Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms

Journal of Leukocyte Biology

Volumn 76, Issue 5, 2004, Pages 994-1001

  Chen, Guoqian ^a   Li, Jianhua ^b   Ochani, Mahendar ^b   Rendon Mitchell, Beatriz ^b   Qiang, Xiaoling ^b   Susarla, Seenu ^b   Ulloa, Luis ^b   Yang, Huan ^b   Fan, Saijun ^b   Goyert, Sanna M ^b   Wang, Ping ^b   Tracey, Kevin J ^b   Sama, Andrew E ^a   Wang, Haichao ^a,b  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b North Shore LIJ Research Institute ^*  (United States)

Author keywords

Lipopolysaccharide; MAP kinases; Spermine

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD14 ANTIGEN; ENDOTOXIN; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRALIZING ANTIBODY; SPERMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; CELL STIMULATION; CONTROLLED STUDY; COVALENT BOND; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; ENDOTOXEMIA; ENZYME ACTIVITY; GENE DISRUPTION; GRAM NEGATIVE BACTERIUM; LUNG INJURY; MACROPHAGE ACTIVATION; MEMBRANE BINDING; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; ANTIGENS, CD14; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; ENZYME INHIBITORS; FEMALE; HMGB1 PROTEIN; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SPERMINE; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 7744222474     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0404242     Document Type: Article

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