Involvement of the nuclear high mobility group B1 peptides released from injured hepatocytes in murine hepatic fibrogenesis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 9, 2014, Pages 1720-1732

  Kao, Ying Hsien ^a   Lin, Yu Chun ^a   Tsai, Ming Shian ^a   Sun, Cheuk Kwan ^a   Yuan, Shyng Shiou ^b   Chang, Chih Yang ^a   Jawan, Bruno ^c   Lee, Po Huang ^a,d  

^a E DA HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Hepatic stellate cells; Oxidative stress; RAGE; Smad2 phosphorylation; TGF 1 signaling; TLR4

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; COLLAGEN TYPE 1; HIGH MOBILITY GROUP B1 PROTEIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTRALIZING ANTIBODY; SMAD2 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1; COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENE SILENCING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL DAMAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RNA INTERFERENCE; STELLATE CELL; UPREGULATION; ANIMAL CELL; CELL ACTIVATION; CELL CULTURE; CELL DAMAGE; CELL TRANSFORMATION; CHEMICAL STRESS; COLLAGEN SYNTHESIS; CYTOPLASM; ENZYME PHOSPHORYLATION; FIBROGENESIS; LIVER; LIVER CELL; LIVER FIBROSIS; LIVER PARENCHYMA; OXIDATIVE STRESS; PARACRINE SIGNALING; PROTEIN BLOOD LEVEL; RAT;

HEPATIC STELLATE CELLS; OXIDATIVE STRESS; RAGE; SMAD2 PHOSPHORYLATION; TGF-Β1 SIGNALING; TLR4;

ANIMALS; BLOTTING, WESTERN; CARBON TETRACHLORIDE; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; CYTOPLASM; HEPATIC STELLATE CELLS; HEPATOCYTES; HMGB1 PROTEIN; HYDROGEN PEROXIDE; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED ICR; OXIDANTS; PEPTIDE FRAGMENTS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 4;

EID: 84904092153     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.06.017     Document Type: Article

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