메뉴 건너뛰기




Volumn 8, Issue 4, 2006, Pages 210-220

Clinical implications of HIV drug resistance to nucleoside and nucleotide reverse transcriptase inhibitors

Author keywords

Fitness; Genotype; Hypersusceptibility; Phenotype; Transmission

Indexed keywords

ABACAVIR; AMPRENAVIR PHOSPHATE; ARGININE; ATAZANAVIR; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; ISOLEUCINE; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; LYSINE; METHIONINE; NELFINAVIR; NEVIRAPINE; PLACEBO; PROTEINASE; PROTEINASE INHIBITOR; RIBONUCLEASE H; RITONAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; UNINDEXED DRUG; VALINE; VIRUS DNA; ZIDOVUDINE;

EID: 33846420173     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (61)
  • 1
    • 33745781478 scopus 로고    scopus 로고
    • Involvement of novel HIV-1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors
    • Svicher V, Sing T, Santoro M, et al. Involvement of novel HIV-1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors. J Virol 2006;80:7186-98.
    • (2006) J Virol , vol.80 , pp. 7186-7198
    • Svicher, V.1    Sing, T.2    Santoro, M.3
  • 2
    • 33846451452 scopus 로고    scopus 로고
    • AZT selects mutations in the connection (A371V) and RNaseH (Q509L) domains of RT that increase AZT resistance in combination with TAM and reduce susceptibility to other NRTI
    • Program and abstracts XV International HIV Drug Resistance Workshop; June 13-17, Sitges, Spain [abstract 125]
    • Brehm J, Koontz D, Pathak D, Sluis-Cremer N, Mellors J. AZT selects mutations in the connection (A371V) and RNaseH (Q509L) domains of RT that increase AZT resistance in combination with TAM and reduce susceptibility to other NRTI. Program and abstracts XV International HIV Drug Resistance Workshop; June 13-17, 2006; Sitges, Spain [abstract 125].
    • (2006)
    • Brehm, J.1    Koontz, D.2    Pathak, D.3    Sluis-Cremer, N.4    Mellors, J.5
  • 3
    • 33846438279 scopus 로고    scopus 로고
    • The HIV-1 reverse transcriptase connection domain from treatment-experienced patients contributes to AZT resistance
    • Program and abstracts XV International HIV Drug Resistance Workshop; June 13-17, Sitges, Spain [abstract 126]
    • Nikolenko G, Frankenberry K, Palmer S, et al. The HIV-1 reverse transcriptase connection domain from treatment-experienced patients contributes to AZT resistance. Program and abstracts XV International HIV Drug Resistance Workshop; June 13-17, 2006; Sitges, Spain [abstract 126].
    • (2006)
    • Nikolenko, G.1    Frankenberry, K.2    Palmer, S.3
  • 4
    • 33747778030 scopus 로고    scopus 로고
    • Relationship between mutations in HIV-1 RNaseH domain and NRTI-resistance mutations in experienced patients
    • Marcelin A, Roquebert B, Malet I, et al. Relationship between mutations in HIV-1 RNaseH domain and NRTI-resistance mutations in experienced patients. Antivir Ther 2005;10:S98.
    • (2005) Antivir Ther , vol.10
    • Marcelin, A.1    Roquebert, B.2    Malet, I.3
  • 5
    • 33846444021 scopus 로고    scopus 로고
    • HIV Drug Resistance in the United Kingdom: Data to end of 2004
    • Health Protection Agency. CDR Weekly HIV/STIs
    • Health Protection Agency. HIV Drug Resistance in the United Kingdom: data to end of 2004. CDR Weekly 2006;6:HIV/STIs.
    • (2006) , pp. 6
  • 6
    • 33846444975 scopus 로고    scopus 로고
    • Evolution of drug-resistance mutations in antiretroviral-experienced individuals seen between 1999-2005
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 15]
    • Garcia-Leon M, de Mendoza C, Corral A, Gonzales-Lahoz J, Soriano V. Evolution of drug-resistance mutations in antiretroviral-experienced individuals seen between 1999-2005. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 15].
