The concept of fitness and drug resistance in leishmania

Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments

Volumn , Issue , 2013, Pages 431-450

  Ponte Sucre, Alicia ^a   Diaz, Emilia ^a   PadrÓn Nieves, Maritza ^a  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84903817919     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-1125-3_20     Document Type: Chapter

References (110)

1. Al-Mohammed HI, Chance ML, Bates PA (2005) Production and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana. Antimicrob Agents Chemother 49:3274-3280
2. Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, LiSpez-Veiez R, Moreno J (2008) The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21(2):334-359
3. Andersson DI (2006) The biological cost of mutational antibiotic resistance: any practical conclusions? Curr Opin Microbiol 9:461-465
4. Andersson DI, Hughes D (2010) Antibiotic resistance and its cost: is it possible to reverse resistance? Nature Rev Microbiol 8:260-271
5. Babiker HA (2009) Seasonal fluctuation of drug-resistant malaria parasites: a sign of fitness cost. Trends Parasitol 25:351-352
6. Babiker HA, Hastings IA, Swedberg G (2009) Impaired fitness of drug resistant malaria parasites: evidence and implication on drug-deployment policies. Expert Rev Anti Infect Ther 7:581-593
7. Basselin M, Robert-Gero M (1998) Alterations in membrane fluidity, lipid metabolism, mitochondrial activity and lipophosphoglycan expression in pentamidine-resistant Leishmania. Parasitol Res 60:78-83
8. Bates PA, Tetley L (1993) Leishmania mexicana: induction of metacyclogenesis by cultivation of promastigotes at acidic pH. Exp Parasitol 76:412-423
9. Bates M et al. (2003) Practical applications of viral fitness in clinical practice. Curr Opin Infect Dis 16:11-18
10. Beitz E (2005) Aquaporins from pathogenic protozoan parasites: structure, function and potential for chemotherapy. Biol Cell 97:373-383
11. Berberich C et al. (1998) The metacyclic stage-expressed Meta-1 gene is conserved between Old and New World Leishmania species. Mem Inst Oswaldo Cruz 93:819-821
12. Blum J (1993) Intermediary metabolism of Leishmania. Parasitol Today 9:118-122
13. J. Blum (1994) Energy metabolism in Leishmania. J Bioenerg Biomembr 26:147-154
14. Bottger EK, Springer B (2008) Tuberculosis: drug resistance, fitness, and strategies for global control. Eur J Pediatr 167:141-148
15. Bradshaw DM, Arceci RJ (1998) Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol 16:3674-3690
16. Cadek R et al. (2004) Impact of the growth phase on the activity of multidrug resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source. Biochim Biophys Acta 1665:111-117
17. Cappai R et al. (1994) Ricin-resistant mutants of Leishmania major which express modified lipophosphoglycan remain infective for mice. Parasitology 108:397-405
18. Chiquero MJ et al. (1998) Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line. Biochem Pharmacol 55:131-139
19. Chow LM, Wong AK, Ullman B, Wirth DF (1993) Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. Mol Biochem Parasitol 60(2):195-208
20. Coelho AC, Yamashiro-Kanashiro EH, Bastos SF, Mortara RA, Cotrim PC (2006) Intracellular location of the ABC transporter PRP1 related to pentamidine resistance in Leishmania major. Mol Biochem Parasitol 150(2):378-83, Epub 2006 Sep 20
21. Cohen ML (1992) Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 257:1050-1082
22. Cortes-Selva F et al. (2005) Functional expression of a multidrug P-glycoprotein transporter of Leishmania. Biochem Biophys Res Commun 329:502-507
23. Cotrim PC, Garrity LK, Beverley SM (1999) Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection. J Biol Chem 274:37723-37730
24. Croft SL, Yardley V (2002) Chemotherapy of leishmaniasis. Curr Pharm Des 8:319-342
25. Croft SL, Seifert K, Yardley V (2006a) Current scenario of drug development for leishmaniasis. Indian J Med Res 123:399-410
26. Croft SL, Sundar S, Fairlamb AH (2006b) Drug resistance in leishmaniasis. Clin Microbiol Rev 19:111-126
