T.E.6
Hammes, A.7
-
39
-
-
0029775625
-
Defective forebrain development in mice lacking gp330/megalin
-
T.E. Willnow, J. Hilpert, S.A. Armstrong, A. Rohlmann, R.E. Hammer, D.K. Burns, and J. Herz Defective forebrain development in mice lacking gp330/megalin Proc Natl Acad Sci U S A 93 1996 8460 8464
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8460-8464
-
-
Willnow, T.E.1
Hilpert, J.2
Armstrong, S.A.3
Rohlmann, A.4
Hammer, R.E.5
Burns, D.K.6
Herz, J.7
-
40
-
-
67649470380
-
Proximal events in Wnt signal transduction
-
S. Angers, and R.T. Moon Proximal events in Wnt signal transduction Nat Rev Mol Cell Biol 10 2009 468 477
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 468-477
-
-
Angers, S.1
Moon, R.T.2
-
41
-
-
80052521709
-
The hedgehog receptor patched is involved in cholesterol transport
-
M. Bidet, O. Joubert, B. Lacombe, M. Ciantar, R. Nehmé, P. Mollat, L. Brétillon, H. Faure, R. Bittman, M. Ruat, and I. Mus-Veteau The hedgehog receptor patched is involved in cholesterol transport PLoS One 6 2011 e23834
-
(2011)
PLoS One
, vol.6
, pp. 23834
-
-
Bidet, M.1
Joubert, O.2
Lacombe, B.3
Ciantar, M.4
Nehmé, R.5
Mollat, P.6
Brétillon, L.7
Faure, H.8
Bittman, R.9
Ruat, M.10
Mus-Veteau, I.11
-
42
-
-
15844386540
-
Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
-
J.A. Porter, S.C. Ekker, W.J. Park, D.P. von Kessler, K.E. Young, C.H. Chen, Y. Ma, A.S. Woods, R.J. Cotter, E.V. Koonin, and P.A. Beachy Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain Cell 86 1996 21 34
-
(1996)
Cell
, vol.86
, pp. 21-34
-
-
Porter, J.A.1
Ekker, S.C.2
Park, W.J.3
Von Kessler, D.P.4
Young, K.E.5
Chen, C.H.6
Ma, Y.7
Woods, A.S.8
Cotter, R.J.9
Koonin, E.V.10
Beachy, P.A.11
-
43
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
J. Taipale, M.K. Cooper, T. Maiti, and P.A. Beachy Patched acts catalytically to suppress the activity of Smoothened Nature 418 2002 892 897
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
44
-
-
44349159118
-
Multiple role for lipids in the Hedgehog signaling pathway
-
S. Eaton Multiple role for lipids in the Hedgehog signaling pathway Nat Rev Mol Cell Biol 9 2008 437 445
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 437-445
-
-
Eaton, S.1
-
45
-
-
84856098531
-
Oxysterols are allosteric activators of the oncoprotein Smoothened
-
S. Nachtergaele, L.K. Mydock, K. Krishnan, J. Rammohan, P.H. Schlesinger, D.F. Covey, and R. Rohatgi Oxysterols are allosteric activators of the oncoprotein Smoothened Nat Chem Biol 8 2012 211 220
-
(2012)
Nat Chem Biol
, vol.8
, pp. 211-220
-
-
Nachtergaele, S.1
Mydock, L.K.2
Krishnan, K.3
Rammohan, J.4
Schlesinger, P.H.5
Covey, D.F.6
Rohatgi, R.7
-
46
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
R.B. Corcoran, and M.P. Scott Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Proc Natl Acad Sci U S A 103 2006 8408 8413
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
47
-
-
34247844371
-
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
-
J.R. Dwyer, N. Sever, M. Carlson, S.F. Nelson, P.A. Beachy, and F. Parhami Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells J Biol Chem 282 2007 8959 8968
-
(2007)
J Biol Chem
, vol.282
, pp. 8959-8968
-
-
Dwyer, J.R.1
Sever, N.2
Carlson, M.3
Nelson, S.F.4
Beachy, P.A.5
Parhami, F.6
-
48
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion
-
M.F. Bijlsma, C.A. Spek, D. Zivkovic, S. van de Water, F. Rezaee, and M.P. Peppelenbosch Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion PLoS Biol 4 2006 e232
-
(2006)
PLoS Biol
, vol.4
, pp. 232
-
-
Bijlsma, M.F.1
Spek, C.A.2
Zivkovic, D.3
Van De Water, S.4
Rezaee, F.5
Peppelenbosch, M.P.6
-
49
-
-
77954214394
-
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
-
C. Mas, and A. Ruiz i Altaba Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations Biochem Pharmacol 80 2010 712 723