    • (2006)
    • Garcia-Leon, M.1    de Mendoza, C.2    Corral, A.3    Gonzales-Lahoz, J.4    Soriano, V.5
  • 7
    • 33846437514 scopus 로고    scopus 로고
    • Patterns of predicted drug susceptibility and its change over time among 2000 isolates across Europe: The CAPTURE study
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 4]
    • Van de Vijver D, Wensing A, Asjo B, et al. Patterns of predicted drug susceptibility and its change over time among 2000 isolates across Europe: the CAPTURE study. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 4].
    • (2006)
    • Van de Vijver, D.1    Wensing, A.2    Asjo, B.3
  • 8
    • 33846427405 scopus 로고    scopus 로고
    • Characterization of patient-derived HIV-1 isolates containing the L74V or K65R mutations in reverse transcriptase
    • Program and abstracts 44th ICAAC. October 30-November 2, Washington, DC [abstract H-178]
    • McColl D, Parkin N, Miller M. Characterization of patient-derived HIV-1 isolates containing the L74V or K65R mutations in reverse transcriptase. Program and abstracts 44th ICAAC. October 30-November 2, 2004; Washington, DC [abstract H-178].
    • (2004)
    • McColl, D.1    Parkin, N.2    Miller, M.3
  • 9
    • 33744773515 scopus 로고    scopus 로고
    • Evidence of differential selection of HIV-1 variants carrying drug-resistant mutations in seroconverters
    • Corvasce S, Violin M, Romano L, et al. Evidence of differential selection of HIV-1 variants carrying drug-resistant mutations in seroconverters. Antivir Ther 2006;11:329-34.
    • (2006) Antivir Ther , vol.11 , pp. 329-334
    • Corvasce, S.1    Violin, M.2    Romano, L.3
  • 10
    • 33846456280 scopus 로고    scopus 로고
    • The prevalence of antiretroviral drug resistance in patients with low-level detectable viremia while on HAART
    • Booth L, Garcia-Diaz A, Nebbia G, Youle M, Johnson M, Geretti A. The prevalence of antiretroviral drug resistance in patients with low-level detectable viremia while on HAART. Antivir Ther 2006;11:S130.
    • (2006) Antivir Ther , vol.11
    • Booth, L.1    Garcia-Diaz, A.2    Nebbia, G.3    Youle, M.4    Johnson, M.5    Geretti, A.6
  • 11
    • 33846025131 scopus 로고    scopus 로고
    • Epidemiology of antiretroviral drug resistance in drug-naive persons
    • (in press)
    • Geretti A. Epidemiology of antiretroviral drug resistance in drug-naive persons. Curr Opin Infect Dis 2007 (in press).
    • (2007) Curr Opin Infect Dis
    • Geretti, A.1
  • 12
    • 33646812239 scopus 로고    scopus 로고
    • Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1: A decade of experience
    • Shet A, Berry L, Mohri H, et al. Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1: a decade of experience. J Acquir Immune Defic Syndr 2006;41:439-46.
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 439-446
    • Shet, A.1    Berry, L.2    Mohri, H.3
  • 14
    • 33646807828 scopus 로고    scopus 로고
    • Primary HIV drug resistance and efficacy of first-line antiretroviral therapy guided by resistance testing
    • Oette M, Kaiser R, Daumer M, et al. Primary HIV drug resistance and efficacy of first-line antiretroviral therapy guided by resistance testing. J Acquir Immune Defic Syndr 2006;41:573-81.
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 573-581
    • Oette, M.1    Kaiser, R.2    Daumer, M.3
  • 15
    • 33646492045 scopus 로고    scopus 로고
    • Trends in drug-resistance mutations in antiretroviral-naive intravenous drug users of Rio de Janeiro
    • Maia Teixeira S, Bastos F, Hacker M, et al. Trends in drug-resistance mutations in antiretroviral-naive intravenous drug users of Rio de Janeiro. J Med Virol 2006;78:764-9.