27. Cruz I et al. (2002) A nested polymerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus. Trans R Soc Trop Med Hyg 96:S185-S189
28. Debrabant A, Nakhasi H (2003) Programmed cell death in trypanosomatids: is it an altruistic mechanism for survival of the fittest? Kinetoplastid Biol Dis 2:7 (http://www.kinetoplastids.com/home/)
29. Desjeux P (2004) Leishmaniasis: current situation and new perspectives.Comp Immunol Microbiol Infect Dis 27:305-318
30. Detke S et al. (1988) DNA amplification in tunicamycin-resistant Leishmania mexicana: multicopies of a single 63-kilobase supercoiled molecule and their expression. J Biol Chem 263:3418-3424
31. Dey S et al. (1994) High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system. Mol Biochem Parasitol 67:49-57
32. Dubessay P et al. (2001) Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania. Nucleic Acids Res 29:3231-3240
33. Elhay M et al. (1990) Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major. Mol Biochem Parasitol 40:255-267
34. Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58:137-171
35. Essodai'gui M et al. (1999) Energy-dependent efflux from Leishmania promastigotes of substrates of the mammalian multidrug resistance pumps. Mol Biochem Parasitol 100:73-84
36. Figarella K et al. (2005) Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. Cell Death Differ 12:335-346
37. Fohl LM, Roos DS (2003) Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites. Mol Microbiol 50:1319-1327
38. Gagneux S et al. (2006) The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 312:1944-1946
39. Gamarro F et al. (1994) P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica. Biochem Pharmacol 47:1939-1947
40. Garcia N et al. (2000) Changes in the infectivity, pyruvate kinase and acid phosphatase activity and p-glycoprotein expression in glibenclamide resistant Leishmania mexicana. Parasitol Res 86:899-904
41. Gazola KC et al. (2001) Cell surface carbohydrates and in vivo infectivity of Glucantime sensitive and resistant Leishmania (viannia) guyanensis cell lines. Parasitol Res 87:935-940
42. George A et al. (2002) Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 16:1550-1557
43. Geretti AM (2005) The clinical significance of viral fitness. J HIV Ther 10:6-10
44. Gradoni L et al. (2005) Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals. Vaccine 23:5245-5251
45. Gramiccia M, Gradoni L, Orsini S (1992) Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatment. Ann Trop Med Parasitol 86:613-620
46. Grogl M, Thomason TN, Franke ED (1991) Drug resistance in leishmaniasis: its implications in systemic chemotherapy of cutaneous and mucocutaneous disease. Am J Trop Med Hyg 47:117-126
47. Gueiros-Filho FJ et al. (1995) Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene. Exp Parasitol 81:480-490
48. In) resistant Leishmania tarentolae. Mol Biochem Parasitol 108:131-135
49. Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, George A, Bartholomew R, Carlo D, Shaikh A, Kupperman J, Newell EW, Bespalov IA, Wallace SS, Liu Y, Rogers JR, Gibbs GL, Leahy JL, Camley RE, Melamede R, Newell MK (2002) Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 16(12):1550-7
50. Harper ME et al. (2006) Clinical implications of HIV drug resistance to nucleoside and nucleotide reverse transcriptase inhibitors. AIDS Rev 8:210-220
51. Hastings IM, Donnelly MJ (2005) The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance. Drug Resist Update 8:43-50
52. Henderson DM et al. (1992) Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Mol Cell Biol 12:2855-2865
53. Hendrickson N et al. (1993) Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Mol Biochem Parasitol 60:53-64
54. Hogberg LD, Heddini A, Cars O (2010) The global need for effective antibiotics: challenges and recent advances. Trends Pharmacol Sci 31:509-515
55. Jha TK et al. (2005) A phase II dose-ranging study of sitamaquine for the treatment of visceral leishmaniasis in India. Am J Trop Med Hyg 73:1005-1011
