The selection landscape of malaria parasites

Science

Volumn 328, Issue 5980, 2010, Pages 866-871

  Mackinnon, M J ^a,b   Marsh, K ^a,b  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; DISEASE CONTROL; DISEASE TRANSMISSION; DISEASE VECTOR; FITNESS; HOMINID; IMMUNE RESPONSE; IMMUNITY; MALARIA; MOSQUITO; NATURAL SELECTION; PARASITE; PARASITE INFESTATION; PHYSIOLOGY; PROTOZOAN; VIRULENCE;

BED NET; CELL ADHESION; CELL SURFACE; CHROMOSOME; COST BENEFIT ANALYSIS; DNA SEQUENCE; DRUG RESISTANCE; EPIGENETICS; ERYTHROCYTE; GAMETOCYTE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MALARIA CONTROL; MITOSIS; MOSQUITO; NONHUMAN; PHENOTYPE; PLASMODIUM; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW; TELOMERE; VIRULENCE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGENIC VARIATION; ANTIGENS, PROTOZOAN; ANTIMALARIALS; CULICIDAE; DRUG RESISTANCE; GENES, PROTOZOAN; GENETIC FITNESS; GENOME, PROTOZOAN; HUMANS; IMMUNE EVASION; INSECT VECTORS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SELECTION, GENETIC;

PLASMODIUM FALCIPARUM;

EID: 77952370937     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1185410     Document Type: Review

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61. We are grateful to P. Bull, V. Thathy, S. Gandon, and an anonymous reviewer for useful comments. M.J.M. is supported by Wellcome Trust Project Grant 088634, and both authors are supported by Wellcome Trust Core Programme Grant 077092. M.J.M. is a member of the GlaxoSmithKline Biologicals advisory board for modeling malaria vaccines. This paper is published with the permission of the director of the Kenya Medical Research Institute.