Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3516-3520

  Rajput, Vishal Kumar ^a,b   Leffler, Hakon ^a   Nilsson, Ulf J ^a   Mukhopadhyay, Balaram ^b  

^a LUND UNIVERSITY   (Sweden)

^b INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA   (India)

Author keywords

Antagonist; Coumarine; Galectin; Iminocoumarine; Multicomponent reaction

Indexed keywords

ACETOPHENONE DERIVATIVE; AZIDE; CARBOHYDRATE; COPPER; COUMARIN DERIVATIVE; ECALECTIN; GALECTIN 1; GALECTIN 2; GALECTIN 3; GALECTIN 4; GALECTIN 7; GALECTIN 8; GLYCOSIDE; SALICYLALDEHYDE; COUMARIC ACID; GALECTIN; ALPHA DEXTRO GALACTOPYRANOSIDE; CARBOHYDRATE DERIVATIVE; CARBOHYDRATE PROPARGYL DERIVATIVE; COUMARYL; GALECTIN 4C; GALECTIN 4N; GALECTIN 8N; GALECTIN 9N; IMINOCOUMARYL; O HYDROXY ACETOPHENONE; PYRANOSIDE; SULFONYL AZIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL REACTION; DRUG BINDING; DRUG SYNTHESIS; EVALUATION STUDY; FLUORESCENCE POLARIZATION; HUMAN; REACTION TIME; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; CARBOXY TERMINAL SEQUENCE; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GLYCOSYLATION; MULTI COMPONENT REACTION;

COUMARIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GALECTINS; GLYCOSIDES; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904068607     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.063     Document Type: Article

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