56. Katakura K et al. (1999) Structural and functional analysis of the LaMDR1 multidrug resistance gene in Leishmania amazonensis. Biochem Biophys Res Commun 255:289-294
57. Kaur K et al. (1998) Methotrexate-resistant Leishmania donovani genetically deficient in the folate methotrexate transporter. J Biol Chem 263:7020-7028
58. Kink JA, Chang KP (1987) Biological and biochemical characterization of tunicamycin-resistant Leishmania mexicana: mechanism of drug resistance and virulence. Infect Immun 55:1692-1700
59. Kiindig C et al. (1999) Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae. Nucleic Acids Res 27:3653-3659
60. Landfear SM (2010) Transporters for drug delivery and as drug targets in parasitic protozoa. Clin Pharmacol Ther 87:122-125
61. Lee HH et al. (2010) Bacterial charity work leads to population-wide resistance. Nature 467:82-85
62. Legare D et al. (2001) The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. J Biol Chem 276:26301-26307
63. Lenski RE (1998) Bacterial evolution and the cost of antibiotic resistance. Int Microbiol 1:265-270
64. Liu X, Chang KP (1992) The 63-kilobase circular amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection. Mol Cell Biol 12:4112-4122
65. Lye LF, Hsieh YH, Su KE, Lee ST (1997) Cloning and functional analysis of the ribonucleotide reductase gene small subunit from hydroxyurea-resistant Leishmania mexicana amazonensis. Mol Biochem Parasitol 90(1):353-8
66. Machuca C et al. (2006) Metabolic adaptations induced by resistance to glibenclamide in Leish-mania amazonensis. Exp Parasitol 114:1-9
67. Mackinnon MJ, Marsh K (2010) The selection landscape of malaria parasites. Science 328:866-871
68. Mandal G et al. (2009) Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates. Indian J Biochem Biophys 46:86-92
69. Natera S et al. (2007) Leishmania sp: proficiency of drug resistant parasites. Int J Antimicrob Agents 29:637-642
70. Newton PN, Green MD, Fernandez FM (2010) Impact of poor-quality medicines in the ‘developing’ world. Trends Pharmacol Sci 31:99-101
71. Nourbakhsh F, Uliana SR, Smith DF (1996) Characterisation and expression of a stage-regulated gene of Leishmania major. Mol Biochem Parasitol 76:201-213
72. Opperdoes FR, Michels PA (2007) Horizontal gene transfer in trypanosomatids. Trends Parasitol 23:470-476
73. Ortiz D et al. (2007) Molecular genetic analysis of purine nucleobase transport in Leishmania major. Mol Microbiol 64:1228-1243
74. Ouellette M, Fase-Fowler F, Borst P (1990) The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene. EMBO J 9(4):1027-33
75. Ouellette M, Borst P (1991) Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania. Res Microbiol 142:737-746
76. Ouellette M et al. (1991) Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. EMBO J 10:1009-1016
77. Ouellette M, Drummelsmith J, Papadopoulou B (2004) Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist Update 7:257-266
78. Padron-Nieves M et al. (2009) Glibenclamide modulates Glucantime activity and disposition in Leishmania major. Exp Parasitol 121:331-337
79. Papadopoulou B, Roy G, Ouellette M (1992) A novel antifolate resistance gene on the amplified H circle of Leishmania. EMBO J 11:3601-3608
80. Papadopoulou B et al. (1994) Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance. J Biol Chem 269:11980-11986
81. Perez-Victoria JM et al. (2001) Alkyl-lysophospholipid resistance in multidrug-resistant Leish-mania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. Antimicrob Agents Chemother 45:2468-2474
82. Perez-Victoria FJ et al. (2003) Functional cloning of the Miltefosine transporter. a novel P-type phospholipid translocase from Leishmania involved in drug resistance. J Biol Chem 278:49965-49971
83. Peyron F et al. (2004) Fitness of Toxoplasma gondii is not related to DHFR single-nucleotide polymorphism during congenital toxoplasmosis. Int J Parasitol 34:1169-1175
