Linking in vitro and in vivo Survival of Clinical Leishmania donovani strains

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Vanaerschot, Manu ^a,b   Maes, Ilse ^a   Ouakad, Meriem ^a   Adaui, Vanessa ^a,c   Maes, Louis ^b   de Doncker, Simonne ^a   Rijal, Suman ^d   Chappuis, François ^e   Dujardin, Jean Claude ^a,b   Decuypere, Saskia ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c INSTITUTO DE MEDICINA TROPICAL ALEXANDER VON HUMBOLDT   (Peru)

^d B P KOIRALA INSTITUTE OF HEALTH SCIENCES   (Nepal)

^e GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY GLUCONATE; STIBOGLUCONATE SODIUM; METAL; NITROSO DERIVATIVE;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; LEISHMANIASIS; MICROBIAL GROWTH; MOUSE; NEPAL; NONHUMAN; OXIDATIVE STRESS; PARASITE ISOLATION; PARASITE SURVIVAL; PROMASTIGOTE; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; GROWTH, DEVELOPMENT AND AGING; PATHOGENICITY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; TEMPERATURE; VISCERAL LEISHMANIASIS;

LEISHMANIA DONOVANI; MAMMALIA; MUS; PHLEBOTOMINAE; PROTOZOA;

ANIMALS; ANTIMONY SODIUM GLUCONATE; DRUG RESISTANCE; FEMALE; HUMANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; METALS; MICE; NITROSO COMPOUNDS; OXIDATIVE STRESS; STRESS, PHYSIOLOGICAL; TEMPERATURE;

EID: 77957879848     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012211     Document Type: Article

References (40)

