메뉴 건너뛰기




Volumn 38, Issue 4, 2003, Pages 879-889

p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0141866937     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50384     Document Type: Article
Times cited : (250)

References (30)
  • 1
    • 33746521801 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies
    • Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993;328:1828-1835.
    • (1993) N Engl J Med , vol.328 , pp. 1828-1835
    • Friedman, S.L.1
  • 2
    • 0000116653 scopus 로고
    • Peptide growth factors and their receptors
    • Roberts AB, Sporn MB, eds. Heidelberg: Springer-Verlag
    • Roberts AB, Sporn MB. Peptide growth factors and their receptors. In: Roberts AB, Sporn MB, eds. Handbook of Experimental Pharmacology. Heidelberg: Springer-Verlag, 1990;419-472.
    • (1990) Handbook of Experimental Pharmacology , pp. 419-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 3
    • 0029121317 scopus 로고
    • Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells
    • Gressner AM, Bachem MG. Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells. Digestion 1995;56:335-346.
    • (1995) Digestion , vol.56 , pp. 335-346
    • Gressner, A.M.1    Bachem, M.G.2
  • 4
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 5
    • 0034695511 scopus 로고    scopus 로고
    • Regulation of Smad activity
    • Wrana JL. Regulation of Smad activity. Cell 2000;100:189-192.
    • (2000) Cell , vol.100 , pp. 189-192
    • Wrana, J.L.1
  • 6
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-β responses
    • Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-β responses. Cell 1998;95:737-740.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.H.3
  • 7
    • 0034023701 scopus 로고    scopus 로고
    • The Smads: Transcriptional regulation and mouse models
    • Datto M, Wang XF. The Smads: transcriptional regulation and mouse models. Cytokine Growth Factor Rev 2000;11:37-48.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 37-48
    • Datto, M.1    Wang, X.F.2
  • 8
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
    • Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, et al. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 1997;89:1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3    Cai, J.4    Xu, Y.Y.5    Grinnell, B.W.6    Richardson, M.A.7
  • 10
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997;9:180-186.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 11
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
    • Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 1995;270:2008-2011.
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1    Shirakabe, K.2    Shibuya, H.3    Irie, K.4    Oishi, I.5    Ueno, N.6    Taniguchi, T.7
  • 12
    • 0033578721 scopus 로고    scopus 로고
    • Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
    • Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, et al. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression. J Biol Chem 1999;274:27161-27167.
    • (1999) J Biol Chem , vol.274 , pp. 27161-27167
    • Hanafusa, H.1    Ninomiya-Tsuji, J.2    Masuyama, N.3    Nishita, M.4    Fujisawa, J.5    Shibuya, H.6    Matsumoto, K.7
  • 13
    • 0034057158 scopus 로고    scopus 로고
    • Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture
    • Reeves HL, Dack CL, Peak M, Burt AD, Day CP. Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture. J Hepatol 2000;32:465-472.
    • (2000) J Hepatol , vol.32 , pp. 465-472
    • Reeves, H.L.1    Dack, C.L.2    Peak, M.3    Burt, A.D.4    Day, C.P.5
  • 14
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar M, Doody J, Timokhina I, Massagué J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999;13:804-816.
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 15
    • 18244401140 scopus 로고    scopus 로고
    • Differential regulation of TGFβ signal in hepatic stellate cells between acute and chronic rat liver injury
    • Tahashi Y, Matsuzaki K, Date M, Yoshida K, Furukawa F, Sugano Y, Matsushita M, et al. Differential regulation of TGFβ signal in hepatic stellate cells between acute and chronic rat liver injury. HEPATOLOGY 2002;35:49-61.
    • (2002) Hepatology , vol.35 , pp. 49-61
    • Tahashi, Y.1    Matsuzaki, K.2    Date, M.3    Yoshida, K.4    Furukawa, F.5    Sugano, Y.6    Matsushita, M.7
  • 16
    • 0035120166 scopus 로고    scopus 로고
    • Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells
    • Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, ten Dijke P, et al. Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 2001;187:117-123.
    • (2001) J Cell Physiol , vol.187 , pp. 117-123