    • (2006) J Med Virol , vol.78 , pp. 764-769
    • Maia Teixeira, S.1    Bastos, F.2    Hacker, M.3
  • 16
    • 33645534025 scopus 로고    scopus 로고
    • Evolution of transmitted HIV-1 with drug-resistance mutations in the absence of therapy: Effects on CD4+ T-cell count and HIV-1 RNA load
    • Bezemer D, de Ronde A, Prins M, et al. Evolution of transmitted HIV-1 with drug-resistance mutations in the absence of therapy: effects on CD4+ T-cell count and HIV-1 RNA load. Antivir Ther 2006;11:173-8.
    • (2006) Antivir Ther , vol.11 , pp. 173-178
    • Bezemer, D.1    de Ronde, A.2    Prins, M.3
  • 17
    • 33646017725 scopus 로고    scopus 로고
    • HIV-1 resistant strains acquired at the time of primary infection massively fuel the cellular reservoir and persist for lengthy periods of time
    • Ghosn J, Pellegrin I, Goujard C, et al. HIV-1 resistant strains acquired at the time of primary infection massively fuel the cellular reservoir and persist for lengthy periods of time. AIDS 2006;20:159-70.
    • (2006) AIDS , vol.20 , pp. 159-170
    • Ghosn, J.1    Pellegrin, I.2    Goujard, C.3
  • 18
    • 85018536379 scopus 로고    scopus 로고
    • Efficacy and safety of tenofovir DF (TDF), emtricitabine (FTC) and efavirenz (EFV) compared to fixed dose zidovudine/lamivudine (CBV) and EFV through 96 weeks in antiretroviral treatment-naive patients
    • Program and abstracts XVI International AIDS Conference. August 13-18, Toronto, Canada [abstract TUPE0064]
    • Gallant J, Pozniak A, DeJesus E, et al. Efficacy and safety of tenofovir DF (TDF), emtricitabine (FTC) and efavirenz (EFV) compared to fixed dose zidovudine/lamivudine (CBV) and EFV through 96 weeks in antiretroviral treatment-naive patients. Program and abstracts XVI International AIDS Conference. August 13-18, 2006; Toronto, Canada [abstract TUPE0064].
    • (2006)
    • Gallant, J.1    Pozniak, A.2    DeJesus, E.3
  • 19
    • 33846459672 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of virologic failure through 48 weeks among treatment-naive patients taking tenofovir DF or stavudine in combination with lamivudine and efavirenz
    • Program and abstracts 6th International Congress on Drug Therapy in HIV infection. November 17-21, Glasgow, UK [abstract P205]
    • Miller M, Margot N, McColl D, Tran S, Coakley D, Cheng A. Genotypic and phenotypic characterization of virologic failure through 48 weeks among treatment-naive patients taking tenofovir DF or stavudine in combination with lamivudine and efavirenz. Program and abstracts 6th International Congress on Drug Therapy in HIV infection. November 17-21, 2002; Glasgow, UK [abstract P205].
    • (2002)
    • Miller, M.1    Margot, N.2    McColl, D.3    Tran, S.4    Coakley, D.5    Cheng, A.6
  • 20
    • 33846415121 scopus 로고    scopus 로고
    • Once-daily vs. twice-daily lopinavir/ritonavir in antiretroviral-naive patients: 96-week results
    • Program and abstracts 3rd IAS Conference on HIV Pathogenesis and Treatment, July 24-27, Rio de Janeiro, Brazil [abstract WePe12.3C12]
    • Molina J, Wilkin A, Domingo P, et al. Once-daily vs. twice-daily lopinavir/ritonavir in antiretroviral-naive patients: 96-week results. Program and abstracts 3rd IAS Conference on HIV Pathogenesis and Treatment, July 24-27, 2005; Rio de Janeiro, Brazil [abstract WePe12.3C12].
    • (2005)
    • Molina, J.1    Wilkin, A.2    Domingo, P.3
  • 21
    • 13644264436 scopus 로고    scopus 로고
    • Efficacy and safety of abacavir versus zidovudine in antiretroviral therapy-naive adults with HIV-1 infection (Study CNA30024)
    • Program and abstracts 43rd ICAAC. September 14-17, Chicago, IL [abstract H-446]
    • Dejesus E, Herrera G, Teofilo E, et al. Efficacy and safety of abacavir versus zidovudine in antiretroviral therapy-naive adults with HIV-1 infection (Study CNA30024). Program and abstracts 43rd ICAAC. September 14-17, 2003; Chicago, IL [abstract H-446].
