Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-κB translocation

Toxicology and Applied Pharmacology

Volumn 229, Issue 3, 2008, Pages 362-373

  Jawan, Bruno ^a   Kao, Ying Hsien ^a,b   Goto, Shigeru ^a,c   Pan, Mei Chun ^a   Lin, Yu Chun ^a   Hsu, Li Wen ^a   Nakano, Toshiaki ^a   Lai, Chia Yun ^a   Sun, Cheuk Kwan ^a   Cheng, Yu Fan ^a   Tai, Ming Hong ^b,d   Eng, Hock Liew ^a   Wang, Chih Shien ^a   Huang, Chia Jung ^a   Lin, Chung Ren ^a   Chen, Chao Long ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c Iwao Hospital   (Japan)

^d KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Granulocyte macrophage colony stimulating factor; Lipopolysaccharides; Mitogen activated protein kinases; NF B translocation; Toll like receptor 4

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CD14 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROPOFOL; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; INCUBATION TIME; LIVER CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANESTHETICS, INTRAVENOUS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEPATOCYTES; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PROPOFOL; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

RATTUS;

EID: 44549088450     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.01.044     Document Type: Article

References (49)

1. Barsness K.A., Arcaroli J., Harken A.H., Abraham E., Banerjee A., Reznikov L., and McIntyre R.C. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (2004) R592-R599
2. Basu S., Dunn A.R., Marino M.W., Savoia H., Hodgson G., Lieschke G.J., and Cebon J. Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice. J. Immunol. 159 (1997) 1412-1417
3. Basu S., Mutschler D.K., Larsson A.O., Kiiski R., Nordgren A., and Eriksson M.B. Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. Resuscitation 50 (2001) 341-348
4. Brasil L.J., San-Miguel B., Kretzmann N.A., Amaral J.L., Zettler C.G., Marroni N., Gonzalez-Gallego J., and Tunon M.J. Halothane induces oxidative stress and NF-kappaB activation in rat liver: protective effect of propofol. Toxicology 227 (2006) 53-61
5. Brookes Z.L., Reilly C.S., Lawton B.K., and Brown N.J. Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of CD11b after hemorrhage. Shock 25 (2006) 492-499
6. Bundschuh D.S., Barsig J., Hartung T., Randow F., Döcke W.D., Volk H.D., and Wendel A. Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. J. Immunol. 158 (1997) 2862-2871
7. Chen R.M., Wu C.H., Chang H.C., Wu G.J., Lin Y.L., Sheu J.R., and Chen T.L. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology 98 (2003) 1178-1185
8. Chen R.M., Wu G.J., Tai Y.T., Sun W.Z., Lin Y.L., Jean W.C., and Chen T.L. Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase. Arch. Toxicol. 77 (2003) 418-423
9. Cheng C., Qin Y., Shao X., Wang H., Gao Y., Cheng M., and Shen A. Induction of TNF-alpha by LPS in Schwann cell is regulated by MAPK activation signals. Cell. Mol. Neurobiol. 27 (2007) 909-921
10. Corcoran T.B., Engel A., and Shorten G.D. The influence of propofol on the expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in reoxygenated human umbilical vein endothelial cells. Eur. J. Anaesthesiol. 23 (2006) 942-947
11. Fibuch E.E., and Wang J.Q. Inhibition of the MAPK/ERK cascade: a potential transcription-dependent mechanism for the amnesic effect of anesthetic propofol. Neurosci. Bull. 23 (2007) 119-124