    • Inagaki, Y.1    Mamura, M.2    Kanamaru, Y.3    Greenwel, P.4    Nemoto, T.5    Takehara, K.6    Ten Dijke, P.7
  • 17
    • 0035958625 scopus 로고    scopus 로고
    • Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFβ signal transduction during transdifferentiation of hepatic stellate cells
    • Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM. Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFβ signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 2001;502:4-10.
    • (2001) FEBS Lett , vol.502 , pp. 4-10
    • Dooley, S.1    Delvoux, B.2    Streckert, M.3    Bonzel, L.4    Stopa, M.5    Ten Dijke, P.6    Gressner, A.M.7
  • 18
    • 0034023752 scopus 로고    scopus 로고
    • Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury
    • Date M, Matsuzaki K, Matsushita M, Tahashi Y, Furukawa F, Inoue K. Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury. Gut 2000;46:719-724.
    • (2000) Gut , vol.46 , pp. 719-724
    • Date, M.1    Matsuzaki, K.2    Matsushita, M.3    Tahashi, Y.4    Furukawa, F.5    Inoue, K.6
  • 19
  • 20
    • 0016438317 scopus 로고
    • Growth and structural properties of epithelial cell cultures established from normal rat liver and chemically induced hepatomas
    • Weinstein IB, Orenstein JM, Gebert R, Kaighn ME, Stadler UC. Growth and structural properties of epithelial cell cultures established from normal rat liver and chemically induced hepatomas. Cancer Res 1975;35:253-263.
    • (1975) Cancer Res , vol.35 , pp. 253-263
    • Weinstein, I.B.1    Orenstein, J.M.2    Gebert, R.3    Kaighn, M.E.4    Stadler, U.C.5
  • 21
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with " mini-extracts," prepared from a small number of cells
    • Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res 1989;17:6419.
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Müller, M.M.3    Schaffner, W.4
  • 22
    • 0031926009 scopus 로고    scopus 로고
    • Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein β and nuclear factor-κB in hepatocytes
    • Sakitani K, Nishizawa M, Inoue K, Masu Y, Okumura T, Ito S. Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein β and nuclear factor-κB in hepatocytes. Genes Cells 1998;3:321-330.
    • (1998) Genes Cells , vol.3 , pp. 321-330
    • Sakitani, K.1    Nishizawa, M.2    Inoue, K.3    Masu, Y.4    Okumura, T.5    Ito, S.6
  • 23
    • 0032191407 scopus 로고    scopus 로고
    • Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
    • Hua X, Liu X, Ansari DO, Lodish HF. Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev 1998;12:3084-3095.
    • (1998) Genes Dev , vol.12 , pp. 3084-3095
    • Hua, X.1    Liu, X.2    Ansari, D.O.3    Lodish, H.F.4
  • 24
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential
    • Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F, Ramadori G. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999;117:1205-1221.
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1    Kobold, D.2    Saile, B.3    Grundmann, A.4    Neubauer, K.5    Piscaglia, F.6    Ramadori, G.7
  • 25
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGF-β signaling
    • Mulder KM. Role of Ras and Mapks in TGF-β signaling. Cytokine Growth Factor Rev 2000;11:23-35.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 26
    • 0028176086 scopus 로고
    • Transforming growth factor-β stimulates α 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site
    • Inagaki Y, Truter S, Ramirez F. Transforming growth factor-β stimulates α 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 1994;269:14828-14834.
    • (1994) J Biol Chem , vol.269 , pp. 14828-14834
    • Inagaki, Y.1    Truter, S.2    Ramirez, F.3
  • 27
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani M, Gesualdo L, Sabbah GM, Abboud HE. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989;84:1786-1793.
    • (1989) J Clin Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 28
    • 0033553558 scopus 로고    scopus 로고
    • Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
    • Matsumoto T, Yokote K, Tamura K, Takemoto M, Ueno H, Saito Y, Mori S. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. J Biol Chem 1999;274:13954-13960.
    • (1999) J Biol Chem , vol.274 , pp. 13954-13960
    • Matsumoto, T.1    Yokote, K.2    Tamura, K.3    Takemoto, M.4    Ueno, H.5    Saito, Y.6    Mori, S.7
  • 30
    • 0034809804 scopus 로고    scopus 로고
    • Hepatic stellate cells as a target for the treatment of liver fibrosis
    • Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001;21:437-451.
    • (2001) Semin Liver Dis , vol.21 , pp. 437-451
    • Bataller, R.1    Brenner, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.