    • (2003)
    • Dejesus, E.1    Herrera, G.2    Teofilo, E.3
  • 22
    • 0344668907 scopus 로고    scopus 로고
    • Abacavir once daily plus lamivudine once daily in combination with efavirenz once daily is well-tolerated and effective in the treatment of antiretroviral therapy naive adults with HIV-1 infection (ZODIAC Study: CNA30021)
    • Program and abstracts 43rd ICAAC. September 14-17, Chicago, IL [abstract H-1722b]
    • Gazzard B, DeJesus E, Cahn P, et al. Abacavir once daily plus lamivudine once daily in combination with efavirenz once daily is well-tolerated and effective in the treatment of antiretroviral therapy naive adults with HIV-1 infection (ZODIAC Study: CNA30021). Program and abstracts 43rd ICAAC. September 14-17, 2003: Chicago, IL [abstract H-1722b].
    • (2003)
    • Gazzard, B.1    DeJesus, E.2    Cahn, P.3
  • 23
    • 1642283134 scopus 로고    scopus 로고
    • GW433908/ritonavir once daily in antiretroviral therapy naive HIV-infected patients: Absence of protease resistance at 48 weeks
    • MacManus S, Yates P, Elston R, White S, Richards N, Snowden W. GW433908/ ritonavir once daily in antiretroviral therapy naive HIV-infected patients: absence of protease resistance at 48 weeks. AIDS 2004;18:651-5.
    • (2004) AIDS , vol.18 , pp. 651-655
    • MacManus, S.1    Yates, P.2    Elston, R.3    White, S.4    Richards, N.5    Snowden, W.6
  • 24
    • 33846461366 scopus 로고    scopus 로고
    • Development of TAM after failure of first ARV treatment in Mexico
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 45]
    • Zurita Macias Valadez L, Rodriguez-Diaz R, Fuentes-Romero L, Andrade-Toscano E, Soto-Ramirez L. Development of TAM after failure of first ARV treatment in Mexico. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 45].
    • (2006)
    • Zurita Macias Valadez, L.1    Rodriguez-Diaz, R.2    Fuentes-Romero, L.3    Andrade-Toscano, E.4    Soto-Ramirez, L.5
  • 25
    • 9144271024 scopus 로고    scopus 로고
    • Incidence of resistance in a double-blind study comparing lopinavir/ ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine
    • Kempf D, King M, Bernstein B, et al. Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine. J Infect Dis 2004;189:51-60.
    • (2004) J Infect Dis , vol.189 , pp. 51-60
    • Kempf, D.1    King, M.2    Bernstein, B.3
  • 26
    • 11144355711 scopus 로고    scopus 로고
    • Long-term safety and durable antiretroviral activity of lopinavir/ ritonavir in treatment-naive patients: 4 year follow-up study
    • Hicks C, King M, Gulick R, White A, et al. Long-term safety and durable antiretroviral activity of lopinavir/ritonavir in treatment-naive patients: 4 year follow-up study. AIDS 2004;18:775-9.
    • (2004) AIDS , vol.18 , pp. 775-779
    • Hicks, C.1    King, M.2    Gulick, R.3    White, A.4
  • 27
    • 33747141841 scopus 로고    scopus 로고
    • Efficacy and safety of atazanavir-based therapy in antiretroviral naive HIV-1 infected subjects, both with and without ritonavir: 48-week results from AI424-089
    • Program and abstracts 13th CROI; February 5-8, Denver, CO [abstract 107LB]
    • Malan N, Krantz E, David N, et al. Efficacy and safety of atazanavir-based therapy in antiretroviral naive HIV-1 infected subjects, both with and without ritonavir: 48-week results from AI424-089. Program and abstracts 13th CROI; February 5-8, 2006; Denver, CO [abstract 107LB].
