Solid-state stability of human insulin I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions

Pharmaceutical Research

Volumn 13, Issue 8, 1996, Pages 1142-1153

  Strickley, Robert G ^a,b   Anderson, Bradley D ^a  

^a UNIVERSITY OF UTAH   (United States)

^b GENENTECH INC   (United States)

Author keywords

Acyl transfer; Covalent dimerization; Deamidation; Intramolecular catalysis; Protein stability; Solid state degradation

Indexed keywords

HUMAN INSULIN; PENTEX; UNCLASSIFIED DRUG;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN DEGRADATION; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN STABILITY;

AMINO ACID SEQUENCE; DRUG STABILITY; FREEZE DRYING; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INSULIN; KINETICS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; WATER;

EID: 0029764145     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016043715791     Document Type: Article

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