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 712-723
-
-
Mas, C.1
Ruiz Altaba I, A.2
-
50
-
-
84861161918
-
Vismodegib granted FDA approval for treatment of basal cell carcinoma
-
213
-
Vismodegib granted FDA approval for treatment of basal cell carcinoma Oncology (Williston Park) 26 2012 174, 213
-
(2012)
Oncology (Williston Park)
, vol.26
, pp. 174
-
-
-
51
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
R.L. Yauch, G.J. Dijkgraaf, B. Alicke, T. Januario, C.P. Ahn, T. Holcomb, K. Pujara, J. Stinson, C.A. Callahan, and T. Tang Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma Science 326 2009 572 574
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
Januario, T.4
Ahn, C.P.5
Holcomb, T.6
Pujara, K.7
Stinson, J.8
Callahan, C.A.9
Tang, T.10
-
52
-
-
84870486273
-
Vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma
-
S. Baek, Y.S. Lee, H.E. Shim, S. Yoon, S.Y. Baek, B.S. Kim, and S.O. Oh Vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma Anat Cell Biol 44 2011 204 209
-
(2011)
Anat Cell Biol
, vol.44
, pp. 204-209
-
-
Baek, S.1
Lee, Y.S.2
Shim, H.E.3
Yoon, S.4
Baek, S.Y.5
Kim, B.S.6
Oh, S.O.7
-
53
-
-
81055149896
-
Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation
-
A. Uhmann, H. Niemann, B. Lammering, C. Henkel, I. Hess, F. Nitzki, A. Fritsch, N. Prüfer, A. Rosenberger, and C. Dullin Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation Mol Cancer Ther 10 2011 2179 2188
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2179-2188
-
-
Uhmann, A.1
Niemann, H.2
Lammering, B.3
Henkel, C.4
Hess, I.5
Nitzki, F.6
Fritsch, A.7
Prüfer, N.8
Rosenberger, A.9
Dullin, C.10
-
54
-
-
79955820914
-
Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas
-
J.Y. Tang, T.Z. Xiao, Y. Oda, K.S. Chang, E. Shpall, A. Wu, P.L. So, J. Hebert, D. Bikle, and E.H. Epstein Jr. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas Cancer Prev Res 4 2011 744 751
-
(2011)
Cancer Prev Res
, vol.4
, pp. 744-751
-
-
Tang, J.Y.1
Xiao, T.Z.2
Oda, Y.3
Chang, K.S.4
Shpall, E.5
Wu, A.6
So, P.L.7
Hebert, J.8
Bikle, D.9
Epstein, Jr.E.H.10
-
55
-
-
77954401002
-
Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenografts model of pancreatic cancer
-
L.W. Bruggemann, K.C. Queiroz, K. Zamani, A. van Straaten, C.A. Spek, and M.F. Bijlsma Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenografts model of pancreatic cancer Cancer Biol Ther 10 2010 79 88
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 79-88
-
-
Bruggemann, L.W.1
Queiroz, K.C.2
Zamani, K.3
Van Straaten, A.4
Spek, C.A.5
Bijlsma, M.F.6
-
56
-
-
19444364509
-
Statins and the risk of colorectal cancer
-
J.N. Poynter, S.B. Gruber, P.D. Higgins, R. Almog, J.D. Bonner, H.S. Rennert, M. Low, J.K. Greenson, and G. Rennert Statins and the risk of colorectal cancer N Engl J Med 352 2005 2184 2192
-
(2005)
N Engl J Med
, vol.352
, pp. 2184-2192
-
-
Poynter, J.N.1
Gruber, S.B.2
Higgins, P.D.3
Almog, R.4
Bonner, J.D.5
Rennert, H.S.6
Low, M.7
Greenson, J.K.8
Rennert, G.9
-
57
-
-
23944487796
-
Statins and prostate cancer risk: A case-control study
-
J. Shannon, S. Tewoderos, M. Garzotto, T.M. Beer, R. Derenick, A. Palma, and P.E. Farris Statins and prostate cancer risk: a case-control study Am J Epidemiol 162 2005 318 325
-
(2005)
Am J Epidemiol
, vol.162
, pp. 318-325
-
-
Shannon, J.1
Tewoderos, S.2
Garzotto, M.3
Beer, T.M.4
Derenick, R.5
Palma, A.6
Farris, P.E.7
-
58
-
-
29944446607
-
Statins and cancer risk: A meta-analysis
-
K.M. Dale, C.I. Coleman, N.N. Henyan, J. Kluger, and C.M. White Statins and cancer risk: a meta-analysis JAMA 295 2006 74 80
-
(2006)
JAMA
, vol.295
, pp. 74-80
-
-
Dale, K.M.1
Coleman, C.I.2
Henyan, N.N.3
Kluger, J.4
White, C.M.5
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