Molecular dynamics simulation of amorphous hydroxypropyl-methylcellulose acetate succinate (HPMCAS): Polymer model development, water distribution, and plasticization

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 2400-2411

  Xiang, Tian Xiang ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

amorphous polymers; glass transition; HPMCAS; molecular dynamics simulations; pharmaceuticals; solid state; water diffusion; water distribution

Indexed keywords

CARBON NANOTUBE; GLUCOSE; GRAPHITE; HYDROGEN; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; OXYGEN; PLASTICIZER; WATER; METHYLCELLULOSE; POLYMER;

AB INITIO CALCULATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COOLING; CRYSTALLIZATION; DEGRADATION; DENSITY; DRUG RELEASE; GLASS TRANSITION TEMPERATURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR WEIGHT; MOLECULE; MOTION; PH; PHASE SEPARATION; PRIORITY JOURNAL; SYNTHESIS; VISCOSITY; WATER CONTENT; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DIFFUSION; DRUG STABILITY; SOLUBILITY;

DIFFUSION; DRUG STABILITY; HYDROGEN BONDING; METHYLCELLULOSE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; POLYMERS; SOLUBILITY; WATER;

EID: 84903949412     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500135f     Document Type: Article

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