1. World Health Organization (2002) World Health Report, 2002: Reducing Risks, Promoting Healthy Life - Annex 3: Burden Of Disease In Dalys By Cause, Sex And Mortality Stratum In Who Regions, Estimates For 2001. Geneva, Switserland. pp 192-197.
2. Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, et al. (2007) Visceral Leishmaniasis: What Are The Needs For Diagnosis, Treatment And Control? Nat Rev Microbiol 5: 873-882.
3. Bates Pa, Rogers Me (2004) New Insights Into The Developmental Biology And Transmission Mechanisms Of Leishmania. Curr Mol Med 4: 601-609.
4. Da Silva R, Sacks Dl (1987) Metacyclogenesis Is A Major Determinant Of Leishmania Promastigote Virulence And Attenuation. Infect Immun 55: 2802-2806.
5. Vincent Sh (1989) Oxidative Effects Of Heme And Porphyrins On Proteins And Lipids. Semin Hematol 26: 105-113.
6. Kamhawi S (2006) Phlebotomine Sand Flies And Leishmania Parasites: Friends Or Foes? Trends Parasitol 22: 439-445.
7. Dominguez M, Moreno I, Aizpurua C, Torano A (2003) Early Mechanisms Of Leishmania Infection In Human Blood. Microbes Infect 5: 507-513.
8. Murray Hw, Nathan Cf (1999) Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen Versus Oxygen Intermediates In The Killing Of Intracellular Visceral Leishmania Donovani. J Exp Med 189: 741-746.
9. Krauth-Siegel Rl, Comini Ma (2008) Redox Control In Trypanosomatids, Parasitic Protozoa With Trypanothione-Based Thiol Metabolism. Biochim Biophys Acta 1780: 1236-1248.
10. Gomez Ma, Contreras I, Halle M, Tremblay Ml, Mcmaster Rw, et al. (2009) Leishmania Gp63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases. Sci Signal 2: Ra58.
11. Nandan D, Reiner Ne (2005) Leishmania Donovani Engages In Regulatory Interference By Targeting Macrophage Protein Tyrosine Phosphatase Shp-1. Clin Immunol 114: 266-277.
12. Nandan D, Tran T, Trinh E, Silverman Jm, Lopez M (2007) Identification Of Leishmania Fructose-1,6-Bisphosphate Aldolase As A Novel Activator Of Host Macrophage Src Homology 2 Domain Containing Protein Tyrosine Phosphatase Shp-1. Biochem Biophys Res Commun 364: 601-607.
13. Bhardwaj S, Srivastava N, Sudan R, Saha B (2010) Leishmania Interferes With Host Cell Signaling To Devise A Survival Strategy. J Biomed Biotechnol 109189 2010: 109189.
14. Rijal S, Chappuis F, Singh R, Bovier Pa, Acharya P, et al. (2003) Treatment Of Visceral Leishmaniasis In South-Eastern Nepal: Decreasing Efficacy Of Sodium Stibogluconate And Need For A Policy To Limit Further Decline. Trans R Soc Trop Med Hyg 97: 350-354.
15. Sundar S, More Dk, Singh Mk, Singh Vp, Sharma S, et al. (2000) Failure Of Pentavalent Antimony In Visceral Leishmaniasis In India: Report From The Center Of The Indian Epidemic. Clin Infect Dis 31: 1104-1107.
16. Rijal S, Yardley V, Chappuis F, Decuypere S, Khanal B, et al. (2007) Antimonial Treatment Of Visceral Leishmaniasis: Are Current In Vitro Susceptibility Assays Adequate For Prognosis Of In Vivo Therapy Outcome? Microbes Infect 9: 529-535.
17. Quispe Tintaya Kw, Ying X, Dedet Jp, Rijal S, De B, X, et al. (2004) Antigen Genes For Molecular Epidemiology Of Leishmaniasis: Polymorphism Of Cysteine Proteinase B And Surface Metalloprotease Glycoprotein 63 In The Leishmania Donovani Complex. J Infect Dis 189: 1035-1043.
18. Laurent T, Rijal S, Yardley V, Croft S, De Ds, et al. (2007) Epidemiological Dynamics Of Antimonial Resistance In Leishmania Donovani: Genotyping Reveals A Polyclonal Population Structure Among Naturally-Resistant Clinical Isolates From Nepal. Infect Genet Evol 7: 206-212.
19. Van Meirvenne N, Janssens Pg, Magnus E (1975) Antigenic Variation In Syringe Passaged Populations Of Trypanosoma (Trypanozoon) Brucei. 1. Rationalization Of The Experimental Approach. Ann Soc Belg Med Trop 55: 1-23.
20. Berens Rl, Brun R, Krassner Sm (1976) A Simple Monophasic Medium For Axenic Culture Of Hemoflagellates. J Parasitol 62: 360-365.
21. Rolao N, Melo C, Campino L (2004) Influence Of The Inoculation Route In Balb/C Mice Infected By Leishmania Infantum. Acta Trop 90: 123-126.
