In vitro life cycle of pentamidine-resistant amastigotes: Stability of the chemoresistant phenotypes is dependent on the level of resistance induced

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 9, 1997, Pages 1898-1903

  Sereno, Denis ^a   Lemesre, Jean Loup ^a  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ARSENITE SODIUM; CALCIUM CHANNEL BLOCKING AGENT; DIMINAZENE ACETURATE; PENTAMIDINE ISETHIONATE; PRIMAQUINE; VERAPAMIL;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CLONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG RESISTANCE; IN VITRO STUDY; LEISHMANIA MEXICANA; LIFE CYCLE; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0030881960     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.9.1898     Document Type: Article

References (32)

1. Basselin, M., F. Lawrence, and M. Robert-Gero. 1996. Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes. Biochem. J. 315:631-634.
2. Bates, P. A., C. D. Robertson, L. Tetley, and G. H. Coombs. 1992. Cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology 105:193-202.
3. Bates, P. A. 1993. Axenic culture of Leishmania amastigotes. Parasitol. Today 9:143-146.
4. Bates, P. A. 1992. Complete developmental cycle of Leishmania mexicana in axenic culture. Parasitology 108:1-9.
5. Berman, J. D., J. V. Gallalee, and B. D. Hansen. 1987. Leishmania mexicana uptake of sodium stibogluconate (pentostam) and pentamidine by parasite and macrophage. Exp. Parasitol. 64:127-131.
6. Bitonti, A. J., A. Sjoersdma, P. P. McCann, D. E. Kyle, A. M. J. Oduola, R. N. Rossan, W. K. Milhous, and D. E. Davidson. 1988. Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. Science 242:1301-1303.
7. Bronner, U., F. Doua, O. Eericsson, L. L. Gustafsson, T. W. Miezan, M. Rais, and L. Rombo. 1991. Pentamidine concentrations in plasma, whole blood and cerebrospinal fluid during treatment of Trypanosoma gambiense infection in Côte d'Ivoire. Trans. R. Soc. Trop. Med. Hyg. 85:608-611.
8. Coombs, G. H., J. A. Craft, and D. T. Hart. 1982. A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations. Mol. Biochem. Parasitol. 5:199-211.
9. Coombs, G. H., L. Tetley, V. A. Moss, and K. Vickerman. 1986. Three-dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial sections. Parasitology 92:13-23.
10. Coons, T., S. Hanson, A. J. Bitonti, P. P. McCann, and B. Ullman. 1990. Difluoromethyl ornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity. Mol. Biochem. Parasitol. 39:77-90.
11. Endicott, J. A., and V. Ling. 1989. The hiochemistry of P-glycoprotein mediated multidrug resistance. Annu. Rev. Microbiol. 58:137-171.
12. Flintoff, W. F., and K. Essani. 1980. Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate. Biochemistry 19:4321-4327.
13. Grögl, M., T. N. Thomason, and E. Franke. 1992. Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease. Am. J. Trop. Med. Hyg. 47:117-126.
14. Hart, D. T., K. Vickerman, and G. H. Coombs. 1981. Transformation in vitro at Leishmania mexicana amastigotes to promastigotes: nutritional requirements and the effect of drugs. Parasitology 83:529-543.
15. Hassan, H. F., and G. H. Coombs. 1985. Leishmania mexicana, purine metabolizing enzymes of amastigotes and promastigotes. Exp. Parasitol. 59:15-28.
16. Hills, M., C. Hudson, and P. G. Smith. 1986. Global monitoring of the resistance of malarial parasites to drugs: statistical treatment of micro-test data. Working paper 2.8.5. Informal consultation on the epidemiology of drug resistance of malaria parasites. Geneva, Switzerland.
17. Jackson, J. E., J. D. Tally, and D. B. Tang. 1989. An in vitro micromethod for drug sensitivity testing of Leishmania. Am. J. Trop. Med. Hyg. 41:318-330.
18. Jackson, J. E., J. D. Tally, W. Y. Ellis, Y. B. Mebrahtu, P. G. Lawyer, J. B. Were, S. G. Reed, D. M. Panisko, and B. L. Limmer. 1990. Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania spp. from patients unresponsive to pentavalent antimony therapy. Am. J. Trop. Med. Hyg. 43:464-480.
19. Jha, S. N., N. K. P. Singh, and T. K. Jha. 1992. Changing response to diamidine compounds in cases of kala-azar unresponsive to antimonials. J. Assoc. Physicians India 46:296-306.
20. Kweider, M. K., J. L. Lemesre, F. Santoro, J. P. Kusnierz, M. Sadigursky, and A. Capron. 1989. Development of metacyclic Leishmania promastigotes is associated with the increasing expression of GP65, the major surface antigen. Parasite Immunol. 11:197-209.
21. Lemesre, J. L., D. Sereno, S. Daulouede, B. Veyret, N. Brajon, and P. Vincendeau. 1997. Leishmania spp: nitric oxide-mediated metabolic inhibition of promastigote and axenically-grown amastigote forms. Exp. Parasitol. 86:58-68.
22. Lemesre, J. L. May 1994. French patent pCT/FR 94/00577.
23. Ouellette, M., and B. Papadopoulou. 1993. Mechanisms of drug resistance in Leishmania. Parasitol. Today 9:150-153.
24. Pan, A. A., and S. C. Pan. 1986. Leishmania mexicana: comparative fine structure of amastigotes and promastigotes in vitro and in vivo. Exp. Parasitol. 62:254-265.
25. Peters, B. S., D. Fish, R. Golden, D. A. Evans, A. D. M. Bryceson, and A. J. Pinching. 1990. Visceral leishmaniasis in HIV infection and AIDS: clinical feature and response to therapy. Q. J. Med. 77:1101-1111.
26. Rainey, P. M., T. W. Spithill, D. McMahon-Pratt, and A. A. Pan. 1991. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. Mol. Biochem. Parasitol. 49:111-118.
27. Safa, A. R. C., J. L. Glover, M. B. Sewell, M. B. Meyers, J. L. Biedler, and R. L. Felsted. 1987. Identification of the multidrug resistance related membrane glycoprotein as an acceptor for calcium channel blockers. J. Biol. Chem. 262:7884-7888.
28. Sereno, D., and J. L. Lemesre. 1997. Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents. Antimicrob. Agents Chemother. 41:972-976.
29. Sereno, D., and J. L. Lemesre. 1997. Use of an enzymatic micromethod to quantify amastigote stage of Leishmania amazonensis in vitro. Parasitol. Res. 83:401-403.
30. Sundar, S., B. B. Thakur, A. K. Tandon, N. R. Agrawal, C. P. Mishra, T. M. Mahapatra, and V. P. Singh. 1994. Clinicoepidemiological study of drug resistance in Indian kala-azar. Br. Med. J. 308:307.
31. Ullman, B. 1995. Multidrug resistance and P-glycoproteins in parasitic protozoa. J. Bioenerg. Biomembr. 27:77-84.
32. Waalkes, T. P., and V. T. Devita. 1970. The determination of pentamidine (4-4′-diaminodinophenoxypentane) in plasma, urine and tissues. J. Lab. Clin. Med. 75:871-878.