    • (2006)
    • Malan, N.1    Krantz, E.2    David, N.3
  • 28
    • 33846423570 scopus 로고    scopus 로고
    • Tenofovir drug resistance and mutational pathways associated with the RT mutation K70E in HIV-1
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 94]
    • Van Houtte M, Staes M, Geretti A, Pattery T, Bacheler L. Tenofovir drug resistance and mutational pathways associated with the RT mutation K70E in HIV-1. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 94].
    • (2006)
    • Van Houtte, M.1    Staes, M.2    Geretti, A.3    Pattery, T.4    Bacheler, L.5
  • 29
    • 33846440585 scopus 로고    scopus 로고
    • Identification of a new HIV-1 in vitro mutation to tenofovir and mutation patterns observed to the drug combinations abacavir/tenofovir/ 3TC, abacavir/3TC and tenofovir/FTC
    • Program and abstracts 3rd European HIV Drug Resistance Workshop; March 30-April 1, Athens, Greece [abstract 98]
    • Stone C, Craig C. Identification of a new HIV-1 in vitro mutation to tenofovir and mutation patterns observed to the drug combinations abacavir/tenofovir/3TC, abacavir/3TC and tenofovir/FTC. Program and abstracts 3rd European HIV Drug Resistance Workshop; March 30-April 1, 2005; Athens, Greece [abstract 98].
    • (2005)
    • Stone, C.1    Craig, C.2
  • 30
    • 0037225839 scopus 로고    scopus 로고
    • Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine
    • Murry J, Higgins J, Matthews T, et al. Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine. J Virol 2003;77:1120-30.
    • (2003) J Virol , vol.77 , pp. 1120-1130
    • Murry, J.1    Higgins, J.2    Matthews, T.3
  • 31
    • 18244406016 scopus 로고    scopus 로고
    • Clinically relevant genotype interpretation of resistance to didanosine
    • Marcelin A, Flandre P, Pavie J, et al. Clinically relevant genotype interpretation of resistance to didanosine. Antimicrob Agents Chemother 2005;49:1739-44.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1739-1744
    • Marcelin, A.1    Flandre, P.2    Pavie, J.3
  • 32
    • 33846415507 scopus 로고    scopus 로고
    • K65R, L74V and thymidine analog mutations in HIV-1 RT associated with reduced response to tenofovir DF in ART-experienced patients
    • Program and abstracts 13th CROI; February 5-8, Denver, CO [abstract 633]
    • Waters J, Margot N, McColl D, Zhong L, Miller M. K65R, L74V and thymidine analog mutations in HIV-1 RT associated with reduced response to tenofovir DF in ART-experienced patients. Program and abstracts 13th CROI; February 5-8, 2006; Denver, CO [abstract 633].
    • (2006)
    • Waters, J.1    Margot, N.2    McColl, D.3    Zhong, L.4    Miller, M.5
  • 33
    • 33846444382 scopus 로고    scopus 로고
    • In vitro selection of a novel reverse transcriptase mutation, D67H, by tenofovir/zidovudine in wild-type virus and of D67N/H by TFV alone in a background of thymidine analog mutations
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 98]
    • Stone C, Lanier E, Craig C. In vitro selection of a novel reverse transcriptase mutation, D67H, by tenofovir/zidovudine in wild-type virus and of D67N/H by TFV alone in a background of thymidine analog mutations. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 98].
    • (2006)
    • Stone, C.1    Lanier, E.2    Craig, C.3
  • 34
    • 2942560805 scopus 로고    scopus 로고
    • The impact of the M184V substitution on drug resistance and viral fitness
    • Wainberg M. The impact of the M184V substitution on drug resistance and viral fitness. Expert Rev Anti Infect Ther 2004;2:147-51.