84. Ponte-Sucre A (2003) Physiological consequences of drug resistance in Leishmania and their relevance for chemotherapy. Kinetoplastid Biol Dis 2:14 (http://www.kinetoplastids.com/home/)
85. Prasad V, Kumar SS, Dey C (2000) Resistance to arsenite modulates levels of a-tubulin and sensitivity to paclitaxel in Leishmania donovani. Parasitol Res 86:838-842
86. Preechapornkul P et al. (2010) Optimizing the culture of Plasmodium falciparum in hollow fiber bioreactors. Southeast Asian J Trop Med Public Health 41:761-769
87. Quinones-Mateu ME, Arts EJ (2006) Virus fitness: concept, quantification, and application to HIV population dynamics. Curr Top Microbiol Immunol 299:83-140
88. Richard D, Kundig C, Ouellette M (2002) A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells. J Biol Chem 277:29460-29467
89. Schnaufer A, Sbicego S, Blum B (2000) Antimycin A resistance in a mutant Leishmania tarentolae strain is correlated to a point mutation in the mitochondrial apocytochrome b gene. Curr Genet 37:234-241
90. Scott P (2003) Development and regulation of cell-mediated immunity in experimental leishmaniasis. Immunol Res 27:489-498
91. Sereno F, Lemesre FJ (1997) In vitro life cycle of pentamidine-resistant amastigotes: stability of the chemoresistant phenotypes is dependent on the level of resistance induced. Antimicrob Agents Chemother 41:1898-1903
92. Sereno D et al. (1997) Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes. Modulation of the resistance during in-vitro developmental life cycle. C R Acad Sci Ser III Sci Vie 320:981-987
93. Serrano-Martin X, Payares G, Mendoza-LeSn A (2006) Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis. Antimicrob Agents Chemother 50:4214-4216
94. Serrano-Martin X et al. (2009) Amiodarone and Miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis. Antimicrob Agents Chemother 53:5108-5113
95. Silva N et al. (2004) Cell differentiation and infectivity of Leishmania mexicana are inhibited in an ABC-transporter blocker resistant strain. Parasitology 128:629-634
96. Singh AK, Lee ST (1999) Status of respiration and ATP content in arsenite resistant Leishmania mexicana amazonensis. Microb Pathog 26:171-174
97. Singh S, Sivakumar R (2004) Challenges and new discoveries in the treatment of leishmaniasis. J Infect Chemother 10:307-315
98. Soto J et al. (2004) Miltefosine for new world cutaneous leishmaniasis. Clin Infect Dis 38:1266-1272
99. Sundar S et al. (2000) Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic. Clin Infect Dis 31:1104-1107
100. T’Kindt R et al. (2010) Metabolomics to unveil and understand phenotypic diversity between pathogen populations. PLoS Negl Trop Dis 4:e904
101. Uliana SR et al. (1999) Overexpression and comparative structural analysis of the stage-regulated meta-1 gene. Exp Parasitol (Jena) 92:183-191
102. Urbina J (1994) Intermediary metabolism of Trypanosoma cruzi. Parasitol Today 10:107-110
103. Uzcategui NL et al. (2005) Substrate preferences and glucose uptake in glibenclamide-resistant Leishmania parasites.Comp Biochem Physiol 140:395-402
104. Vanaerschot M et al. (2010) Linking in vitro and in vivo survival of clinical Leishmania donovani strains. PLoS One 5:e12211
105. Vasudevan G, Ullman B, Landfear SM (2001) Point mutations in a nucleoside transporter gene from Leishmania donovani confers drug resistance and alter substrate selectivity. Proc Natl Acad Sci USA 98:6092-6097
106. (+)-pump generated membrane potential. Mol Biochem Parasitol 75(1):15-23
107. Whitaker JW, McConkey GA, Westhead DR (2009) The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular. Genome Biol 10: R36
108. William S et al. (2001) Stability and reproductive fitness of Schistosoma mansoni isolates with decreased sensitivity to praziquantel. Int J Parasitol 31:1093-1100
109. Workman P, Travers J (2010) Cancer: drug-tolerant insurgen. Nature 464:844-845
110. Zakai HA, Chance ML, Bates PA (1997) In vitro stimulation of metacyclogenesis in Leishmania braziliensis, L. donovani, L. major and L. mexicana. Parasitology 116:305-309