12. Garcia-Lazaro J.F., Thieringer F., Luth S., Czochra P., Meyer E., Renteria I.B., Galle P.R., Lohse A.W., Herkel J., and Kanzler S. Hepatic over-expression of TGF-beta1 promotes LPS-induced inflammatory cytokine secretion by liver cells and endotoxemic shock. Immunol. Lett. 101 (2005) 217-222
13. Ha U., Lim J.H., Jono H., Koga T., Srivastava A., Malley R., Pages G., Pouyssegur J., and Li J.D. A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J. Immunol. 178 (2007) 1736-1747
14. Hamada E., Nishida T., Uchiyama Y., Nakamura J., Isahara K., Kazuo H., Huang T.P., Momoi T., Ito T., and Matsuda H. Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin. J. Hepatol. 30 (1999) 807-818
15. Hayashi T., Kishiwada M., Fujii K., Yuasa H., Nishioka J., Ido M., Gabazza E.C., and Suzuki K. Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4. J. Thromb. Haemost. 4 (2006) 1763-1773
16. Hirano K., Shimizu Y., Nakayama Y., Minemura M., Yasumura S., and Sugiyama T. Overexpression of granulocyte-macrophage colony-stimulating factor in mouse liver enhances the susceptibility of lipopolysaccharide leading to massive apoptosis of hepatocytes. Liver. Int. 25 (2005) 1027-1035
17. Kelbel I., and Weiss M. Anaesthetics and immune function. Curr. Opin. Anaesthesiol. 14 (2001) 685-691
18. Kobayashi I., Kokita N., and Namiki A. Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo. Eur. J. Anaesthesiol. (2007) 1-8
19. Koch A., Giembycz M., Ito K., Lim S., Jazrawi E., Barnes P.J., Adcock I., Erdmann E., and Chung K.F. Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. Am. J. Respir. Cell. Mol. Biol. 30 (2004) 342-349
20. Kozinn J., Mao L., Arora A., Yang L., Fibuch E.E., and Wang J.Q. Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol. Anesthesiology 105 (2006) 1182-1191
21. Lee F.S., Hagler J., Chen Z.J., and Maniatis T. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88 (1997) 213-222
22. Liu S., Gallo D.J., Green A.M., Williams D.L., Gong X., Shapiro R.A., Gambotto A.A., Humphris E.L., Vodovotz Y., and Billiar T.R. Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect. Immun. 70 (2002) 3433-3442
23. Medvedev A.E., Piao W., Shoenfelt J., Rhee S.H., Chen H., Basu S., Wahl L.M., Fenton M.J., and Vogel S.N. Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance. J. Biol. Chem. 282 (2007) 16042-16053
24. Meja K.K., Seldon P.M., Nasuhara Y., Ito K., Barnes P.J., Lindsay M.A., and Giembycz M.A. p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism. Br. J. Pharmacol. 131 (2000) 1143-1153
25. Murphy P.G., Bennett J.R., Myers D.S., Davies M.J., and Jones J.G. The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes. Eur. J. Anaesthesiol. 10 (1993) 261-266
26. Nagata T., Kansha M., Irita K., and Takahashi S. Propofol inhibits FMLP-stimulated phosphorylation of p42 mitogen-activated protein kinase and chemotaxis in human neutrophils. Br. J. Anaesth. 86 (2001) 853-858
27. Navapurkar V.U., Skepper J.N., Jones J.G., and Menon D.K. Propofol preserves the viability of isolated rat hepatocyte suspensions under an oxidant stress. Anesth. Analg. 87 (1998) 1152-1157
28. O'Toole T., and Peppelenbosch M.P. Phosphatidyl inositol-3-phosphate kinase mediates CD14 dependent signaling. Mol. Immunol. 44 (2007) 2362-2369
29. Pan Z., Zhou L., Hetherington C.J., and Zhang D.-E. Hepatocytes contribute to soluble CD14 production, and CD14 expression is differentially regulated in hepatocytes and monocytes. J. Biol. Chem. 275 (2000) 36430-36435
30. Parker L.C., Jones E.C., Prince L.R., Dower S.K., Whyte M.K.B., and Sabroe I. Endotoxin tolerance induces selective alterations in neutrophil function. J. Leukoc. Biol. 78 (2005) 1301-1305