    • (2004) Expert Rev Anti Infect Ther , vol.2 , pp. 147-151
    • Wainberg, M.1
  • 35
    • 0242354002 scopus 로고    scopus 로고
    • Molecular impact of the M184V mutation in HIV-1 reverse transcriptase
    • Diallo K, Gotte M, Weinberg M. Molecular impact of the M184V mutation in HIV-1 reverse transcriptase. Antimicrob Agents Chemother 2003;47:3377-83.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3377-3383
    • Diallo, K.1    Gotte, M.2    Weinberg, M.3
  • 36
    • 33846419838 scopus 로고    scopus 로고
    • The Impact of the M184V substitution in HIV-1 reverse transcriptase on DNA 3′-end and RNA 5′-end-directed ribonuclease H (RNaseH) activity
    • Program and abstracts 13th CROI; February 5-8, Denver, CO [abstract 600]
    • Liang F, Miranda L, Kuritzkes D. The Impact of the M184V substitution in HIV-1 reverse transcriptase on DNA 3′-end and RNA 5′-end-directed ribonuclease H (RNaseH) activity. Program and abstracts 13th CROI; February 5-8, 2006; Denver, CO [abstract 600].
    • (2006)
    • Liang, F.1    Miranda, L.2    Kuritzkes, D.3
  • 38
    • 0030997937 scopus 로고    scopus 로고
    • Randomized trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: The CAESAR trial
    • The CAESAR Trial Study Group
    • The CAESAR Trial Study Group. Randomized trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial. Lancet 1997;349:1413-21.
    • (1997) Lancet , vol.349 , pp. 1413-1421
  • 39
    • 33646682878 scopus 로고    scopus 로고
    • Lamivudine monotherapy in HIV-1-infected patients harboring a lamivudine-resistant virus: A randomized pilot study (E-184V study)
    • Castagna A, Danise A, Menzo S, et al. Lamivudine monotherapy in HIV-1-infected patients harboring a lamivudine-resistant virus: a randomized pilot study (E-184V study). AIDS 2006;20:795-803.
    • (2006) AIDS , vol.20 , pp. 795-803
    • Castagna, A.1    Danise, A.2    Menzo, S.3
  • 40
    • 3042740596 scopus 로고    scopus 로고
    • Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virologic failure to all three antiretroviral-drug classes
    • Ledergerber B, Lundgren J, Walker A, et al. Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virologic failure to all three antiretroviral-drug classes. Lancet 2004;364:51-62.
    • (2004) Lancet , vol.364 , pp. 51-62
    • Ledergerber, B.1    Lundgren, J.2    Walker, A.3
  • 41
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks S, Hoh R, Neilands T, et al. Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J Infect Dis 2005;192:1537-44.
    • (2005) J Infect Dis , vol.192 , pp. 1537-1544
    • Deeks, S.1    Hoh, R.2    Neilands, T.3
  • 42
    • 33846438665 scopus 로고    scopus 로고
    • Interruption of enfuvirtide in patients with enfuvirtide resistance
    • Program and abstracts 12th CROI; February 22-25, Boston, MA [abstract 680]
    • Deeks S, Lu J, Hoh R, et al. Interruption of enfuvirtide in patients with enfuvirtide resistance. Program and abstracts 12th CROI; February 22-25, 2005; Boston, MA [abstract 680].
    • (2005)
    • Deeks, S.1    Lu, J.2    Hoh, R.3
  • 43
    • 33846416565 scopus 로고    scopus 로고
    • The H208Y mutation in reverse transcriptase is significantly associated with NRTI exposure, M184V and TAM mutation pathways
    • Geretti A, Sabin C, Dunn D. The H208Y mutation in reverse transcriptase is significantly associated with NRTI exposure, M184V and TAM mutation pathways. Antivir Ther 2006;11:S158.
    • (2006) Antivir Ther , vol.11
    • Geretti, A.1    Sabin, C.2    Dunn, D.3
  • 44
    • 33845360017 scopus 로고    scopus 로고
    • Differential impact of thymidine analog mutations on emtricitabine and lamivudine susceptibility
    • Ross L, Parkin N, Gerondelis P, et al. Differential impact of thymidine analog mutations on emtricitabine and lamivudine susceptibility. J Acquir Immune Defic Syndr 2006;43:567-70.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 567-570
    • Ross, L.1    Parkin, N.2    Gerondelis, P.3
  • 45
    • 0038033098 scopus 로고    scopus 로고
    • A novel genetic pathway of HIV-1 resistance to stavudine mediated by the K65R mutation
    • Garcia-Lerma J, MacInnes H, Bennett D. A novel genetic pathway of HIV-1 resistance to stavudine mediated by the K65R mutation. J Virol 2003;77:5685-93.