22. Nicolas L, Prina E, Lang T, Milon G (2002) Real-Time Pcr For Detection And Quantitation Of Leishmania In Mouse Tissues. J Clin Microbiol 40: 1666-1669.
23. Hellemans J, Mortier G, De Pa, Speleman F, Vandesompele J (2007) Qbase Relative Quantification Framework And Software For Management And Automated Analysis Of Real-Time Quantitative Pcr Data. Genome Biol 8: R19.
24. Zilberstein D, Shapira M (1994) The Role Of Ph And Temperature In The Development Of Leishmania Parasites. Annu Rev Microbiol 48: 449-470.
25. Miller Mb, Bassler Bl (2001) Quorum Sensing In Bacteria. Annu Rev Microbiol 55: 165-199.
26. Lazazzera Ba (2000) Quorum Sensing And Starvation: Signals For Entry Into Stationary Phase. Curr Opin Microbiol 3: 177-182.
27. Vassella E, Reuner B, Yutzy B, Boshart M (1997) Differentiation Of African Trypanosomes Is Controlled By A Density Sensing Mechanism Which Signals Cell Cycle Arrest Via The Camp Pathway. J Cell Sci 110(Pt 21): 2661-2671.
28. Gaetke Lm, Chow Ck (2003) Copper Toxicity, Oxidative Stress, And Antioxidant Nutrients. Toxicology 189: 147-163.
29. Poljsak B, Gazdag Z, Jenko-Brinovec S, Fujs S, Pesti M, et al. (2005) Pro-Oxidative Vs Antioxidative Properties Of Ascorbic Acid In Chromium(Vi)- Induced Damage: An In Vivo And In Vitro Approach. J Appl Toxicol 25: 535-548.
30. Cunningham Ml, Fairlamb Ah (1995) Trypanothione Reductase From Leishmania Donovani. Purification, Characterisation And Inhibition By Trivalent Antimonials. Eur J Biochem 230: 460-468.
31. Wyllie S, Cunningham Ml, Fairlamb Ah (2004) Dual Action Of Antimonial Drugs On Thiol Redox Metabolism In The Human Pathogen Leishmania Donovani. J Biol Chem 279: 39925-39932.
32. Mookerjee Bj, Mookerjee A, Sen P, Bhaumik S, Sen P, et al. (2006) Sodium Antimony Gluconate Induces Generation Of Reactive Oxygen Species And Nitric Oxide Via Phosphoinositide 3-Kinase And Mitogen-Activated Protein Kinase Activation In Leishmania Donovani-Infected Macrophages. Antimicrob Agents Chemother 50: 1788-1797.
33. Carter Kc, Hutchison S, Boitelle A, Murray Hw, Sundar S, et al. (2005) Sodium Stibogluconate Resistance In Leishmania Donovani Correlates With Greater Tolerance To Macrophage Antileishmanial Responses And Trivalent Antimony Therapy. Parasitology 131: 747-757.
34. Mandal G, Wyllie S, Singh N, Sundar S, Fairlamb Ah, et al. (2007) Increased Levels Of Thiols Protect Antimony Unresponsive Leishmania Donovani Field Isolates Against Reactive Oxygen Species Generated By Trivalent Antimony. Parasitology 134: 1679-1687.
35. Holzmuller P, Sereno D, Lemesre Jl (2005) Lower Nitric Oxide Susceptibility Of Trivalent Antimony-Resistant Amastigotes Of Leishmania Infantum. Antimicrob Agents Chemother 49: 4406-4409.
36. Bandyopadhyay P, Ghosh Dk, De A, Ghosh Kn, Chaudhuri Pp, et al. (1991) Metacyclogenesis Of Leishmania Spp: Species-Specific In Vitro Transformation, Complement Resistance, And Cell Surface Carbohydrate And Protein Profiles. J Parasitol 77: 411-416.
37. Ouakad M, Decuypere S, Vanaerschot M, Kestens L, Boel L, et al. (2009) A Possible Link Between Drug Resistance And L. Donovani Infectivity? Study Of Metacyclogenesis In Clinical Isolates From Nepal. Proceedings Of The 4th World Congress On Leishmaniasis 2009 (Worldleish4), Lucknow, India Abstract 194.
38. Thakur Cp, Mitra Dk, Narayan S (2003) Skewing Of Cytokine Profiles Towards T Helper Cell Type 2 Response In Visceral Leishmaniasis Patients Unresponsive To Sodium Antimony Gluconate. Trans R Soc Trop Med Hyg 97: 409-412.
39. Andersson Di, Hughes D (2010) Antibiotic Resistance And Its Cost: Is It Possible To Reverse Resistance? Nat Rev Microbiol 8: 260-271.
40. Kumar D, Kulshrestha A, Singh R, Salotra P (2009) In Vitro Susceptibility Of Field Isolates Of Leishmania Donovani To Miltefosine And Amphotericin B: Correlation With Sodium Antimony Gluconate Susceptibility And Implications For Treatment In Areas Of Endemicity. Antimicrob Agents Chemother 53: 835-838.