31. Pillarisetty V.G., Miller G., Shah A.B., and DeMatteo R.P. GM-CSF expands dendritic cells and their progenitors in mouse livers. Hepatology 37 (2003) 641-652
32. Rodriguez-Lopez J.M., Sanchez-Conde P., Lozano F.S., Nicolas J.L., Garcia-Criado F.J., Cascajo C., and Muriel C. Laboratory investigation: effects of propofol on the systemic inflammatory response during aortic surgery. Can. J. Anaesth. 53 (2006) 701-710
33. Scott M.J., Liu S., Su G.L., Vodovotz Y., and Billiar T.R. Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock 23 (2005) 453-458
34. Shah B.H., Alberto Olivares-Reyes J., Yesilkaya A., and Catt K.J. Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Mol. Endocrinol. 16 (2002) 610-620
35. Shelley O., Murphy T., Paterson H., Mannick J.A., and Lederer J.A. Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury. Shock 20 (2003) 123-129
36. Shimono H., Goromaru T., Kadota Y., Tsurumaru T., and Kanmura Y. Propofol displays no protective effect against hypoxia/reoxygenation injury in rat liver slices. Anesth. Analg. 97 (2003) 442-448 table of contents
37. Skoutelis A., Lianou P., Papageorgiou E., Kokkinis K., Alexopoulos K., and Bassaris H. Effects of propofol and thiopentone on polymorphonuclear leukocyte functions in vitro. Acta. Anaesthesiol. Scand. 38 (1994) 858-862
38. Song H.K., and Jeong D.C. The effect of propofol on cytotoxicity and apoptosis of lipopolysaccharide-treated mononuclear cells and lymphocytes. Anesth. Analg. 98 (2004) 1724-1728
39. Su G.L., Dorko K., Strom S.C., Nussler A.K., and Wang S.C. CD14 expression and production by human hepatocytes. J. Hepatol. 31 (1999) 435-442
40. Su G.L., Klein R.D., Aminlari A., Zhang H.Y., Steinstraesser L., Alarcon W.H., Remick D.G., and Wang S.C. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31 (2000) 932-936
41. Sung E.G., Jee D., Song I.H., Kim H.S., Bae J.H., and Park S.H. Propofol attenuates Kupffer cell activation during hypoxia-reoxygenation. Can. J. Anaesth. 52 (2005) 921-926
42. Takayashiki T., Yoshidome H., Kimura F., Ohtsuka M., Shimizu Y., Kato A., Ito H., Shimizu H., Ambiru S., Togawa A., and Miyazaki M. Increased expression of toll-like receptor 4 enhances endotoxin-induced hepatic failure in partially hepatectomized mice. J. Hepatol. 41 (2004) 621-628
43. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17 (2005) 1-14
44. Takizawa D., Sato E., Hiraoka H., Tomioka A., Yamamoto K., Horiuchi R., and Goto F. Changes in apparent systemic clearance of propofol during transplantation of living related donor liver. Br. J. Anaesth. 95 (2005) 643-647
45. Tiegs G., Barsig J., Matiba B., Uhlig S., and Wendel A. Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. J. Clin. Invest. 93 (1994) 2616-2622
46. van den Blink B., Branger J., Weijer S., Deventer S.H., van der Poll T., and Peppelenbosch M.P. Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal kinase. Mol. Med. 7 (2001) 755-760
47. van der Bruggen T., Nijenhuis S., van Raaij E., Verhoef J., and van Asbeck B.S. Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway. Infect. Immun. 67 (1999) 3824-3829
48. Wang X., Li W., Lu J., Li N., and Li J. Lipopolysaccharide suppresses albumin expression by activating NF-kappaB in rat hepatocytes. J. Surg. Res. 122 (2004) 274-279
49. Zhou L., Tan A., Iasvovskaia S., Li J., Lin A., and Hershenson M.B. Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells. Am. J. Respir. Cell. Mol. Biol. 28 (2003) 762-769