    • (2003) J Virol , vol.77 , pp. 5685-5693
    • Garcia-Lerma, J.1    MacInnes, H.2    Bennett, D.3
  • 46
    • 33646440592 scopus 로고    scopus 로고
    • The K65R mutation in HIV-1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations
    • Parikh U, Bacheler L, Koontz D, Mellors J. The K65R mutation in HIV-1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations. J Virol 2006; 80:4971-7.
    • (2006) J Virol , vol.80 , pp. 4971-4977
    • Parikh, U.1    Bacheler, L.2    Koontz, D.3    Mellors, J.4
  • 47
    • 33645500469 scopus 로고    scopus 로고
    • The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations
    • White K, Chen J, Feng J, et al. The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations. Antivir Ther 2006;11:155-63.
    • (2006) Antivir Ther , vol.11 , pp. 155-163
    • White, K.1    Chen, J.2    Feng, J.3
  • 48
    • 27544431950 scopus 로고    scopus 로고
    • A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT
    • White K, Margot N, Ly J, et al. A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. AIDS 2005;19:1751-60.
    • (2005) AIDS , vol.19 , pp. 1751-1760
    • White, K.1    Margot, N.2    Ly, J.3
  • 49
    • 33846448538 scopus 로고    scopus 로고
    • Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of the K65R mutation
    • Program and abstracts 13th CROI; February 5-8, Denver, CO [abstract 635]
    • Staszewski S, Dauer B, Locher L, Moesch M, Gute P, Stuermer M. Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of the K65R mutation. Program and abstracts 13th CROI; February 5-8, 2006; Denver, CO [abstract 635].
    • (2006)
    • Staszewski, S.1    Dauer, B.2    Locher, L.3    Moesch, M.4    Gute, P.5    Stuermer, M.6
  • 50
    • 33745450105 scopus 로고    scopus 로고
    • Virologic response to a triple nucleoside/nucleotide analog regimen over 48 weeks in HIV-1-infected adults in Africa
    • DART Virology Group and Trial Team
    • DART Virology Group and Trial Team. Virologic response to a triple nucleoside/nucleotide analog regimen over 48 weeks in HIV-1-infected adults in Africa. AIDS 2006;20:1391-9.
    • (2006) AIDS , vol.20 , pp. 1391-1399
  • 51
    • 21444443785 scopus 로고    scopus 로고
    • Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in HIV-1 reverse transcriptase
    • Frankel F, Marchand B, Turner D, Gotte M, Wainberg M. Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in HIV-1 reverse transcriptase. Antimicrob Agents Chemother 2005;49:2657-64.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2657-2664
    • Frankel, F.1    Marchand, B.2    Turner, D.3    Gotte, M.4    Wainberg, M.5
  • 52
    • 21444452131 scopus 로고    scopus 로고
    • The L74V mutation in HIV-1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations
    • Miranda L, Gotte M, Liang F, Kuritzkes D. The L74V mutation in HIV-1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations. Antimicrob Agents Chemother 2005;49: 2648-56.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2648-2656
    • Miranda, L.1    Gotte, M.2    Liang, F.3    Kuritzkes, D.4
  • 53
    • 33745602528 scopus 로고    scopus 로고
    • Risk factors for selection of the L74I reverse transcriptase mutation in HIV-1-infected patients
    • Wirden M, Roquebert B, Derache A, et al. Risk factors for selection of the L74I reverse transcriptase mutation in HIV-1-infected patients. Antimicrob Agents Chemother 2006;50:2553-6.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2553-2556
    • Wirden, M.1    Roquebert, B.2    Derache, A.3
  • 54
    • 33846410324 scopus 로고    scopus 로고
    • [accessed 03/12/ ]
    • http://www.vircolab.com/bgdisplay.jhtml?itemname= vircotype_ccoffs&product=vircotype [accessed 03/ 12/2006].
    • (2006)
  • 55
    • 33846409515 scopus 로고    scopus 로고
    • [accessed 03/12/ ]
    • http://www.monogramhiv.com/assays/hcp/phenoGTReport.aspx [accessed 03/12/ 2006].
