Growth-regulatory human galectin-1: Crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding

Journal of Molecular Biology

Volumn 343, Issue 4, 2004, Pages 957-970

  López Lucendo, María F ^a   Solís, Dolores ^b   André, Sabine ^c   Hirabayashi, Jun ^d   Kasai, Ken Ichi ^e   Kaltner, Herbert ^c   Gabius, Hans Joachim ^c   Romero, Antonio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^c UNIVERSITY OF MUNICH   (Germany)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^e TEIKYO UNIVERSITY   (Japan)

Author keywords

apoptosis; galectin; glycoprotein; lectin; neuroblastoma

Indexed keywords

ASPARTIC ACID; CARBOHYDRATE; DISULFIDE; GALECTIN; GALECTIN 1; LECTIN; LIGAND; REDUCING AGENT; SUGAR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CRYSTALLOGRAPHY; DRUG DESIGN; ENTHALPY; ENTROPY; GROWTH; LIGAND BINDING; MOLECULE; MUTANT; MUTATION; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS; THERMODYNAMICS; TITRIMETRY; X RAY CRYSTALLOGRAPHY;

EID: 5144232009     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.08.078     Document Type: Article

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