Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes

Journal of Pharmaceutical Sciences

Volumn 88, Issue 10, 1999, Pages 1073-1080

  Lai, Mei C ^a   Hageman, Michael J ^a,b   Schowen, Richard L ^a   Borchardt, Ronald T ^a   Topp, Elizabeth M ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRVOL 103; AIRVOL 125; ASPARAGINE DERIVATIVE; HEXAPEPTIDE; KOLLIDON K 12; KOLLIDON K 17; PLASTICIZER; POLYMER; POLYVINYL ALCOHOL; POVIDONE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL REACTION KINETICS; DEAMINATION; DRUG FORMULATION; HUMIDITY; PHYSICAL CHEMISTRY; PREDICTION; PROTEIN DEGRADATION; PROTEIN STABILITY; TEMPERATURE; WATER CONTENT;

EID: 0032882072     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980227g     Document Type: Article

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