    • (2006)
  • 56
    • 33846454394 scopus 로고    scopus 로고
    • Cross-resistance of Clinical Samples with K65R, L74V, and M184V Mutations
    • Program and abstracts 12th CROI; February 22-25, Boston, MA [abstract 714]
    • Underwood M, St Clair M, Ross L, Gerondelis P, Parkin N, Lanier R. Cross-resistance of Clinical Samples with K65R, L74V, and M184V Mutations. Program and abstracts 12th CROI; February 22-25, 2005; Boston, MA [abstract 714].
    • (2005)
    • Underwood, M.1    St Clair, M.2    Ross, L.3    Gerondelis, P.4    Parkin, N.5    Lanier, R.6
  • 57
    • 10744228522 scopus 로고    scopus 로고
    • Risk of failure of patients with 215 HIV-1 revertants starting their first thymidine analog-containing HAART
    • Violin M, Cozzi-Lepri A, Velleca R, et al. Risk of failure of patients with 215 HIV-1 revertants starting their first thymidine analog-containing HAART. AIDS 2004;18:227-35.
    • (2004) AIDS , vol.18 , pp. 227-235
    • Violin, M.1    Cozzi-Lepri, A.2    Velleca, R.3
  • 58
    • 3042856914 scopus 로고    scopus 로고
    • Genotypic determinants of the virologic response to tenofovir disoproxil fumarate in NRTI-experienced patients
    • Masquelier B, Tamalet C, Montes B, et al. Genotypic determinants of the virologic response to tenofovir disoproxil fumarate in NRTI-experienced patients. Antivir Ther 2004;9:315-23.
    • (2004) Antivir Ther , vol.9 , pp. 315-323
    • Masquelier, B.1    Tamalet, C.2    Montes, B.3
  • 59
    • 33846410323 scopus 로고    scopus 로고
    • Effect of L74V or M184V, with multiple thymidine analog-associated mutations, on reverse transcriptase inhibitor phenotypic sensitivity
    • Program and abstracts 12th CROI; February 22-25, Boston, MA [abstract 703]
    • Trivedi V, Han X, Montes-Walters M, Filizzola M, Ferguson M, O'Brien W. Effect of L74V or M184V, with multiple thymidine analog-associated mutations, on reverse transcriptase inhibitor phenotypic sensitivity. Program and abstracts 12th CROI; February 22-25, 2005; Boston, MA [abstract 703].
    • (2005)
    • Trivedi, V.1    Han, X.2    Montes-Walters, M.3    Filizzola, M.4    Ferguson, M.5    O'Brien, W.6
  • 60
    • 33846452579 scopus 로고    scopus 로고
    • Allele-specific PCR shows low-level K65R in treatment experienced patients with L74V in the absence of TAM
    • Svarovoskaia E, Margot N, Bae A, Waters J, Borroto-Esoda K, Miller M. Allele-specific PCR shows low-level K65R in treatment experienced patients with L74V in the absence of TAM. Antivir Ther 2006;11:S80.
    • (2006) Antivir Ther , vol.11
    • Svarovoskaia, E.1    Margot, N.2    Bae, A.3    Waters, J.4    Borroto-Esoda, K.5    Miller, M.6
  • 61
    • 33846440938 scopus 로고    scopus 로고
    • Rare selection of the K65R mutation in antiretroviral-naive patients failing a first-line abacavir/lamivudine containing HAART regimen
    • Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, Monte Carlo, Monaco [abstract 64]
    • Descamps D, Delarue S, Ait-Khaled M, Craig C, Collin G, Brun-Vézinet F. Rare selection of the K65R mutation in antiretroviral-naive patients failing a first-line abacavir/lamivudine containing HAART regimen. Program and abstracts 4th European HIV Drug Resistance Workshop; March 29-31, 2006; Monte Carlo, Monaco [abstract 64].
    • (2006)
    • Descamps, D.1    Delarue, S.2    Ait-Khaled, M.3    Craig, C.4    Collin, G.5    Brun-Vézinet, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.